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Protein
Submitted name:

Matrix metallopeptidase 28 (epilysin)

Gene

Mmp28

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of macrophage chemotaxis Source: MGI

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metallopeptidase 28 (epilysin)Imported
Gene namesi
Name:Mmp28Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2153062 Mmp28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500426269523 – 407Sequence analysisAdd BLAST385

Proteomic databases

MaxQBiQ5SSG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000020682
ExpressionAtlasiQ5SSG2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SSG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 285ZnMcInterPro annotationAdd BLAST160
Repeati325 – 369HemopexinPROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00910000144034
HOGENOMiHOG000217927
HOVERGENiHBG052484

Family and domain databases

CDDicd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.101 hit
3.40.390.101 hit
InterProiView protein in InterPro
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR028735 MMP28
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
PANTHERiPTHR10201:SF16 PTHR10201:SF16, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 1 hit
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 1 hit
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS51642 HEMOPEXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SSG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGVSLLLR ALPLLLWGCQ DAQPTQHGLP ELRQEAEAFL EKYGYLSEQG
60 70 80 90 100
SKAPASAQFR NAIREFQWIS QLPLSGVLDQ ATLRQMTRPR CGVADTDSHA
110 120 130 140 150
TWTERISTLL AGHRAKMRRK KRFAKPGNKW YKQHLSYRLV NWPERLPEPA
160 170 180 190 200
VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG
210 220 230 240 250
PGGALAHAFL PRRGEAHFDG DERWSLSRRR GRNLFVVLAH EIGHTLGLTH
260 270 280 290 300
SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ SLYGKPLGRS VATQLPGKVF
310 320 330 340 350
TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSYFWEV
360 370 380 390 400
TVDGNVSEPR PLQKRWPGLP PGIEAAAVSL EDGDFYFFKG TGRRKDREQT

PFPSGNY
Length:407
Mass (Da):45,838
Last modified:April 8, 2008 - v2
Checksum:i291BE954C1669FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663096 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000119346; ENSMUSP00000112566; ENSMUSG00000020682
UCSCiuc007kpd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ5SSG2_MOUSE
AccessioniPrimary (citable) accession number: Q5SSG2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported