Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mucin-21

Gene

MUC21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33901-MONOMER.
ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-21
Short name:
MUC-21
Alternative name(s):
Epiglycanin
Gene namesi
Name:MUC21
Synonyms:C6orf205
ORF Names:UNQ697/PRO1342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21661. MUC21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 479ExtracellularSequence analysisAdd BLAST455
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 566CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi lumen Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi394263.
OpenTargetsiENSG00000204544.
ENSG00000227506.
PharmGKBiPA162396305.

Polymorphism and mutation databases

BioMutaiMUC21.
DMDMi296439229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000034010225 – 566Mucin-21Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei502 – 503CleavageSequence analysis2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SSG8.
PeptideAtlasiQ5SSG8.
PRIDEiQ5SSG8.

PTM databases

iPTMnetiQ5SSG8.
PhosphoSitePlusiQ5SSG8.

Expressioni

Tissue specificityi

Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000204544.
CleanExiHS_MUC21.
ExpressionAtlasiQ5SSG8. baseline and differential.

Organism-specific databases

HPAiHPA052028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365473.

Structurei

3D structure databases

ProteinModelPortaliQ5SSG8.
SMRiQ5SSG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 441Add BLAST14
Repeati45 – 592Add BLAST15
Repeati60 – 743Add BLAST15
Repeati75 – 894Add BLAST15
Repeati90 – 1045Add BLAST15
Repeati105 – 1196Add BLAST15
Repeati120 – 1347Add BLAST15
Repeati135 – 1498Add BLAST15
Repeati150 – 1649Add BLAST15
Repeati165 – 17910Add BLAST15
Repeati180 – 19411Add BLAST15
Repeati195 – 20912Add BLAST15
Repeati210 – 22413Add BLAST15
Repeati225 – 23914Add BLAST15
Repeati244 – 25415Add BLAST11
Repeati255 – 26916Add BLAST15
Repeati270 – 28417Add BLAST15
Repeati285 – 29918Add BLAST15
Repeati300 – 31419Add BLAST15
Repeati315 – 32920Add BLAST15
Repeati330 – 34421Add BLAST15
Repeati345 – 35922Add BLAST15
Repeati360 – 37423Add BLAST15
Repeati375 – 38924Add BLAST15
Repeati390 – 40425Add BLAST15
Repeati405 – 41926Add BLAST15
Repeati420 – 43427Add BLAST15
Repeati435 – 44928Add BLAST15

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 43528 X 15 AA approximate tandem repeatsAdd BLAST405
Regioni521 – 566Cytoplasmic tailAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 447Ser-richAdd BLAST423

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1U4. Eukaryota.
ENOG4111D80. LUCA.
GeneTreeiENSGT00730000111569.
InParanoidiQ5SSG8.
OMAiNCPATEK.
OrthoDBiEOG091G0XMP.

Family and domain databases

InterProiIPR033534. MUC21.
IPR028199. Mucin_dom.
IPR008519. Tandem-repeating_mucin.
[Graphical view]
PANTHERiPTHR39408:SF1. PTHR39408:SF1. 1 hit.
PfamiPF14654. Epiglycanin_C. 1 hit.
PF05647. Epiglycanin_TR. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SSG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS
60 70 80 90 100
SVTSSGVSTA TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTVSS
110 120 130 140 150
GISIATNSES STTSSGASTA TNSESSTPSS GASTATNSDS STTSSGASTA
160 170 180 190 200
TNSDSSTTSS EASTATNSES STTSSGASTA TNSESSTVSS RASTATNSES
210 220 230 240 250
STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA TNSESSTPSS
260 270 280 290 300
GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA
310 320 330 340 350
TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES
360 370 380 390 400
STTSSGASTA TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS
410 420 430 440 450
GASTATNSES STVSSGASTA TNSESSTTSS GANTATNSGS SVTSAGSGTA
460 470 480 490 500
ALTGMHTTSH SASTAVSEAK PGGSLVPWEI FLITLVSVVA AVGLFAGLFF
510 520 530 540 550
CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP RWSPNWFWRR
560
PVSSIAMEMS GRNSGP
Length:566
Mass (Da):54,228
Last modified:May 18, 2010 - v2
Checksum:i196A43738C47F9C7
GO
Isoform 2 (identifier: Q5SSG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: T → TVTNSGSSVTSSGASTATNSESSTVSSRAST

Show »
Length:596
Mass (Da):57,018
Checksum:i0B8A0F41024DD35C
GO
Isoform 3 (identifier: Q5SSG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-337: Missing.

