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Q5SS91

- SUN3_MOUSE

UniProt

Q5SS91 - SUN3_MOUSE

Protein

SUN domain-containing protein 3

Gene

Sun3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SUN domain-containing protein 3
    Alternative name(s):
    Sad1/unc-84 domain-containing protein 1
    Gene namesi
    Name:Sun3
    Synonyms:Sunc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:3041199. Sun3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. SUN-KASH complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320SUN domain-containing protein 3PRO_0000312222Add
    BLAST

    Proteomic databases

    PaxDbiQ5SS91.
    PRIDEiQ5SS91.

    PTM databases

    PhosphoSiteiQ5SS91.

    Expressioni

    Gene expression databases

    BgeeiQ5SS91.
    CleanExiMM_SUNC1.
    GenevestigatoriQ5SS91.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SS91.
    SMRiQ5SS91. Positions 124-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 317162SUNPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili63 – 10240Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SUN domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285464.
    GeneTreeiENSGT00390000011587.
    HOGENOMiHOG000007503.
    HOVERGENiHBG108520.
    InParanoidiQ5SS91.
    OMAiRVHGTPG.
    OrthoDBiEOG7J446H.
    PhylomeDBiQ5SS91.
    TreeFamiTF323915.

    Family and domain databases

    InterProiIPR012919. Sad1_UNC_C.
    [Graphical view]
    PfamiPF07738. Sad1_UNC. 1 hit.
    [Graphical view]
    PROSITEiPS51469. SUN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SS91-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTRSWKIIL STVFISTFLL VGLLNHQWLK ETEFPQKPRQ LYTVIAEYGS    50
    RLYNYQARLR MPKEQQELLK KESQTLENNF REILFLIEQI DVLKALLKDM 100
    KDGVHNHSLP VHRDAVQDQA TTDVLDEEMS NLVHYVLKKF RGDQIQLADY 150
    ALKSAGASVI EAGTSESYKN NKAKLYWHGI GFLNYEMPPD MILQPDVHPG 200
    KCWAFPGSQG HILIKLARKI IPTAVTMEHI SEKVSPSGNI SSAPKEFSVY 250
    GVMKKCEGEE IFLGQFIYNK MEATIQTFEL QNEASESLLC VKLQILSNWG 300
    HPKYTCLYRF RVHGIPSDYT 320
    Length:320
    Mass (Da):36,758
    Last modified:December 21, 2004 - v1
    Checksum:i8DEC1E6B0D0BC1FB
    GO
    Isoform 2 (identifier: Q5SS91-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Show »
    Length:260
    Mass (Da):29,544
    Checksum:iABF66504F0D13B7F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform 2. 2 PublicationsVSP_029750Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052771 mRNA. Translation: BAC35140.1.
    AK132922 mRNA. Translation: BAE21423.1.
    AL669837 Genomic DNA. Translation: CAI24620.1.
    AL669837 Genomic DNA. Translation: CAI24621.1.
    BC109334 mRNA. Translation: AAI09335.1.
    CCDSiCCDS24430.1. [Q5SS91-2]
    CCDS70140.1. [Q5SS91-1]
    RefSeqiNP_001277448.1. NM_001290519.1. [Q5SS91-1]
    NP_001277449.1. NM_001290520.1. [Q5SS91-2]
    NP_808244.1. NM_177576.3. [Q5SS91-2]
    UniGeneiMm.79210.

    Genome annotation databases

    EnsembliENSMUST00000043377; ENSMUSP00000045199; ENSMUSG00000040985. [Q5SS91-1]
    ENSMUST00000102909; ENSMUSP00000099973; ENSMUSG00000040985. [Q5SS91-2]
    GeneIDi194974.
    KEGGimmu:194974.
    UCSCiuc007hzt.1. mouse. [Q5SS91-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052771 mRNA. Translation: BAC35140.1 .
    AK132922 mRNA. Translation: BAE21423.1 .
    AL669837 Genomic DNA. Translation: CAI24620.1 .
    AL669837 Genomic DNA. Translation: CAI24621.1 .
    BC109334 mRNA. Translation: AAI09335.1 .
    CCDSi CCDS24430.1. [Q5SS91-2 ]
    CCDS70140.1. [Q5SS91-1 ]
    RefSeqi NP_001277448.1. NM_001290519.1. [Q5SS91-1 ]
    NP_001277449.1. NM_001290520.1. [Q5SS91-2 ]
    NP_808244.1. NM_177576.3. [Q5SS91-2 ]
    UniGenei Mm.79210.

    3D structure databases

    ProteinModelPortali Q5SS91.
    SMRi Q5SS91. Positions 124-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045199.

    PTM databases

    PhosphoSitei Q5SS91.

    Proteomic databases

    PaxDbi Q5SS91.
    PRIDEi Q5SS91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043377 ; ENSMUSP00000045199 ; ENSMUSG00000040985 . [Q5SS91-1 ]
    ENSMUST00000102909 ; ENSMUSP00000099973 ; ENSMUSG00000040985 . [Q5SS91-2 ]
    GeneIDi 194974.
    KEGGi mmu:194974.
    UCSCi uc007hzt.1. mouse. [Q5SS91-1 ]

    Organism-specific databases

    CTDi 256979.
    MGIi MGI:3041199. Sun3.

    Phylogenomic databases

    eggNOGi NOG285464.
    GeneTreei ENSGT00390000011587.
    HOGENOMi HOG000007503.
    HOVERGENi HBG108520.
    InParanoidi Q5SS91.
    OMAi RVHGTPG.
    OrthoDBi EOG7J446H.
    PhylomeDBi Q5SS91.
    TreeFami TF323915.

    Miscellaneous databases

    NextBioi 371685.
    PROi Q5SS91.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SS91.
    CleanExi MM_SUNC1.
    Genevestigatori Q5SS91.

    Family and domain databases

    InterProi IPR012919. Sad1_UNC_C.
    [Graphical view ]
    Pfami PF07738. Sad1_UNC. 1 hit.
    [Graphical view ]
    PROSITEi PS51469. SUN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Kidney and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiSUN3_MOUSE
    AccessioniPrimary (citable) accession number: Q5SS91
    Secondary accession number(s): Q8BHY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3