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Protein

Cytoplasmic FMR1-interacting protein 2

Gene

Cyfip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).By similarity2 Publications

GO - Biological processi

  • activation of cysteine-type endopeptidase activity Source: MGI
  • apoptotic process Source: UniProtKB
  • cell-cell adhesion Source: UniProtKB
  • dendrite extension Source: UniProtKB
  • neuron projection development Source: UniProtKB
  • positive regulation of neurotrophin TRK receptor signaling pathway Source: UniProtKB
  • positive regulation of proteolysis Source: MGI

Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein 2
Alternative name(s):
p53-inducible protein 121
Gene namesi
Name:Cyfip2Imported
Synonyms:Kiaa1168Imported, Pir121Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924134 Cyfip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797101 – 1253Cytoplasmic FMR1-interacting protein 2Add BLAST1253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1037N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5SQX6
MaxQBiQ5SQX6
PaxDbiQ5SQX6
PeptideAtlasiQ5SQX6
PRIDEiQ5SQX6

PTM databases

iPTMnetiQ5SQX6
PhosphoSitePlusiQ5SQX6
SwissPalmiQ5SQX6

Expressioni

Tissue specificityi

Expressed in hippocampus (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000020340
CleanExiMM_CYFIP2
ExpressionAtlasiQ5SQX6 baseline and differential
GenevisibleiQ5SQX6 MM

Interactioni

Subunit structurei

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Interacts with FMR1, FXR1 and FXR2 (PubMed:11438699). Interacts with FMR1; the interaction occurs in a RNA-dependent manner (By similarity). Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1 (By similarity). The complex can also be activated by NCK1 (By similarity). Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (PubMed:24153177). Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (PubMed:27605705).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Shank3Q4ACU63EBI-773783,EBI-771450

Protein-protein interaction databases

BioGridi218375, 41 interactors
DIPiDIP-32111N
IntActiQ5SQX6, 63 interactors
STRINGi10090.ENSMUSP00000090853

Structurei

3D structure databases

ProteinModelPortaliQ5SQX6
SMRiQ5SQX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CYFIP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3534 Eukaryota
ENOG410XPKW LUCA
GeneTreeiENSGT00500000044831
HOVERGENiHBG053209
InParanoidiQ5SQX6
KOiK05749
OMAiDHAISRF
OrthoDBiEOG091G0105
PhylomeDBiQ5SQX6
TreeFamiTF312925

Family and domain databases

InterProiView protein in InterPro
IPR008081 Cytoplasmic_FMR1-int
IPR009828 DUF1394
PANTHERiPTHR12195 PTHR12195, 1 hit
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit
PF05994 FragX_IP, 1 hit
PIRSFiPIRSF008153 FMR1_interacting, 1 hit
PRINTSiPR01698 CYTOFMRPINTP

Sequencei

Sequence statusi: Complete.

Q5SQX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN EMLEEGHDYA VMLYTWRSCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVT KLMKFMYFQR KAIERFCSEV KRLCHAERRK
160 170 180 190 200
DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD
210 220 230 240 250
PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD IVNICVDYYE
260 270 280 290 300
NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIK TSAHYEENKS KWTCTQSSIS PQYNICEQMV
360 370 380 390 400
QIRDDHIRFI SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL
410 420 430 440 450
SKWSAHVMEV YSWKLVHPTD KFCNKDCPGT AEEYERATRY NYTSEEKFAF
460 470 480 490 500
VEVIAMIKGL QVLMGRMESV FNQAIRNTIY AALQDFAQVT LREPLRQAVR
510 520 530 540 550
KKKNVLISVL QAIRKTICDW EGGREPPNDP CLRGEKDPKG GFDIKVPRRA
560 570 580 590 600
VGPSSTQLYM VRTMLESLIA DKSGSKKTLR SSLDGPIVLA IEDFHKQSFF
610 620 630 640 650
FTHLLNISEA LQQCCDLSQL WFREFFLELT MGRRIQFPIE MSMPWILTDH
660 670 680 690 700
ILETKEPSMM EYVLYPLDLY NDSAYYALTK FKKQFLYDEI EAEVNLCFDQ
710 720 730 740 750
FVYKLADQIF AYYKAMAGSV LLDKRFRAEC KNYGVIIPYP PSNRYETLLK
760 770 780 790 800
QRHVQLLGRS IDLNRLITQR ISAAMYKSLD QAISRFESED LTSIVELEWL
810 820 830 840 850
LEINRLTHRL LCKHMTLDSF DAMFREANHN VSAPYGRITL HVFWELNFDF
860 870 880 890 900
LPNYCYNGST NRFVRTAIPF TQEPQRDKPA NVQPYYLYGS KPLNIAYSHI
910 920 930 940 950
YSSYRNFVGP PHFKTICRLL GYQGIAVVME ELLKIVKSLL QGTILQYVKT
960 970 980 990 1000
LIEVMPKICR LPRHEYGSPG ILEFFHHQLK DIIEYAELKT DVFQSLREVG
1010 1020 1030 1040 1050
NAILFCLLIE QALSQEEVCD LLHAAPFQNI LPRVYIKEGE RLEVRMKRLE
1060 1070 1080 1090 1100
AKYAPLHLVP LIERLGTPQQ IAIAREGDLL TKERLCCGLS MFEVILTRIR
1110 1120 1130 1140 1150
SYLQDPIWRG PPPTNGVMHV DECVEFHRLW SAMQFVYCIP VGTNEFTAEQ
1160 1170 1180 1190 1200
CFGDGLNWAG CSIIVLLGQQ RRFDLFDFCY HLLKVQRQDG KDEIIKNVPL
1210 1220 1230 1240 1250
KKMADRIRKY QILNNEVFAI LNKYMKSVET DSSTVEHVRC FQPPIHQSLA

TTC
Length:1,253
Mass (Da):145,659
Last modified:February 1, 2005 - v2
Checksum:i321011BF830F424E
GO

Sequence cautioni

The sequence BAC41472 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76G → V in BAC26942 (PubMed:16141072).Curated1
Sequence conflicti229E → G in BAE27779 (PubMed:16141072).Curated1
Sequence conflicti242V → A in BAE27779 (PubMed:16141072).Curated1
Sequence conflicti678L → P in BAC26942 (PubMed:16141072).Curated1
Sequence conflicti1080L → P in BAC26942 (PubMed:16141072).Curated1

RNA editingi

Edited at position 320.1 Publication
Partially edited. Editing appears to be brain-specific.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti320K → E in RNA edited version. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334144 mRNA Translation: AAK81821.1
AB093288 mRNA Translation: BAC41472.2 Different initiation.
AK030397 mRNA Translation: BAC26942.1
AK147224 mRNA Translation: BAE27779.1
AK147586 mRNA Translation: BAE28010.1
AK147632 mRNA Translation: BAE28036.1
AL662806, AL713958 Genomic DNA Translation: CAI24844.2
AL713958, AL662806 Genomic DNA Translation: CAI25371.2
AF162472 mRNA Translation: AAD45803.1
CCDSiCCDS24573.1
RefSeqiNP_001239388.1, NM_001252459.1
NP_001239389.1, NM_001252460.1
NP_598530.2, NM_133769.3
UniGeneiMm.154358
Mm.454389

Genome annotation databases

EnsembliENSMUST00000093165; ENSMUSP00000090853; ENSMUSG00000020340
ENSMUST00000093166; ENSMUSP00000090854; ENSMUSG00000020340
ENSMUST00000165599; ENSMUSP00000127586; ENSMUSG00000020340
GeneIDi76884
KEGGimmu:76884
UCSCiuc007iob.2 mouse

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiCYFP2_MOUSE
AccessioniPrimary (citable) accession number: Q5SQX6
Secondary accession number(s): Q3UH21
, Q3UHS8, Q8BSW0, Q8CHA9, Q924D3, Q9R181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health