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Q5SRD0

- FA21D_HUMAN

UniProt

Q5SRD0 - FA21D_HUMAN

Protein

Putative WASH complex subunit FAM21

Gene

FAM21D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. retrograde transport, endosome to Golgi Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative WASH complex subunit FAM21
    Gene namesi
    Name:FAM21D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23418. FAM21D.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. WASH complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134905390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Putative WASH complex subunit FAM21PRO_0000340252Add
    BLAST

    Proteomic databases

    MaxQBiQ5SRD0.
    PRIDEiQ5SRD0.

    PTM databases

    PhosphoSiteiQ5SRD0.

    Expressioni

    Gene expression databases

    BgeeiQ5SRD0.
    GenevestigatoriQ5SRD0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000309786.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SRD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 687Poly-Ala

    Sequence similaritiesi

    Belongs to the FAM21 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000112469.
    HOVERGENiHBG107897.
    InParanoidiQ5SRD0.
    OrthoDBiEOG7GBFWP.

    Family and domain databases

    InterProiIPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view]
    PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
    PfamiPF15255. CAP-ZIP_m. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SRD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL    50
    RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS RGEADLFDSG 100
    DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP ALGEASSDDD 150
    LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS QQDVILTTQD 200
    IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK 250
    KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD 300
    PLNAFGGQ 308
    Length:308
    Mass (Da):33,372
    Last modified:June 10, 2008 - v2
    Checksum:i6BC93DABE55D4E19
    GO

    Sequence cautioni

    The sequence CAI16093.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

    Genome annotation databases

    UCSCiuc001jcw.3. human.

    Polymorphism databases

    DMDMi190359329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672187 Genomic DNA. Translation: CAI16093.1 . Different initiation.

    3D structure databases

    ProteinModelPortali Q5SRD0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000309786.

    PTM databases

    PhosphoSitei Q5SRD0.

    Polymorphism databases

    DMDMi 190359329.

    Proteomic databases

    MaxQBi Q5SRD0.
    PRIDEi Q5SRD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc001jcw.3. human.

    Organism-specific databases

    GeneCardsi GC10P051187.
    HGNCi HGNC:23418. FAM21D.
    neXtProti NX_Q5SRD0.
    PharmGKBi PA134905390.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000112469.
    HOVERGENi HBG107897.
    InParanoidi Q5SRD0.
    OrthoDBi EOG7GBFWP.

    Miscellaneous databases

    NextBioi 13622617.
    PROi Q5SRD0.

    Gene expression databases

    Bgeei Q5SRD0.
    Genevestigatori Q5SRD0.

    Family and domain databases

    InterProi IPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view ]
    PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
    Pfami PF15255. CAP-ZIP_m. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFA21D_HUMAN
    AccessioniPrimary (citable) accession number: Q5SRD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3