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Q5SR56 (HIAL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hippocampus abundant transcript-like protein 1
Gene names
Name:HIATL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence caution

The sequence AAI06063.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55274.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD96556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Hippocampus abundant transcript-like protein 1
PRO_0000239229

Regions

Topological domain1 – 4949Extracellular Potential
Transmembrane50 – 7021Helical; Potential
Topological domain71 – 8212Cytoplasmic Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 1118Extracellular Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 1342Cytoplasmic Potential
Transmembrane135 – 15521Helical; Potential
Topological domain156 – 16813Extracellular Potential
Transmembrane169 – 18921Helical; Potential
Topological domain190 – 1967Cytoplasmic Potential
Transmembrane197 – 21721Helical; Potential
Topological domain218 – 25538Extracellular Potential
Transmembrane256 – 27621Helical; Potential
Topological domain277 – 2815Cytoplasmic Potential
Transmembrane282 – 30221Helical; Potential
Topological domain303 – 31917Extracellular Potential
Transmembrane320 – 34021Helical; Potential
Topological domain3411Cytoplasmic Potential
Transmembrane342 – 36221Helical; Potential
Topological domain363 – 38725Extracellular Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 42820Cytoplasmic Potential
Transmembrane429 – 44921Helical; Potential
Topological domain450 – 50657Extracellular Potential

Amino acid modifications

Glycosylation4631N-linked (GlcNAc...) Potential

Natural variations

Natural variant4061V → L. Ref.2
Corresponds to variant rs17851857 [ dbSNP | Ensembl ].
VAR_055401

Experimental info

Sequence conflict3671S → T in BAB55274. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5SR56 [UniParc].

Last modified May 26, 2009. Version 3.
Checksum: 4CD09B8A06EC6EA5

FASTA50654,545
        10         20         30         40         50         60 
MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG 

        70         80         90        100        110        120 
LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT 

       130        140        150        160        170        180 
CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV 

       190        200        210        220        230        240 
SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD 

       250        260        270        280        290        300 
PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL 

       310        320        330        340        350        360 
SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP 

       370        380        390        400        410        420 
AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV 

       430        440        450        460        470        480 
PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED 

       490        500 
IEPLLQDSSI WELSSFEEPG NQCTEL 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-406.
Tissue: Skin.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-506.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-506.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL691447, AL358232 Genomic DNA. Translation: CAI13281.1.
AL358232, AL691447 Genomic DNA. Translation: CAI15197.1.
BC106062 mRNA. Translation: AAI06063.1. Different initiation.
BC021093 mRNA. Translation: AAH21093.2.
AK027659 mRNA. Translation: BAB55274.1. Different initiation.
AK222836 mRNA. Translation: BAD96556.1. Different initiation.
RefSeqNP_115947.2. NM_032558.2.
UniGeneHs.555996.

3D structure databases

ProteinModelPortalQ5SR56.
SMRQ5SR56. Positions 90-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124166. 2 interactions.
IntActQ5SR56. 1 interaction.
STRING9606.ENSP00000364493.

Protein family/group databases

TCDB2.A.1.2.30. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ5SR56.

Polymorphism databases

DMDM238054382.

Proteomic databases

PaxDbQ5SR56.
PRIDEQ5SR56.

Protocols and materials databases

DNASU84641.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375344; ENSP00000364493; ENSG00000148110.
GeneID84641.
KEGGhsa:84641.
UCSCuc004aur.3. human.

Organism-specific databases

CTD84641.
GeneCardsGC09P097136.
HGNCHGNC:23376. HIATL1.
HPAHPA017978.
neXtProtNX_Q5SR56.
PharmGKBPA142671691.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000007094.
HOVERGENHBG051902.
InParanoidQ5SR56.
OMAIGFSIIM.
OrthoDBEOG712TW3.
PhylomeDBQ5SR56.
TreeFamTF313511.

Gene expression databases

ArrayExpressQ5SR56.
BgeeQ5SR56.
CleanExHS_HIATL1.
GenevestigatorQ5SR56.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSPR01035. TCRTETA.
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHIATL1. human.
GenomeRNAi84641.
NextBio74579.
PROQ5SR56.

Entry information

Entry nameHIAL1_HUMAN
AccessionPrimary (citable) accession number: Q5SR56
Secondary accession number(s): Q3KQT4 expand/collapse secondary AC list , Q53GU5, Q8WU95, Q96SM4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 26, 2009
Last modified: April 16, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM