Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5SQU3 (Q5SQU3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. PIRNR PIRNR000559

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. PIRNR PIRNR000559

Contains AGC-kinase C-terminal domain. SAAS SAAS000961

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000363097

Sequences

Sequence LengthMass (Da)Tools
Q5SQU3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: A5172D8CB92803E2

FASTA65974,958
        10         20         30         40         50         60 
MLKEERIKEL EKRLSEKEEE IQELKRKLHK CQSVLPVPST HIGPRTTRAQ GISAEPQTYR 

        70         80         90        100        110        120 
SFHDLRQAFR KFTKSERSKD LIKEAILDND FMKNLELSQI QEIVDCMYPV EYGKDSCIIK 

       130        140        150        160        170        180 
EGDVGSLVYV MEDGKVEVTK EGVKLCTMGP GKVFGELAIL YNCTRTATVK TLVNVKLWAI 

       190        200        210        220        230        240 
DRQCFQTIMM RTGLIKHTEY MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG 

       250        260        270        280        290        300 
ARGDTFFIIS KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT 

       310        320        330        340        350        360 
CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI IDTLGVGGFG 

       370        380        390        400        410        420 
RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ QEHIRSEKQI MQGAHSDFIV RLYRTFKDSK 

       430        440        450        460        470        480 
YLYMLMEACL GGELWTILRD RGSFEDSTTR FYTACVVEAF AYLHSKGIIY RDLKPENLIL 

       490        500        510        520        530        540 
DHRGYAKLVD FGFAKKIGFG KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL 

       550        560        570        580        590        600 
TGSPPFSGPD PMKTYNIILR GIDMIEFPKK IAKNAANLIK KLCRDNPSER LGNLKNGVKD 

       610        620        630        640        650 
IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS PTDTSNFDSF PEDNDEPPPD DNSGWDIDF 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]Ensembl
Submitted (AUG-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalQ5SQU3.
SMRQ5SQU3. Positions 1-32, 48-643.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373985; ENSP00000363097; ENSG00000185532.

Organism-specific databases

HGNCHGNC:9414. PRKG1.
GenAtlasSearch...

Phylogenomic databases

OrthoDBEOG75B84Q.

Enzyme and pathway databases

SignaLinkQ5SQU3.

Gene expression databases

ArrayExpressQ5SQU3.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSPR00104. CGMPKINASE.
SMARTSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRKG1. human.

Entry information

Entry nameQ5SQU3_HUMAN
AccessionPrimary (citable) accession number: Q5SQU3
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.