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Protein

HORMA domain-containing protein 2

Gene

Hormad2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.2 Publications

GO - Biological processi

  • meiotic nuclear division Source: UniProtKB
  • meiotic sister chromatid cohesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
HORMA domain-containing protein 2
Gene namesi
Name:Hormad2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923078. Hormad2.

Subcellular locationi

  • Nucleus
  • Chromosome

  • Note: Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes.

GO - Cellular componenti

  • chromosome Source: UniProtKB
  • nucleus Source: UniProtKB
  • synaptonemal complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice are infertile due to spermatocyte loss as a result of characteristic impairment of sex body formation. Spermatocyte apoptosis is confined to the stage IV seminiferous tubules. In contrast to males, female mice are fertile.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846701 – 306HORMA domain-containing protein 2Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in a SPO11-dependent manner.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SQP1.
PRIDEiQ5SQP1.

PTM databases

iPTMnetiQ5SQP1.
PhosphoSitePlusiQ5SQP1.

Expressioni

Tissue specificityi

Specifically expressed in meiotic germ cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000020419.
CleanExiMM_HORMAD2.
ExpressionAtlasiQ5SQP1. baseline and differential.
GenevisibleiQ5SQP1. MM.

Interactioni

Subunit structurei

Interacts with HORMAD1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105574.

Structurei

3D structure databases

ProteinModelPortaliQ5SQP1.
SMRiQ5SQP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 232HORMAPROSITE-ProRule annotationAdd BLAST204

Sequence similaritiesi

Contains 1 HORMA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4652. Eukaryota.
ENOG410XT4N. LUCA.
GeneTreeiENSGT00390000018130.
HOGENOMiHOG000293366.
HOVERGENiHBG074209.
InParanoidiQ5SQP1.
OMAiKEPINVQ.
OrthoDBiEOG091G0F8O.
PhylomeDBiQ5SQP1.
TreeFamiTF313989.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SQP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAQLSHNT RTLKASKNTI FPSQVTNEHE SLVVVKKLFA TCISCITYLR
60 70 80 90 100
GLFPESSYRD RRLDDLSLKI LREDKKCPGS LHIIKWIQGC FDALEKRYLH
110 120 130 140 150
MAVLTLYTNP KEPEKVTEIY QFRFKYTKKG TTMDFDSSST SFESGTDSED
160 170 180 190 200
IKKACSLLIR QLYILMQNLG PLPNDVILTM KLHYYNSVTP HDYQPPGFKE
210 220 230 240 250
AVNSHFLLFE GEPVSLRMGS VSSGFHSMKV KVTTEATRML DGENSVSQDD
260 270 280 290 300
GTTEIAHQGL DCDEEEEACG SQVQRMNFVH IEPSFESSRK KKKVSEPVTV

FIPNRK
Length:306
Mass (Da):34,812
Last modified:December 21, 2004 - v1
Checksum:iA0E41A74BA7E3A63
GO
Isoform 2 (identifier: Q5SQP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-65: DRRLDD → MRRDPN

Show »
Length:247
Mass (Da):28,196
Checksum:iE3865E18FE343DA6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246051 – 59Missing in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_02460660 – 65DRRLDD → MRRDPN in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015939 mRNA. Translation: BAB30043.1.
AL731658, AL645910 Genomic DNA. Translation: CAI25202.1.
AL731658, AL645910 Genomic DNA. Translation: CAI25203.1.
AL645910, AL731658 Genomic DNA. Translation: CAI35181.1.
AL645910, AL731658 Genomic DNA. Translation: CAI35183.1.
BC120781 mRNA. Translation: AAI20782.1.
BC120783 mRNA. Translation: AAI20784.1.
BC144842 mRNA. Translation: AAI44843.1.
CCDSiCCDS36096.1. [Q5SQP1-1]
RefSeqiNP_083734.1. NM_029458.1. [Q5SQP1-1]
XP_011242079.1. XM_011243777.2. [Q5SQP1-1]
XP_011242081.1. XM_011243779.2. [Q5SQP1-1]
XP_011242082.1. XM_011243780.2. [Q5SQP1-1]
XP_011242083.1. XM_011243781.1. [Q5SQP1-1]
UniGeneiMm.159592.

Genome annotation databases

EnsembliENSMUST00000109948; ENSMUSP00000105574; ENSMUSG00000020419. [Q5SQP1-1]
ENSMUST00000109949; ENSMUSP00000105575; ENSMUSG00000020419. [Q5SQP1-1]
GeneIDi75828.
KEGGimmu:75828.
UCSCiuc007huv.1. mouse. [Q5SQP1-1]
uc011xqw.1. mouse. [Q5SQP1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015939 mRNA. Translation: BAB30043.1.
AL731658, AL645910 Genomic DNA. Translation: CAI25202.1.
AL731658, AL645910 Genomic DNA. Translation: CAI25203.1.
AL645910, AL731658 Genomic DNA. Translation: CAI35181.1.
AL645910, AL731658 Genomic DNA. Translation: CAI35183.1.
BC120781 mRNA. Translation: AAI20782.1.
BC120783 mRNA. Translation: AAI20784.1.
BC144842 mRNA. Translation: AAI44843.1.
CCDSiCCDS36096.1. [Q5SQP1-1]
RefSeqiNP_083734.1. NM_029458.1. [Q5SQP1-1]
XP_011242079.1. XM_011243777.2. [Q5SQP1-1]
XP_011242081.1. XM_011243779.2. [Q5SQP1-1]
XP_011242082.1. XM_011243780.2. [Q5SQP1-1]
XP_011242083.1. XM_011243781.1. [Q5SQP1-1]
UniGeneiMm.159592.

3D structure databases

ProteinModelPortaliQ5SQP1.
SMRiQ5SQP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105574.

PTM databases

iPTMnetiQ5SQP1.
PhosphoSitePlusiQ5SQP1.

Proteomic databases

PaxDbiQ5SQP1.
PRIDEiQ5SQP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109948; ENSMUSP00000105574; ENSMUSG00000020419. [Q5SQP1-1]
ENSMUST00000109949; ENSMUSP00000105575; ENSMUSG00000020419. [Q5SQP1-1]
GeneIDi75828.
KEGGimmu:75828.
UCSCiuc007huv.1. mouse. [Q5SQP1-1]
uc011xqw.1. mouse. [Q5SQP1-2]

Organism-specific databases

CTDi150280.
MGIiMGI:1923078. Hormad2.

Phylogenomic databases

eggNOGiKOG4652. Eukaryota.
ENOG410XT4N. LUCA.
GeneTreeiENSGT00390000018130.
HOGENOMiHOG000293366.
HOVERGENiHBG074209.
InParanoidiQ5SQP1.
OMAiKEPINVQ.
OrthoDBiEOG091G0F8O.
PhylomeDBiQ5SQP1.
TreeFamiTF313989.

Miscellaneous databases

PROiQ5SQP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020419.
CleanExiMM_HORMAD2.
ExpressionAtlasiQ5SQP1. baseline and differential.
GenevisibleiQ5SQP1. MM.

Family and domain databases

Gene3Di3.30.900.10. 1 hit.
InterProiIPR003511. HORMA_dom.
[Graphical view]
PfamiPF02301. HORMA. 1 hit.
[Graphical view]
SUPFAMiSSF56019. SSF56019. 1 hit.
PROSITEiPS50815. HORMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHORM2_MOUSE
AccessioniPrimary (citable) accession number: Q5SQP1
Secondary accession number(s): B7ZMW2, Q9D507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.