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Q5SRY7

- FBW1B_MOUSE

UniProt

Q5SRY7 - FBW1B_MOUSE

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Protein

F-box/WD repeat-containing protein 11

Gene

Fbxw11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.2 Publications

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. negative regulation of NF-kappaB import into nucleus Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: Ensembl
  4. positive regulation of circadian rhythm Source: UniProtKB
  5. positive regulation of proteolysis Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  8. protein dephosphorylation Source: UniProtKB
  9. protein destabilization Source: UniProtKB
  10. protein polyubiquitination Source: UniProtKB
  11. regulation of circadian rhythm Source: UniProtKB
  12. rhythmic process Source: UniProtKB-KW
  13. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  14. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Cell cycle, Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_199121. Activation of NF-kappaB in B cells.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 11
Alternative name(s):
F-box and WD repeats protein beta-TrCP2
F-box/WD repeat-containing protein 1B
Homologous to Slimb protein
Short name:
HOS
Gene namesi
Name:Fbxw11
Synonyms:Btrcp2, Fbw1b, Fbxw1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2144023. Fbxw11.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542F-box/WD repeat-containing protein 11PRO_0000396126Add
BLAST

Proteomic databases

MaxQBiQ5SRY7.
PaxDbiQ5SRY7.
PRIDEiQ5SRY7.

PTM databases

PhosphoSiteiQ5SRY7.

Expressioni

Inductioni

Expression is negatively regulated by Wnt/beta-catenin pathway.1 Publication

Gene expression databases

BgeeiQ5SRY7.
ExpressionAtlasiQ5SRY7. baseline and differential.
GenevestigatoriQ5SRY7.

Interactioni

Subunit structurei

Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1, PER1 and PER2; the interaction requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. Interacts with TRIM21. Interacts with PER3.3 Publications

Protein-protein interaction databases

BioGridi222123. 4 interactions.
DIPiDIP-59921N.
STRINGi10090.ENSMUSP00000075721.

Structurei

3D structure databases

ProteinModelPortaliQ5SRY7.
SMRiQ5SRY7. Positions 67-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 16747F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati238 – 27538WD 1Add
BLAST
Repeati278 – 31538WD 2Add
BLAST
Repeati318 – 35538WD 3Add
BLAST
Repeati361 – 39838WD 4Add
BLAST
Repeati401 – 44040WD 5Add
BLAST
Repeati442 – 47837WD 6Add
BLAST
Repeati490 – 52738WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 11650Homodimerization domain DBy similarityAdd
BLAST

Domaini

The N-terminal D domain mediates homodimerization.By similarity

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000006638.
HOVERGENiHBG002521.
InParanoidiQ5SRY7.
KOiK03362.
OMAiFDQWSEA.
OrthoDBiEOG76DTS5.
TreeFamiTF105679.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SRY7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI
60 70 80 90 100
SNGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC
110 120 130 140 150
HYQHGHINSY LKPMLQRDFI TALPEQGLDH IAENILSYLD ARSLCAAELV
160 170 180 190 200
CKEWQRVISE GMLWKKLIER MVRTDPLWKG LSERRGWDQY LFKNRPTDGP
210 220 230 240 250
PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS KGVYCLQYDD
260 270 280 290 300
DKIISGLRDN SIKIWDKSSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS
310 320 330 340 350
TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA
360 370 380 390 400
TDITLRRVLV GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN
410 420 430 440 450
GHKRGIACLQ YRDRLVVSGS SDNTIRLWDI ECGACLRVLE GHEELVRCIR
460 470 480 490 500
FDNKRIVSGA YDGKIKVWDL QAALDPRAPA STLCLRTLVE HSGRVFRLQF
510 520 530 540
DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI SR
Length:542
Mass (Da):62,063
Last modified:December 21, 2004 - v1
Checksum:iD95A78A6977B828A
GO
Isoform 2 (identifier: Q5SRY7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-49: Q → QNTSVMEDQNEDESPKKSALWQ

Show »
Length:563
Mass (Da):64,481
Checksum:i74D07E6BB850ABED
GO
Isoform 3 (identifier: Q5SRY7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-48: CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL → NTSVMEDQNEDESPKKSALW

Show »
Length:529
Mass (Da):60,813
Checksum:iD2F382457FD80080
GO
Isoform 4 (identifier: Q5SRY7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.

Show »
Length:508
Mass (Da):58,394
Checksum:iA048E9FA4A78C550
GO

Sequence cautioni

The sequence AAK72095.1 differs from that shown. Reason: Frameshift at position 349.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191I → V in BAE38644. (PubMed:16141072)Curated
Sequence conflicti534 – 5341S → F in AAK72095. (PubMed:11896578)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 4934Missing in isoform 4. 1 PublicationVSP_039579Add
BLAST
Alternative sequencei16 – 4833CSVPR…SVRCL → NTSVMEDQNEDESPKKSALW in isoform 3. 1 PublicationVSP_039580Add
BLAST
Alternative sequencei49 – 491Q → QNTSVMEDQNEDESPKKSAL WQ in isoform 2. 2 PublicationsVSP_039581

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038079 mRNA. Translation: AAK72095.1. Frameshift.
AK041532 mRNA. Translation: BAC30975.1.
AK149139 mRNA. Translation: BAE28749.1.
AK152181 mRNA. Translation: BAE31012.1.
AK160086 mRNA. Translation: BAE35617.1.
AK166226 mRNA. Translation: BAE38644.1.
AK168667 mRNA. Translation: BAE40519.1.
AL669844, AL669951 Genomic DNA. Translation: CAI25519.1.
AL669844, AL669951 Genomic DNA. Translation: CAI25520.1.
AL669951, AL669844 Genomic DNA. Translation: CAI26097.1.
AL669951, AL669844 Genomic DNA. Translation: CAI26098.1.
BC034261 mRNA. Translation: AAH34261.1.
CCDSiCCDS36125.1. [Q5SRY7-2]
CCDS70157.1. [Q5SRY7-1]
CCDS70158.1. [Q5SRY7-3]
RefSeqiNP_001258276.1. NM_001271347.1. [Q5SRY7-1]
NP_001258277.1. NM_001271348.1. [Q5SRY7-3]
NP_001258278.1. NM_001271349.1. [Q5SRY7-4]
NP_598776.1. NM_134015.3. [Q5SRY7-2]
UniGeneiMm.28017.
Mm.491286.

