Q5SSL4 (ABR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Active breakpoint cluster region-related protein

Gene names

Name:

Abr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	859 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them By similarity.
Sequence similarities	Contains 1 C2 domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 Rho-GAP domain.
Sequence caution	The sequence CAI24542.3 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ11499.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	GTPase activation Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from genetic interaction. Source: MGI brain development Inferred from genetic interaction. Source: MGI inner ear morphogenesis Inferred from genetic interaction. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of cell migration Inferred from genetic interaction. Source: MGI negative regulation of inflammatory response Inferred from mutant phenotype. Source: MGI negative regulation of neutrophil degranulation Inferred from genetic interaction. Source: MGI neuromuscular process controlling balance Inferred from genetic interaction. Source: MGI positive regulation of phagocytosis Inferred from genetic interaction. Source: MGI response to lipopolysaccharide Inferred from mutant phenotype. Source: MGI
Cellular component	cytosol Inferred from direct assay. Source: MGI plasma membrane Inferred from direct assay. Source: MGI
Molecular function	Rac GTPase activator activity Inferred from direct assay. Source: MGI Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SSL4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SSL4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEPLSHRGLPRLSWIDTLYSN → MAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSD

Isoform 3 (identifier: Q5SSL4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.
     219-233: GPKDSKDSHTSVTME → MEILLIIRFCCNCTY

