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Protein

Tetratricopeptide repeat protein 39A

Gene

TTC39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 39A
Short name:
TPR repeat protein 39A
Alternative name(s):
Differentially expressed in MCF7 with estradiol protein 6
Short name:
DEME-6
Gene namesi
Name:TTC39A
Synonyms:C1orf34, KIAA0452
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000085831.15
HGNCiHGNC:18657 TTC39A
neXtProtiNX_Q5SRH9

Pathology & Biotechi

Organism-specific databases

DisGeNETi22996
OpenTargetsiENSG00000085831
PharmGKBiPA162407260

Polymorphism and mutation databases

BioMutaiTTC39A
DMDMi74743633

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919961 – 613Tetratricopeptide repeat protein 39AAdd BLAST613

Proteomic databases

MaxQBiQ5SRH9
PeptideAtlasiQ5SRH9
PRIDEiQ5SRH9
ProteomicsDBi63849
63850 [Q5SRH9-2]
63851 [Q5SRH9-3]
63852 [Q5SRH9-4]
TopDownProteomicsiQ5SRH9-1 [Q5SRH9-1]

PTM databases

iPTMnetiQ5SRH9
PhosphoSitePlusiQ5SRH9

Expressioni

Gene expression databases

BgeeiENSG00000085831
CleanExiHS_TTC39A
ExpressionAtlasiQ5SRH9 baseline and differential
GenevisibleiQ5SRH9 HS

Organism-specific databases

HPAiHPA028098
HPA043440

Interactioni

Protein-protein interaction databases

BioGridi116643, 2 interactors
IntActiQ5SRH9, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5SRH9
SMRiQ5SRH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati315 – 348TPR 1Add BLAST34
Repeati505 – 538TPR 2Add BLAST34
Repeati546 – 579TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TTC39 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00390000009763
HOGENOMiHOG000016942
HOVERGENiHBG057941
InParanoidiQ5SRH9
OMAiTKDSMYH
OrthoDBiEOG091G0NXI
PhylomeDBiQ5SRH9
TreeFamiTF313761

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR030416 TTC39A
PANTHERiPTHR31859 PTHR31859, 1 hit
PTHR31859:SF3 PTHR31859:SF3, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 3 hits

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQKGHKDSL YPCGGTPESS LHEALDQCMT ALDLFLTNQF SEALSYLKPR
60 70 80 90 100
TKESMYHSLT YATILEMQAM MTFDPQDILL AGNMMKEAQM LCQRHRRKSS
110 120 130 140 150
VTDSFSSLVN RPTLGQFTEE EIHAEVCYAE CLLQRAALTF LQGSSHGGAV
160 170 180 190 200
RPRALHDPSH ACSCPPGPGR QHLFLLQDEN MVSFIKGGIK VRNSYQTYKE
210 220 230 240 250
LDSLVQSSQY CKGENHPHFE GGVKLGVGAF NLTLSMLPTR ILRLLEFVGF
260 270 280 290 300
SGNKDYGLLQ LEEGASGHSF RSVLCVMLLL CYHTFLTFVL GTGNVNIEEA
310 320 330 340 350
EKLLKPYLNR YPKGAIFLFF AGRIEVIKGN IDAAIRRFEE CCEAQQHWKQ
360 370 380 390 400
FHHMCYWELM WCFTYKGQWK MSYFYADLLS KENCWSKATY IYMKAAYLSM
410 420 430 440 450
FGKEDHKPFG DDEVELFRAV PGLKLKIAGK SLPTEKFAIR KSRRYFSSNP
460 470 480 490 500
ISLPVPALEM MYIWNGYAVI GKQPKLTDGI LEIITKAEEM LEKGPENEYS
510 520 530 540 550
VDDECLVKLL KGLCLKYLGR VQEAEENFRS ISANEKKIKY DHYLIPNALL
560 570 580 590 600
ELALLLMEQD RNEEAIKLLE SAKQNYKNYS MESRTHFRIQ AATLQAKSSL
610
ENSSRSMVSS VSL
Length:613
Mass (Da):69,778
Last modified:December 21, 2004 - v1
Checksum:i23B898B6016F7E6F
GO
Isoform 2 (identifier: Q5SRH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:221
Mass (Da):25,147
Checksum:i7CFC06CC98B35CAE
GO
Isoform 3 (identifier: Q5SRH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MDSSPSLPLIR
     334-424: AIRRFEECCE...ELFRAVPGLK → VSDGGPGRGW...LQWREVEGGA
     425-613: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):46,394
Checksum:iF015AB6661598C91
GO
Isoform 4 (identifier: Q5SRH9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGQKGHKDSLYPCGG → MAFLTTWKEAASGKSDRR
     143-177: Missing.

