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Protein

Neuferricin

Gene

Cyb5d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Heme-binding protein which promotes neuronal but not astrocyte differentiation.1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

  • heme binding Source: MGI

GO - Biological processi

  • positive regulation of neuron differentiation Source: MGI

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuferricin
Alternative name(s):
Cytochrome b5 domain-containing protein 2
Gene namesi
Name:Cyb5d2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2684848. Cyb5d2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031232223 – 263NeuferricinAdd BLAST241

Proteomic databases

PaxDbiQ5SSH8.
PeptideAtlasiQ5SSH8.
PRIDEiQ5SSH8.

PTM databases

PhosphoSitePlusiQ5SSH8.
SwissPalmiQ5SSH8.

Expressioni

Tissue specificityi

Expressed in various tissues including brain, heart, adrenal gland, and kidney. In the brain, mainly expressed in pyramidal cells around the CA3 region of Ammon horn in hippocampus. Present in brain (at protein level).1 Publication

Developmental stagei

Abundantly expressed in the developing brain, in subventricular and ventricular zones of the cerebrum, where neural stem cells and neural precursor cells primarily exist. Expression levels gradually increase during brain development, between E14.5 and P49.1 Publication

Gene expression databases

BgeeiENSMUSG00000057778.
CleanExiMM_CYB5D2.
GenevisibleiQ5SSH8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078623.

Structurei

3D structure databases

ProteinModelPortaliQ5SSH8.
SMRiQ5SSH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 134Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106.

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1108. Eukaryota.
ENOG4111JSU. LUCA.
GeneTreeiENSGT00730000110948.
HOGENOMiHOG000012760.
HOVERGENiHBG105428.
InParanoidiQ5SSH8.
OMAiNSKWSQQ.
OrthoDBiEOG091G0FYY.
PhylomeDBiQ5SSH8.
TreeFamiTF313943.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SSH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRICGLGVV LSLAVAAVAV MAVWLMDWWG PRPGIRLFLP EELARYRGGP
60 70 80 90 100
GDPGLYLALL GRVYDVSSGR RHYEPGAHYS GFAGRDASRA FVTGDYSEAG
110 120 130 140 150
LVDDINGLSS SEILTLHNWL SFYEKNYVFV GRLVGRFYRK DGLPTSELTQ
160 170 180 190 200
VEAMVTKGME ANEQEQREKQ KFPPCNSEWS SAKGSRLWCS QKSGGVHRDW
210 220 230 240 250
IGVPRKLYKP GAKEPHCVCV RTTGPPSDQQ DNPRHSNHGD LDNPNLEEYT
260
GCPPLATTCS FPL
Length:263
Mass (Da):29,162
Last modified:December 21, 2004 - v1
Checksum:i41156B54DBF3218E
GO
Isoform 2 (identifier: Q5SSH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:110
Mass (Da):12,293
Checksum:i7EA4AB237CD40115
GO

Sequence cautioni

The sequence BAC37998 differs from that shown. Probable cloning artifact.Curated
The sequence BAE23849 differs from that shown. Probable cloning artifact.Curated
The sequence BAE25095 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76G → V in AAH86682 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298271 – 153Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663082 Genomic DNA. Translation: CAI25189.1.
BC086682 mRNA. Translation: AAH86682.1.
BC117721 mRNA. Translation: AAI17722.2.
AK080730 mRNA. Translation: BAC37998.1. Sequence problems.
AK138991 mRNA. Translation: BAE23849.1. Sequence problems.
AK142515 mRNA. Translation: BAE25095.1. Sequence problems.
CCDSiCCDS24990.2. [Q5SSH8-1]
RefSeqiNP_001020097.2. NM_001024926.3. [Q5SSH8-1]
UniGeneiMm.194755.

Genome annotation databases

EnsembliENSMUST00000079681; ENSMUSP00000078623; ENSMUSG00000057778. [Q5SSH8-1]
ENSMUST00000156294; ENSMUSP00000131961; ENSMUSG00000057778. [Q5SSH8-2]
GeneIDi192986.
KEGGimmu:192986.
UCSCiuc007jzi.2. mouse. [Q5SSH8-1]
uc007jzj.2. mouse. [Q5SSH8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEUFC_MOUSE
AccessioniPrimary (citable) accession number: Q5SSH8
Secondary accession number(s): A0AUN6, Q0VGS6, Q8BHV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families