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Protein

Tensin-3

Gene

Tns3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development.By similarity1 Publication

GO - Biological processi

  • cell migration Source: MGI
  • lung alveolus development Source: MGI
  • positive regulation of cell proliferation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-8875513 MET interacts with TNS proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Gene namesi
Name:Tns3
Synonyms:Tens1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443012 Tns3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Disruption phenotypei

Mice display growth retardation and incomplete development of small intestine, lung, and bone. Postnatal lethality is detected in one third of the homozygous mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959161 – 1440Tensin-3Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei440PhosphoserineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei571PhosphoserineCombined sources1
Modified residuei632PhosphothreonineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei773PhosphotyrosineBy similarity1
Modified residuei804PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei894PhosphoserineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei1144PhosphoserineBy similarity1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1436PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SSZ5
PeptideAtlasiQ5SSZ5
PRIDEiQ5SSZ5

PTM databases

iPTMnetiQ5SSZ5
PhosphoSitePlusiQ5SSZ5

Expressioni

Tissue specificityi

Expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, skin, thymus, testis, uterus, placenta, aorta and trachea.1 Publication

Developmental stagei

Expressed at E13.5 in lung, liver, spleen, stomach, aorta, trachea, and perichondrium.1 Publication

Gene expression databases

BgeeiENSMUSG00000020422
CleanExiMM_TNS3
GenevisibleiQ5SSZ5 MM

Interactioni

Subunit structurei

EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5SSZ5, 2 interactors
MINTiQ5SSZ5
STRINGi10090.ENSMUSP00000020695

Structurei

3D structure databases

ProteinModelPortaliQ5SSZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 170Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini175 – 301C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1167 – 1277SH2PROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000060090
HOVERGENiHBG060186
InParanoidiQ5SSZ5
KOiK18080
OMAiEPRGCPE
OrthoDBiEOG091G0G8Y
PhylomeDBiQ5SSZ5
TreeFamiTF315996

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SSZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSHELDLT YVTERIIAVS FPASCSEESY LHSLQEVTRM LKCKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNNDPQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKISA
160 170 180 190 200
LMEPSQKRYV QFLSGLLSGA MKMNTSPLFL HFVIMHGVPS FDTGGACRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGS ENPSRIRIAI EPAQLLKGDI MVKCYHKKFR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLLFGKEELD SACKDDRFPD YGKIELVFSA
310 320 330 340 350
TPEKIQGSEH LYSDQGVTVD YNTADPLIRW DSYENMSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SASDTGIPSS PQGMPATSSP DHGDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLT PGARRGLSPQ EKAELDQLLS GFGLEDSASS HKDMTDMRSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSTHLGPF TCLKSSQNSL LSDGFGNGVA EDHNGVLSPD LGLGVDTLYD
560 570 580 590 600
RERMCGGREQ KPLQPLLRKP SAPTPVQAYG QSNYSTQTWV RQQQMVAAHQ
610 620 630 640 650
YSFASDGEAR LGSRSTVDNT GLAQPPPHIP VTPNRGASSR VAVQRGISNG
660 670 680 690 700
PNPPDTQQLC PGKALQPRFQ DDRVTNGVHQ EPNTGSSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHL NALGISAVCP DGVGSGLRCS GRLDSVDGPG
760 770 780 790 800
RSPGRQGDDP IGGRLRKLSI GQYDNDAASQ VTFSKCGWGK AGVDPAPSLG
810 820 830 840 850
SFSSPEDIKE TVITAYPSDL NMIDGRIPNS KESSMCLTPS FPVSPETPYV
860 870 880 890 900
KTSPRYPPFS PPEPQLSSPA SLHKGREPRG CPEIISHTVG MSESPVGPKP
910 920 930 940 950
TMLRADMPAT PNFQQVFASS CTVSSNGPGQ RRESPPSAER QWVESSPKST
960 970 980 990 1000
LTLLGNSHPS ESPLGTHEFC SSGKDSPGLP CFQSSELQAS FHSHELSMSE
1010 1020 1030 1040 1050
PQGALPPAGS QTFLGFNTVT TATSVLPPGE DAGTLLVNSH GTSPAPGTPL
1060 1070 1080 1090 1100
LTTGAADNGF LPHNFLTVSP GASSHHSPGL QNQNVSLPGQ PPLPEKKRAS
1110 1120 1130 1140 1150
EGDRSLGSVS PSSSGFSSPH SGSTMSIPFP NVLPDFCKPS EVASPLPDSP
1160 1170 1180 1190 1200
NDKLVIVKFV QDTSKFWYKA DISREQAIAM LKDKAPGSFI VRDSHSFRGA
1210 1220 1230 1240 1250
YGLAMKVATP PPSVLHLNKK AGDLSNELVR HFLIECTPKG VRLKGCSNEP
1260 1270 1280 1290 1300
YFGSLTALVC QHSITPLALP CKLLIPERDP LEEIAENSPQ TAANSAAELL
1310 1320 1330 1340 1350
KQGAACNVWY LNSVEMESLT GHQAVQKALS MTLVQEPPPV STVVHFKVSA
1360 1370 1380 1390 1400
QGITLTDNQR KLFFRRHYPV SSVIFCALDP QDRKWIKDGP SSKVFGFVAR
1410 1420 1430 1440
KQGSATDNVC HLFAEHDPEQ PASAIVNFVS KVMIGSPKKI
Length:1,440
Mass (Da):155,589
Last modified:December 21, 2004 - v1
Checksum:i83A07D855EE0D463
GO
Isoform 2 (identifier: Q5SSZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-890: Missing.

Note: No experimental confirmation available.
Show »
Length:550
Mass (Da):58,725
Checksum:i3A569B9A486B64EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti910T → A in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1025V → I in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1051L → M in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1067T → M in BAE34356 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271281 – 890Missing in isoform 2. 1 PublicationAdd BLAST890

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089717 mRNA Translation: BAC40948.1
AK158101 mRNA Translation: BAE34356.1
AL603845, AL662881 Genomic DNA Translation: CAI24138.1
AL662881, AL603845 Genomic DNA Translation: CAI25142.1
CCDSiCCDS36109.1 [Q5SSZ5-1]
RefSeqiNP_001077056.1, NM_001083587.1 [Q5SSZ5-1]
XP_006514804.1, XM_006514741.2 [Q5SSZ5-1]
XP_011242030.1, XM_011243728.2 [Q5SSZ5-1]
XP_017170096.1, XM_017314607.1 [Q5SSZ5-1]
UniGeneiMm.337820

Genome annotation databases

EnsembliENSMUST00000020695; ENSMUSP00000020695; ENSMUSG00000020422 [Q5SSZ5-1]
GeneIDi319939
KEGGimmu:319939
UCSCiuc007hzj.1 mouse [Q5SSZ5-2]
uc007hzk.1 mouse [Q5SSZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTENS3_MOUSE
AccessioniPrimary (citable) accession number: Q5SSZ5
Secondary accession number(s): Q3TZ54, Q8BJA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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