Q5SRD1 (TI23B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative mitochondrial import inner membrane translocase subunit Tim23B

Gene names

Name:

TIMM23B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the Tim17/Tim22/Tim23 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane presequence translocase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Putative mitochondrial import inner membrane translocase subunit Tim23B		PRO_0000349114
Regions
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5SRD1 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: 790E6568B34BA830	FASTA	257	28,048
	10 20 30 40 50 60 MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF 70 80 90 100 110 120 ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV 130 140 150 160 170 180 TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ 190 200 210 220 230 240 ANFQSEIIFR FLTRFFYAKK KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL 250 KNRIPQRIKC LMHNKPT

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL672187 Genomic DNA. Translation: CAI16097.1. AL672187 Genomic DNA. Translation: CAI16098.1.
IPI	IPI00640747.
UniGene	Hs.499594.
3D structure databases
ProteinModelPortal	Q5SRD1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000414899.
PTM databases
PhosphoSite	Q5SRD1.
Polymorphism databases
DMDM	205830480.
Proteomic databases
PaxDb	Q5SRD1.
PRIDE	Q5SRD1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374097; ENSP00000363210; ENSG00000204152. ENST00000374098; ENSP00000363211; ENSG00000204152.
Organism-specific databases
GeneCards	GC10P051371.
HGNC	HGNC:23581. TIMM23B.
neXtProt	NX_Q5SRD1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5596.
HOGENOM	HOG000208442.
HOVERGEN	HBG057526.
InParanoid	Q5SRD1.
Gene expression databases
ArrayExpress	Q5SRD1.
Bgee	Q5SRD1.
CleanEx	HS_TIMM23B.
Genevestigator	Q5SRD1.
Family and domain databases
InterPro	IPR003397. Tim17/Tim22/Tim23/PMP24. IPR005681. Tim23. [Graphical view]
Pfam	PF02466. Tim17. 1 hit. [Graphical view]
TIGRFAMs	TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TI23B_HUMAN

Accession

Primary (citable) accession number: Q5SRD1
Secondary accession number(s): Q5SRD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.