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Protein

Putative mitochondrial import inner membrane translocase subunit Tim23B

Gene

TIMM23B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitochondrial import inner membrane translocase subunit Tim23B
Gene namesi
Name:TIMM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204152.10
HGNCiHGNC:23581 TIMM23B
neXtProtiNX_Q5SRD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491141 – 257Putative mitochondrial import inner membrane translocase subunit Tim23BAdd BLAST257

Proteomic databases

EPDiQ5SRD1
MaxQBiQ5SRD1
PaxDbiQ5SRD1
PeptideAtlasiQ5SRD1
PRIDEiQ5SRD1

PTM databases

iPTMnetiQ5SRD1
PhosphoSitePlusiQ5SRD1
SwissPalmiQ5SRD1

Expressioni

Gene expression databases

BgeeiENSG00000204152
CleanExiHS_TIMM23B
ExpressionAtlasiQ5SRD1 baseline and differential
GenevisibleiQ5SRD1 HS

Interactioni

Protein-protein interaction databases

IntActiQ5SRD1, 10 interactors
MINTiQ5SRD1
STRINGi9606.ENSP00000363211

Structurei

3D structure databases

ProteinModelPortaliQ5SRD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3324 Eukaryota
COG5596 LUCA
HOGENOMiHOG000208442
HOVERGENiHBG057526
InParanoidiQ5SRD1
OrthoDBiEOG091G0NP6
PhylomeDBiQ5SRD1
TreeFamiTF106196

Family and domain databases

InterProiView protein in InterPro
IPR003397 Tim17/Tim22/Tim23/PMP24
IPR005681 Tim23
PfamiView protein in Pfam
PF02466 Tim17, 1 hit
TIGRFAMsiTIGR00983 3a0801s02tim23, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SRD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP
60 70 80 90 100
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL
110 120 130 140 150
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG
160 170 180 190 200
AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ ANFQSEIIFR FLTRFFYAKK
210 220 230 240 250
KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL KNRIPQRIKC

LMHNKPT
Length:257
Mass (Da):28,048
Last modified:September 2, 2008 - v2
Checksum:i790E6568B34BA830
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA No translation available.
UniGeneiHs.499594
Hs.524308

Genome annotation databases

EnsembliENST00000374097; ENSP00000363210; ENSG00000204152
ENST00000374098; ENSP00000363211; ENSG00000204152
UCSCiuc031wgt.2 human

Similar proteinsi

Entry informationi

Entry nameiTI23B_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD1
Secondary accession number(s): Q5SRD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health