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Protein
Submitted name:

Matrix metallopeptidase 28 (epilysin)

Gene

Mmp28

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of macrophage chemotaxis Source: MGI

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metallopeptidase 28 (epilysin)Imported
Gene namesi
Name:Mmp28Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2153062. Mmp28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500426269523 – 407Sequence analysisAdd BLAST385

Proteomic databases

MaxQBiQ5SSG2.
PaxDbiQ5SSG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020682.
ExpressionAtlasiQ5SSG2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5SSG2.
SMRiQ5SSG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 285ZnMcInterPro annotationAdd BLAST160
Repeati325 – 369HemopexinPROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00900000140889.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.

Family and domain databases

CDDicd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR036375. Hemopexin-like_dom_sf.
IPR018487. Hemopexin-like_repeat.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom_sf.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
IPR036365. PGBD-like_sf.
PANTHERiPTHR10201:SF16. PTHR10201:SF16. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 1 hit.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 1 hit.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS51642. HEMOPEXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SSG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGVSLLLR ALPLLLWGCQ DAQPTQHGLP ELRQEAEAFL EKYGYLSEQG
60 70 80 90 100
SKAPASAQFR NAIREFQWIS QLPLSGVLDQ ATLRQMTRPR CGVADTDSHA
110 120 130 140 150
TWTERISTLL AGHRAKMRRK KRFAKPGNKW YKQHLSYRLV NWPERLPEPA
160 170 180 190 200
VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG
210 220 230 240 250
PGGALAHAFL PRRGEAHFDG DERWSLSRRR GRNLFVVLAH EIGHTLGLTH
260 270 280 290 300
SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ SLYGKPLGRS VATQLPGKVF
310 320 330 340 350
TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSYFWEV
360 370 380 390 400
TVDGNVSEPR PLQKRWPGLP PGIEAAAVSL EDGDFYFFKG TGRRKDREQT

PFPSGNY
Length:407
Mass (Da):45,838
Last modified:April 8, 2008 - v2
Checksum:i291BE954C1669FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663096 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000119346; ENSMUSP00000112566; ENSMUSG00000020682.
UCSCiuc007kpd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ5SSG2_MOUSE
AccessioniPrimary (citable) accession number: Q5SSG2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: April 8, 2008
Last modified: November 22, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported