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Protein

Lymphocyte antigen 6 complex locus protein G5c

Gene

LY6G5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in hematopoietic cell differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G5c
Gene namesi
Name:LY6G5C
Synonyms:C6orf20, G5C, NG33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13932. LY6G5C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37827.

Polymorphism and mutation databases

BioMutaiLY6G5C.
DMDMi172045918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 150109Lymphocyte antigen 6 complex locus protein G5cPRO_0000323016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 89By similarity
Disulfide bondi65 ↔ 74By similarity
Disulfide bondi81 ↔ 107By similarity
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 139By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5SRR4.
PRIDEiQ5SRR4.

Expressioni

Tissue specificityi

Detected in T-cell lines and fetal and adult lung.1 Publication

Gene expression databases

BgeeiQ5SRR4.
CleanExiHS_LY6G5C.
ExpressionAtlasiQ5SRR4. baseline and differential.
GenevisibleiQ5SRR4. HS.

Organism-specific databases

HPAiHPA038690.

Interactioni

Subunit structurei

Forms oligomers.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5SRR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 15091UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBV4. Eukaryota.
ENOG411150E. LUCA.
GeneTreeiENSGT00390000011513.
HOGENOMiHOG000043065.
HOVERGENiHBG098498.
InParanoidiQ5SRR4.
KOiK06846.
OMAiPGSSCMT.
PhylomeDBiQ5SRR4.
TreeFamiTF338717.

Family and domain databases

InterProiIPR026110. LY6G5C.
[Graphical view]
PANTHERiPTHR14909. PTHR14909. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFMAGPAGS QSLGPLCFHS SPQALYTVLL IVLVMMSLVF GKFVPVNWEP
60 70 80 90 100
PQPLPFPKYL RCYRCLLETK ELGCLLGSDI CLTPAGSSCI TLHKKNSSGS
110 120 130 140 150
DVMVSDCRSK EQMSDCSNTR TSPVSGFWIF SQYCFLDFCN DPQNRGLYTP
Length:150
Mass (Da):16,650
Last modified:February 20, 2007 - v1
Checksum:i986130D4D1A9B59C
GO
Isoform 2 (identifier: Q5SRR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MRFMAGPAGSQSLGPLCFHSS → MQTFPVAGALDPAILDTSS

Show »
Length:148
Mass (Da):16,403
Checksum:i1EC6DB6562EB67DB
GO
Isoform 3 (identifier: Q5SRR4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MRFMAGPAGS...IVLVMMSLVF → MISRDADLPS...IIRGNIPRML

Show »
Length:229
Mass (Da):25,503
Checksum:i8C768C198D7509F3
GO

Sequence cautioni

The sequence CAI18529.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAM45830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAQ06577.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAQ07007.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAQ10884.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040MRFMA…MSLVF → MISRDADLPSCWGAGPCYTG HKVGALRRDTVICCCRHGDY STPCLFTPGKPSRNPSPWKR TLWTLSAPWAGPAGWTGEEQ NATKTGLITRRPRPLRRRPH PAPASPLPEIIRGNIPRML in isoform 3. 1 PublicationVSP_042107Add
BLAST
Alternative sequencei1 – 2121MRFMA…CFHSS → MQTFPVAGALDPAILDTSS in isoform 2. CuratedVSP_032004Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315541 mRNA. Translation: CAC85522.1.
AJ315542 mRNA. Translation: CAC85542.1.
AF129756 Genomic DNA. Translation: AAD18080.1.
BA000025 Genomic DNA. Translation: BAB63384.1.
AL670886 Genomic DNA. Translation: CAI17805.2.
AL662899 Genomic DNA. Translation: CAI18398.2.
AL805934 Genomic DNA. Translation: CAI18528.2.
AL805934 Genomic DNA. Translation: CAI18529.1. Different initiation.
BX511262 Genomic DNA. Translation: CAM45829.1.
BX511262 Genomic DNA. Translation: CAM45830.1. Different initiation.
CR753842 Genomic DNA. Translation: CAQ06576.1.
CR753842 Genomic DNA. Translation: CAQ06577.1. Different initiation.
CR354443 Genomic DNA. Translation: CAQ07006.1.
CR354443 Genomic DNA. Translation: CAQ07007.1. Different initiation.
CR759761 Genomic DNA. Translation: CAQ10883.1.
CR759761 Genomic DNA. Translation: CAQ10884.1. Different initiation.
CH471081 Genomic DNA. Translation: EAX03478.1.
CCDSiCCDS34401.2. [Q5SRR4-1]
RefSeqiNP_079538.3. NM_025262.3. [Q5SRR4-1]
UniGeneiHs.25738.