Isoform 4 (identifier: Q5SSL4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEPLSHRGLP...PTPPEGLAPG → MEEEEEAIGF...SGSPFLVAVK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 859	859	Active breakpoint cluster region-related protein		PRO_0000355539
Regions
	Domain	91 – 284	194	DH
	Domain	301 – 459	159	PH
	Domain	491 – 595	105	C2
	Domain	647 – 845	199	Rho-GAP
Natural variations
	Alternative sequence	1 – 218	218	Missing in isoform 3.		VSP_035903
	Alternative sequence	1 – 82	82	MEPLS…GLAPG → MEEEEEAIGFLDKVLEDEDV FLLEECELGTPTSPGSGSPF LVAVK in isoform 4.		VSP_035904
	Alternative sequence	1 – 21	21	MEPLS…TLYSN → MAAGGRRRRPLRYQSLAALV EDSQWPFLFLVSD in isoform 2.		VSP_035905
	Alternative sequence	219 – 233	15	GPKDS…SVTME → MEILLIIRFCCNCTY in isoform 3.		VSP_035906
Experimental info
	Sequence conflict	164	1	W → R in BAE32119. Ref.1
	Sequence conflict	630	1	D → E in BAE22375. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 79ED2F432899A1F9	FASTA	859	97,667
	10 20 30 40 50 60 MEPLSHRGLP RLSWIDTLYS NFSYGAEDYD AEGHEEQKGP PEGSETMPYI DESPTMSPQL 70 80 90 100 110 120 SARSQGGGDS VSPTPPEGLA PGVEAGKGLE MRKLVLSGFL ASEEIYINQL EALLLPMKPL 130 140 150 160 170 180 KATATTSQPV LTIQQIETIF YKIQDIYEIH KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ 190 200 210 220 230 240 LGVYKAFVDN YKVALETAEK CSQSNNQFQK ISEELKVKGP KDSKDSHTSV TMEALLYKPI 250 260 270 280 290 300 DRVTRSTLVL HDLLKHTPVD HPDYPLLQDA LRISQNFLSS INEDIDPRRT AVTTPKGETR 310 320 330 340 350 360 QLVKDGFLVE MSESSRKLRH VFLFTDVLLC AKLKKTSAGK HQQYDCKWYI PLADLVFPSP 370 380 390 400 410 420 EESEASPQVH PFPDHELEDM KTKISALKSE IQKEKANKGQ SRAIERLKKK MFENEFLLLL 430 440 450 460 470 480 NSPTIPFRIH NRNGKSYLFL LSSDYERSEW REAIQKLQKK DLQAFVLSSV ELQVLTGSCF 490 500 510 520 530 540 KLRTVHNIPV TSNKDDDESP GLYGFLHVIV HSAKGFKQSA NLYCTLEVDS FGYFVSKAKT 550 560 570 580 590 600 RVFRDTTEPK WDEEFEIELE GSQSLRILCY EKCYDKTKVN KDNNEIVDKI MGKGQIQLDP 610 620 630 640 650 660 QTVESKNWHT DVIEMNGIKV EFSMKFTSRD MSLKRTPSKK QTGVFGVKIS VVTKRERSKV 670 680 690 700 710 720 PYIVRQCIEE VEKRGIEEVG IYRISGVATD IQALKAVFDA NNKDILLMLS DMDINAIAGT 730 740 750 760 770 780 LKLYFRELPE PLLTDRLYPA FMEGIALSDP AAKENCMMHL LRSLPDPNLI TFLFLLEHLK 790 800 810 820 830 840 RVAEKEPINK MSLHNLATVF GPTLLRPSEV ESKAHLTSAA DIWSHDVMAQ VQVLLYYLQH 850 PPISFAELKR NTLYFSTDV
	Isoform 2 [UniParc]. Checksum: F55B406BB440733F	FASTA	871	98,988
	10 20 30 40 50 60 MAAGGRRRRP LRYQSLAALV EDSQWPFLFL VSDFSYGAED YDAEGHEEQK GPPEGSETMP 70 80 90 100 110 120 YIDESPTMSP QLSARSQGGG DSVSPTPPEG LAPGVEAGKG LEMRKLVLSG FLASEEIYIN 130 140 150 160 170 180 QLEALLLPMK PLKATATTSQ PVLTIQQIET IFYKIQDIYE IHKEFYDNLC PKVQQWDSQV 190 200 210 220 230 240 TMGHLFQKLA SQLGVYKAFV DNYKVALETA EKCSQSNNQF QKISEELKVK GPKDSKDSHT 250 260 270 280 290 300 SVTMEALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ DALRISQNFL SSINEDIDPR 310 320 330 340 350 360 RTAVTTPKGE TRQLVKDGFL VEMSESSRKL RHVFLFTDVL LCAKLKKTSA GKHQQYDCKW 370 380 390 400 410 420 YIPLADLVFP SPEESEASPQ VHPFPDHELE DMKTKISALK SEIQKEKANK GQSRAIERLK 430 440 450 460 470 480 KKMFENEFLL LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ KKDLQAFVLS 490 500 510 520 530 540 SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ SANLYCTLEV 550 560 570 580 590 600 DSFGYFVSKA KTRVFRDTTE PKWDEEFEIE LEGSQSLRIL CYEKCYDKTK VNKDNNEIVD 610 620 630 640 650 660 KIMGKGQIQL DPQTVESKNW HTDVIEMNGI KVEFSMKFTS RDMSLKRTPS KKQTGVFGVK 670 680 690 700 710 720 ISVVTKRERS KVPYIVRQCI EEVEKRGIEE VGIYRISGVA TDIQALKAVF DANNKDILLM 730 740 750 760 770 780 LSDMDINAIA GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM HLLRSLPDPN 790 800 810 820 830 840 LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS AADIWSHDVM 850 860 870 AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V
	Isoform 3 [UniParc]. Checksum: CACCE137EDA9D9F7	FASTA	641	73,549
	10 20 30 40 50 60 MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ DALRISQNFL 70 80 90 100 110 120 SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEMSESSRKL RHVFLFTDVL LCAKLKKTSA 130 140 150 160 170 180 GKHQQYDCKW YIPLADLVFP SPEESEASPQ VHPFPDHELE DMKTKISALK SEIQKEKANK 190 200 210 220 230 240 GQSRAIERLK KKMFENEFLL LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ 250 260 270 280 290 300 KKDLQAFVLS SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ 310 320 330 340 350 360 SANLYCTLEV DSFGYFVSKA KTRVFRDTTE PKWDEEFEIE LEGSQSLRIL CYEKCYDKTK 370 380 390 400 410 420 VNKDNNEIVD KIMGKGQIQL DPQTVESKNW HTDVIEMNGI KVEFSMKFTS RDMSLKRTPS 430 440 450 460 470 480 KKQTGVFGVK ISVVTKRERS KVPYIVRQCI EEVEKRGIEE VGIYRISGVA TDIQALKAVF 490 500 510 520 530 540 DANNKDILLM LSDMDINAIA GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM 550 560 570 580 590 600 HLLRSLPDPN LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS 610 620 630 640 AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V
	Isoform 4 [UniParc]. Checksum: 10529465B3E4920A	FASTA	822	93,773
	10 20 30 40 50 60 MEEEEEAIGF LDKVLEDEDV FLLEECELGT PTSPGSGSPF LVAVKVEAGK GLEMRKLVLS 70 80 90 100 110 120 GFLASEEIYI NQLEALLLPM KPLKATATTS QPVLTIQQIE TIFYKIQDIY EIHKEFYDNL 130 140 150 160 170 180 CPKVQQWDSQ VTMGHLFQKL ASQLGVYKAF VDNYKVALET AEKCSQSNNQ FQKISEELKV 190 200 210 220 230 240 KGPKDSKDSH TSVTMEALLY KPIDRVTRST LVLHDLLKHT PVDHPDYPLL QDALRISQNF 250 260 270 280 290 300 LSSINEDIDP RRTAVTTPKG ETRQLVKDGF LVEMSESSRK LRHVFLFTDV LLCAKLKKTS 310 320 330 340 350 360 AGKHQQYDCK WYIPLADLVF PSPEESEASP QVHPFPDHEL EDMKTKISAL KSEIQKEKAN 370 380 390 400 410 420 KGQSRAIERL KKKMFENEFL LLLNSPTIPF RIHNRNGKSY LFLLSSDYER SEWREAIQKL 430 440 450 460 470 480 QKKDLQAFVL SSVELQVLTG SCFKLRTVHN IPVTSNKDDD ESPGLYGFLH VIVHSAKGFK 490 500 510 520 530 540 QSANLYCTLE VDSFGYFVSK AKTRVFRDTT EPKWDEEFEI ELEGSQSLRI LCYEKCYDKT 550 560 570 580 590 600 KVNKDNNEIV DKIMGKGQIQ LDPQTVESKN WHTDVIEMNG IKVEFSMKFT SRDMSLKRTP 610 620 630 640 650 660 SKKQTGVFGV KISVVTKRER SKVPYIVRQC IEEVEKRGIE EVGIYRISGV ATDIQALKAV 670 680 690 700 710 720 FDANNKDILL MLSDMDINAI AGTLKLYFRE LPEPLLTDRL YPAFMEGIAL SDPAAKENCM 730 740 750 760 770 780 MHLLRSLPDP NLITFLFLLE HLKRVAEKEP INKMSLHNLA TVFGPTLLRP SEVESKAHLT 790 800 810 820 SAADIWSHDV MAQVQVLLYY LQHPPISFAE LKRNTLYFST DV

