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Q5SS91 (SUN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SUN domain-containing protein 3
Alternative name(s):
Sad1/unc-84 domain-containing protein 1
Gene names
Name:Sun3
Synonyms:Sunc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 SUN domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentSUN-KASH complex

Inferred from direct assay PubMed 20711465. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5SS91-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5SS91-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320SUN domain-containing protein 3
PRO_0000312222

Regions

Transmembrane7 – 2923Helical; Potential
Domain156 – 317162SUN
Coiled coil63 – 10240 Potential

Natural variations

Alternative sequence1 – 6060Missing in isoform 2.
VSP_029750

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 8DEC1E6B0D0BC1FB

FASTA32036,758
        10         20         30         40         50         60 
MLTRSWKIIL STVFISTFLL VGLLNHQWLK ETEFPQKPRQ LYTVIAEYGS RLYNYQARLR 

        70         80         90        100        110        120 
MPKEQQELLK KESQTLENNF REILFLIEQI DVLKALLKDM KDGVHNHSLP VHRDAVQDQA 

       130        140        150        160        170        180 
TTDVLDEEMS NLVHYVLKKF RGDQIQLADY ALKSAGASVI EAGTSESYKN NKAKLYWHGI 

       190        200        210        220        230        240 
GFLNYEMPPD MILQPDVHPG KCWAFPGSQG HILIKLARKI IPTAVTMEHI SEKVSPSGNI 

       250        260        270        280        290        300 
SSAPKEFSVY GVMKKCEGEE IFLGQFIYNK MEATIQTFEL QNEASESLLC VKLQILSNWG 

       310        320 
HPKYTCLYRF RVHGIPSDYT 

« Hide

Isoform 2 [UniParc].

Checksum: ABF66504F0D13B7F
Show »

FASTA26029,544

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Kidney and Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK052771 mRNA. Translation: BAC35140.1.
AK132922 mRNA. Translation: BAE21423.1.
AL669837 Genomic DNA. Translation: CAI24620.1.
AL669837 Genomic DNA. Translation: CAI24621.1.
BC109334 mRNA. Translation: AAI09335.1.
RefSeqNP_808244.1. NM_177576.3.
XP_006514659.1. XM_006514596.1.
UniGeneMm.79210.

3D structure databases

ProteinModelPortalQ5SS91.
SMRQ5SS91. Positions 123-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045199.

PTM databases

PhosphoSiteQ5SS91.

Proteomic databases

PaxDbQ5SS91.
PRIDEQ5SS91.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043377; ENSMUSP00000045199; ENSMUSG00000040985. [Q5SS91-1]
ENSMUST00000102909; ENSMUSP00000099973; ENSMUSG00000040985. [Q5SS91-2]
GeneID194974.
KEGGmmu:194974.
UCSCuc007hzt.1. mouse. [Q5SS91-1]

Organism-specific databases

CTD256979.
MGIMGI:3041199. Sun3.

Phylogenomic databases

eggNOGNOG285464.
GeneTreeENSGT00390000011587.
HOGENOMHOG000007503.
HOVERGENHBG108520.
InParanoidQ5SS91.
OMARVHGTPG.
OrthoDBEOG7J446H.
TreeFamTF323915.

Gene expression databases

ArrayExpressQ5SS91.
BgeeQ5SS91.
CleanExMM_SUNC1.
GenevestigatorQ5SS91.

Family and domain databases

InterProIPR012919. Sad1_UNC_C.
[Graphical view]
PfamPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio371685.
PROQ5SS91.
SOURCESearch...

Entry information

Entry nameSUN3_MOUSE
AccessionPrimary (citable) accession number: Q5SS91
Secondary accession number(s): Q8BHY0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: March 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot