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Q5SR56

- HIAL1_HUMAN

UniProt

Q5SR56 - HIAL1_HUMAN

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Protein
Hippocampus abundant transcript-like protein 1
Gene
HIATL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.2.30. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocampus abundant transcript-like protein 1
Gene namesi
Name:HIATL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23376. HIATL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949Extracellular Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Reviewed prediction
Add
BLAST
Topological domaini71 – 8212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 1118Extracellular Reviewed prediction
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Topological domaini133 – 1342Cytoplasmic Reviewed prediction
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST
Topological domaini156 – 16813Extracellular Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Reviewed prediction
Add
BLAST
Topological domaini190 – 1967Cytoplasmic Reviewed prediction
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Topological domaini218 – 25538Extracellular Reviewed prediction
Add
BLAST
Transmembranei256 – 27621Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 2815Cytoplasmic Reviewed prediction
Transmembranei282 – 30221Helical; Reviewed prediction
Add
BLAST
Topological domaini303 – 31917Extracellular Reviewed prediction
Add
BLAST
Transmembranei320 – 34021Helical; Reviewed prediction
Add
BLAST
Topological domaini341 – 3411Cytoplasmic Reviewed prediction
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 38725Extracellular Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Topological domaini409 – 42820Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei429 – 44921Helical; Reviewed prediction
Add
BLAST
Topological domaini450 – 50657Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Hippocampus abundant transcript-like protein 1
PRO_0000239229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi463 – 4631N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5SR56.
PaxDbiQ5SR56.
PRIDEiQ5SR56.

PTM databases

PhosphoSiteiQ5SR56.

Expressioni

Gene expression databases

ArrayExpressiQ5SR56.
BgeeiQ5SR56.
CleanExiHS_HIATL1.
GenevestigatoriQ5SR56.

Organism-specific databases

HPAiHPA017978.

Interactioni

Protein-protein interaction databases

BioGridi124166. 2 interactions.
IntActiQ5SR56. 1 interaction.
STRINGi9606.ENSP00000364493.

Structurei

3D structure databases

ProteinModelPortaliQ5SR56.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000007094.
HOVERGENiHBG051902.
InParanoidiQ5SR56.
OMAiVSWGAQI.
OrthoDBiEOG712TW3.
PhylomeDBiQ5SR56.
TreeFamiTF313511.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SR56-1 [UniParc]FASTAAdd to Basket

« Hide

MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI    50
VIFLEFFAWG LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI 100
GALSDVWGRK PFLLGTVFFT CFPIPLMRIS PWWYFAMISV SGVFSVTFSV 150
IFAYVADVTQ EHERSTAYGW VSATFAASLV SSPAIGAYLS ASYGDSLVVL 200
VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD PFASLKKVGK 250
DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL 300
SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT 350
VAAMSSITFP AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI 400
FYMFHVELTE LGPKLNSNNV PLQGAVIPGP PFLFGACIVL MSFLVALFIP 450
EYSKASGVQK HSNSSSGSLT NTPERGSDED IEPLLQDSSI WELSSFEEPG 500
NQCTEL 506
Length:506
Mass (Da):54,545
Last modified:May 26, 2009 - v3
Checksum:i4CD09B8A06EC6EA5
GO

Sequence cautioni

The sequence AAI06063.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55274.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD96556.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti406 – 4061V → L.1 Publication
Corresponds to variant rs17851857 [ dbSNP | Ensembl ].
VAR_055401

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti367 – 3671S → T in BAB55274. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL691447, AL358232 Genomic DNA. Translation: CAI13281.1.
AL358232, AL691447 Genomic DNA. Translation: CAI15197.1.
BC106062 mRNA. Translation: AAI06063.1. Different initiation.
BC021093 mRNA. Translation: AAH21093.2.
AK027659 mRNA. Translation: BAB55274.1. Different initiation.
AK222836 mRNA. Translation: BAD96556.1. Different initiation.
CCDSiCCDS6710.2.
RefSeqiNP_115947.2. NM_032558.2.
UniGeneiHs.555996.

Genome annotation databases

EnsembliENST00000375344; ENSP00000364493; ENSG00000148110.
GeneIDi84641.
KEGGihsa:84641.
UCSCiuc004aur.3. human.

Polymorphism databases

DMDMi238054382.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL691447 , AL358232 Genomic DNA. Translation: CAI13281.1 .
AL358232 , AL691447 Genomic DNA. Translation: CAI15197.1 .
BC106062 mRNA. Translation: AAI06063.1 . Different initiation.
BC021093 mRNA. Translation: AAH21093.2 .
AK027659 mRNA. Translation: BAB55274.1 . Different initiation.
AK222836 mRNA. Translation: BAD96556.1 . Different initiation.
CCDSi CCDS6710.2.
RefSeqi NP_115947.2. NM_032558.2.
UniGenei Hs.555996.

3D structure databases

ProteinModelPortali Q5SR56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124166. 2 interactions.
IntActi Q5SR56. 1 interaction.
STRINGi 9606.ENSP00000364493.

Protein family/group databases

TCDBi 2.A.1.2.30. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q5SR56.

Polymorphism databases

DMDMi 238054382.

Proteomic databases

MaxQBi Q5SR56.
PaxDbi Q5SR56.
PRIDEi Q5SR56.

Protocols and materials databases

DNASUi 84641.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375344 ; ENSP00000364493 ; ENSG00000148110 .
GeneIDi 84641.
KEGGi hsa:84641.
UCSCi uc004aur.3. human.

Organism-specific databases

CTDi 84641.
GeneCardsi GC09P097136.
HGNCi HGNC:23376. HIATL1.
HPAi HPA017978.
neXtProti NX_Q5SR56.
PharmGKBi PA142671691.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000007094.
HOVERGENi HBG051902.
InParanoidi Q5SR56.
OMAi VSWGAQI.
OrthoDBi EOG712TW3.
PhylomeDBi Q5SR56.
TreeFami TF313511.

Miscellaneous databases

ChiTaRSi HIATL1. human.
GenomeRNAii 84641.
NextBioi 74579.
PROi Q5SR56.

Gene expression databases

ArrayExpressi Q5SR56.
Bgeei Q5SR56.
CleanExi HS_HIATL1.
Genevestigatori Q5SR56.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
PRINTSi PR01035. TCRTETA.
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-406.
    Tissue: Skin.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-506.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-506.
    Tissue: Liver.

Entry informationi

Entry nameiHIAL1_HUMAN
AccessioniPrimary (citable) accession number: Q5SR56
Secondary accession number(s): Q3KQT4
, Q53GU5, Q8WU95, Q96SM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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