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Protein

Putative mitochondrial import inner membrane translocase subunit Tim23B

Gene

TIMM23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).By similarity

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitochondrial import inner membrane translocase subunit Tim23B
Gene namesi
Name:TIMM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 10, Unplaced

Organism-specific databases

HGNCiHGNC:23581. TIMM23B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Putative mitochondrial import inner membrane translocase subunit Tim23BPRO_0000349114Add
BLAST

Proteomic databases

MaxQBiQ5SRD1.
PaxDbiQ5SRD1.
PRIDEiQ5SRD1.

PTM databases

PhosphoSiteiQ5SRD1.

Expressioni

Gene expression databases

BgeeiQ5SRD1.
CleanExiHS_TIMM23B.
ExpressionAtlasiQ5SRD1. baseline and differential.
GenevestigatoriQ5SRD1.

Organism-specific databases

HPAiHPA047180.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000414899.

Structurei

3D structure databases

ProteinModelPortaliQ5SRD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000208442.
HOVERGENiHBG057526.
InParanoidiQ5SRD1.
PhylomeDBiQ5SRD1.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SRD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL
110 120 130 140 150
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ ANFQSEIIFR FLTRFFYAKK
210 220 230 240 250
KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL KNRIPQRIKC

LMHNKPT
Length:257
Mass (Da):28,048
Last modified:September 2, 2008 - v2
Checksum:i790E6568B34BA830
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16097.1.
AL672187 Genomic DNA. Translation: CAI16098.1.
UniGeneiHs.499594.
Hs.524308.

Genome annotation databases

EnsembliENST00000374097; ENSP00000363210; ENSG00000204152.
ENST00000374098; ENSP00000363211; ENSG00000204152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16097.1.
AL672187 Genomic DNA. Translation: CAI16098.1.
UniGeneiHs.499594.
Hs.524308.

3D structure databases

ProteinModelPortaliQ5SRD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000414899.

PTM databases

PhosphoSiteiQ5SRD1.

Proteomic databases

MaxQBiQ5SRD1.
PaxDbiQ5SRD1.
PRIDEiQ5SRD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374097; ENSP00000363210; ENSG00000204152.
ENST00000374098; ENSP00000363211; ENSG00000204152.

Organism-specific databases

GeneCardsiGC10P051729.
HGNCiHGNC:23581. TIMM23B.
HPAiHPA047180.
neXtProtiNX_Q5SRD1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000208442.
HOVERGENiHBG057526.
InParanoidiQ5SRD1.
PhylomeDBiQ5SRD1.
TreeFamiTF106196.

Gene expression databases

BgeeiQ5SRD1.
CleanExiHS_TIMM23B.
ExpressionAtlasiQ5SRD1. baseline and differential.
GenevestigatoriQ5SRD1.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTI23B_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD1
Secondary accession number(s): Q5SRD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 4, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.