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Protein

SUN domain-containing protein 3

Gene

Sun3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 3
Alternative name(s):
Sad1/unc-84 domain-containing protein 1
Gene namesi
Name:Sun3
Synonyms:Sunc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3041199. Sun3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6NuclearCurated6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 320Perinuclear spaceCuratedAdd BLAST291

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • LINC complex Source: MGI
  • nuclear inner membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122221 – 320SUN domain-containing protein 3Add BLAST320

Proteomic databases

PaxDbiQ5SS91.
PRIDEiQ5SS91.

PTM databases

PhosphoSitePlusiQ5SS91.

Expressioni

Tissue specificityi

Specifically expressed in testis (at protein level).1 Publication

Developmental stagei

Exclusively expressed in postmeiotic stages of male germ cell development. First detected at day 25 p.p. when spermatids are most frequent within seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSMUSG00000040985.
CleanExiMM_SUNC1.
ExpressionAtlasiQ5SS91. baseline and differential.
GenevisibleiQ5SS91. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1. Can interact with SYNE3; the interaction is questioned by missing colocalization in spermatids.2 Publications

Protein-protein interaction databases

IntActiQ5SS91. 1 interactor.
STRINGi10090.ENSMUSP00000099973.

Structurei

3D structure databases

ProteinModelPortaliQ5SS91.
SMRiQ5SS91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 317SUNPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 102Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG108520.
InParanoidiQ5SS91.
OMAiEYGSRLY.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ5SS91.
TreeFamiTF323915.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR030274. SUN3.
IPR012919. SUN_dom.
PANTHERiPTHR12911:SF30. PTHR12911:SF30. 1 hit.
PfamiView protein in Pfam
PF07738. Sad1_UNC. 1 hit.
PROSITEiView protein in PROSITE
PS51469. SUN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SS91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRSWKIIL STVFISTFLL VGLLNHQWLK ETEFPQKPRQ LYTVIAEYGS
60 70 80 90 100
RLYNYQARLR MPKEQQELLK KESQTLENNF REILFLIEQI DVLKALLKDM
110 120 130 140 150
KDGVHNHSLP VHRDAVQDQA TTDVLDEEMS NLVHYVLKKF RGDQIQLADY
160 170 180 190 200
ALKSAGASVI EAGTSESYKN NKAKLYWHGI GFLNYEMPPD MILQPDVHPG
210 220 230 240 250
KCWAFPGSQG HILIKLARKI IPTAVTMEHI SEKVSPSGNI SSAPKEFSVY
260 270 280 290 300
GVMKKCEGEE IFLGQFIYNK MEATIQTFEL QNEASESLLC VKLQILSNWG
310 320
HPKYTCLYRF RVHGIPSDYT
Length:320
Mass (Da):36,758
Last modified:December 21, 2004 - v1
Checksum:i8DEC1E6B0D0BC1FB
GO
Isoform 2 (identifier: Q5SS91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:260
Mass (Da):29,544
Checksum:iABF66504F0D13B7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297501 – 60Missing in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052771 mRNA. Translation: BAC35140.1.
AK132922 mRNA. Translation: BAE21423.1.
AL669837 Genomic DNA. Translation: CAI24620.1.
AL669837 Genomic DNA. Translation: CAI24621.1.
BC109334 mRNA. Translation: AAI09335.1.
CCDSiCCDS24430.1. [Q5SS91-2]
CCDS70140.1. [Q5SS91-1]
RefSeqiNP_001277448.1. NM_001290519.1. [Q5SS91-1]
NP_001277449.1. NM_001290520.1. [Q5SS91-2]
NP_808244.1. NM_177576.3. [Q5SS91-2]
UniGeneiMm.79210.

Genome annotation databases

EnsembliENSMUST00000043377; ENSMUSP00000045199; ENSMUSG00000040985. [Q5SS91-1]
ENSMUST00000102909; ENSMUSP00000099973; ENSMUSG00000040985. [Q5SS91-2]
GeneIDi194974.
KEGGimmu:194974.
UCSCiuc007hzt.1. mouse. [Q5SS91-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052771 mRNA. Translation: BAC35140.1.
AK132922 mRNA. Translation: BAE21423.1.
AL669837 Genomic DNA. Translation: CAI24620.1.
AL669837 Genomic DNA. Translation: CAI24621.1.
BC109334 mRNA. Translation: AAI09335.1.
CCDSiCCDS24430.1. [Q5SS91-2]
CCDS70140.1. [Q5SS91-1]
RefSeqiNP_001277448.1. NM_001290519.1. [Q5SS91-1]
NP_001277449.1. NM_001290520.1. [Q5SS91-2]
NP_808244.1. NM_177576.3. [Q5SS91-2]
UniGeneiMm.79210.

3D structure databases

ProteinModelPortaliQ5SS91.
SMRiQ5SS91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SS91. 1 interactor.
STRINGi10090.ENSMUSP00000099973.

PTM databases

PhosphoSitePlusiQ5SS91.

Proteomic databases

PaxDbiQ5SS91.
PRIDEiQ5SS91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043377; ENSMUSP00000045199; ENSMUSG00000040985. [Q5SS91-1]
ENSMUST00000102909; ENSMUSP00000099973; ENSMUSG00000040985. [Q5SS91-2]
GeneIDi194974.
KEGGimmu:194974.
UCSCiuc007hzt.1. mouse. [Q5SS91-1]

Organism-specific databases

CTDi256979.
MGIiMGI:3041199. Sun3.

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000007503.
HOVERGENiHBG108520.
InParanoidiQ5SS91.
OMAiEYGSRLY.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ5SS91.
TreeFamiTF323915.

Miscellaneous databases

PROiPR:Q5SS91.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040985.
CleanExiMM_SUNC1.
ExpressionAtlasiQ5SS91. baseline and differential.
GenevisibleiQ5SS91. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR030274. SUN3.
IPR012919. SUN_dom.
PANTHERiPTHR12911:SF30. PTHR12911:SF30. 1 hit.
PfamiView protein in Pfam
PF07738. Sad1_UNC. 1 hit.
PROSITEiView protein in PROSITE
PS51469. SUN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUN3_MOUSE
AccessioniPrimary (citable) accession number: Q5SS91
Secondary accession number(s): Q8BHY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.