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Protein

Tetratricopeptide repeat protein 39A

Gene

TTC39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39A
Short name:
TPR repeat protein 39A
Alternative name(s):
Differentially expressed in MCF7 with estradiol protein 6
Short name:
DEME-6
Gene namesi
Name:TTC39A
Synonyms:C1orf34, KIAA0452
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18657. TTC39A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407260.

Polymorphism and mutation databases

BioMutaiTTC39A.
DMDMi74743633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Tetratricopeptide repeat protein 39APRO_0000291996Add
BLAST

Proteomic databases

MaxQBiQ5SRH9.
PeptideAtlasiQ5SRH9.
PRIDEiQ5SRH9.
TopDownProteomicsiQ5SRH9-1. [Q5SRH9-1]

PTM databases

iPTMnetiQ5SRH9.
PhosphoSiteiQ5SRH9.

Expressioni

Gene expression databases

BgeeiENSG00000085831.
CleanExiHS_TTC39A.
ExpressionAtlasiQ5SRH9. baseline and differential.
GenevisibleiQ5SRH9. HS.

Organism-specific databases

HPAiHPA028098.
HPA043440.

Interactioni

Protein-protein interaction databases

BioGridi116643. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5SRH9.
SMRiQ5SRH9. Positions 511-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati315 – 34834TPR 1Add
BLAST
Repeati505 – 53834TPR 2Add
BLAST
Repeati546 – 57934TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC39 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00390000009763.
HOGENOMiHOG000016942.
HOVERGENiHBG057941.
InParanoidiQ5SRH9.
OMAiTKDSMYH.
OrthoDBiEOG091G0NXI.
PhylomeDBiQ5SRH9.
TreeFamiTF313761.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019412. OMP_Iml2/TPR_39.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030416. TTC39A/B.
[Graphical view]
PANTHERiPTHR31859:SF3. PTHR31859:SF3. 2 hits.
PfamiPF10300. DUF3808. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQKGHKDSL YPCGGTPESS LHEALDQCMT ALDLFLTNQF SEALSYLKPR
60 70 80 90 100
TKESMYHSLT YATILEMQAM MTFDPQDILL AGNMMKEAQM LCQRHRRKSS
110 120 130 140 150
VTDSFSSLVN RPTLGQFTEE EIHAEVCYAE CLLQRAALTF LQGSSHGGAV
160 170 180 190 200
RPRALHDPSH ACSCPPGPGR QHLFLLQDEN MVSFIKGGIK VRNSYQTYKE
210 220 230 240 250
LDSLVQSSQY CKGENHPHFE GGVKLGVGAF NLTLSMLPTR ILRLLEFVGF
260 270 280 290 300
SGNKDYGLLQ LEEGASGHSF RSVLCVMLLL CYHTFLTFVL GTGNVNIEEA
310 320 330 340 350
EKLLKPYLNR YPKGAIFLFF AGRIEVIKGN IDAAIRRFEE CCEAQQHWKQ
360 370 380 390 400
FHHMCYWELM WCFTYKGQWK MSYFYADLLS KENCWSKATY IYMKAAYLSM
410 420 430 440 450
FGKEDHKPFG DDEVELFRAV PGLKLKIAGK SLPTEKFAIR KSRRYFSSNP
460 470 480 490 500
ISLPVPALEM MYIWNGYAVI GKQPKLTDGI LEIITKAEEM LEKGPENEYS
510 520 530 540 550
VDDECLVKLL KGLCLKYLGR VQEAEENFRS ISANEKKIKY DHYLIPNALL
560 570 580 590 600
ELALLLMEQD RNEEAIKLLE SAKQNYKNYS MESRTHFRIQ AATLQAKSSL
610
ENSSRSMVSS VSL
Length:613
Mass (Da):69,778
Last modified:December 21, 2004 - v1
Checksum:i23B898B6016F7E6F
GO
Isoform 2 (identifier: Q5SRH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:221
Mass (Da):25,147
Checksum:i7CFC06CC98B35CAE
GO
Isoform 3 (identifier: Q5SRH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MDSSPSLPLIR
     334-424: AIRRFEECCE...ELFRAVPGLK → VSDGGPGRGW...LQWREVEGGA
     425-613: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):46,394
Checksum:iF015AB6661598C91
GO
Isoform 4 (identifier: Q5SRH9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MAFLTTWKEAASGKSDRR
     143-177: Missing.

