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Protein

Mucin-21

Gene

MUC21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-21
Short name:
MUC-21
Alternative name(s):
Epiglycanin
Gene namesi
Name:MUC21
Synonyms:C6orf205
ORF Names:UNQ697/PRO1342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21661. MUC21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 479455ExtracellularSequence analysisAdd
BLAST
Transmembranei480 – 50021HelicalSequence analysisAdd
BLAST
Topological domaini501 – 56666CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi lumen Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396305.

Polymorphism and mutation databases

BioMutaiMUC21.
DMDMi296439229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 566542Mucin-21PRO_0000340102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei502 – 5032CleavageSequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SSG8.
PRIDEiQ5SSG8.

Expressioni

Tissue specificityi

Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.1 Publication

Gene expression databases

BgeeiQ5SSG8.
CleanExiHS_MUC21.
ExpressionAtlasiQ5SSG8. baseline and differential.

Organism-specific databases

HPAiHPA052028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365473.

Structurei

3D structure databases

ProteinModelPortaliQ5SSG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 44141Add
BLAST
Repeati45 – 59152Add
BLAST
Repeati60 – 74153Add
BLAST
Repeati75 – 89154Add
BLAST
Repeati90 – 104155Add
BLAST
Repeati105 – 119156Add
BLAST
Repeati120 – 134157Add
BLAST
Repeati135 – 149158Add
BLAST
Repeati150 – 164159Add
BLAST
Repeati165 – 1791510Add
BLAST
Repeati180 – 1941511Add
BLAST
Repeati195 – 2091512Add
BLAST
Repeati210 – 2241513Add
BLAST
Repeati225 – 2391514Add
BLAST
Repeati244 – 2541115Add
BLAST
Repeati255 – 2691516Add
BLAST
Repeati270 – 2841517Add
BLAST
Repeati285 – 2991518Add
BLAST
Repeati300 – 3141519Add
BLAST
Repeati315 – 3291520Add
BLAST
Repeati330 – 3441521Add
BLAST
Repeati345 – 3591522Add
BLAST
Repeati360 – 3741523Add
BLAST
Repeati375 – 3891524Add
BLAST
Repeati390 – 4041525Add
BLAST
Repeati405 – 4191526Add
BLAST
Repeati420 – 4341527Add
BLAST
Repeati435 – 4491528Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 43540528 X 15 AA approximate tandem repeatsAdd
BLAST
Regioni521 – 56646Cytoplasmic tailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 447423Ser-richAdd
BLAST

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1U4. Eukaryota.
ENOG4111D80. LUCA.
GeneTreeiENSGT00730000111569.
InParanoidiQ5SSG8.
OMAiNCPATEK.
OrthoDBiEOG7T7GWQ.

Family and domain databases

InterProiIPR028199. Mucin_dom.
IPR008519. Tandem-repeating_mucin.
[Graphical view]
PfamiPF14654. Epiglycanin_C. 1 hit.
PF05647. Epiglycanin_TR. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SSG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS
60 70 80 90 100
SVTSSGVSTA TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTVSS
110 120 130 140 150
GISIATNSES STTSSGASTA TNSESSTPSS GASTATNSDS STTSSGASTA
160 170 180 190 200
TNSDSSTTSS EASTATNSES STTSSGASTA TNSESSTVSS RASTATNSES
210 220 230 240 250
STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA TNSESSTPSS
260 270 280 290 300
GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA
310 320 330 340 350
TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES
360 370 380 390 400
STTSSGASTA TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS
410 420 430 440 450
GASTATNSES STVSSGASTA TNSESSTTSS GANTATNSGS SVTSAGSGTA
460 470 480 490 500
ALTGMHTTSH SASTAVSEAK PGGSLVPWEI FLITLVSVVA AVGLFAGLFF
510 520 530 540 550
CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP RWSPNWFWRR
560
PVSSIAMEMS GRNSGP
Length:566
Mass (Da):54,228
Last modified:May 18, 2010 - v2
Checksum:i196A43738C47F9C7
GO
Isoform 2 (identifier: Q5SSG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-134: T → TVTNSGSSVTSSGASTATNSESSTVSSRAST

Show »
Length:596
Mass (Da):57,018
Checksum:i0B8A0F41024DD35C
GO
Isoform 3 (identifier: Q5SSG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-337: Missing.

