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Q5SQU3

- Q5SQU3_HUMAN

UniProt

Q5SQU3 - Q5SQU3_HUMAN

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Protein

cGMP-dependent protein kinase

Gene
PRKG1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cGMP binding Source: UniProtKB-KW
  3. cGMP-dependent protein kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, cGMP, cGMP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ5SQU3.

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-dependent protein kinaseUniRule annotation (EC:2.7.11.12UniRule annotation)
Gene namesi
Name:PRKG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:9414. PRKG1.

Expressioni

Gene expression databases

ArrayExpressiQ5SQU3.

Structurei

3D structure databases

ProteinModelPortaliQ5SQU3.
SMRiQ5SQU3. Positions 1-32, 48-643.

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotations

Phylogenomic databases

OrthoDBiEOG75B84Q.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSiPR00104. CGMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SQU3-1 [UniParc]FASTAAdd to Basket

« Hide

MLKEERIKEL EKRLSEKEEE IQELKRKLHK CQSVLPVPST HIGPRTTRAQ    50
GISAEPQTYR SFHDLRQAFR KFTKSERSKD LIKEAILDND FMKNLELSQI 100
QEIVDCMYPV EYGKDSCIIK EGDVGSLVYV MEDGKVEVTK EGVKLCTMGP 150
GKVFGELAIL YNCTRTATVK TLVNVKLWAI DRQCFQTIMM RTGLIKHTEY 200
MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG ARGDTFFIIS 250
KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT 300
CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI 350
IDTLGVGGFG RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ QEHIRSEKQI 400
MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD RGSFEDSTTR 450
FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG 500
KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL TGSPPFSGPD 550
PMKTYNIILR GIDMIEFPKK IAKNAANLIK KLCRDNPSER LGNLKNGVKD 600
IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS PTDTSNFDSF PEDNDEPPPD 650
DNSGWDIDF 659
Length:659
Mass (Da):74,958
Last modified:December 21, 2004 - v1
Checksum:iA5172D8CB92803E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000373985; ENSP00000363097; ENSG00000185532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5SQU3.
SMRi Q5SQU3. Positions 1-32, 48-643.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373985 ; ENSP00000363097 ; ENSG00000185532 .

Organism-specific databases

HGNCi HGNC:9414. PRKG1.
GenAtlasi Search...

Phylogenomic databases

OrthoDBi EOG75B84Q.

Enzyme and pathway databases

SignaLinki Q5SQU3.

Miscellaneous databases

ChiTaRSi PRKG1. human.

Gene expression databases

ArrayExpressi Q5SQU3.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSi PR00104. CGMPKINASE.
SMARTi SM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5SQU3_HUMAN
AccessioniPrimary (citable) accession number: Q5SQU3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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