Genome annotation databases

EnsembliENST00000324540; ENSP00000313380; ENSG00000111971. [Q5SRR4-1]
ENST00000383237; ENSP00000372724; ENSG00000204428. [Q5SRR4-1]
ENST00000383425; ENSP00000372917; ENSG00000206404. [Q5SRR4-1]
ENST00000418117; ENSP00000391301; ENSG00000228883. [Q5SRR4-1]
ENST00000431114; ENSP00000391878; ENSG00000231325. [Q5SRR4-1]
ENST00000455753; ENSP00000413765; ENSG00000226404. [Q5SRR4-1]
ENST00000458081; ENSP00000414953; ENSG00000237495. [Q5SRR4-1]
GeneIDi80741.
KEGGihsa:80741.
UCSCiuc003nvu.3. human. [Q5SRR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315541 mRNA. Translation: CAC85522.1.
AJ315542 mRNA. Translation: CAC85542.1.
AF129756 Genomic DNA. Translation: AAD18080.1.
BA000025 Genomic DNA. Translation: BAB63384.1.
AL670886 Genomic DNA. Translation: CAI17805.2.
AL662899 Genomic DNA. Translation: CAI18398.2.
AL805934 Genomic DNA. Translation: CAI18528.2.
AL805934 Genomic DNA. Translation: CAI18529.1. Different initiation.
BX511262 Genomic DNA. Translation: CAM45829.1.
BX511262 Genomic DNA. Translation: CAM45830.1. Different initiation.
CR753842 Genomic DNA. Translation: CAQ06576.1.
CR753842 Genomic DNA. Translation: CAQ06577.1. Different initiation.
CR354443 Genomic DNA. Translation: CAQ07006.1.
CR354443 Genomic DNA. Translation: CAQ07007.1. Different initiation.
CR759761 Genomic DNA. Translation: CAQ10883.1.
CR759761 Genomic DNA. Translation: CAQ10884.1. Different initiation.
CH471081 Genomic DNA. Translation: EAX03478.1.
CCDSiCCDS34401.2. [Q5SRR4-1]
RefSeqiNP_079538.3. NM_025262.3. [Q5SRR4-1]
UniGeneiHs.25738.

3D structure databases

ProteinModelPortaliQ5SRR4.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiLY6G5C.
DMDMi172045918.

Proteomic databases

PaxDbiQ5SRR4.
PRIDEiQ5SRR4.

Protocols and materials databases

DNASUi80741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324540; ENSP00000313380; ENSG00000111971. [Q5SRR4-1]
ENST00000383237; ENSP00000372724; ENSG00000204428. [Q5SRR4-1]
ENST00000383425; ENSP00000372917; ENSG00000206404. [Q5SRR4-1]
ENST00000418117; ENSP00000391301; ENSG00000228883. [Q5SRR4-1]
ENST00000431114; ENSP00000391878; ENSG00000231325. [Q5SRR4-1]
ENST00000455753; ENSP00000413765; ENSG00000226404. [Q5SRR4-1]
ENST00000458081; ENSP00000414953; ENSG00000237495. [Q5SRR4-1]
GeneIDi80741.
KEGGihsa:80741.
UCSCiuc003nvu.3. human. [Q5SRR4-1]

Organism-specific databases

CTDi80741.
GeneCardsiLY6G5C.
H-InvDBHIX0166166.
HIX0166451.
HIX0166705.
HIX0166964.
HIX0167204.
HIX0167442.
HIX0184235.
HGNCiHGNC:13932. LY6G5C.
HPAiHPA038690.
MIMi610434. gene.
neXtProtiNX_Q5SRR4.
PharmGKBiPA37827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBV4. Eukaryota.
ENOG411150E. LUCA.
GeneTreeiENSGT00390000011513.
HOGENOMiHOG000043065.
HOVERGENiHBG098498.
InParanoidiQ5SRR4.
KOiK06846.
OMAiPGSSCMT.
PhylomeDBiQ5SRR4.
TreeFamiTF338717.

Miscellaneous databases

GenomeRNAii80741.
NextBioi71084.
PROiQ5SRR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ5SRR4.
CleanExiHS_LY6G5C.
ExpressionAtlasiQ5SRR4. baseline and differential.
GenevisibleiQ5SRR4. HS.

Family and domain databases

InterProiIPR026110. LY6G5C.
[Graphical view]
PANTHERiPTHR14909. PTHR14909. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms."
    Mallya M., Campbell R.D., Aguado B.
    Genomics 80:113-123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 3), TISSUE SPECIFICITY.
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands."
    Mallya M., Campbell R.D., Aguado B.
    Protein Sci. 15:2244-2256(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBUNIT.

Entry informationi

Entry nameiLY65C_HUMAN
AccessioniPrimary (citable) accession number: Q5SRR4
Secondary accession number(s): A6NCW4
, B0UXB3, B0UXB4, B0UZ69, B0UZQ0, B1B0L9, O95871, Q5SQ59, Q8NDY0, Q8NDY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: March 16, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.