Show »
Length:581
Mass (Da):66,630
Checksum:i18D58CC091644EA4
GO
Isoform 5 (identifier: Q5SRH9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGQKGHKDSLYPCG → MTSAGGAPGALPA
     143-177: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):65,732
Checksum:iF975764F4EF63FD7
GO
Isoform 6 (identifier: Q5SRH9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-177: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:578
Mass (Da):66,152
Checksum:i84D3025AFABC23D4
GO

Sequence cautioni

The sequence AAH28374 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA32297 differs from that shown. Reason: Frameshift at position 373. Curated
The sequence BAA32297 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → V in AAH28374 (PubMed:15489334).Curated
Sequence conflicti338 – 3381F → L in BAH13518 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 392392Missing in isoform 2. 1 PublicationVSP_026348Add
BLAST
Alternative sequencei1 – 1515MGQKG…YPCGG → MDSSPSLPLIR in isoform 3. 1 PublicationVSP_026349Add
BLAST
Alternative sequencei1 – 1515MGQKG…YPCGG → MAFLTTWKEAASGKSDRR in isoform 4. 2 PublicationsVSP_026350Add
BLAST
Alternative sequencei1 – 1414MGQKG…LYPCG → MTSAGGAPGALPA in isoform 5. 1 PublicationVSP_047198Add
BLAST
Alternative sequencei143 – 17735Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_026351Add
BLAST
Alternative sequencei334 – 42491AIRRF…VPGLK → VSDGGPGRGWGSLGVSQTSR KSGTCDILRDRIDWGRGGGQ ERTNQRAGAGEALLAEQPGK TREEEAFVVPGILTGRYRTA ALQWREVEGGA in isoform 3. 1 PublicationVSP_026352Add
BLAST
Alternative sequencei425 – 613189Missing in isoform 3. 1 PublicationVSP_026353Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007921 mRNA. Translation: BAA32297.1. Sequence problems.
AK301587 mRNA. Translation: BAH13518.1.
AL162430 Genomic DNA. No translation available.
AL671986 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06826.1.
BC004399 mRNA. Translation: AAH04399.1.
BC028374 mRNA. Translation: AAH28374.1. Different initiation.
CX788693 mRNA. No translation available.
AF007170 mRNA. Translation: AAC39582.1.
CCDSiCCDS44143.1. [Q5SRH9-4]
CCDS44144.1. [Q5SRH9-6]
CCDS72790.1. [Q5SRH9-1]
CCDS76162.1. [Q5SRH9-2]
RefSeqiNP_001073963.1. NM_001080494.3. [Q5SRH9-6]
NP_001138304.1. NM_001144832.2. [Q5SRH9-4]
NP_001284592.1. NM_001297663.1. [Q5SRH9-5]
NP_001284593.1. NM_001297664.1.
NP_001284594.1. NM_001297665.1. [Q5SRH9-1]
NP_001284595.1. NM_001297666.1. [Q5SRH9-2]
NP_001284596.1. NM_001297667.1.
UniGeneiHs.112949.

