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Q5SRD1

- TI23B_HUMAN

UniProt

Q5SRD1 - TI23B_HUMAN

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Protein
Putative mitochondrial import inner membrane translocase subunit Tim23B
Gene
TIMM23B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Functioni

May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex By similarity.

GO - Molecular functioni

  1. P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitochondrial import inner membrane translocase subunit Tim23B
Gene namesi
Name:TIMM23B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23581. TIMM23B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane presequence translocase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Putative mitochondrial import inner membrane translocase subunit Tim23B
PRO_0000349114Add
BLAST

Proteomic databases

MaxQBiQ5SRD1.
PaxDbiQ5SRD1.
PRIDEiQ5SRD1.

PTM databases

PhosphoSiteiQ5SRD1.

Expressioni

Gene expression databases

BgeeiQ5SRD1.
CleanExiHS_TIMM23B.
GenevestigatoriQ5SRD1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000414899.

Structurei

3D structure databases

ProteinModelPortaliQ5SRD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000208442.
HOVERGENiHBG057526.
InParanoidiQ5SRD1.
PhylomeDBiQ5SRD1.
TreeFamiTF106196.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00983. 3a0801s02tim23. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SRD1-1 [UniParc]FASTAAdd to Basket

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MEGGGGSGNK TTGGLAGFFG AGGAGYSHAD LAGVPLTGMN PLSPYLNVDP    50
RYLVQDTDEF ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL 100
KETQNMAWSK PRNVQILNMV TRQGALWANT LGSLALLYSA FGVIIEKTRG 150
AEDDLNTVAA GTMTGMLYKC TETGFHHGAQ ANFQSEIIFR FLTRFFYAKK 200
KASYSQISQK NLDFTILLRL KTLRSVESKC YVIFVVDELL KNRIPQRIKC 250
LMHNKPT 257
Length:257
Mass (Da):28,048
Last modified:September 2, 2008 - v2
Checksum:i790E6568B34BA830
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672187 Genomic DNA. Translation: CAI16097.1.
AL672187 Genomic DNA. Translation: CAI16098.1.
UniGeneiHs.499594.
Hs.524308.

Genome annotation databases

EnsembliENST00000374097; ENSP00000363210; ENSG00000204152.
ENST00000374098; ENSP00000363211; ENSG00000204152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672187 Genomic DNA. Translation: CAI16097.1 .
AL672187 Genomic DNA. Translation: CAI16098.1 .
UniGenei Hs.499594.
Hs.524308.

3D structure databases

ProteinModelPortali Q5SRD1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000414899.

PTM databases

PhosphoSitei Q5SRD1.

Proteomic databases

MaxQBi Q5SRD1.
PaxDbi Q5SRD1.
PRIDEi Q5SRD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374097 ; ENSP00000363210 ; ENSG00000204152 .
ENST00000374098 ; ENSP00000363211 ; ENSG00000204152 .

Organism-specific databases

GeneCardsi GC10P051371.
HGNCi HGNC:23581. TIMM23B.
neXtProti NX_Q5SRD1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5596.
HOGENOMi HOG000208442.
HOVERGENi HBG057526.
InParanoidi Q5SRD1.
PhylomeDBi Q5SRD1.
TreeFami TF106196.

Gene expression databases

Bgeei Q5SRD1.
CleanExi HS_TIMM23B.
Genevestigatori Q5SRD1.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
IPR005681. Tim23.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00983. 3a0801s02tim23. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTI23B_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD1
Secondary accession number(s): Q5SRD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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