Show »
Length:416
Mass (Da):40,331
Checksum:i67F5E6BC67F525C8
GO

Sequence cautioni

The sequence AAI05737 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143T → L in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti143T → L in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti180A → V in CAQ07653 (PubMed:14574404).Curated1
Sequence conflicti248P → V in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti248P → V in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti268G → S in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti268G → S in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti278V → T in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti278V → T in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti282I → A in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti282I → A in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti293P → T in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti293P → T in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti298N → G in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti298N → G in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti308T → V in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti308T → V in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti312A → I in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti312A → I in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti343S → N in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti343S → N in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti353T → V in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti353T → V in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti364G → E in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti364G → E in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti372T → V in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti372T → V in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti383V → T in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti383V → T in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti392T → N in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti392T → N in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti394E → D in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti394E → D in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti401G → E in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti401G → E in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti417A → I in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti417A → I in CAQ08321 (PubMed:14574404).Curated1
Sequence conflicti420A → V in AAQ88781 (PubMed:12975309).Curated1
Sequence conflicti420A → V in CAQ08321 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06045798V → A.5 PublicationsCorresponds to variant rs1634730dbSNPEnsembl.1
Natural variantiVAR_043995139D → E.2 PublicationsCorresponds to variant rs9262324dbSNPEnsembl.1
Natural variantiVAR_043996161E → G.2 PublicationsCorresponds to variant rs9262337dbSNPEnsembl.1
Natural variantiVAR_043997244E → D.2 PublicationsCorresponds to variant rs41288649dbSNPEnsembl.1
Natural variantiVAR_043998253G → S.2 PublicationsCorresponds to variant rs41288655dbSNPEnsembl.1
Natural variantiVAR_060458282I → T.Corresponds to variant rs9262368dbSNPEnsembl.1
Natural variantiVAR_060459282I → V.Corresponds to variant rs9262367dbSNPEnsembl.1
Natural variantiVAR_043999285V → A.2 PublicationsCorresponds to variant rs9262370dbSNPEnsembl.1
Natural variantiVAR_044000289E → D.2 PublicationsCorresponds to variant rs41288665dbSNPEnsembl.1
Natural variantiVAR_044001313N → S.2 PublicationsCorresponds to variant rs9262379dbSNPEnsembl.1
Natural variantiVAR_044002315A → V.2 PublicationsCorresponds to variant rs41288675dbSNPEnsembl.1
Natural variantiVAR_044003319D → E.2 PublicationsCorresponds to variant rs9262380dbSNPEnsembl.1
Natural variantiVAR_044004323T → P.2 PublicationsCorresponds to variant rs41288679dbSNPEnsembl.1
Natural variantiVAR_044005328S → N.2 PublicationsCorresponds to variant rs41288681dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034188134T → TVTNSGSSVTSSGASTATNS ESSTVSSRAST in isoform 2. 1 Publication1
Alternative sequenceiVSP_034189188 – 337Missing in isoform 3. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298642 mRNA. Translation: BAG60817.1.
AB242595 mRNA. Translation: BAF92842.1.
HM596784 mRNA. Translation: ADJ96647.1.
AY358415 mRNA. Translation: AAQ88781.1.
AL663093 Genomic DNA. Translation: CAI17705.1.
AL669830 Genomic DNA. Translation: CAI18008.1.
CR759747 Genomic DNA. Translation: CAQ06767.1.
CR759772 Genomic DNA. Translation: CAQ07653.1.
CT009610 Genomic DNA. Translation: CAQ08321.1.
CR759964 Genomic DNA. Translation: CAQ09393.1.
CH471081 Genomic DNA. Translation: EAX03353.1. Sequence problems.
BC105735 mRNA. Translation: AAI05736.1.
BC105736 mRNA. Translation: AAI05737.1. Different initiation.
BC105737 mRNA. Translation: AAI05738.1.
BC107478 mRNA. Translation: AAI07479.1.
CCDSiCCDS34388.1. [Q5SSG8-1]
RefSeqiNP_001010909.2. NM_001010909.3. [Q5SSG8-1]
NP_001309299.1. NM_001322370.1.
UniGeneiHs.448277.

