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Q5SRD1

- TI23B_HUMAN

UniProt

Q5SRD1 - TI23B_HUMAN

Protein

Putative mitochondrial import inner membrane translocase subunit Tim23B

Gene

TIMM23B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex By similarity.By similarity

    GO - Molecular functioni

    1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative mitochondrial import inner membrane translocase subunit Tim23B
    Gene namesi
    Name:TIMM23B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23581. TIMM23B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane presequence translocase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Putative mitochondrial import inner membrane translocase subunit Tim23BPRO_0000349114Add
    BLAST

    Proteomic databases

    MaxQBiQ5SRD1.
    PaxDbiQ5SRD1.
    PRIDEiQ5SRD1.

    PTM databases

    PhosphoSiteiQ5SRD1.

    Expressioni

    Gene expression databases

    BgeeiQ5SRD1.
    CleanExiHS_TIMM23B.
    GenevestigatoriQ5SRD1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000414899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SRD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    HOGENOMiHOG000208442.
    HOVERGENiHBG057526.
    InParanoidiQ5SRD1.
    PhylomeDBiQ5SRD1.
    TreeFamiTF106196.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SRD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP    50
    RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL 100
    KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
    AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ ANFQSEIIFR FLTRFFYAKK 200
    KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL KNRIPQRIKC 250
    LMHNKPT 257
    Length:257
    Mass (Da):28,048
    Last modified:September 2, 2008 - v2
    Checksum:i790E6568B34BA830
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672187 Genomic DNA. Translation: CAI16097.1.
    AL672187 Genomic DNA. Translation: CAI16098.1.
    UniGeneiHs.499594.
    Hs.524308.

    Genome annotation databases

    EnsembliENST00000374097; ENSP00000363210; ENSG00000204152.
    ENST00000374098; ENSP00000363211; ENSG00000204152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672187 Genomic DNA. Translation: CAI16097.1 .
    AL672187 Genomic DNA. Translation: CAI16098.1 .
    UniGenei Hs.499594.
    Hs.524308.

    3D structure databases

    ProteinModelPortali Q5SRD1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000414899.

    PTM databases

    PhosphoSitei Q5SRD1.

    Proteomic databases

    MaxQBi Q5SRD1.
    PaxDbi Q5SRD1.
    PRIDEi Q5SRD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374097 ; ENSP00000363210 ; ENSG00000204152 .
    ENST00000374098 ; ENSP00000363211 ; ENSG00000204152 .

    Organism-specific databases

    GeneCardsi GC10P051371.
    HGNCi HGNC:23581. TIMM23B.
    neXtProti NX_Q5SRD1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5596.
    HOGENOMi HOG000208442.
    HOVERGENi HBG057526.
    InParanoidi Q5SRD1.
    PhylomeDBi Q5SRD1.
    TreeFami TF106196.

    Gene expression databases

    Bgeei Q5SRD1.
    CleanExi HS_TIMM23B.
    Genevestigatori Q5SRD1.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    IPR005681. Tim23.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTI23B_HUMAN
    AccessioniPrimary (citable) accession number: Q5SRD1
    Secondary accession number(s): Q5SRD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3