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Protein

Nucleoporin NUP188 homolog

Gene

NUP188

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a component of the nuclear pore complex (NPC).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP188 homolog
Short name:
hNup188
Gene namesi
Name:NUP188
Synonyms:KIAA0169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17859. NUP188.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nuclear envelope Source: Reactome
  • nuclear pore inner ring Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Involvement in diseasei

Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.

Organism-specific databases

OpenTargetsiENSG00000095319.
PharmGKBiPA134908952.

Polymorphism and mutation databases

DMDMi74743623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002991722 – 1749Nucleoporin NUP188 homologAdd BLAST1748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei1523PhosphoserineCombined sources1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1712PhosphothreonineCombined sources1
Modified residuei1717PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5SRE5.
MaxQBiQ5SRE5.
PaxDbiQ5SRE5.
PeptideAtlasiQ5SRE5.
PRIDEiQ5SRE5.

PTM databases

iPTMnetiQ5SRE5.
PhosphoSitePlusiQ5SRE5.

Expressioni

Gene expression databases

BgeeiENSG00000095319.
CleanExiHS_NUP188.
GenevisibleiQ5SRE5. HS.

Organism-specific databases

HPAiHPA061750.
HPA063942.

Interactioni

Protein-protein interaction databases

BioGridi117058. 48 interactors.
IntActiQ5SRE5. 25 interactors.
MINTiMINT-4994959.
STRINGi9606.ENSP00000361658.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJOelectron microscopy21.40J/V1-1749[»]
ProteinModelPortaliQ5SRE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4833. Eukaryota.
ENOG410Z045. LUCA.
GeneTreeiENSGT00390000005742.
HOGENOMiHOG000113876.
HOVERGENiHBG055598.
InParanoidiQ5SRE5.
KOiK14311.
OMAiLHHTGFL.
OrthoDBiEOG091G02FQ.
PhylomeDBiQ5SRE5.
TreeFamiTF101106.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018864. Nucleoporin_Nup188.
[Graphical view]
PfamiPF10487. Nup188. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SRE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY
60 70 80 90 100
KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQSV QLLQCYLQED
110 120 130 140 150
YRGTRDSVKT VLQDERQSQA LILKIADYYY EERTCILRCV LHLLTYFQDE
160 170 180 190 200
RHPYRVEYAD CVDKLEKELV SKYRQQFEEL YKTEAPTWET HGNLMTERQV
210 220 230 240 250
SRWFVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK EQGFGSRQTN
260 270 280 290 300
RHLVDETMDP FVDRIGYFSA LILVEGMDIE SLHKCALDDR RELHQFAQDG
310 320 330 340 350
LICQDMDCLM LTFGDIPHHA PVLLAWALLR HTLNPEETSS VVRKIGGTAI
360 370 380 390 400
QLNVFQYLTR LLQSLASGGN DCTTSTACMC VYGLLSFVLT SLELHTLGNQ
410 420 430 440 450
QDIIDTACEV LADPSLPELF WGTEPTSGLG IILDSVCGMF PHLLSPLLQL
460 470 480 490 500
LRALVSGKST AKKVYSFLDK MSFYNELYKH KPHDVISHED GTLWRRQTPK
510 520 530 540 550
LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT LFTCEIEMLL
560 570 580 590 600
HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL
610 620 630 640 650
TTVISPPVDV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSSLS
660 670 680 690 700
QMISAEGMNA GGYGNLLMNS EQPQGEYGVT IAFLRLITTL VKGQLGSTQS
710 720 730 740 750
QGLVPCVMFV LKEMLPSYHK WRYNSHGVRE QIGCLILELI HAILNLCHET
760 770 780 790 800
DLHSSHTPSL QFLCICSLAY TEAGQTVINI MGIGVDTIDM VMAAQPRSDG
810 820 830 840 850
AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LSQHGAHGNN
860 870 880 890 900
LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYACL GNDAAAIRDA
910 920 930 940 950
FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSDGSKE
960 970 980 990 1000
FSLGMWSCLH AVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM
1010 1020 1030 1040 1050
LVLRTKPKFW ENLTSPLFGT LSPPSETSEP SILETCALIM KIICLEIYYV
1060 1070 1080 1090 1100
VKGSLDQSLK DTLKKFSIEK RFAYWSGYVK SLAVHVAETE GSSCTSLLEY
1110 1120 1130 1140 1150
QMLVSAWRML LIIATTHADI MHLTDSVVRR QLFLDVLDGT KALLLVPASV
1160 1170 1180 1190 1200
NCLRLGSMKC TLLLILLRQW KRELGSVDEI LGPLTEILEG VLQADQQLME
1210 1220 1230 1240 1250
KTKAKVFSAF ITVLQMKEMK VSDIPQYSQL VLNVCETLQE EVIALFDQTR
1260 1270 1280 1290 1300
HSLALGSATE DKDSMETDDC SRSRHRDQRD GVCVLGLHLA KELCEVDEDG
1310 1320 1330 1340 1350
DSWLQVTRRL PILPTLLTTL EVSLRMKQNL HFTEATLHLL LTLARTQQGA
1360 1370 1380 1390 1400
TAVAGAGITQ SICLPLLSVY QLSTNGTAQT PSASRKSLDA PSWPGVYRLS
1410 1420 1430 1440 1450
MSLMEQLLKT LRYNFLPEAL DFVGVHQERT LQCLNAVRTV QSLACLEEAD
1460 1470 1480 1490 1500
HTVGFILQLS NFMKEWHFHL PQLMRDIQVN LGYLCQACTS LLHSRKMLQH
1510 1520 1530 1540 1550
YLQNKNGDGL PSAVAQRVQR PPSAASAAPS SSKQPAADTE ASEQQALHTV
1560 1570 1580 1590 1600
QYGLLKILSK TLAALRHFTP DVCQILLDQS LDLAEYNFLF ALSFTTPTFD
1610 1620 1630 1640 1650
SEVAPSFGTL LATVNVALNM LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL
1660 1670 1680 1690 1700
LMFTMENCFY LLISQAMRYL RDPAVHPRDK QRMKQELSSE LSTLLSSLSR
1710 1720 1730 1740
YFRRGAPSSP ATGVLPSPQG KSTSLSKASP ESQEPLIQLV QAFVRHMQR
Length:1,749
Mass (Da):196,043
Last modified:December 21, 2004 - v1
Checksum:iE7856A552698F542
GO
Isoform 2 (identifier: Q5SRE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-226: Missing.

