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Protein

Putative WASH complex subunit FAM21

Gene

FAM21D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative WASH complex subunit FAM21
Gene namesi
Name:FAM21D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:23418. FAM21D.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. WASH complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Putative WASH complex subunit FAM21PRO_0000340252Add
BLAST

Proteomic databases

MaxQBiQ5SRD0.
PRIDEiQ5SRD0.

PTM databases

PhosphoSiteiQ5SRD0.

Expressioni

Gene expression databases

BgeeiQ5SRD0.
ExpressionAtlasiQ5SRD0. baseline.
GenevestigatoriQ5SRD0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309786.

Structurei

3D structure databases

ProteinModelPortaliQ5SRD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 687Poly-Ala

Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

HOGENOMiHOG000112469.
HOVERGENiHBG107897.
InParanoidiQ5SRD0.
OrthoDBiEOG7GBFWP.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL
60 70 80 90 100
RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS RGEADLFDSG
110 120 130 140 150
DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP ALGEASSDDD
160 170 180 190 200
LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS QQDVILTTQD
210 220 230 240 250
IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK
260 270 280 290 300
KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD

PLNAFGGQ
Length:308
Mass (Da):33,372
Last modified:June 10, 2008 - v2
Checksum:i6BC93DABE55D4E19
GO

Sequence cautioni

The sequence CAI16093.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

Genome annotation databases

UCSCiuc001jcw.3. human.

Polymorphism databases

DMDMi190359329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672187 Genomic DNA. Translation: CAI16093.1. Different initiation.

3D structure databases

ProteinModelPortaliQ5SRD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309786.

PTM databases

PhosphoSiteiQ5SRD0.

Polymorphism databases

DMDMi190359329.

Proteomic databases

MaxQBiQ5SRD0.
PRIDEiQ5SRD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc001jcw.3. human.

Organism-specific databases

GeneCardsiGC10P051187.
HGNCiHGNC:23418. FAM21D.
neXtProtiNX_Q5SRD0.
PharmGKBiPA134905390.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000112469.
HOVERGENiHBG107897.
InParanoidiQ5SRD0.
OrthoDBiEOG7GBFWP.

Miscellaneous databases

NextBioi13622617.
PROiQ5SRD0.

Gene expression databases

BgeeiQ5SRD0.
ExpressionAtlasiQ5SRD0. baseline.
GenevestigatoriQ5SRD0.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFA21D_HUMAN
AccessioniPrimary (citable) accession number: Q5SRD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 7, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.