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Protein

WASH complex subunit 2D

Gene

WASHC2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

In human, WASHC2 has undergone evolutionary duplication, with 4 highly homologous family members existing, including WASHC2A, WASHC2C, and an N-terminally truncated WASHC2D form.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit 2DImported
Gene namesi
Name:WASHC2DImported
Synonyms:FAM21D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23418. WASHC2D.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905390.

Polymorphism and mutation databases

DMDMi190359329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003402521 – 308WASH complex subunit 2DAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5SRD0.
PaxDbiQ5SRD0.
PeptideAtlasiQ5SRD0.
PRIDEiQ5SRD0.

PTM databases

iPTMnetiQ5SRD0.
PhosphoSitePlusiQ5SRD0.

Expressioni

Gene expression databases

BgeeiENSG00000174196.

Organism-specific databases

HPAiHPA060975.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309786.

Structurei

3D structure databases

ProteinModelPortaliQ5SRD0.
SMRiQ5SRD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 68Poly-Ala7

Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

eggNOGiENOG410IEJH. Eukaryota.
ENOG4110AMY. LUCA.
HOGENOMiHOG000112469.
HOVERGENiHBG107897.
InParanoidiQ5SRD0.

Family and domain databases

InterProiView protein in InterPro
IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
PANTHERiPTHR21669:SF21. PTHR21669:SF21. 1 hit.
PfamiView protein in Pfam
PF15255. CAP-ZIP_m. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL
60 70 80 90 100
RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS RGEADLFDSG
110 120 130 140 150
DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP ALGEASSDDD
160 170 180 190 200
LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS QQDVILTTQD
210 220 230 240 250
IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK
260 270 280 290 300
KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD

PLNAFGGQ
Length:308
Mass (Da):33,372
Last modified:June 10, 2008 - v2
Checksum:i6BC93DABE55D4E19
GO

Sequence cautioni

The sequence CAI16093 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

3D structure databases

ProteinModelPortaliQ5SRD0.
SMRiQ5SRD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309786.

PTM databases

iPTMnetiQ5SRD0.
PhosphoSitePlusiQ5SRD0.

Polymorphism and mutation databases

DMDMi190359329.

Proteomic databases

MaxQBiQ5SRD0.
PaxDbiQ5SRD0.
PeptideAtlasiQ5SRD0.
PRIDEiQ5SRD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiFAM21D.
HGNCiHGNC:23418. WASHC2D.
HPAiHPA060975.
neXtProtiNX_Q5SRD0.
PharmGKBiPA134905390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJH. Eukaryota.
ENOG4110AMY. LUCA.
HOGENOMiHOG000112469.
HOVERGENiHBG107897.
InParanoidiQ5SRD0.

Miscellaneous databases

PROiPR:Q5SRD0.

Gene expression databases

BgeeiENSG00000174196.

Family and domain databases

InterProiView protein in InterPro
IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
PANTHERiPTHR21669:SF21. PTHR21669:SF21. 1 hit.
PfamiView protein in Pfam
PF15255. CAP-ZIP_m. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWAC2D_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 15, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.