Q5SR56 (HIAL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hippocampus abundant transcript-like protein 1

Gene names

Name:

HIATL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the major facilitator superfamily.
Sequence caution	The sequence AAI06063.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55274.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD96556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Hippocampus abundant transcript-like protein 1		PRO_0000239229
Regions
	Topological domain	1 – 49	49	Extracellular Potential
	Transmembrane	50 – 70	21	Helical; Potential
	Topological domain	71 – 82	12	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Topological domain	104 – 111	8	Extracellular Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Topological domain	133 – 134	2	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Topological domain	156 – 168	13	Extracellular Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Topological domain	190 – 196	7	Cytoplasmic Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Topological domain	218 – 255	38	Extracellular Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Topological domain	277 – 281	5	Cytoplasmic Potential
	Transmembrane	282 – 302	21	Helical; Potential
	Topological domain	303 – 319	17	Extracellular Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Topological domain	341	1	Cytoplasmic Potential
	Transmembrane	342 – 362	21	Helical; Potential
	Topological domain	363 – 387	25	Extracellular Potential
	Transmembrane	388 – 408	21	Helical; Potential
	Topological domain	409 – 428	20	Cytoplasmic Potential
	Transmembrane	429 – 449	21	Helical; Potential
	Topological domain	450 – 506	57	Extracellular Potential
Amino acid modifications
	Glycosylation	463	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	406	1	V → L. Ref.2 Corresponds to variant rs17851857 [ dbSNP | Ensembl ].		VAR_055401
Experimental info
	Sequence conflict	367	1	S → T in BAB55274. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5SR56 [UniParc]. Last modified May 26, 2009. Version 3. Checksum: 4CD09B8A06EC6EA5	FASTA	506	54,545
	10 20 30 40 50 60 MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG 70 80 90 100 110 120 LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT 130 140 150 160 170 180 CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV 190 200 210 220 230 240 SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD 250 260 270 280 290 300 PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL 310 320 330 340 350 360 SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP 370 380 390 400 410 420 AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV 430 440 450 460 470 480 PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED 490 500 IEPLLQDSSI WELSSFEEPG NQCTEL

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-406. Tissue: Skin.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-506.
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-506. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL691447, AL358232 Genomic DNA. Translation: CAI13281.1. AL358232, AL691447 Genomic DNA. Translation: CAI15197.1. BC106062 mRNA. Translation: AAI06063.1. Different initiation. BC021093 mRNA. Translation: AAH21093.2. AK027659 mRNA. Translation: BAB55274.1. Different initiation. AK222836 mRNA. Translation: BAD96556.1. Different initiation.
IPI	IPI00291042.
RefSeq	NP_115947.2. NM_032558.2.
UniGene	Hs.555996.
3D structure databases
ProteinModelPortal	Q5SR56.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SR56. 1 interaction.
STRING	9606.ENSP00000364493.
Protein family/group databases
TCDB	2.A.1.2.30. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	Q5SR56.
Polymorphism databases
DMDM	238054382.
Proteomic databases
PaxDb	Q5SR56.
PRIDE	Q5SR56.
Protocols and materials databases
DNASU	84641.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375344; ENSP00000364493; ENSG00000148110.
GeneID	84641.
KEGG	hsa:84641.
UCSC	uc004aur.3. human.
Organism-specific databases
CTD	84641.
GeneCards	GC09P097136.
HGNC	HGNC:23376. HIATL1.
HPA	HPA017978.
neXtProt	NX_Q5SR56.
PharmGKB	PA142671691.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000007094.
HOVERGEN	HBG051902.
InParanoid	Q5SR56.
OMA	GPKLNSN.
OrthoDB	EOG4B8JD1.
Gene expression databases
ArrayExpress	Q5SR56.
Bgee	Q5SR56.
CleanEx	HS_HIATL1.
Genevestigator	Q5SR56.
GermOnline	ENSG00000148110. Homo sapiens.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005829. Sugar_transporter_CS. IPR001958. Tet-R_TetA/multi-R_MdtG. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PRINTS	PR01035. TCRTETA.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HIATL1. human.
GenomeRNAi	84641.
NextBio	74579.

Entry information

Entry name

HIAL1_HUMAN

Accession

Primary (citable) accession number: Q5SR56
Secondary accession number(s): Q3KQT4 , Q53GU5, Q8WU95, Q96SM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	May 26, 2009
Last modified:	April 3, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.