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Protein

Tubulin beta chain

Gene

TUBB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196230.12.
HGNCiHGNC:20778. TUBB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196230.

PTM / Processingi

Proteomic databases

EPDiQ5ST81.
MaxQBiQ5ST81.

Expressioni

Gene expression databases

BgeeiENSG00000196230.
ExpressionAtlasiQ5ST81. baseline and differential.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Structurei

3D structure databases

SMRiQ5ST81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TubulinInterPro annotationAdd BLAST172
Domaini174 – 311Tubulin_CInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili336 – 363Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119061.
HOVERGENiHBG000089.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ST81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVRSGPFG QIFRPDNFVF GQSGAGNNWA KGHYTEGAEL VDSVLDVVRK
60 70 80 90 100
EAESCDCLQG FQLTHSLGGG TGSGMGTLLI SKIREEYPDR IMNTFSVVPS
110 120 130 140 150
PKVSDTVVEP YNATLSVHQL VENTDETYCI DNEALYDICF RTLKLTTPTY
160 170 180 190 200
GDLNHLVSAT MSGVTTCLRF PGQLNADLRK LAVNMVPFPR LHFFMPGFAP
210 220 230 240 250
LTSRGSQQYR ALTVPELTQQ VFDAKNMMAA CDPRHGRYLT VAAVFRGRMS
260 270 280 290 300
MKEVDEQMLN VQNKNSSYFV EWIPNNVKTA VCDIPPRGLK MAVTFIGNST
310 320 330 340 350
AIQELFKRIS EQFTAMFRRK AFLHWYTGEG MDEMEFTEAE SNMNDLVSEY
360 370
QQYQDATAEE EEDFGEEAEE EA
Length:372
Mass (Da):41,742
Last modified:December 21, 2004 - v1
Checksum:i1C31F252FFD2B86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA. No translation available.
AL662848 Genomic DNA. No translation available.
AL845353 Genomic DNA. No translation available.
BX248307 Genomic DNA. No translation available.
BX927283 Genomic DNA. No translation available.
CR759873 Genomic DNA. No translation available.
CR788240 Genomic DNA. No translation available.
CR936878 Genomic DNA. No translation available.
RefSeqiNP_001280144.1. NM_001293215.1.
NP_001280145.1. NM_001293216.1.
UniGeneiHs.636480.

Genome annotation databases

EnsembliENST00000330914; ENSP00000365578; ENSG00000196230.
ENST00000396384; ENSP00000379668; ENSG00000196230.
ENST00000400530; ENSP00000383374; ENSG00000183311.
ENST00000400531; ENSP00000383375; ENSG00000183311.
ENST00000413547; ENSP00000414479; ENSG00000224156.
ENST00000420618; ENSP00000392914; ENSG00000232421.
ENST00000425102; ENSP00000394841; ENSG00000232575.
ENST00000427480; ENSP00000407673; ENSG00000232421.
ENST00000435546; ENSP00000399046; ENSG00000227739.
ENST00000436335; ENSP00000416480; ENSG00000235067.
ENST00000437490; ENSP00000391515; ENSG00000232575.
ENST00000444441; ENSP00000393340; ENSG00000235067.
ENST00000446385; ENSP00000395838; ENSG00000229684.
ENST00000453350; ENSP00000406981; ENSG00000227739.
ENST00000454454; ENSP00000403213; ENSG00000229684.
ENST00000454620; ENSP00000394124; ENSG00000224156.
GeneIDi203068.
UCSCiuc011dmq.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ5ST81_HUMAN
AccessioniPrimary (citable) accession number: Q5ST81
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported