Q5ST30 (SYVM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Valine--tRNA ligase, mitochondrial
EC=6.1.1.9

Alternative name(s):
Valyl-tRNA synthetase
Short name=ValRS
Valyl-tRNA synthetase-like

Gene names

Name:	VARS2
Synonyms:	KIAA1885, VARS2L, VARSL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1063 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.
Sequence caution	The sequence BAB15191.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB67778.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAD92716.1 differs from that shown. Reason: The sequence differs from that shown because it seems to be derived from a pre-mRNA. The sequence CAM24842.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM25404.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ06763.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ09774.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ10925.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translational fidelity Inferred from electronic annotation. Source: GOC tRNA aminoacylation for protein translation Traceable author statement. Source: Reactome valyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aminoacyl-tRNA editing activity Inferred from electronic annotation. Source: InterPro valine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5ST30-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5ST30-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-644: MPHLPLASFR...QLTGQLPFSK → MVFFCPVPLF...PPLLTPPCPQ

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5ST30-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5ST30-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGGKAWPRRAVGTAGGPCAEQISAPFQTLLM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 26	26	Mitochondrion Potential
	Chain	27 – 1063	1037	Valine--tRNA ligase, mitochondrial		PRO_0000338000
Regions
	Motif	146 – 156	11	"HIGH" region
	Motif	658 – 662	5	"KMSKS" region
Sites
	Binding site	661	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 644	644	MPHLP…LPFSK → MVFFCPVPLFCPGLAPRDPR PCSFLPPVTFGNGQRPSAVL GGPHGHVGDPAHRAAALQQV WRPEIPRHLQGNPPLLTPPC PQ in isoform 2.		VSP_034032
	Alternative sequence	1 – 140	140	Missing in isoform 3.		VSP_045483
	Alternative sequence	1	1	M → MGGKAWPRRAVGTAGGPCAE QISAPFQTLLM in isoform 4.		VSP_046102
	Natural variant	26	1	H → Y. Corresponds to variant rs6926224 [ dbSNP | Ensembl ].		VAR_052651
	Natural variant	64	1	G → R. Corresponds to variant rs6926723 [ dbSNP | Ensembl ].		VAR_043730
	Natural variant	449	1	W → R. Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs2249464 [ dbSNP | Ensembl ].		VAR_043731
	Natural variant	680	1	V → L. Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs2074506 [ dbSNP | Ensembl ].		VAR_043732
	Natural variant	765	1	V → M. Corresponds to variant rs55865499 [ dbSNP | Ensembl ].		VAR_061910
	Natural variant	917	1	R → Q. Ref.2 Ref.4 Ref.5 Corresponds to variant rs9394021 [ dbSNP | Ensembl ].		VAR_043733
	Natural variant	965	1	A → T. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Corresponds to variant rs2252863 [ dbSNP | Ensembl ].		VAR_043734
	Natural variant	1049	1	R → Q. Ref.1 Ref.4 Ref.5 Corresponds to variant rs4678 [ dbSNP | Ensembl ].		VAR_043735
Experimental info
	Sequence conflict	25	1	F → S in BAG65557. Ref.2
	Sequence conflict	156	1	H → R in BAG57195. Ref.2
	Sequence conflict	985	1	E → G in BAB15191. Ref.2
	Sequence conflict	1060	1	S → G in BAG65557. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 0212C6361A87DF8B	FASTA	1,063	118,490
	10 20 30 40 50 60 MPHLPLASFR PPFWGLRHSR GLPRFHSVST QSEPHGSPIS RRNREAKQKR LREKQATLEA 70 80 90 100 110 120 EIAGESKSPA ESIKAWRPKE LVLYEIPTKP GEKKDVSGPL PPAYSPRYVE AAWYPWWVRE 130 140 150 160 170 180 GFFKPEYQAR LPQATGETFS MCIPPPNVTG SLHIGHALTV AIQDALVRWH RMRGDQVLWV 190 200 210 220 230 240 PGSDHAGIAT QAVVEKQLWK ERGVRRHELS REAFLREVWQ WKEAKGGEIC EQLRALGASL 250 260 270 280 290 300 DWDRECFTMD VGSSVAVTEA FVRLYKAGLL YRNHQLVNWS CALRSAISDI EVENRPLPGH 310 320 330 340 350 360 TQLRLPGCPT PVSFGLLFSV AFPVDGEPDA EVVVGTTRPE TLPGDVAVAV HPDDSRYTHL 370 380 390 400 410 420 HGRQLRHPLM GQPLPLITDY AVQPHVGTGA VKVTPAHSPA DAEMGARHGL SPLNVIAEDG 430 440 450 460 470 480 TMTSLCGDWL QGLHRFVARE KIMSVLSEWG LFRGLQNHPM VLPICSRSGD VIEYLLKNQW 490 500 510 520 530 540 FVRCQEMGAR AAKAVESGAL ELSPSFHQKN WQHWFSHIGD WCVSRQLWWG HQIPAYLVVE 550 560 570 580 590 600 DHAQGEEDCW VVGRSEAEAR EVAAELTGRP GAELTLERDP DVLDTWFSSA LFPFSALGWP 610 620 630 640 650 660 QETPDLARFY PLSLLETGSD LLLFWVGRMV MLGTQLTGQL PFSKVLLHPM VRDRQGRKMS 670 680 690 700 710 720 KSLGNVLDPR DIISGVEMQV LQEKLRSGNL DPAELAIVAA AQKKDFPHGI PECGTDALRF 730 740 750 760 770 780 TLCSHGVQAG DLHLSVSEVQ SCRHFCNKIW NALRFILNAL GEKFVPQPAE ELSPSSPMDA 790 800 810 820 830 840 WILSRLALAA QECERGFLTR ELSLVTHALH HFWLHNLCDV YLEAVKPVLW HSPRPLGPPQ 850 860 870 880 890 900 VLFSCADLGL RLLAPLMPFL AEELWQRLPP RPGCPPAPSI SVAPYPSACS LEHWRQPELE 910 920 930 940 950 960 RRFSRVQEVV QVLRALRATY QLTKARPRVL LQSSEPGDQG LFEAFLEPLG TLGYCGAVGL 970 980 990 1000 1010 1020 LPPGAAAPSG WAQAPLSDTA QVYMELQGLV DPQIQLPLLA ARRYKLQKQL DSLTARTPSE 1030 1040 1050 1060 GEAGTQRQQK LSSLQLELSK LDKAASHLRQ LMDEPPAPGS PEL
	Isoform 2 [UniParc]. Checksum: 6F274961A95460AF	FASTA	501	55,078
	10 20 30 40 50 60 MVFFCPVPLF CPGLAPRDPR PCSFLPPVTF GNGQRPSAVL GGPHGHVGDP AHRAAALQQV 70 80 90 100 110 120 WRPEIPRHLQ GNPPLLTPPC PQVLLHPMVR DRQGRKMSKS LGNVLDPRDI ISGVEMQVLQ 130 140 150 160 170 180 EKLRSGNLDP AELAIVAAAQ KKDFPHGIPE CGTDALRFTL CSHGVQAGDL HLSVSEVQSC 190 200 210 220 230 240 RHFCNKIWNA LRFILNALGE KFVPQPAEEL SPSSPMDAWI LSRLALAAQE CERGFLTREL 250 260 270 280 290 300 SLVTHALHHF WLHNLCDVYL EAVKPVLWHS PRPLGPPQVL FSCADLGLRL LAPLMPFLAE 310 320 330 340 350 360 ELWQRLPPRP GCPPAPSISV APYPSACSLE HWRQPELERR FSRVQEVVQV LRALRATYQL 370 380 390 400 410 420 TKARPRVLLQ SSEPGDQGLF EAFLEPLGTL GYCGAVGLLP PGAAAPSGWA QAPLSDTAQV 430 440 450 460 470 480 YMELQGLVDP QIQLPLLAAR RYKLQKQLDS LTARTPSEGE AGTQRQQKLS SLQLELSKLD 490 500 KAASHLRQLM DEPPAPGSPE L
	Isoform 3 [UniParc]. Checksum: 2949E6A77692F99D	FASTA	923	102,416
	10 20 30 40 50 60 MCIPPPNVTG SLHIGHALTV AIQDALVRWH RMRGDQVLWV PGSDHAGIAT QAVVEKQLWK 70 80 90 100 110 120 ERGVRRHELS REAFLREVWQ WKEAKGGEIC EQLRALGASL DWDRECFTMD VGSSVAVTEA 130 140 150 160 170 180 FVRLYKAGLL YRNHQLVNWS CALRSAISDI EVENRPLPGH TQLRLPGCPT PVSFGLLFSV 190 200 210 220 230 240 AFPVDGEPDA EVVVGTTRPE TLPGDVAVAV HPDDSRYTHL HGRQLRHPLM GQPLPLITDY 250 260 270 280 290 300 AVQPHVGTGA VKVTPAHSPA DAEMGARHGL SPLNVIAEDG TMTSLCGDWL QGLHRFVARE 310 320 330 340 350 360 KIMSVLSEWG LFRGLQNHPM VLPICSRSGD VIEYLLKNQW FVRCQEMGAR AAKAVESGAL 370 380 390 400 410 420 ELSPSFHQKN WQHWFSHIGD WCVSRQLWWG HQIPAYLVVE DHAQGEEDCW VVGRSEAEAR 430 440 450 460 470 480 EVAAELTGRP GAELTLERDP DVLDTWFSSA LFPFSALGWP QETPDLARFY PLSLLETGSD 490 500 510 520 530 540 LLLFWVGRMV MLGTQLTGQL PFSKVLLHPM VRDRQGRKMS KSLGNVLDPR DIISGVEMQV 550 560 570 580 590 600 LQEKLRSGNL DPAELAIVAA AQKKDFPHGI PECGTDALRF TLCSHGVQAG DLHLSVSEVQ 610 620 630 640 650 660 SCRHFCNKIW NALRFILNAL GEKFVPQPAE ELSPSSPMDA WILSRLALAA QECERGFLTR 670 680 690 700 710 720 ELSLVTHALH HFWLHNLCDV YLEAVKPVLW HSPRPLGPPQ VLFSCADLGL RLLAPLMPFL 730 740 750 760 770 780 AEELWQRLPP RPGCPPAPSI SVAPYPSACS LEHWRQPELE RRFSRVQEVV QVLRALRATY 790 800 810 820 830 840 QLTKARPRVL LQSSEPGDQG LFEAFLEPLG TLGYCGAVGL LPPGAAAPSG WAQAPLSDTA 850 860 870 880 890 900 QVYMELQGLV DPQIQLPLLA ARRYKLQKQL DSLTARTPSE GEAGTQRQQK LSSLQLELSK 910 920 LDKAASHLRQ LMDEPPAPGS PEL
	Isoform 4 [UniParc]. Checksum: 6CE3ECF0345D3D78	FASTA	1,093	121,543
	10 20 30 40 50 60 MGGKAWPRRA VGTAGGPCAE QISAPFQTLL MPHLPLASFR PPFWGLRHSR GLPRFHSVST 70 80 90 100 110 120 QSEPHGSPIS RRNREAKQKR LREKQATLEA EIAGESKSPA ESIKAWRPKE LVLYEIPTKP 130 140 150 160 170 180 GEKKDVSGPL PPAYSPRYVE AAWYPWWVRE GFFKPEYQAR LPQATGETFS MCIPPPNVTG 190 200 210 220 230 240 SLHIGHALTV AIQDALVRWH RMRGDQVLWV PGSDHAGIAT QAVVEKQLWK ERGVRRHELS 250 260 270 280 290 300 REAFLREVWQ WKEAKGGEIC EQLRALGASL DWDRECFTMD VGSSVAVTEA FVRLYKAGLL 310 320 330 340 350 360 YRNHQLVNWS CALRSAISDI EVENRPLPGH TQLRLPGCPT PVSFGLLFSV AFPVDGEPDA 370 380 390 400 410 420 EVVVGTTRPE TLPGDVAVAV HPDDSRYTHL HGRQLRHPLM GQPLPLITDY AVQPHVGTGA 430 440 450 460 470 480 VKVTPAHSPA DAEMGARHGL SPLNVIAEDG TMTSLCGDWL QGLHRFVARE KIMSVLSEWG 490 500 510 520 530 540 LFRGLQNHPM VLPICSRSGD VIEYLLKNQW FVRCQEMGAR AAKAVESGAL ELSPSFHQKN 550 560 570 580 590 600 WQHWFSHIGD WCVSRQLWWG HQIPAYLVVE DHAQGEEDCW VVGRSEAEAR EVAAELTGRP 610 620 630 640 650 660 GAELTLERDP DVLDTWFSSA LFPFSALGWP QETPDLARFY PLSLLETGSD LLLFWVGRMV 670 680 690 700 710 720 MLGTQLTGQL PFSKVLLHPM VRDRQGRKMS KSLGNVLDPR DIISGVEMQV LQEKLRSGNL 730 740 750 760 770 780 DPAELAIVAA AQKKDFPHGI PECGTDALRF TLCSHGVQAG DLHLSVSEVQ SCRHFCNKIW 790 800 810 820 830 840 NALRFILNAL GEKFVPQPAE ELSPSSPMDA WILSRLALAA QECERGFLTR ELSLVTHALH 850 860 870 880 890 900 HFWLHNLCDV YLEAVKPVLW HSPRPLGPPQ VLFSCADLGL RLLAPLMPFL AEELWQRLPP 910 920 930 940 950 960 RPGCPPAPSI SVAPYPSACS LEHWRQPELE RRFSRVQEVV QVLRALRATY QLTKARPRVL 970 980 990 1000 1010 1020 LQSSEPGDQG LFEAFLEPLG TLGYCGAVGL LPPGAAAPSG WAQAPLSDTA QVYMELQGLV 1030 1040 1050 1060 1070 1080 DPQIQLPLLA ARRYKLQKQL DSLTARTPSE GEAGTQRQQK LSSLQLELSK LDKAASHLRQ 1090 LMDEPPAPGS PEL

