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Protein

Dehydrogenase/reductase SDR family member 13

Gene

Dhrs13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateSequence analysis1
Active sitei197Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 49NAD or NADPBy similarity7

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 13 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 7C member 5By similarity
Gene namesi
Name:Dhrs13
Synonyms:Sdr7c5By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917701 Dhrs13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031192126 – 376Dehydrogenase/reductase SDR family member 13Add BLAST351

Proteomic databases

EPDiQ5SS80
PaxDbiQ5SS80
PeptideAtlasiQ5SS80
PRIDEiQ5SS80

PTM databases

iPTMnetiQ5SS80
PhosphoSitePlusiQ5SS80
SwissPalmiQ5SS80

Expressioni

Gene expression databases

BgeeiENSMUSG00000020834
CleanExiMM_DHRS13
ExpressionAtlasiQ5SS80 baseline and differential
GenevisibleiQ5SS80 MM

Interactioni

Protein-protein interaction databases

BioGridi214059, 1 interactor
STRINGi10090.ENSMUSP00000021187

Structurei

3D structure databases

ProteinModelPortaliQ5SS80
SMRiQ5SS80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi317 – 330Asp/Glu-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ5SS80
KOiK11169
OMAiCGRTRET
OrthoDBiEOG091G0FGA
PhylomeDBiQ5SS80
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SS80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMLLLGAGL LLGAYVLVYY NLVKAPSCGG IGSLRGRTVV VTGANSGIGK
60 70 80 90 100
MTALELARRG ARVVLACRSR ERGEAAAFDL RQESGNNEVI FMALDLASLA
110 120 130 140 150
SVQAFATAFL SSEPRLDVLI HNAGISSCGR TRETFNLLLR VNHVGPFLLT
160 170 180 190 200
HLLLPRLRSC APSRVVIVSS AAHRRGRLDF TRLDCPVVGW QQELRAYADS
210 220 230 240 250
KLANVLFARE LATQLEGTGV TCYAAHPGPV NSELFLRHLP GWLRPILRPL
260 270 280 290 300
AWLVLRAPQG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV SPAARDDQAA
310 320 330 340 350
QRLWKATKKL AGLAPGDDDD DPDEEPEPED PRAPSSQSAP SPEKTTVSGP
360 370
SHSYQGSQDL SKLTQRRIQV KDEPTP
Length:376
Mass (Da):40,745
Last modified:December 21, 2004 - v1
Checksum:iB4C77A8058948865
GO
Isoform 2 (identifier: Q5SS80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,162
Checksum:iB7F2077BF23D576B
GO

Sequence cautioni

The sequence BAC25347 differs from that shown. Reason: Frameshift at positions 254, 256, 270 and 290.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240P → R in BAC25347 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296411 – 91Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011939 mRNA Translation: BAC25347.1 Frameshift.
AL669840 Genomic DNA Translation: CAI25703.1
BC115881 mRNA Translation: AAI15882.1
CCDSiCCDS36236.1 [Q5SS80-1]
RefSeqiNP_899109.2, NM_183286.2 [Q5SS80-1]
XP_011247557.1, XM_011249255.2 [Q5SS80-2]
UniGeneiMm.390342

Genome annotation databases

EnsembliENSMUST00000021187; ENSMUSP00000021187; ENSMUSG00000020834 [Q5SS80-1]
GeneIDi70451
KEGGimmu:70451
UCSCiuc007khu.1 mouse [Q5SS80-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHR13_MOUSE
AccessioniPrimary (citable) accession number: Q5SS80
Secondary accession number(s): Q14BH2, Q8BMX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health