Q5SSQ6 (SAPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor APC domain-containing protein 1

Alternative name(s):
Protein G7d

Gene names

Name:	SAPCD1
Synonyms:	C6orf26, G7D, NG23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence CAI18428.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM24986.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM26109.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SSQ6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SSQ6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-117: K → KFSPSPLNKASSCTTQDSKERRREQNLWQQQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Suppressor APC domain-containing protein 1		PRO_0000244082
Natural variations
	Alternative sequence	117	1	K → KFSPSPLNKASSCTTQDSKE RRREQNLWQQQ in isoform 2.		VSP_040223
	Natural variant	30	1	P → S. Corresponds to variant rs17201151 [ dbSNP | Ensembl ].		VAR_056889
	Natural variant	99	1	P → L. Corresponds to variant rs6905572 [ dbSNP | Ensembl ].		VAR_056890

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 6311AF525675DDFF	FASTA	148	16,650
	10 20 30 40 50 60 MGSQGSGGVP LVQAPYTVLL LPLGTSRQDP GAQSFFLWLR RMQALEREQD ALWQGLELLQ 70 80 90 100 110 120 HGQAWFEDHL REAQRQQLHL GALGENFLTD LHSEPGRPPL AQIQKVNICL QNLIHEKELS 130 140 RQQKGVTQPK EEMAQRGCTK GPRGPTRV
	Isoform 2 [UniParc]. Checksum: 32A02509CC44E793	FASTA	178	20,183
	10 20 30 40 50 60 MGSQGSGGVP LVQAPYTVLL LPLGTSRQDP GAQSFFLWLR RMQALEREQD ALWQGLELLQ 70 80 90 100 110 120 HGQAWFEDHL REAQRQQLHL GALGENFLTD LHSEPGRPPL AQIQKVNICL QNLIHEKFSP 130 140 150 160 170 SPLNKASSCT TQDSKERRRE QNLWQQQELS RQQKGVTQPK EEMAQRGCTK GPRGPTRV

References

[1]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF134726 Genomic DNA. Translation: AAD21821.1. BA000025 Genomic DNA. Translation: BAB63305.1. AL662834 Genomic DNA. Translation: CAI17728.1. AL662834 Genomic DNA. Translation: CAM24986.1. Sequence problems. AL662899 Genomic DNA. Translation: CAI18428.2. Sequence problems. AL662899 Genomic DNA. Translation: CAM25673.1. BX248133 Genomic DNA. Translation: CAM26109.1. Sequence problems. BX248133 Genomic DNA. Translation: CAM26110.1. CR759787 Genomic DNA. Translation: CAQ10123.1. CR759915 Genomic DNA. Translation: CAQ07250.1. CR925765 Genomic DNA. Translation: CAQ10617.1. BC137541 mRNA. Translation: AAI37542.1. BC137542 mRNA. Translation: AAI37543.1.
IPI	IPI00019313. IPI00513990.
RefSeq	NP_001034740.1. NM_001039651.1.
UniGene	Hs.371225.
3D structure databases
ProteinModelPortal	Q5SSQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000387942.
Polymorphism databases
DMDM	109829408.
Proteomic databases
PaxDb	Q5SSQ6.
PRIDE	Q5SSQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000415669; ENSP00000411948; ENSG00000228727. ENST00000425424; ENSP00000413372; ENSG00000228727. ENST00000443153; ENSP00000403687; ENSG00000227074. ENST00000447852; ENSP00000403346; ENSG00000227861. ENST00000449857; ENSP00000387942; ENSG00000237918. ENST00000453534; ENSP00000404105; ENSG00000234951. ENST00000457185; ENSP00000405513; ENSG00000229176. ENST00000547662; ENSP00000447344; ENSG00000229176. ENST00000548003; ENSP00000450332; ENSG00000237918. ENST00000548987; ENSP00000448208; ENSG00000227074. ENST00000551778; ENSP00000450257; ENSG00000234951. ENST00000552302; ENSP00000446749; ENSG00000227861.
GeneID	401251.
KEGG	hsa:401251.
UCSC	uc003nwz.4. human.
Organism-specific databases
CTD	401251.
GeneCards	GC06P031732.
HGNC	HGNC:13938. SAPCD1.
neXtProt	NX_Q5SSQ6.
PharmGKB	PA134974558.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG75708.
HOGENOM	HOG000231231.
HOVERGEN	HBG057982.
OMA	PLETSRQ.
OrthoDB	EOG4R503V.
Gene expression databases
ArrayExpress	Q5SSQ6.
Bgee	Q5SSQ6.
CleanEx	HS_C6orf26.
Genevestigator	Q5SSQ6.
GermOnline	ENSG00000204410. Homo sapiens.
Family and domain databases
InterPro	IPR026831. APC_dom. IPR026828. Suppressor_APCD_1/2. [Graphical view]
PANTHER	PTHR14907. PTHR14907. 1 hit.
Pfam	PF11414. Suppressor_APC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	401251.
NextBio	106660.

Entry information

Entry name

SAPC1_HUMAN

Accession

Primary (citable) accession number: Q5SSQ6
Secondary accession number(s): A2ABF2, A2ABS9, Q9Y335

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	April 3, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.