Genome annotation databases

EnsembliENSMUST00000076383; ENSMUSP00000075721; ENSMUSG00000020271. [Q5SRY7-2]
ENSMUST00000093205; ENSMUSP00000090893; ENSMUSG00000020271. [Q5SRY7-1]
ENSMUST00000109366; ENSMUSP00000104991; ENSMUSG00000020271. [Q5SRY7-3]
GeneIDi103583.
KEGGimmu:103583.
UCSCiuc007ijx.1. mouse. [Q5SRY7-2]
uc007ijy.1. mouse. [Q5SRY7-3]
uc007ijz.1. mouse. [Q5SRY7-1]
uc007ika.1. mouse. [Q5SRY7-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038079 mRNA. Translation: AAK72095.1 . Frameshift.
AK041532 mRNA. Translation: BAC30975.1 .
AK149139 mRNA. Translation: BAE28749.1 .
AK152181 mRNA. Translation: BAE31012.1 .
AK160086 mRNA. Translation: BAE35617.1 .
AK166226 mRNA. Translation: BAE38644.1 .
AK168667 mRNA. Translation: BAE40519.1 .
AL669844 , AL669951 Genomic DNA. Translation: CAI25519.1 .
AL669844 , AL669951 Genomic DNA. Translation: CAI25520.1 .
AL669951 , AL669844 Genomic DNA. Translation: CAI26097.1 .
AL669951 , AL669844 Genomic DNA. Translation: CAI26098.1 .
BC034261 mRNA. Translation: AAH34261.1 .
CCDSi CCDS36125.1. [Q5SRY7-2 ]
CCDS70157.1. [Q5SRY7-1 ]
CCDS70158.1. [Q5SRY7-3 ]
RefSeqi NP_001258276.1. NM_001271347.1. [Q5SRY7-1 ]
NP_001258277.1. NM_001271348.1. [Q5SRY7-3 ]
NP_001258278.1. NM_001271349.1. [Q5SRY7-4 ]
NP_598776.1. NM_134015.3. [Q5SRY7-2 ]
UniGenei Mm.28017.
Mm.491286.

3D structure databases

ProteinModelPortali Q5SRY7.
SMRi Q5SRY7. Positions 67-518.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222123. 4 interactions.
DIPi DIP-59921N.
STRINGi 10090.ENSMUSP00000075721.

PTM databases

PhosphoSitei Q5SRY7.

Proteomic databases

MaxQBi Q5SRY7.
PaxDbi Q5SRY7.
PRIDEi Q5SRY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076383 ; ENSMUSP00000075721 ; ENSMUSG00000020271 . [Q5SRY7-2 ]
ENSMUST00000093205 ; ENSMUSP00000090893 ; ENSMUSG00000020271 . [Q5SRY7-1 ]
ENSMUST00000109366 ; ENSMUSP00000104991 ; ENSMUSG00000020271 . [Q5SRY7-3 ]
GeneIDi 103583.
KEGGi mmu:103583.
UCSCi uc007ijx.1. mouse. [Q5SRY7-2 ]
uc007ijy.1. mouse. [Q5SRY7-3 ]
uc007ijz.1. mouse. [Q5SRY7-1 ]
uc007ika.1. mouse. [Q5SRY7-4 ]

Organism-specific databases

CTDi 23291.
MGIi MGI:2144023. Fbxw11.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119106.
HOGENOMi HOG000006638.
HOVERGENi HBG002521.
InParanoidi Q5SRY7.
KOi K03362.
OMAi FDQWSEA.
OrthoDBi EOG76DTS5.
TreeFami TF105679.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_199121. Activation of NF-kappaB in B cells.

Miscellaneous databases

ChiTaRSi FBXW11. mouse.
NextBioi 356027.
PROi Q5SRY7.
SOURCEi Search...

Gene expression databases

Bgeei Q5SRY7.
ExpressionAtlasi Q5SRY7. baseline and differential.
Genevestigatori Q5SRY7.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12125. Beta-TrCP_D. 1 hit.
PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB."
    Bhatia N., Herter J.R., Slaga T.J., Fuchs S.Y., Spiegelman V.S.
    Oncogene 21:1501-1509(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH SKP1 AND NFKBIA.
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Strain: C57BL/6J.
    Tissue: Kidney, Mammary gland, Osteoclast, Sympathetic ganglion and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Inhibition of HOS expression and activities by Wnt pathway."
    Spiegelman V.S., Tang W., Katoh M., Slaga T.J., Fuchs S.Y.
    Oncogene 21:856-860(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."
    Shirogane T., Jin J., Ang X.L., Harper J.W.
    J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PER3.
  7. "The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2."
    Ohsaki K., Oishi K., Kozono Y., Nakayama K., Nakayama K.I., Ishida N.
    J. Biochem. 144:609-618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH PER2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFBW1B_MOUSE
AccessioniPrimary (citable) accession number: Q5SRY7
Secondary accession number(s): Q3TGM9
, Q3TLZ8, Q8BY90, Q8K022, Q923H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3