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Q5SQU3

- Q5SQU3_HUMAN

UniProt

Q5SQU3 - Q5SQU3_HUMAN

Protein

cGMP-dependent protein kinase

Gene

PRKG1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cGMP binding Source: UniProtKB-KW
    3. cGMP-dependent protein kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, cGMP, cGMP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ5SQU3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-dependent protein kinaseUniRule annotation (EC:2.7.11.12UniRule annotation)
    Gene namesi
    Name:PRKG1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9414. PRKG1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SQU3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SQU3.
    SMRiQ5SQU3. Positions 1-32, 48-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.UniRule annotation
    Contains AGC-kinase C-terminal domain.SAAS annotation

    Phylogenomic databases

    OrthoDBiEOG75B84Q.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSiPR00104. CGMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 2 hits.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SQU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKEERIKEL EKRLSEKEEE IQELKRKLHK CQSVLPVPST HIGPRTTRAQ    50
    GISAEPQTYR SFHDLRQAFR KFTKSERSKD LIKEAILDND FMKNLELSQI 100
    QEIVDCMYPV EYGKDSCIIK EGDVGSLVYV MEDGKVEVTK EGVKLCTMGP 150
    GKVFGELAIL YNCTRTATVK TLVNVKLWAI DRQCFQTIMM RTGLIKHTEY 200
    MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG ARGDTFFIIS 250
    KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT 300
    CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI 350
    IDTLGVGGFG RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ QEHIRSEKQI 400
    MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD RGSFEDSTTR 450
    FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG 500
    KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL TGSPPFSGPD 550
    PMKTYNIILR GIDMIEFPKK IAKNAANLIK KLCRDNPSER LGNLKNGVKD 600
    IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS PTDTSNFDSF PEDNDEPPPD 650
    DNSGWDIDF 659
    Length:659
    Mass (Da):74,958
    Last modified:December 21, 2004 - v1
    Checksum:iA5172D8CB92803E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009986 Genomic DNA. No translation available.
    AC022025 Genomic DNA. No translation available.
    AC022537 Genomic DNA. No translation available.
    AC026228 Genomic DNA. No translation available.
    AC027118 Genomic DNA. No translation available.
    AC068062 Genomic DNA. No translation available.
    AC069079 Genomic DNA. No translation available.
    AC073584 Genomic DNA. No translation available.
    AL157399 Genomic DNA. No translation available.
    AL391378 Genomic DNA. No translation available.
    AL596105 Genomic DNA. No translation available.
    AL607031 Genomic DNA. No translation available.
    AL731537 Genomic DNA. No translation available.
    AL928686 Genomic DNA. No translation available.
    KF455236 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000373985; ENSP00000363097; ENSG00000185532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009986 Genomic DNA. No translation available.
    AC022025 Genomic DNA. No translation available.
    AC022537 Genomic DNA. No translation available.
    AC026228 Genomic DNA. No translation available.
    AC027118 Genomic DNA. No translation available.
    AC068062 Genomic DNA. No translation available.
    AC069079 Genomic DNA. No translation available.
    AC073584 Genomic DNA. No translation available.
    AL157399 Genomic DNA. No translation available.
    AL391378 Genomic DNA. No translation available.
    AL596105 Genomic DNA. No translation available.
    AL607031 Genomic DNA. No translation available.
    AL731537 Genomic DNA. No translation available.
    AL928686 Genomic DNA. No translation available.
    KF455236 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5SQU3.
    SMRi Q5SQU3. Positions 1-32, 48-643.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373985 ; ENSP00000363097 ; ENSG00000185532 .

    Organism-specific databases

    HGNCi HGNC:9414. PRKG1.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG75B84Q.

    Enzyme and pathway databases

    SignaLinki Q5SQU3.

    Miscellaneous databases

    ChiTaRSi PRKG1. human.

    Gene expression databases

    ArrayExpressi Q5SQU3.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR000961. AGC-kinase_C.
    IPR016232. cGMP-dependent_protein_kinase.
    IPR002374. cGMP_dep_kinase.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014710. RmlC-like_jellyroll.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000559. cGMP-dep_kinase. 1 hit.
    PRINTSi PR00104. CGMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00888. CNMP_BINDING_1. 2 hits.
    PS00889. CNMP_BINDING_2. 2 hits.
    PS50042. CNMP_BINDING_3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (AUG-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ5SQU3_HUMAN
    AccessioniPrimary (citable) accession number: Q5SQU3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3