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Protein

Chloride intracellular channel protein

Gene

CLIC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC1Imported
ORF Names:hCG_2005611Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26588.

Expressioni

Gene expression databases

BgeeiENSG00000213719.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 233GST C-terminalInterPro annotationAdd BLAST141

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410INGZ. Eukaryota.
ENOG410ZZZX. LUCA.
HOVERGENiHBG050994.
KOiK05021.
OMAiLWRYLNA.
OrthoDBiEOG091G0IHT.

Family and domain databases

InterProiView protein in InterPro
IPR002946. CLIC.
IPR030259. CLIC-1.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11260:SF473. PTHR11260:SF473. 1 hit.
PfamiView protein in Pfam
PF13409. GST_N_2. 1 hit.
PRINTSiPR01263. INTCLCHANNEL.
SFLDiSFLDG01175. Main.10_. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SRT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR
60 70 80 90 100
RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN
110 120 130 140 150
PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE
160 170 180 190 200
EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP
210 220 230 240
EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
Length:241
Mass (Da):26,923
Last modified:February 20, 2007 - v2
Checksum:i163EEB7481826A0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500788 Genomic DNA. Translation: AQY77258.1.
AK314014 mRNA. Translation: BAG36725.1.
CH471081 Genomic DNA. Translation: EAX03503.1.
CH471081 Genomic DNA. Translation: EAX03504.1.
RefSeqiNP_001274522.1. NM_001287593.1.
NP_001274523.1. NM_001287594.1.
NP_001279.2. NM_001288.4.
UniGeneiHs.414565.

Genome annotation databases

GeneIDi1192.
KEGGihsa:1192.
UCSCiuc003nwr.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ5SRT3_HUMAN
AccessioniPrimary (citable) accession number: Q5SRT3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: February 20, 2007
Last modified: August 30, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.