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Q5SRD0

- FA21D_HUMAN

UniProt

Q5SRD0 - FA21D_HUMAN

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Protein

Putative WASH complex subunit FAM21

Gene

FAM21D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative WASH complex subunit FAM21
Gene namesi
Name:FAM21D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23418. FAM21D.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. WASH complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Putative WASH complex subunit FAM21PRO_0000340252Add
BLAST

Proteomic databases

MaxQBiQ5SRD0.
PRIDEiQ5SRD0.

PTM databases

PhosphoSiteiQ5SRD0.

Expressioni

Gene expression databases

BgeeiQ5SRD0.
ExpressionAtlasiQ5SRD0. baseline.
GenevestigatoriQ5SRD0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309786.

Structurei

3D structure databases

ProteinModelPortaliQ5SRD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 687Poly-Ala

Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

HOGENOMiHOG000112469.
HOVERGENiHBG107897.
InParanoidiQ5SRD0.
OrthoDBiEOG7GBFWP.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SRD0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL
60 70 80 90 100
RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS RGEADLFDSG
110 120 130 140 150
DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP ALGEASSDDD
160 170 180 190 200
LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS QQDVILTTQD
210 220 230 240 250
IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK
260 270 280 290 300
KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD

PLNAFGGQ
Length:308
Mass (Da):33,372
Last modified:June 10, 2008 - v2
Checksum:i6BC93DABE55D4E19
GO

Sequence cautioni

The sequence CAI16093.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

Genome annotation databases

UCSCiuc001jcw.3. human.

Polymorphism databases

DMDMi190359329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1 . Different initiation.

3D structure databases

ProteinModelPortali Q5SRD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000309786.

PTM databases

PhosphoSitei Q5SRD0.

Polymorphism databases

DMDMi 190359329.

Proteomic databases

MaxQBi Q5SRD0.
PRIDEi Q5SRD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc001jcw.3. human.

Organism-specific databases

GeneCardsi GC10P051187.
HGNCi HGNC:23418. FAM21D.
neXtProti NX_Q5SRD0.
PharmGKBi PA134905390.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000112469.
HOVERGENi HBG107897.
InParanoidi Q5SRD0.
OrthoDBi EOG7GBFWP.

Miscellaneous databases

NextBioi 13622617.
PROi Q5SRD0.

Gene expression databases

Bgeei Q5SRD0.
ExpressionAtlasi Q5SRD0. baseline.
Genevestigatori Q5SRD0.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFA21D_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3