Q5SRE5 (NU188_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoporin NUP188 homolog
Short name=hNup188

Gene names

Name:	NUP188
Synonyms:	KIAA0169

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1749 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a component of the nuclear pore complex (NPC).
Subcellular location	Nucleus › nuclear pore complex Probable.
Sequence caution	The sequence CAD97835.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	nuclear envelope Traceable author statement. Source: Reactome nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SRE5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SRE5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     116-226: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1749	1749	Nucleoporin NUP188 homolog		PRO_0000299172
Amino acid modifications
	Modified residue	1709	1	Phosphoserine Ref.10
	Modified residue	1717	1	Phosphoserine Ref.8 Ref.9 Ref.10 Ref.12 Ref.13 Ref.15
Natural variations
	Alternative sequence	116 – 226	111	Missing in isoform 2.		VSP_027585
	Natural variant	1419	1	A → V. Corresponds to variant rs17433024 [ dbSNP | Ensembl ].		VAR_034792
	Natural variant	1587	1	N → K. Corresponds to variant rs12350674 [ dbSNP | Ensembl ].		VAR_034793
Experimental info
	Sequence conflict	773	1	A → T in CAD97835. Ref.1
	Sequence conflict	995	1	R → W in AAH40352. Ref.5
	Sequence conflict	1196	1	Q → R in CAD97835. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: E7856A552698F542	FASTA	1,749	196,043
	10 20 30 40 50 60 MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK 70 80 90 100 110 120 VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED YRGTRDSVKT VLQDERQSQA 130 140 150 160 170 180 LILKIADYYY EERTCILRCV LHLLTYFQDE RHPYRVEYAD CVDKLEKELV SKYRQQFEEL 190 200 210 220 230 240 YKTEAPTWET HGNLMTERQV SRWFVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK 250 260 270 280 290 300 EQGFGSRQTN RHLVDETMDP FVDRIGYFSA LILVEGMDIE SLHKCALDDR RELHQFAQDG 310 320 330 340 350 360 LICQDMDCLM LTFGDIPHHA PVLLAWALLR HTLNPEETSS VVRKIGGTAI QLNVFQYLTR 370 380 390 400 410 420 LLQSLASGGN DCTTSTACMC VYGLLSFVLT SLELHTLGNQ QDIIDTACEV LADPSLPELF 430 440 450 460 470 480 WGTEPTSGLG IILDSVCGMF PHLLSPLLQL LRALVSGKST AKKVYSFLDK MSFYNELYKH 490 500 510 520 530 540 KPHDVISHED GTLWRRQTPK LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT 550 560 570 580 590 600 LFTCEIEMLL HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL 610 620 630 640 650 660 TTVISPPVDV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSSLS QMISAEGMNA 670 680 690 700 710 720 GGYGNLLMNS EQPQGEYGVT IAFLRLITTL VKGQLGSTQS QGLVPCVMFV LKEMLPSYHK 730 740 750 760 770 780 WRYNSHGVRE QIGCLILELI HAILNLCHET DLHSSHTPSL QFLCICSLAY TEAGQTVINI 790 800 810 820 830 840 MGIGVDTIDM VMAAQPRSDG AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA 850 860 870 880 890 900 LSQHGAHGNN LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYACL GNDAAAIRDA 910 920 930 940 950 960 FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSDGSKE FSLGMWSCLH 970 980 990 1000 1010 1020 AVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM LVLRTKPKFW ENLTSPLFGT 1030 1040 1050 1060 1070 1080 LSPPSETSEP SILETCALIM