Show »
Length:416
Mass (Da):40,331
Checksum:i67F5E6BC67F525C8
GO

Sequence cautioni

The sequence AAI05737.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431T → L in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti143 – 1431T → L in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti180 – 1801A → V in CAQ07653 (PubMed:14574404).Curated
Sequence conflicti248 – 2481P → V in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti248 – 2481P → V in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti268 – 2681G → S in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti268 – 2681G → S in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti278 – 2781V → T in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti278 – 2781V → T in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti282 – 2821I → A in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti282 – 2821I → A in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti293 – 2931P → T in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti293 – 2931P → T in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti298 – 2981N → G in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti298 – 2981N → G in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti308 – 3081T → V in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti308 – 3081T → V in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti312 – 3121A → I in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti312 – 3121A → I in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti343 – 3431S → N in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti343 – 3431S → N in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti353 – 3531T → V in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti353 – 3531T → V in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti364 – 3641G → E in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti364 – 3641G → E in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti372 – 3721T → V in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti372 – 3721T → V in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti383 – 3831V → T in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti383 – 3831V → T in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti392 – 3921T → N in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti392 – 3921T → N in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti394 – 3941E → D in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti394 – 3941E → D in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti401 – 4011G → E in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti401 – 4011G → E in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti417 – 4171A → I in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti417 – 4171A → I in CAQ08321 (PubMed:14574404).Curated
Sequence conflicti420 – 4201A → V in AAQ88781 (PubMed:12975309).Curated
Sequence conflicti420 – 4201A → V in CAQ08321 (PubMed:14574404).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981V → A.5 Publications
Corresponds to variant rs1634730 [ dbSNP | Ensembl ].
VAR_060457
Natural varianti139 – 1391D → E.2 Publications
Corresponds to variant rs9262324 [ dbSNP | Ensembl ].
VAR_043995
Natural varianti161 – 1611E → G.2 Publications
Corresponds to variant rs9262337 [ dbSNP | Ensembl ].
VAR_043996
Natural varianti244 – 2441E → D.2 Publications
Corresponds to variant rs41288649 [ dbSNP | Ensembl ].
VAR_043997
Natural varianti253 – 2531G → S.2 Publications
Corresponds to variant rs41288655 [ dbSNP | Ensembl ].
VAR_043998
Natural varianti282 – 2821I → T.
Corresponds to variant rs9262368 [ dbSNP | Ensembl ].
VAR_060458
Natural varianti282 – 2821I → V.
Corresponds to variant rs9262367 [ dbSNP | Ensembl ].
VAR_060459
Natural varianti285 – 2851V → A.2 Publications
Corresponds to variant rs9262370 [ dbSNP | Ensembl ].
VAR_043999
Natural varianti289 – 2891E → D.2 Publications
Corresponds to variant rs41288665 [ dbSNP | Ensembl ].
VAR_044000
Natural varianti313 – 3131N → S.2 Publications
Corresponds to variant rs9262379 [ dbSNP | Ensembl ].
VAR_044001
Natural varianti315 – 3151A → V.2 Publications
Corresponds to variant rs41288675 [ dbSNP | Ensembl ].
VAR_044002
Natural varianti319 – 3191D → E.2 Publications
Corresponds to variant rs9262380 [ dbSNP | Ensembl ].
VAR_044003
Natural varianti323 – 3231T → P.2 Publications
Corresponds to variant rs41288679 [ dbSNP | Ensembl ].
VAR_044004
Natural varianti328 – 3281S → N.2 Publications
Corresponds to variant rs41288681 [ dbSNP | Ensembl ].
VAR_044005

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei134 – 1341T → TVTNSGSSVTSSGASTATNS ESSTVSSRAST in isoform 2. 1 PublicationVSP_034188
Alternative sequencei188 – 337150Missing in isoform 3. 1 PublicationVSP_034189Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298642 mRNA. Translation: BAG60817.1.
AB242595 mRNA. Translation: BAF92842.1.
HM596784 mRNA. Translation: ADJ96647.1.
AY358415 mRNA. Translation: AAQ88781.1.
AL663093 Genomic DNA. Translation: CAI17705.1.
AL669830 Genomic DNA. Translation: CAI18008.1.
CR759747 Genomic DNA. Translation: CAQ06767.1.
CR759772 Genomic DNA. Translation: CAQ07653.1.
CT009610 Genomic DNA. Translation: CAQ08321.1.
CR759964 Genomic DNA. Translation: CAQ09393.1.
CH471081 Genomic DNA. Translation: EAX03353.1. Sequence problems.
BC105735 mRNA. Translation: AAI05736.1.
BC105736 mRNA. Translation: AAI05737.1. Different initiation.
BC105737 mRNA. Translation: AAI05738.1.
BC107478 mRNA. Translation: AAI07479.1.
CCDSiCCDS34388.1. [Q5SSG8-1]
RefSeqiNP_001010909.2. NM_001010909.3. [Q5SSG8-1]
XP_005275180.1. XM_005275123.2.
UniGeneiHs.448277.