Genome annotation databases

EnsembliENST00000376296; ENSP00000365473; ENSG00000204544. [Q5SSG8-1]
ENST00000549059; ENSP00000447840; ENSG00000227506. [Q5SSG8-3]
GeneIDi394263.
KEGGihsa:394263.
UCSCiuc003nsh.3. human. [Q5SSG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298642 mRNA. Translation: BAG60817.1.
AB242595 mRNA. Translation: BAF92842.1.
HM596784 mRNA. Translation: ADJ96647.1.
AY358415 mRNA. Translation: AAQ88781.1.
AL663093 Genomic DNA. Translation: CAI17705.1.
AL669830 Genomic DNA. Translation: CAI18008.1.
CR759747 Genomic DNA. Translation: CAQ06767.1.
CR759772 Genomic DNA. Translation: CAQ07653.1.
CT009610 Genomic DNA. Translation: CAQ08321.1.
CR759964 Genomic DNA. Translation: CAQ09393.1.
CH471081 Genomic DNA. Translation: EAX03353.1. Sequence problems.
BC105735 mRNA. Translation: AAI05736.1.
BC105736 mRNA. Translation: AAI05737.1. Different initiation.
BC105737 mRNA. Translation: AAI05738.1.
BC107478 mRNA. Translation: AAI07479.1.
CCDSiCCDS34388.1. [Q5SSG8-1]
RefSeqiNP_001010909.2. NM_001010909.3. [Q5SSG8-1]
NP_001309299.1. NM_001322370.1.
UniGeneiHs.448277.

3D structure databases

ProteinModelPortaliQ5SSG8.
SMRiQ5SSG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365473.

PTM databases

iPTMnetiQ5SSG8.
PhosphoSitePlusiQ5SSG8.

Polymorphism and mutation databases

BioMutaiMUC21.
DMDMi296439229.

Proteomic databases

PaxDbiQ5SSG8.
PeptideAtlasiQ5SSG8.
PRIDEiQ5SSG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376296; ENSP00000365473; ENSG00000204544. [Q5SSG8-1]
ENST00000549059; ENSP00000447840; ENSG00000227506. [Q5SSG8-3]
GeneIDi394263.
KEGGihsa:394263.
UCSCiuc003nsh.3. human. [Q5SSG8-1]

Organism-specific databases

CTDi394263.
DisGeNETi394263.
GeneCardsiMUC21.
H-InvDBHIX0058199.
HIX0166716.
HGNCiHGNC:21661. MUC21.
HPAiHPA052028.
MIMi616991. gene.
neXtProtiNX_Q5SSG8.
OpenTargetsiENSG00000204544.
ENSG00000227506.
PharmGKBiPA162396305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1U4. Eukaryota.
ENOG4111D80. LUCA.
GeneTreeiENSGT00730000111569.
InParanoidiQ5SSG8.
OMAiNCPATEK.
OrthoDBiEOG091G0XMP.

Enzyme and pathway databases

BioCyciZFISH:G66-33901-MONOMER.
ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiMUC21. human.
GenomeRNAii394263.
PROiQ5SSG8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204544.
CleanExiHS_MUC21.
ExpressionAtlasiQ5SSG8. baseline and differential.

Family and domain databases

InterProiIPR033534. MUC21.
IPR028199. Mucin_dom.
IPR008519. Tandem-repeating_mucin.
[Graphical view]
PANTHERiPTHR39408:SF1. PTHR39408:SF1. 1 hit.
PfamiPF14654. Epiglycanin_C. 1 hit.
PF05647. Epiglycanin_TR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC21_HUMAN
AccessioniPrimary (citable) accession number: Q5SSG8
Secondary accession number(s): B0UZT7
, B4DQ55, C9JMK2, D9N007, Q0VGF1, Q3B7T2, Q5SS94, Q6UXC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Could be considered as a marker for lung carcinomas.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.