KIICLEIYYV VKGSLDQSLK DTLKKFSIEK RFAYWSGYVK 1090 1100 1110 1120 1130 1140 SLAVHVAETE GSSCTSLLEY QMLVSAWRML LIIATTHADI MHLTDSVVRR QLFLDVLDGT 1150 1160 1170 1180 1190 1200 KALLLVPASV NCLRLGSMKC TLLLILLRQW KRELGSVDEI LGPLTEILEG VLQADQQLME 1210 1220 1230 1240 1250 1260 KTKAKVFSAF ITVLQMKEMK VSDIPQYSQL VLNVCETLQE EVIALFDQTR HSLALGSATE 1270 1280 1290 1300 1310 1320 DKDSMETDDC SRSRHRDQRD GVCVLGLHLA KELCEVDEDG DSWLQVTRRL PILPTLLTTL 1330 1340 1350 1360 1370 1380 EVSLRMKQNL HFTEATLHLL LTLARTQQGA TAVAGAGITQ SICLPLLSVY QLSTNGTAQT 1390 1400 1410 1420 1430 1440 PSASRKSLDA PSWPGVYRLS MSLMEQLLKT LRYNFLPEAL DFVGVHQERT LQCLNAVRTV 1450 1460 1470 1480 1490 1500 QSLACLEEAD HTVGFILQLS NFMKEWHFHL PQLMRDIQVN LGYLCQACTS LLHSRKMLQH 1510 1520 1530 1540 1550 1560 YLQNKNGDGL PSAVAQRVQR PPSAASAAPS SSKQPAADTE ASEQQALHTV QYGLLKILSK 1570 1580 1590 1600 1610 1620 TLAALRHFTP DVCQILLDQS LDLAEYNFLF ALSFTTPTFD SEVAPSFGTL LATVNVALNM 1630 1640 1650 1660 1670 1680 LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL LMFTMENCFY LLISQAMRYL RDPAVHPRDK 1690 1700 1710 1720 1730 1740 QRMKQELSSE LSTLLSSLSR YFRRGAPSSP ATGVLPSPQG KSTSLSKASP ESQEPLIQLV QAFVRHMQR
	Isoform 2 [UniParc]. Checksum: 14E227EADB7DEAE7	FASTA	1,638	182,293
	10 20 30 40 50 60 MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK 70 80 90 100 110 120 VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED YRGTRDSVKT VLQDEMAPSD 130 140 150 160 170 180 LLVLTKMFKE QGFGSRQTNR HLVDETMDPF VDRIGYFSAL ILVEGMDIES LHKCALDDRR 190 200 210 220 230 240 ELHQFAQDGL ICQDMDCLML TFGDIPHHAP VLLAWALLRH TLNPEETSSV VRKIGGTAIQ 250 260 270 280 290 300 LNVFQYLTRL LQSLASGGND CTTSTACMCV YGLLSFVLTS LELHTLGNQQ DIIDTACEVL 310 320 330 340 350 360 ADPSLPELFW GTEPTSGLGI ILDSVCGMFP HLLSPLLQLL RALVSGKSTA KKVYSFLDKM 370 380 390 400 410 420 SFYNELYKHK PHDVISHEDG TLWRRQTPKL LYPLGGQTNL RIPQGTVGQV MLDDRAYLVR 430 440 450 460 470 480 WEYSYSSWTL FTCEIEMLLH VVSTADVIQH CQRVKPIIDL VHKVISTDLS IADCLLPITS 490 500 510 520 530 540 RIYMLLQRLT TVISPPVDVI ASCVNCLTVL AARNPAKVWT DLRHTGFLPF VAHPVSSLSQ 550 560 570 580 590 600 MISAEGMNAG GYGNLLMNSE QPQGEYGVTI AFLRLITTLV KGQLGSTQSQ GLVPCVMFVL 610 620 630 640 650 660 KEMLPSYHKW RYNSHGVREQ IGCLILELIH AILNLCHETD LHSSHTPSLQ FLCICSLAYT 670 680 690 700 710 720 EAGQTVINIM GIGVDTIDMV MAAQPRSDGA EGQGQGQLLI KTVKLAFSVT NNVIRLKPPS 730 740 750 760 770 780 NVVSPLEQAL SQHGAHGNNL IAVLAKYIYH KHDPALPRLA IQLLKRLATV APMSVYACLG 790 800 810 820 830 840 NDAAAIRDAF LTRLQSKIED MRIKVMILEF LTVAVETQPG LIELFLNLEV KDGSDGSKEF 850 860 870 880 890 900 SLGMWSCLHA VLELIDSQQQ DRYWCPPLLH RAAIAFLHAL WQDRRDSAML VLRTKPKFWE 910 920 930 940 950 960 NLTSPLFGTL SPPSETSEPS ILETCALIMK IICLEIYYVV KGSLDQSLKD TLKKFSIEKR 970 980 990 1000 1010 1020 FAYWSGYVKS LAVHVAETEG SSCTSLLEYQ MLVSAWRMLL IIATTHADIM HLTDSVVRRQ 1030 1040 1050 1060 1070 1080 LFLDVLDGTK ALLLVPASVN CLRLGSMKCT LLLILLRQWK RELGSVDEIL GPLTEILEGV 1090 1100 1110 1120 1130 1140 LQADQQLMEK TKAKVFSAFI TVLQMKEMKV SDIPQYSQLV LNVCETLQEE VIALFDQTRH 1150 1160 1170 1180 1190 1200 SLALGSATED KDSMETDDCS RSRHRDQRDG VCVLGLHLAK ELCEVDEDGD SWLQVTRRLP 1210 1220 1230 1240 1250 1260 ILPTLLTTLE VSLRMKQNLH FTEATLHLLL TLARTQQGAT AVAGAGITQS ICLPLLSVYQ 1270 1280 1290 1300 1310 1320 LSTNGTAQTP SASRKSLDAP SWPGVYRLSM