Genome annotation databases

EnsembliENST00000376296; ENSP00000365473; ENSG00000204544. [Q5SSG8-1]
ENST00000549059; ENSP00000447840; ENSG00000227506. [Q5SSG8-3]
GeneIDi394263.
KEGGihsa:394263.
UCSCiuc003nsh.3. human. [Q5SSG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298642 mRNA. Translation: BAG60817.1.
AB242595 mRNA. Translation: BAF92842.1.
HM596784 mRNA. Translation: ADJ96647.1.
AY358415 mRNA. Translation: AAQ88781.1.
AL663093 Genomic DNA. Translation: CAI17705.1.
AL669830 Genomic DNA. Translation: CAI18008.1.
CR759747 Genomic DNA. Translation: CAQ06767.1.
CR759772 Genomic DNA. Translation: CAQ07653.1.
CT009610 Genomic DNA. Translation: CAQ08321.1.
CR759964 Genomic DNA. Translation: CAQ09393.1.
CH471081 Genomic DNA. Translation: EAX03353.1. Sequence problems.
BC105735 mRNA. Translation: AAI05736.1.
BC105736 mRNA. Translation: AAI05737.1. Different initiation.
BC105737 mRNA. Translation: AAI05738.1.
BC107478 mRNA. Translation: AAI07479.1.
CCDSiCCDS34388.1. [Q5SSG8-1]
RefSeqiNP_001010909.2. NM_001010909.3. [Q5SSG8-1]
XP_005275180.1. XM_005275123.2.
UniGeneiHs.448277.

3D structure databases

ProteinModelPortaliQ5SSG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365473.

Polymorphism and mutation databases

BioMutaiMUC21.
DMDMi296439229.

Proteomic databases

PaxDbiQ5SSG8.
PRIDEiQ5SSG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376296; ENSP00000365473; ENSG00000204544. [Q5SSG8-1]
ENST00000549059; ENSP00000447840; ENSG00000227506. [Q5SSG8-3]
GeneIDi394263.
KEGGihsa:394263.
UCSCiuc003nsh.3. human. [Q5SSG8-1]

Organism-specific databases

CTDi394263.
GeneCardsiMUC21.
H-InvDBHIX0058199.
HIX0166716.
HGNCiHGNC:21661. MUC21.
HPAiHPA052028.
neXtProtiNX_Q5SSG8.
PharmGKBiPA162396305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1U4. Eukaryota.
ENOG4111D80. LUCA.
GeneTreeiENSGT00730000111569.
InParanoidiQ5SSG8.
OMAiNCPATEK.
OrthoDBiEOG7T7GWQ.

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiMUC21. human.
GenomeRNAii394263.
NextBioi105412.
PROiQ5SSG8.

Gene expression databases

BgeeiQ5SSG8.
CleanExiHS_MUC21.
ExpressionAtlasiQ5SSG8. baseline and differential.

Family and domain databases

InterProiIPR028199. Mucin_dom.
IPR008519. Tandem-repeating_mucin.
[Graphical view]
PfamiPF14654. Epiglycanin_C. 1 hit.
PF05647. Epiglycanin_TR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-98.
    Tissue: Esophagus.
  2. "Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin."
    Itoh Y., Kamata-Sakurai M., Denda-Nagai K., Nagai S., Tsuiji M., Ishii-Schrade K., Okada K., Goto A., Fukayama M., Irimura T.
    Glycobiology 18:74-83(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, VARIANT ALA-98.
    Tissue: Cervix adenocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ALA-98; GLU-139; GLY-161; ASP-244; SER-253; ALA-285; ASP-289; SER-313; VAL-315; GLU-319; PRO-323 AND ASN-328.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ALA-98; GLU-139; GLY-161; ASP-244; SER-253; ALA-285; ASP-289; SER-313; VAL-315; GLU-319; PRO-323 AND ASN-328.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-98.

Entry informationi

Entry nameiMUC21_HUMAN
AccessioniPrimary (citable) accession number: Q5SSG8
Secondary accession number(s): B0UZT7
, B4DQ55, C9JMK2, D9N007, Q0VGF1, Q3B7T2, Q5SS94, Q6UXC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Could be considered as a marker for lung carcinomas.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.