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Q5SRD1 (TI23B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative mitochondrial import inner membrane translocase subunit Tim23B
Gene names
Name:TIMM23B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Caution

Could be the product of a pseudogene.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Putative mitochondrial import inner membrane translocase subunit Tim23B
PRO_0000349114

Regions

Transmembrane73 – 9321Helical; Potential
Transmembrane125 – 14521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5SRD1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 790E6568B34BA830

FASTA25728,048
        10         20         30         40         50         60 
MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF 

        70         80         90        100        110        120 
ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQNMAWSK PRNVQILNMV 

       130        140        150        160        170        180 
TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ 

       190        200        210        220        230        240 
ANFQSEIIFR FLTRFFYAKK KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL 

       250 
KNRIPQRIKC LMHNKPT 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL672187 Genomic DNA. Translation: CAI16097.1.
AL672187 Genomic DNA. Translation: CAI16098.1.
UniGeneHs.499594.
Hs.524308.

3D structure databases

ProteinModelPortalQ5SRD1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000414899.

PTM databases

PhosphoSiteQ5SRD1.

Proteomic databases

MaxQBQ5SRD1.
PaxDbQ5SRD1.
PRIDEQ5SRD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374097; ENSP00000363210; ENSG00000204152.
ENST00000374098; ENSP00000363211; ENSG00000204152.

Organism-specific databases

GeneCardsGC10P051371.
HGNCHGNC:23581. TIMM23B.
neXtProtNX_Q5SRD1.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5596.
HOGENOMHOG000208442.
HOVERGENHBG057526.
InParanoidQ5SRD1.
PhylomeDBQ5SRD1.
TreeFamTF106196.

Gene expression databases

BgeeQ5SRD1.
CleanExHS_TIMM23B.
GenevestigatorQ5SRD1.

Family and domain databases

InterProIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsTIGR00983. 3a0801s02tim23. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTI23B_HUMAN
AccessionPrimary (citable) accession number: Q5SRD1
Secondary accession number(s): Q5SRD2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM