ID   MF14B_HUMAN             Reviewed;         506 AA.
AC   Q5SR56; B4DUE6; E9PD58; Q3KQT4; Q53GU5; Q8WU95; Q96SM4;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 3.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=Hippocampus abundant transcript-like protein 1 {ECO:0000312|HGNC:HGNC:23376};
DE   AltName: Full=Major facilitator superfamily domain-containing 14B {ECO:0000312|HGNC:HGNC:23376};
GN   Name=MFSD14B {ECO:0000312|HGNC:HGNC:23376};
GN   Synonyms=HIATL1 {ECO:0000312|HGNC:HGNC:23376};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 143-506 (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-406.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-506 (ISOFORM 1).
RC   TISSUE=Liver;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q5SR56; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-373355, EBI-10827839;
CC       Q5SR56; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-373355, EBI-2803601;
CC       Q5SR56; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-373355, EBI-1754287;
CC       Q5SR56; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-373355, EBI-714543;
CC       Q5SR56; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-373355, EBI-12069500;
CC       Q5SR56; Q12983: BNIP3; NbExp=3; IntAct=EBI-373355, EBI-749464;
CC       Q5SR56; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-373355, EBI-12003442;
CC       Q5SR56; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-373355, EBI-10271156;
CC       Q5SR56; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-373355, EBI-11579371;
CC       Q5SR56; O14493: CLDN4; NbExp=3; IntAct=EBI-373355, EBI-9316372;
CC       Q5SR56; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-373355, EBI-7247651;
CC       Q5SR56; P21964: COMT; NbExp=3; IntAct=EBI-373355, EBI-372265;
CC       Q5SR56; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-373355, EBI-10267100;
CC       Q5SR56; O43169: CYB5B; NbExp=3; IntAct=EBI-373355, EBI-1058710;
CC       Q5SR56; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-373355, EBI-2680384;
CC       Q5SR56; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-373355, EBI-10305240;
CC       Q5SR56; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-373355, EBI-8639143;
CC       Q5SR56; Q9BV81: EMC6; NbExp=3; IntAct=EBI-373355, EBI-2820492;
CC       Q5SR56; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-373355, EBI-711490;
CC       Q5SR56; Q14318: FKBP8; NbExp=3; IntAct=EBI-373355, EBI-724839;
CC       Q5SR56; Q01740: FMO1; NbExp=3; IntAct=EBI-373355, EBI-12701460;
CC       Q5SR56; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-373355, EBI-714482;
CC       Q5SR56; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-373355, EBI-11991950;
CC       Q5SR56; O14653: GOSR2; NbExp=3; IntAct=EBI-373355, EBI-4401517;
CC       Q5SR56; Q14416: GRM2; NbExp=3; IntAct=EBI-373355, EBI-10232876;
CC       Q5SR56; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-373355, EBI-12007212;
CC       Q5SR56; O43561-2: LAT; NbExp=3; IntAct=EBI-373355, EBI-8070286;
CC       Q5SR56; O95214: LEPROTL1; NbExp=3; IntAct=EBI-373355, EBI-750776;
CC       Q5SR56; Q7L5N7: LPCAT2; NbExp=3; IntAct=EBI-373355, EBI-4280011;
CC       Q5SR56; Q7Z4F1: LRP10; NbExp=3; IntAct=EBI-373355, EBI-2830349;
CC       Q5SR56; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-373355, EBI-12866138;
CC       Q5SR56; P11836: MS4A1; NbExp=3; IntAct=EBI-373355, EBI-2808234;
CC       Q5SR56; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-373355, EBI-2863634;
CC       Q5SR56; Q8N912: NRAC; NbExp=3; IntAct=EBI-373355, EBI-12051377;
CC       Q5SR56; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-373355, EBI-1054848;
CC       Q5SR56; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-373355, EBI-981985;
CC       Q5SR56; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-373355, EBI-12257782;
CC       Q5SR56; Q59EV6: PPGB; NbExp=3; IntAct=EBI-373355, EBI-14210385;
CC       Q5SR56; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-373355, EBI-722696;
CC       Q5SR56; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-373355, EBI-13044680;
CC       Q5SR56; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-373355, EBI-3917235;
CC       Q5SR56; O00767: SCD; NbExp=3; IntAct=EBI-373355, EBI-2684237;
CC       Q5SR56; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-373355, EBI-10329948;
CC       Q5SR56; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-373355, EBI-749270;
CC       Q5SR56; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-373355, EBI-10281975;
CC       Q5SR56; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-373355, EBI-2823239;
CC       Q5SR56; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-373355, EBI-3907610;
CC       Q5SR56; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-373355, EBI-10226799;
CC       Q5SR56; Q13277: STX3; NbExp=3; IntAct=EBI-373355, EBI-1394295;
CC       Q5SR56; Q9NZ01: TECR; NbExp=3; IntAct=EBI-373355, EBI-2877718;
CC       Q5SR56; Q9C0I4: THSD7B; NbExp=3; IntAct=EBI-373355, EBI-311394;
CC       Q5SR56; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-373355, EBI-6268651;
CC       Q5SR56; P55061: TMBIM6; NbExp=3; IntAct=EBI-373355, EBI-1045825;
CC       Q5SR56; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-373355, EBI-17684533;
CC       Q5SR56; Q96HP8: TMEM176A; NbExp=3; IntAct=EBI-373355, EBI-2800645;
CC       Q5SR56; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-373355, EBI-741829;
CC       Q5SR56; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-373355, EBI-12876824;
CC       Q5SR56; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-373355, EBI-12195227;
CC       Q5SR56; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-373355, EBI-11528917;
CC       Q5SR56; Q9Y320: TMX2; NbExp=3; IntAct=EBI-373355, EBI-6447886;
CC       Q5SR56; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-373355, EBI-17249488;
CC       Q5SR56; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-373355, EBI-16746122;
CC       Q5SR56; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-373355, EBI-12003468;
CC       Q5SR56; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-373355, EBI-11988865;
CC       Q5SR56; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-373355, EBI-988826;
CC       Q5SR56; Q53HI1: UNC50; NbExp=3; IntAct=EBI-373355, EBI-7601760;
CC       Q5SR56; Q9NZ43: USE1; NbExp=3; IntAct=EBI-373355, EBI-742842;
CC       Q5SR56; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-373355, EBI-7850136;
CC       Q5SR56; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-373355, EBI-751204;
CC       Q5SR56; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-373355, EBI-751253;
CC       Q5SR56; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-373355, EBI-751210;
CC       Q5SR56; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-373355, EBI-10254561;
CC       Q5SR56; O95159: ZFPL1; NbExp=3; IntAct=EBI-373355, EBI-718439;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5SR56-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5SR56-2; Sequence=VSP_056692, VSP_056693, VSP_056694;
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI06063.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB55274.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAD96556.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK027659; BAB55274.1; ALT_INIT; mRNA.
DR   EMBL; AK300615; BAG62308.1; -; mRNA.
DR   EMBL; AL358232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC106062; AAI06063.1; ALT_INIT; mRNA.
DR   EMBL; BC021093; AAH21093.2; -; mRNA.
DR   EMBL; AK222836; BAD96556.1; ALT_INIT; mRNA.
DR   CCDS; CCDS6710.2; -. [Q5SR56-1]
DR   RefSeq; NP_115947.2; NM_032558.2. [Q5SR56-1]
DR   RefSeq; XP_016870710.1; XM_017015221.1.
DR   AlphaFoldDB; Q5SR56; -.
DR   SMR; Q5SR56; -.
DR   BioGRID; 124166; 78.
DR   IntAct; Q5SR56; 75.
DR   STRING; 9606.ENSP00000364493; -.
DR   TCDB; 2.A.1.2.30; the major facilitator superfamily (mfs).
DR   GlyCosmos; Q5SR56; 1 site, No reported glycans.
