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Protein

F-box/WD repeat-containing protein 11

Gene

Fbxw11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: MGI
  • positive regulation of circadian rhythm Source: UniProtKB
  • positive regulation of proteolysis Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • protein destabilization Source: UniProtKB
  • protein polyubiquitination Source: UniProtKB
  • protein ubiquitination Source: MGI
  • regulation of circadian rhythm Source: UniProtKB
  • rhythmic process Source: UniProtKB-KW
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processBiological rhythms, Cell cycle, Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-202424 Downstream TCR signaling
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 11
Alternative name(s):
F-box and WD repeats protein beta-TrCP2
F-box/WD repeat-containing protein 1B
Homologous to Slimb protein
Short name:
HOS
Gene namesi
Name:Fbxw11
Synonyms:Btrcp2, Fbw1b, Fbxw1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144023 Fbxw11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003961261 – 542F-box/WD repeat-containing protein 11Add BLAST542

Proteomic databases

EPDiQ5SRY7
PaxDbiQ5SRY7
PeptideAtlasiQ5SRY7
PRIDEiQ5SRY7

PTM databases

iPTMnetiQ5SRY7
PhosphoSitePlusiQ5SRY7
SwissPalmiQ5SRY7

Expressioni

Inductioni

Expression is negatively regulated by Wnt/beta-catenin pathway.1 Publication

Gene expression databases

BgeeiENSMUSG00000020271
ExpressionAtlasiQ5SRY7 baseline and differential
GenevisibleiQ5SRY7 MM

Interactioni

Subunit structurei

Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1, PER1 and PER2; the interaction requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. Interacts with TRIM21. Interacts with PER3. Interacts with phosphorylated ubiquitination substrate CEP68 (By similarity). Interacts with INAVA (By similarity).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222123, 24 interactors
DIPiDIP-59921N
IntActiQ5SRY7, 21 interactors
STRINGi10090.ENSMUSP00000075721

Structurei

3D structure databases

ProteinModelPortaliQ5SRY7
SMRiQ5SRY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 167F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati238 – 275WD 1Add BLAST38
Repeati278 – 315WD 2Add BLAST38
Repeati318 – 355WD 3Add BLAST38
Repeati361 – 398WD 4Add BLAST38
Repeati401 – 440WD 5Add BLAST40
Repeati442 – 478WD 6Add BLAST37
Repeati490 – 527WD 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 116Homodimerization domain DBy similarityAdd BLAST50

Domaini

The N-terminal D domain mediates homodimerization.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0281 Eukaryota
ENOG410XTA8 LUCA
GeneTreeiENSGT00760000119106
HOGENOMiHOG000006638
HOVERGENiHBG002521
InParanoidiQ5SRY7
KOiK03362
OMAiRLISRMC
OrthoDBiEOG091G0437
TreeFamiTF105679

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR021977 Beta-TrCP_D
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12125 Beta-TrCP_D, 1 hit
PF12937 F-box-like, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM01028 Beta-TrCP_D, 1 hit
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI
60 70 80 90 100
SNGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC
110 120 130 140 150
HYQHGHINSY LKPMLQRDFI TALPEQGLDH IAENILSYLD ARSLCAAELV
160 170 180 190 200
CKEWQRVISE GMLWKKLIER MVRTDPLWKG LSERRGWDQY LFKNRPTDGP
210 220 230 240 250
PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS KGVYCLQYDD
260 270 280 290 300
DKIISGLRDN SIKIWDKSSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS
310 320 330 340 350
TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA
360 370 380 390 400
TDITLRRVLV GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN
410 420 430 440 450
GHKRGIACLQ YRDRLVVSGS SDNTIRLWDI ECGACLRVLE GHEELVRCIR
460 470 480 490 500
FDNKRIVSGA YDGKIKVWDL QAALDPRAPA STLCLRTLVE HSGRVFRLQF
510 520 530 540
DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI SR
Length:542
Mass (Da):62,063
Last modified:December 21, 2004 - v1
Checksum:iD95A78A6977B828A
GO
Isoform 2 (identifier: Q5SRY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-49: Q → QNTSVMEDQNEDESPKKSALWQ

Show »
Length:563
Mass (Da):64,481
Checksum:i74D07E6BB850ABED
GO
Isoform 3 (identifier: Q5SRY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-48: CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL → NTSVMEDQNEDESPKKSALW

Show »
Length:529
Mass (Da):60,813
Checksum:iD2F382457FD80080
GO
Isoform 4 (identifier: Q5SRY7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.

Show »
Length:508
Mass (Da):58,394
Checksum:iA048E9FA4A78C550
GO

Sequence cautioni

The sequence AAK72095 differs from that shown. Reason: Frameshift at position 349.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219I → V in BAE38644 (PubMed:16141072).Curated1
Sequence conflicti534S → F in AAK72095 (PubMed:11896578).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03957916 – 49Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_03958016 – 48CSVPR…SVRCL → NTSVMEDQNEDESPKKSALW in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_03958149Q → QNTSVMEDQNEDESPKKSAL WQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038079 mRNA Translation: AAK72095.1 Frameshift.
AK041532 mRNA Translation: BAC30975.1
AK149139 mRNA Translation: BAE28749.1
AK152181 mRNA Translation: BAE31012.1
AK160086 mRNA Translation: BAE35617.1
AK166226 mRNA Translation: BAE38644.1
AK168667 mRNA Translation: BAE40519.1
AL669844, AL669951 Genomic DNA Translation: CAI25519.1
AL669844, AL669951 Genomic DNA Translation: CAI25520.1
AL669951, AL669844 Genomic DNA Translation: CAI26097.1
AL669951, AL669844 Genomic DNA Translation: CAI26098.1
BC034261 mRNA Translation: AAH34261.1
CCDSiCCDS36125.1 [Q5SRY7-2]
CCDS70157.1 [Q5SRY7-1]
CCDS70158.1 [Q5SRY7-3]
RefSeqiNP_001258276.1, NM_001271347.1 [Q5SRY7-1]
NP_001258277.1, NM_001271348.1 [Q5SRY7-3]
NP_001258278.1, NM_001271349.1 [Q5SRY7-4]
NP_598776.1, NM_134015.3 [Q5SRY7-2]
UniGeneiMm.28017
Mm.491286

Genome annotation databases

EnsembliENSMUST00000076383; ENSMUSP00000075721; ENSMUSG00000020271 [Q5SRY7-2]
ENSMUST00000093205; ENSMUSP00000090893; ENSMUSG00000020271 [Q5SRY7-1]
ENSMUST00000109366; ENSMUSP00000104991; ENSMUSG00000020271 [Q5SRY7-3]
GeneIDi103583
KEGGimmu:103583
UCSCiuc007ijx.2 mouse [Q5SRY7-2]
uc007ijy.2 mouse [Q5SRY7-3]
uc007ijz.2 mouse [Q5SRY7-1]
uc007ika.2 mouse [Q5SRY7-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBW1B_MOUSE
AccessioniPrimary (citable) accession number: Q5SRY7
Secondary accession number(s): Q3TGM9
, Q3TLZ8, Q8BY90, Q8K022, Q923H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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