Show »
Length:581
Mass (Da):66,630
Checksum:i18D58CC091644EA4
GO
Isoform 5 (identifier: Q5SRH9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGQKGHKDSLYPCG → MTSAGGAPGALPA
     143-177: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):65,732
Checksum:iF975764F4EF63FD7
GO
Isoform 6 (identifier: Q5SRH9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-177: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:578
Mass (Da):66,152
Checksum:i84D3025AFABC23D4
GO

Sequence cautioni

The sequence AAH28374 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA32297 differs from that shown. Reason: Frameshift at position 373.Curated
The sequence BAA32297 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → V in AAH28374 (PubMed:15489334).Curated1
Sequence conflicti338F → L in BAH13518 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0263481 – 392Missing in isoform 2. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_0263491 – 15MGQKG…YPCGG → MDSSPSLPLIR in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0263501 – 15MGQKG…YPCGG → MAFLTTWKEAASGKSDRR in isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0471981 – 14MGQKG…LYPCG → MTSAGGAPGALPA in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026351143 – 177Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_026352334 – 424AIRRF…VPGLK → VSDGGPGRGWGSLGVSQTSR KSGTCDILRDRIDWGRGGGQ ERTNQRAGAGEALLAEQPGK TREEEAFVVPGILTGRYRTA ALQWREVEGGA in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_026353425 – 613Missing in isoform 3. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007921 mRNA Translation: BAA32297.1 Sequence problems.
AK301587 mRNA Translation: BAH13518.1
AL162430 Genomic DNA No translation available.
AL671986 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06826.1
BC004399 mRNA Translation: AAH04399.1
BC028374 mRNA Translation: AAH28374.1 Different initiation.
CX788693 mRNA No translation available.
AF007170 mRNA Translation: AAC39582.1
CCDSiCCDS44143.1 [Q5SRH9-4]
CCDS44144.1 [Q5SRH9-6]
CCDS72790.1 [Q5SRH9-1]
CCDS76162.1 [Q5SRH9-2]
RefSeqiNP_001073963.1, NM_001080494.3 [Q5SRH9-6]
NP_001138304.1, NM_001144832.2 [Q5SRH9-4]
NP_001284592.1, NM_001297663.1 [Q5SRH9-5]
NP_001284593.1, NM_001297664.1
NP_001284594.1, NM_001297665.1 [Q5SRH9-1]
NP_001284595.1, NM_001297666.1 [Q5SRH9-2]
NP_001284596.1, NM_001297667.1
UniGeneiHs.112949

Genome annotation databases

EnsembliENST00000262676; ENSP00000262676; ENSG00000085831 [Q5SRH9-3]
ENST00000371750; ENSP00000360815; ENSG00000085831 [Q5SRH9-6]
ENST00000413473; ENSP00000406144; ENSG00000085831 [Q5SRH9-4]
ENST00000447632; ENSP00000393952; ENSG00000085831 [Q5SRH9-1]
ENST00000530004; ENSP00000431228; ENSG00000085831 [Q5SRH9-2]
GeneIDi22996
KEGGihsa:22996
UCSCiuc001csj.4 human [Q5SRH9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTT39A_HUMAN
AccessioniPrimary (citable) accession number: Q5SRH9
Secondary accession number(s): B7Z782
, E7EQY9, G3XAF8, O43417, O75040, Q5SRH5, Q5SRH6, Q5SRH7, Q5SRH8, Q5SRI0, Q5SRI1, Q5SRI2, Q5T7S1, Q6PIU8, Q9BT24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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