DR   GlyGen; Q5SR56; 1 site.
DR   iPTMnet; Q5SR56; -.
DR   PhosphoSitePlus; Q5SR56; -.
DR   BioMuta; MFSD14B; -.
DR   DMDM; 238054382; -.
DR   EPD; Q5SR56; -.
DR   jPOST; Q5SR56; -.
DR   MassIVE; Q5SR56; -.
DR   MaxQB; Q5SR56; -.
DR   PaxDb; 9606-ENSP00000364493; -.
DR   PeptideAtlas; Q5SR56; -.
DR   ProteomicsDB; 5181; -.
DR   ProteomicsDB; 63839; -. [Q5SR56-1]
DR   Antibodypedia; 3023; 73 antibodies from 17 providers.
DR   DNASU; 84641; -.
DR   Ensembl; ENST00000375344.8; ENSP00000364493.3; ENSG00000148110.17. [Q5SR56-1]
DR   GeneID; 84641; -.
DR   KEGG; hsa:84641; -.
DR   MANE-Select; ENST00000375344.8; ENSP00000364493.3; NM_032558.3; NP_115947.2.
DR   UCSC; uc004aur.4; human. [Q5SR56-1]
DR   AGR; HGNC:23376; -.
DR   CTD; 84641; -.
DR   DisGeNET; 84641; -.
DR   GeneCards; MFSD14B; -.
DR   HGNC; HGNC:23376; MFSD14B.
DR   HPA; ENSG00000148110; Low tissue specificity.
DR   MIM; 620348; gene.
DR   neXtProt; NX_Q5SR56; -.
DR   OpenTargets; ENSG00000148110; -.
DR   PharmGKB; PA142671691; -.
DR   VEuPathDB; HostDB:ENSG00000148110; -.
DR   eggNOG; KOG2816; Eukaryota.
DR   GeneTree; ENSGT00940000156081; -.
DR   HOGENOM; CLU_001265_10_5_1; -.
DR   InParanoid; Q5SR56; -.
DR   OMA; GNFQNWY; -.
DR   OrthoDB; 1078604at2759; -.
DR   PhylomeDB; Q5SR56; -.
DR   TreeFam; TF313511; -.
DR   PathwayCommons; Q5SR56; -.
DR   SignaLink; Q5SR56; -.
DR   BioGRID-ORCS; 84641; 7 hits in 1129 CRISPR screens.
DR   ChiTaRS; MFSD14B; human.
DR   GenomeRNAi; 84641; -.
DR   Pharos; Q5SR56; Tdark.
DR   PRO; PR:Q5SR56; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5SR56; Protein.
DR   Bgee; ENSG00000148110; Expressed in oviduct epithelium and 184 other cell types or tissues.
DR   ExpressionAtlas; Q5SR56; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd17387; MFS_MFSD14; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR   PANTHER; PTHR23504:SF32; HIPPOCAMPUS ABUNDANT TRANSCRIPT-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR23504; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   Genevisible; Q5SR56; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..506
FT                   /note="Hippocampus abundant transcript-like protein 1"
FT                   /id="PRO_0000239229"
FT   TOPO_DOM        1..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..196
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..255
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..281
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..319
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        363..387
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        409..428
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        450..506
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        463
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..65
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056692"
FT   VAR_SEQ         344..376
FT                   /note="MMWAAGTVAAMSSITFPAISALVSRNAESDQQG -> SCPGDHNWNKRTMQW
FT                   PGASTVWLHILHVPCGTD (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056693"
FT   VAR_SEQ         377..506
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056694"
FT   VARIANT         406
FT                   /note="V -> L (in dbSNP:rs17851857)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_055401"
FT   CONFLICT        367
FT                   /note="S -> T (in Ref. 4; BAB55274)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   506 AA;  54545 MW;  4CD09B8A06EC6EA5 CRC64;
     MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG
     LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
     CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV
     SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD
     PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL
     SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP
     AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV
     PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED
     IEPLLQDSSI WELSSFEEPG NQCTEL
//