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Q5SSK3 (TEFM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription elongation factor, mitochondrial
Gene names
Name:Tefm
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery By similarity.

Subunit structure

Interacts with POLRMT By similarity.

Subcellular location

Mitochondrion matrix By similarity. Mitochondrion matrix › mitochondrion nucleoid By similarity.

Sequence similarities

Belongs to the TEFM family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 364325Transcription elongation factor, mitochondrial
PRO_0000406330

Sequences

Sequence LengthMass (Da)Tools
Q5SSK3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 37A54216F0E53DF4

FASTA36441,874
        10         20         30         40         50         60 
MAWRTNLACL IKAGGRRWFP VPEYSSLPPV LNNTCSVRKS TAPEKRVASV AACDTDGKEP 

        70         80         90        100        110        120 
GNPLDRLFSL EQQASILQVL NTASDKELEA FRLLRGRKSV NIVEHRKKFG PFQRLENLID 

       130        140        150        160        170        180 
VPLIQYKTAV EVCNSILCPE NRRRKKSQEK WLLRKFIKPG VEQERLKAVK SIVSIVFGTR 

       190        200        210        220        230        240 
RIAWAHLDRR PTVLDWQQTE CWKLTNKTYP TSFYLEEISS VISKIPKADL YILEKSGLSI 

       250        260        270        280        290        300 
QNTSLLPILL HFLITEAMLY ALLNKTFAED GQHRVLSINR NAVGKHFDLM IGDTRTSGRE 

       310        320        330        340        350        360 
LVKQFLSESV LKERPRVFFP QDLLVQYRQK VVKSSYRIEE LYDSLLQAVA FYELVFGKDS 


ELKC

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Stomach.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK146639 mRNA. Translation: BAE27323.1.
AL663057 Genomic DNA. Translation: CAI26035.1.
IPIIPI00404845.
RefSeqNP_899098.2. NM_183275.2.
UniGeneMm.18466.

3D structure databases

ProteinModelPortalQ5SSK3.
SMRQ5SSK3. Positions 80-133.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SSK3.

Proteomic databases

PRIDEQ5SSK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050207; ENSMUSP00000059304; ENSMUSG00000046909.
GeneID68550.
KEGGmmu:68550.
NMPDRfig|10090.3.peg.24845.
UCSCuc007klj.1. mouse.

Organism-specific databases

MGIMGI:1915800. 1110002N22Rik.

Phylogenomic databases

HOGENOMHBG716768.
HOVERGENHBG107754.
InParanoidQ5SSK3.
OMAMNRNAVG.
PhylomeDBQ5SSK3.

Gene expression databases

ArrayExpressQ5SSK3.
BgeeQ5SSK3.
GenevestigatorQ5SSK3.

Family and domain databases

InterProIPR023097. Tex_RuvX-like_dom.
[Graphical view]
Gene3DG3DSA:1.10.150.310. G3DSA:1.10.150.310. 1 hit.
ProtoNetSearch...

Other

NextBio327432.
SOURCESearch...

Entry information

Entry nameTEFM_MOUSE
AccessionPrimary (citable) accession number: Q5SSK3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 21, 2004
Last modified: September 21, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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