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Protein

cGMP-dependent protein kinase

Gene

PRKG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei378 – 3781ATPUniRule annotation
Active sitei472 – 4721Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3629ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cGMP binding Source: UniProtKB-KW
  3. cGMP-dependent protein kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, cGMP, cGMP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ5SQU3.

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-dependent protein kinaseUniRule annotation (EC:2.7.11.12UniRule annotation)
Gene namesi
Name:PRKG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:9414. PRKG1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5SQU3. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ5SQU3.
SMRiQ5SQU3. Positions 1-32, 48-643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121885.
OrthoDBiEOG75B84Q.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSiPR00104. CGMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SQU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKEERIKEL EKRLSEKEEE IQELKRKLHK CQSVLPVPST HIGPRTTRAQ
60 70 80 90 100
GISAEPQTYR SFHDLRQAFR KFTKSERSKD LIKEAILDND FMKNLELSQI
110 120 130 140 150
QEIVDCMYPV EYGKDSCIIK EGDVGSLVYV MEDGKVEVTK EGVKLCTMGP
160 170 180 190 200
GKVFGELAIL YNCTRTATVK TLVNVKLWAI DRQCFQTIMM RTGLIKHTEY
210 220 230 240 250
MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG ARGDTFFIIS
260 270 280 290 300
KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT
310 320 330 340 350
CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI
360 370 380 390 400
IDTLGVGGFG RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ QEHIRSEKQI
410 420 430 440 450
MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD RGSFEDSTTR
460 470 480 490 500
FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG
510 520 530 540 550
KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL TGSPPFSGPD
560 570 580 590 600
PMKTYNIILR GIDMIEFPKK IAKNAANLIK KLCRDNPSER LGNLKNGVKD
610 620 630 640 650
IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS PTDTSNFDSF PEDNDEPPPD

DNSGWDIDF
Length:659
Mass (Da):74,958
Last modified:December 21, 2004 - v1
Checksum:iA5172D8CB92803E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.
KF455236 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000373985; ENSP00000363097; ENSG00000185532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.
KF455236 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5SQU3.
SMRiQ5SQU3. Positions 1-32, 48-643.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ5SQU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373985; ENSP00000363097; ENSG00000185532.

Organism-specific databases

HGNCiHGNC:9414. PRKG1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00780000121885.
OrthoDBiEOG75B84Q.

Enzyme and pathway databases

SignaLinkiQ5SQU3.

Miscellaneous databases

ChiTaRSiPRKG1. human.

Gene expression databases

ExpressionAtlasiQ5SQU3. baseline and differential.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSiPR00104. CGMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5SQU3_HUMAN
AccessioniPrimary (citable) accession number: Q5SQU3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.