Genome annotation databases

EnsembliENST00000262676; ENSP00000262676; ENSG00000085831. [Q5SRH9-3]
ENST00000371750; ENSP00000360815; ENSG00000085831. [Q5SRH9-6]
ENST00000413473; ENSP00000406144; ENSG00000085831. [Q5SRH9-4]
ENST00000447632; ENSP00000393952; ENSG00000085831. [Q5SRH9-1]
ENST00000530004; ENSP00000431228; ENSG00000085831. [Q5SRH9-2]
GeneIDi22996.
KEGGihsa:22996.
UCSCiuc001csj.4. human. [Q5SRH9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007921 mRNA. Translation: BAA32297.1. Sequence problems.
AK301587 mRNA. Translation: BAH13518.1.
AL162430 Genomic DNA. No translation available.
AL671986 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06826.1.
BC004399 mRNA. Translation: AAH04399.1.
BC028374 mRNA. Translation: AAH28374.1. Different initiation.
CX788693 mRNA. No translation available.
AF007170 mRNA. Translation: AAC39582.1.
CCDSiCCDS44143.1. [Q5SRH9-4]
CCDS44144.1. [Q5SRH9-6]
CCDS72790.1. [Q5SRH9-1]
CCDS76162.1. [Q5SRH9-2]
RefSeqiNP_001073963.1. NM_001080494.3. [Q5SRH9-6]
NP_001138304.1. NM_001144832.2. [Q5SRH9-4]
NP_001284592.1. NM_001297663.1. [Q5SRH9-5]
NP_001284593.1. NM_001297664.1.
NP_001284594.1. NM_001297665.1. [Q5SRH9-1]
NP_001284595.1. NM_001297666.1. [Q5SRH9-2]
NP_001284596.1. NM_001297667.1.
UniGeneiHs.112949.

3D structure databases

ProteinModelPortaliQ5SRH9.
SMRiQ5SRH9. Positions 511-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116643. 1 interaction.

PTM databases

iPTMnetiQ5SRH9.
PhosphoSiteiQ5SRH9.

Polymorphism and mutation databases

BioMutaiTTC39A.
DMDMi74743633.

Proteomic databases

MaxQBiQ5SRH9.
PeptideAtlasiQ5SRH9.
PRIDEiQ5SRH9.
TopDownProteomicsiQ5SRH9-1. [Q5SRH9-1]

Protocols and materials databases

DNASUi22996.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262676; ENSP00000262676; ENSG00000085831. [Q5SRH9-3]
ENST00000371750; ENSP00000360815; ENSG00000085831. [Q5SRH9-6]
ENST00000413473; ENSP00000406144; ENSG00000085831. [Q5SRH9-4]
ENST00000447632; ENSP00000393952; ENSG00000085831. [Q5SRH9-1]
ENST00000530004; ENSP00000431228; ENSG00000085831. [Q5SRH9-2]
GeneIDi22996.
KEGGihsa:22996.
UCSCiuc001csj.4. human. [Q5SRH9-1]

Organism-specific databases

CTDi22996.
GeneCardsiTTC39A.
HGNCiHGNC:18657. TTC39A.
HPAiHPA028098.
HPA043440.
neXtProtiNX_Q5SRH9.
PharmGKBiPA162407260.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009763.
HOGENOMiHOG000016942.
HOVERGENiHBG057941.
InParanoidiQ5SRH9.
OMAiTKDSMYH.
OrthoDBiEOG091G0NXI.
PhylomeDBiQ5SRH9.
TreeFamiTF313761.

Miscellaneous databases

GeneWikiiTetratricopeptide_Repeat_39A.
GenomeRNAii22996.
PROiQ5SRH9.

Gene expression databases

BgeeiENSG00000085831.
CleanExiHS_TTC39A.
ExpressionAtlasiQ5SRH9. baseline and differential.
GenevisibleiQ5SRH9. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019412. OMP_Iml2/TPR_39.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030416. TTC39A/B.
[Graphical view]
PANTHERiPTHR31859:SF3. PTHR31859:SF3. 2 hits.
PfamiPF10300. DUF3808. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTT39A_HUMAN
AccessioniPrimary (citable) accession number: Q5SRH9
Secondary accession number(s): B7Z782
, E7EQY9, G3XAF8, O43417, O75040, Q5SRH5, Q5SRH6, Q5SRH7, Q5SRH8, Q5SRI0, Q5SRI1, Q5SRI2, Q5T7S1, Q6PIU8, Q9BT24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.