Show »
Length:1,638
Mass (Da):182,293
Checksum:i14E227EADB7DEAE7
GO

Sequence cautioni

The sequence CAD97835 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti773A → T in CAD97835 (PubMed:17974005).Curated1
Sequence conflicti995R → W in AAH40352 (PubMed:15489334).Curated1
Sequence conflicti1196Q → R in CAD97835 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0347921419A → V.Corresponds to variant rs17433024dbSNPEnsembl.1
Natural variantiVAR_0347931587N → K.Corresponds to variant rs12350674dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027585116 – 226Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537774 mRNA. Translation: CAD97835.1. Different initiation.
AL672142, AL592211 Genomic DNA. Translation: CAI10845.1.
AL592211, AL672142 Genomic DNA. Translation: CAI12368.1.
CH471090 Genomic DNA. Translation: EAW87850.1.
D79991 mRNA. Translation: BAA11486.1.
BC040352 mRNA. Translation: AAH40352.1.
BC111045 mRNA. Translation: AAI11046.1.
CCDSiCCDS35156.1. [Q5SRE5-1]
RefSeqiNP_056169.1. NM_015354.2. [Q5SRE5-1]
UniGeneiHs.308340.

Genome annotation databases

EnsembliENST00000372577; ENSP00000361658; ENSG00000095319. [Q5SRE5-1]
GeneIDi23511.
KEGGihsa:23511.
UCSCiuc004bws.3. human. [Q5SRE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537774 mRNA. Translation: CAD97835.1. Different initiation.
AL672142, AL592211 Genomic DNA. Translation: CAI10845.1.
AL592211, AL672142 Genomic DNA. Translation: CAI12368.1.
CH471090 Genomic DNA. Translation: EAW87850.1.
D79991 mRNA. Translation: BAA11486.1.
BC040352 mRNA. Translation: AAH40352.1.
BC111045 mRNA. Translation: AAI11046.1.
CCDSiCCDS35156.1. [Q5SRE5-1]
RefSeqiNP_056169.1. NM_015354.2. [Q5SRE5-1]
UniGeneiHs.308340.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IJOelectron microscopy21.40J/V1-1749[»]
ProteinModelPortaliQ5SRE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117058. 48 interactors.
IntActiQ5SRE5. 25 interactors.
MINTiMINT-4994959.
STRINGi9606.ENSP00000361658.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ5SRE5.
PhosphoSitePlusiQ5SRE5.

Polymorphism and mutation databases

DMDMi74743623.

Proteomic databases

EPDiQ5SRE5.
MaxQBiQ5SRE5.
PaxDbiQ5SRE5.
PeptideAtlasiQ5SRE5.
PRIDEiQ5SRE5.

Protocols and materials databases

DNASUi23511.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372577; ENSP00000361658; ENSG00000095319. [Q5SRE5-1]
GeneIDi23511.
KEGGihsa:23511.
UCSCiuc004bws.3. human. [Q5SRE5-1]

Organism-specific databases

CTDi23511.
GeneCardsiNUP188.
HGNCiHGNC:17859. NUP188.
HPAiHPA061750.
HPA063942.
MIMi615587. gene.
neXtProtiNX_Q5SRE5.
OpenTargetsiENSG00000095319.
PharmGKBiPA134908952.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4833. Eukaryota.
ENOG410Z045. LUCA.
GeneTreeiENSGT00390000005742.
HOGENOMiHOG000113876.
HOVERGENiHBG055598.
InParanoidiQ5SRE5.
KOiK14311.
OMAiLHHTGFL.
OrthoDBiEOG091G02FQ.
PhylomeDBiQ5SRE5.
TreeFamiTF101106.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Miscellaneous databases

ChiTaRSiNUP188. human.
GenomeRNAii23511.
PROiQ5SRE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095319.
CleanExiHS_NUP188.
GenevisibleiQ5SRE5. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018864. Nucleoporin_Nup188.
[Graphical view]
PfamiPF10487. Nup188. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNU188_HUMAN
AccessioniPrimary (citable) accession number: Q5SRE5
Secondary accession number(s): Q14675
, Q2TA87, Q7Z3K8, Q8IWF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.