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Protein

Chloride intracellular channel protein

Gene

CLIC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC1Imported
ORF Names:hCG_2005611Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000213719.8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26588

Expressioni

Gene expression databases

BgeeiENSG00000213719

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 233GST C-terminalInterPro annotationAdd BLAST141

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410INGZ Eukaryota
ENOG410ZZZX LUCA
HOVERGENiHBG050994
KOiK05021
OMAiLWRYLNA
OrthoDBiEOG091G0IHT

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030259 CLIC-1
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF2 PTHR43920:SF2, 1 hit
PfamiView protein in Pfam
PF13409 GST_N_2, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SRT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR
60 70 80 90 100
RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN
110 120 130 140 150
PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE
160 170 180 190 200
EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP
210 220 230 240
EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
Length:241
Mass (Da):26,923
Last modified:February 20, 2007 - v2
Checksum:i163EEB7481826A0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500788 Genomic DNA Translation: AQY77258.1
AK314014 mRNA Translation: BAG36725.1
CH471081 Genomic DNA Translation: EAX03503.1
CH471081 Genomic DNA Translation: EAX03504.1
RefSeqiNP_001274522.1, NM_001287593.1
NP_001274523.1, NM_001287594.1
NP_001279.2, NM_001288.4
UniGeneiHs.414565

Genome annotation databases

GeneIDi1192
KEGGihsa:1192
UCSCiuc003nwr.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5SRT3_HUMAN
AccessioniPrimary (citable) accession number: Q5SRT3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health