Q5SQS7 (SH24B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH2 domain-containing protein 4B

Gene names

Name:

SH2D4B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH2 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SQS7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SQS7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: R → RA
     329-431: IISREDAEAL...SPPDYHLLFE → GNYHCFRRRVTSGTLRTEGQPTRLPSVV

Isoform 3 (identifier: Q5SQS7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKR → MLPEDSGGSPDAA
     285-285: V → VS
     329-431: IISREDAEAL...SPPDYHLLFE → GNYHCFRRRVTSGTLRTEGQPTRLPSVV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	SH2 domain-containing protein 4B		PRO_0000308600
Regions
	Domain	325 – 417	93	SH2
	Compositional bias	92 – 223	132	Glu-rich
Natural variations
	Alternative sequence	1 – 61	61	MLQQI…PKTKR → MLPEDSGGSPDAA in isoform 3.		VSP_029009
	Alternative sequence	61	1	R → RA in isoform 2.		VSP_029010
	Alternative sequence	285	1	V → VS in isoform 3.		VSP_029011
	Alternative sequence	329 – 431	103	IISRE…HLLFE → GNYHCFRRRVTSGTLRTEGQ PTRLPSVV in isoform 2 and isoform 3.		VSP_029012
	Natural variant	237	1	H → R. Corresponds to variant rs7075840 [ dbSNP | Ensembl ].		VAR_056987
	Natural variant	239	1	S → L. Corresponds to variant rs11817391 [ dbSNP | Ensembl ].		VAR_056988
Experimental info
	Sequence conflict	148	1	D → G in BAC85715. Ref.1
	Sequence conflict	177	1	Q → R in BAC85715. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 5AB83BC426B0F8E9	FASTA	431	51,232
	10 20 30 40 50 60 MLQQILHDMY IDPELLAELS DVQKHILFYK MREEQLRRWK ERETWEALAQ DEGLRPPKTK 70 80 90 100 110 120 RASDKHIQWL LGADGEVWVW IMGEGPGDKP YEEISEELIA ERARLQAQRE AEELWRQKEA 130 140 150 160 170 180 EITKKFRDAL ANEKARILAE KWKVEMEDRK AAKVLEERIH EEFKRKEEEE RKRGEEQIRL 190 200 210 220 230 240 QEEQRAKELY WTLKQAQLHC QASEKEEREW EEQLRRSKAA DEERSRRAQR ARDEYRHHSL 250 260 270 280 290 300 RAIQKGTVAG LSSMFRELGQ SHEQEARLYH HLPDPGLPQP LALPVRTWER PLRPVSRDVI 310 320 330 340 350 360 VRWFKEEQLP RRAGFERNTK FIAPWFHGII SREDAEALLE NMTEGAFLVR VSEKIWGYTL 370 380 390 400 410 420 SYRLQKGFKH FLVDASGDFY SFLGVDPNRH ATLTDLVDFH KEEIITVSGG ELLQEPCGQR 430 DSPPDYHLLF E
	Isoform 2 [UniParc]. Checksum: FC26E899C3C35E9D	FASTA	357	42,756
	10 20 30 40 50 60 MLQQILHDMY IDPELLAELS DVQKHILFYK MREEQLRRWK ERETWEALAQ DEGLRPPKTK 70 80 90 100 110 120 RAASDKHIQW LLGADGEVWV WIMGEGPGDK PYEEISEELI AERARLQAQR EAEELWRQKE 130 140 150 160 170 180 AEITKKFRDA LANEKARILA EKWKVEMEDR KAAKVLEERI HEEFKRKEEE ERKRGEEQIR 190 200 210 220 230 240 LQEEQRAKEL YWTLKQAQLH CQASEKEERE WEEQLRRSKA ADEERSRRAQ RARDEYRHHS 250 260 270 280 290 300 LRAIQKGTVA GLSSMFRELG QSHEQEARLY HHLPDPGLPQ PLALPVRTWE RPLRPVSRDV 310 320 330 340 350 IVRWFKEEQL PRRAGFERNT KFIAPWFHGG NYHCFRRRVT SGTLRTEGQP TRLPSVV
	Isoform 3 [UniParc]. Checksum: 2ADACD02D1D4DBDD	FASTA	309	36,467
	10 20 30 40 50 60 MLPEDSGGSP DAAASDKHIQ WLLGADGEVW VWIMGEGPGD KPYEEISEEL IAERARLQAQ 70 80 90 100 110 120 REAEELWRQK EAEITKKFRD ALANEKARIL AEKWKVEMED RKAAKVLEER IHEEFKRKEE 130 140 150 160 170 180 EERKRGEEQI RLQEEQRAKE LYWTLKQAQL HCQASEKEER EWEEQLRRSK AADEERSRRA 190 200 210 220 230 240 QRARDEYRHH SLRAIQKGTV AGLSSMFREL GQSHEQEARL YHHLPDPGLP QPLALPVSRT 250 260 270 280 290 300 WERPLRPVSR DVIVRWFKEE QLPRRAGFER NTKFIAPWFH GGNYHCFRRR VTSGTLRTEG QPTRLPSVV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Spleen.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123885 mRNA. Translation: BAC85715.1. AK123978 mRNA. Translation: BAC85741.1. AL731544, AC021028 Genomic DNA. Translation: CAI14997.1. AL731544, AC021028 Genomic DNA. Translation: CAI14998.1.
IPI	IPI00410443. IPI00514668. IPI00869143.
RefSeq	NP_001139191.1. NM_001145719.1. NP_997255.2. NM_207372.2.
UniGene	Hs.147643.
3D structure databases
HSSP	HSSP built from PDB template 2CS0 based on UniProtKB Q96JZ2.
ProteinModelPortal	Q5SQS7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000345295.
PTM databases
PhosphoSite	Q5SQS7.
Polymorphism databases
DMDM	74743565.
Proteomic databases
PaxDb	Q5SQS7.
PRIDE	Q5SQS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313455; ENSP00000314242; ENSG00000178217. ENST00000339284; ENSP00000345295; ENSG00000178217. ENST00000470604; ENSP00000417953; ENSG00000178217.
GeneID	387694.
KEGG	hsa:387694.
UCSC	uc001kck.1. human. uc001kcl.1. human.
Organism-specific databases
CTD	387694.
GeneCards	GC10P082297.
HGNC	HGNC:31440. SH2D4B.
HPA	HPA040022.
neXtProt	NX_Q5SQS7.
PharmGKB	PA134943660.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77708.
HOGENOM	HOG000031527.
HOVERGEN	HBG057918.
InParanoid	Q5SQS7.
OMA	SMFQELG.
Gene expression databases
ArrayExpress	Q5SQS7.
Bgee	Q5SQS7.
CleanEx	HS_SH2D4B.
Genevestigator	Q5SQS7.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. [Graphical view]
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	387694.
NextBio	101513.

Entry information

Entry name

SH24B_HUMAN

Accession

Primary (citable) accession number: Q5SQS7
Secondary accession number(s): Q5SQS5, Q6ZVW9, Q6ZVZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.