References

[1]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-1049. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-1063 (ISOFORM 1), VARIANTS ARG-449; LEU-680; GLN-917 AND THR-965. Tissue: Cerebellum, Thalamus and Uterus.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-449; LEU-680 AND THR-965. Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ARG-449; LEU-680; GLN-917; THR-965 AND GLN-1049.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-449; LEU-680; GLN-917; THR-965 AND GLN-1049. Tissue: Brain, Eye and Skin.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 748-1063 (ISOFORM 1), VARIANT THR-965. Tissue: Testis.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB067472 mRNA. Translation: BAB67778.1. Different initiation. AK025618 mRNA. Translation: BAB15191.1. Different initiation. AK125069 mRNA. No translation available. AK293780 mRNA. Translation: BAG57195.1. AK304807 mRNA. Translation: BAG65557.1. AB209479 Transcribed RNA. Translation: BAD92716.1. Sequence problems. AL662854 Genomic DNA. Translation: CAI17437.1. AL662854 Genomic DNA. Translation: CAM24842.1. Sequence problems. AL669830 Genomic DNA. Translation: CAI18004.1. AL669830 Genomic DNA. Translation: CAM25404.1. Sequence problems. AL773541 Genomic DNA. Translation: CAI18453.1. BX927194 Genomic DNA. Translation: CAQ09774.1. Sequence problems. BX927194 Genomic DNA. Translation: CAQ09775.1. CR759747 Genomic DNA. Translation: CAQ06763.1. Sequence problems. CR759747 Genomic DNA. Translation: CAQ06764.1. CR936875 Genomic DNA. Translation: CAQ10925.1. Sequence problems. CR936875 Genomic DNA. Translation: CAQ10926.1. BC008844 mRNA. Translation: AAH08844.2. BC009355 mRNA. Translation: AAH09355.2. BC073838 mRNA. Translation: AAH73838.1. BC112054 mRNA. Translation: AAI12055.1. BC113605 mRNA. Translation: AAI13606.1. AL122037 mRNA. Translation: CAB59177.1.
IPI	IPI00644468. IPI00873561. IPI00895822. IPI00965955.
RefSeq	NP_001161205.1. NM_001167733.1. NP_001161206.1. NM_001167734.1. NP_065175.4. NM_020442.4.
UniGene	Hs.597526.
3D structure databases
HSSP	HSSP built from PDB template 1WKA based on UniProtKB P96142.
ProteinModelPortal	Q5ST30.
SMR	Q5ST30. Positions 100-945.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5ST30. 1 interaction.
STRING	9606.ENSP00000408337.
PTM databases
PhosphoSite	Q5ST30.
Polymorphism databases
DMDM	296452917.
Proteomic databases
PaxDb	Q5ST30.
PRIDE	Q5ST30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321897; ENSP00000316092; ENSG00000137411. ENST00000416670; ENSP00000394802; ENSG00000137411. ENST00000541562; ENSP00000441000; ENSG00000137411. ENST00000542001; ENSP00000438200; ENSG00000137411.
GeneID	57176.
KEGG	hsa:57176.
UCSC	uc003nsc.2. human. uc010jsg.2. human.
Organism-specific databases
CTD	57176.
GeneCards	GC06P030876.
H-InvDB	HIX0166334. HIX0166693. HIX0200924.
HGNC	HGNC:21642. VARS2.
MIM	612802. gene.
neXtProt	NX_Q5ST30.
PharmGKB	PA164742816.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0525.
HOVERGEN	HBG017878.
InParanoid	Q5ST30.
KO	K01873.
OrthoDB	EOG4W9J34.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q5ST30.
Bgee	Q5ST30.
CleanEx	HS_VARS2.
Genevestigator	Q5ST30.
Family and domain databases
Gene3D	3.40.50.620. 3 hits. 3.90.740.10. 1 hit.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. IPR013155. V/L/I-tRNA-synth_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. IPR002303. Valyl-tRNA_ligase. [Graphical view]
PANTHER	PTHR11946:SF5. PTHR11946:SF5. 1 hit.
Pfam	PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 1 hit. [Graphical view]
PRINTS	PR00986. TRNASYNTHVAL.
SUPFAM	SSF47323. tRNAsyn_1a_bind. 1 hit. SSF50677. ValRS_IleRS_edit. 1 hit.
TIGRFAMs	TIGR00422. valS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VARS2. human.
GenomeRNAi	57176.
NextBio	63203.
SOURCE	Search...

Entry information

Entry name

SYVM_HUMAN

Accession

Primary (citable) accession number: Q5ST30
Secondary accession number(s): A2ABL7 , B4DET4, B4E3P5, F5GXJ0, F5H323, Q2M2A0, Q59FI1, Q5SQ96, Q5SS98, Q6DKJ5, Q6ZV24, Q96GN2, Q96H77, Q96Q02, Q9H6R2, Q9UFH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.