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-407 (ISOFORM 1). Strain: C57BL/6J. Tissue: Lung, Olfactory bulb and Thymus.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK134993 mRNA. Translation: BAE22375.1. AK142364 mRNA. Translation: BAE25044.1. AK153615 mRNA. Translation: BAE32119.1. AL591143, AL663050 Genomic DNA. Translation: CAI24541.2. AL591143, AL663050 Genomic DNA. Translation: CAI24542.3. Sequence problems. AL591143, AL663050 Genomic DNA. Translation: CAI24543.2. AL591143, AL663050 Genomic DNA. Translation: CAI24545.1. AL591143 Genomic DNA. Translation: CAI24547.2. AL663050, AL591143 Genomic DNA. Translation: CAI25860.1. AL663050, AL591143 Genomic DNA. Translation: CAQ11498.1. AL663050, AL591143 Genomic DNA. Translation: CAQ11499.1. Sequence problems. AL663050, AL591143 Genomic DNA. Translation: CAQ11500.1. BC056385 mRNA. Translation: AAH56385.1. BC058708 mRNA. Translation: AAH58708.1. BC059064 mRNA. Translation: AAH59064.1.
IPI	IPI00381365. IPI00395178. IPI00515365. IPI00761596.
RefSeq	NP_932135.1. NM_198018.1. NP_942597.1. NM_198894.1. NP_942598.1. NM_198895.1.
UniGene	Mm.258939.
3D structure databases
HSSP	HSSP built from PDB template 1XA6 based on UniProtKB P52757.
ProteinModelPortal	Q5SSL4.
SMR	Q5SSL4. Positions 504-600, 640-846.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SSL4. 1 interaction.
STRING	Q5SSL4.
PTM databases
PhosphoSite	Q5SSL4.
Proteomic databases
PRIDE	Q5SSL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065028; ENSMUSP00000068982; ENSMUSG00000017631. ENSMUST00000072740; ENSMUSP00000072522; ENSMUSG00000017631. ENSMUST00000094012; ENSMUSP00000091551; ENSMUSG00000017631. ENSMUST00000108408; ENSMUSP00000104045; ENSMUSG00000017631. ENSMUST00000119983; ENSMUSP00000113893; ENSMUSG00000017631. ENSMUST00000155035; ENSMUSP00000122614; ENSMUSG00000017631.
GeneID	109934.
KEGG	mmu:109934.
UCSC	uc007kfr.1. mouse. uc007kfs.1. mouse. uc007kft.1. mouse. uc007kfv.1. mouse.
Organism-specific databases
CTD	29.
MGI	MGI:107771. Abr.
Phylogenomic databases
eggNOG	roNOG15048.
GeneTree	ENSGT00600000084231.
HOVERGEN	HBG004165.
OMA	AEGHEEQ.
OrthoDB	EOG476JZJ.
PhylomeDB	Q5SSL4.
Gene expression databases
ArrayExpress	Q5SSL4.
Bgee	Q5SSL4.
Genevestigator	Q5SSL4.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 2 hits. G3DSA:1.10.555.10. RhoGAP. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
Pfam	PF00168. C2. 1 hit. PF00169. PH. 1 hit. PF00620. RhoGAP. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48065. DH-domain. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	363025.
SOURCE	Search...

Entry information

Entry name

ABR_MOUSE

Accession

Primary (citable) accession number: Q5SSL4
Secondary accession number(s): Q3U5G0 , Q3UQJ6, Q3UY38, Q5SYJ5, Q5SYJ7, Q5SYJ8, Q5SYJ9, Q6PCY1, Q6PDH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	December 21, 2004
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program