SLMEQLLKTL RYNFLPEALD FVGVHQERTL 1330 1340 1350 1360 1370 1380 QCLNAVRTVQ SLACLEEADH TVGFILQLSN FMKEWHFHLP QLMRDIQVNL GYLCQACTSL 1390 1400 1410 1420 1430 1440 LHSRKMLQHY LQNKNGDGLP SAVAQRVQRP PSAASAAPSS SKQPAADTEA SEQQALHTVQ 1450 1460 1470 1480 1490 1500 YGLLKILSKT LAALRHFTPD VCQILLDQSL DLAEYNFLFA LSFTTPTFDS EVAPSFGTLL 1510 1520 1530 1540 1550 1560 ATVNVALNML GELDKKKEPL TQAVGLSTQA EGTRTLKSLL MFTMENCFYL LISQAMRYLR 1570 1580 1590 1600 1610 1620 DPAVHPRDKQ RMKQELSSEL STLLSSLSRY FRRGAPSSPA TGVLPSPQGK STSLSKASPE 1630 SQEPLIQLVQ AFVRHMQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Endometrium.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-1749 (ISOFORM 1). Tissue: Bone marrow.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-1749. Tissue: Ovary and Uterus.
[6]	"Identification of a new vertebrate nucleoporin, Nup188, with the use of a novel organelle trap assay." Miller B.R., Powers M., Park M., Fischer W., Forbes D.J. Mol. Biol. Cell 11:3381-3396(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS NUCLEOPORIN.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1717, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1717, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1709 AND SER-1717, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1717, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1717, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1717, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX537774 mRNA. Translation: CAD97835.1. Different initiation. AL672142, AL592211 Genomic DNA. Translation: CAI10845.1. AL592211, AL672142 Genomic DNA. Translation: CAI12368.1. CH471090 Genomic DNA. Translation: EAW87850.1. D79991 mRNA. Translation: BAA11486.1. BC040352 mRNA. Translation: AAH40352.1. BC111045 mRNA. Translation: AAI11046.1.
IPI	IPI00385001. IPI00477040.
RefSeq	NP_056169.1. NM_015354.2.
UniGene	Hs.308340.
3D structure databases
ProteinModelPortal	Q5SRE5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SRE5. 7 interactions.
STRING	9606.ENSP00000361658.
PTM databases
PhosphoSite	Q5SRE5.
Polymorphism databases
DMDM	74743623.
Proteomic databases
PaxDb	Q5SRE5.
PRIDE	Q5SRE5.
Protocols and materials databases
DNASU	23511.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372577; ENSP00000361658; ENSG00000095319.
GeneID	23511.
KEGG	hsa:23511.
UCSC	uc004bws.1. human.
Organism-specific databases
CTD	23511.
GeneCards	GC09P131709.
HGNC	HGNC:17859. NUP188.
neXtProt	NX_Q5SRE5.
PharmGKB	PA134908952.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG280768.
HOGENOM	HOG000113876.
HOVERGEN	HBG055598.
InParanoid	Q5SRE5.
KO	K14311.
OMA	KELCEVD.
OrthoDB	EOG4HDSSM.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q5SRE5.
Bgee	Q5SRE5.
CleanEx	HS_NUP188.
Genevestigator	Q5SRE5.
Family and domain databases
InterPro	IPR018864. Nucleoporin_Nup188. [Graphical view]
Pfam	PF10487. Nup188. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NUP188. human.
GenomeRNAi	23511.
NextBio	45927.

Entry information

Entry name

NU188_HUMAN

Accession

Primary (citable) accession number: Q5SRE5
Secondary accession number(s): Q14675 , Q2TA87, Q7Z3K8, Q8IWF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.