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Protein

Alpha-tubulin N-acetyltransferase 1

Gene

ATAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.UniRule annotation4 Publications

Catalytic activityi

Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.UniRule annotation4 Publications

Kineticsi

kcat is 2.2 h(-1) for the acetylation of polymerized tubulin (microtubules), 0.35 h(-1) for the acetylation of free tubulin, and 1.47 h(-1)with acetyl-CoA as substrate.

  1. KM=2.0 µM for free alpha-tubulin2 Publications
  2. KM=1.6 µM for polymerized tubulin (microtubules)2 Publications
  3. KM=2.2 µM for acetyl-CoA2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei58Crucial for catalytic activityUniRule annotation1 Publication1

    GO - Molecular functioni

    • coenzyme binding Source: UniProtKB
    • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor Source: UniProtKB
    • tubulin N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000137343-MONOMER.
    ReactomeiR-HSA-5617833. Assembly of the primary cilium.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-tubulin N-acetyltransferase 1UniRule annotation (EC:2.3.1.108UniRule annotation3 Publications)
    Short name:
    Alpha-TATUniRule annotation
    Short name:
    Alpha-TAT1UniRule annotation
    Short name:
    TATUniRule annotation
    Alternative name(s):
    Acetyltransferase mec-17 homologUniRule annotation
    Gene namesi
    Name:ATAT1UniRule annotation
    Synonyms:C6orf134, MEC17UniRule annotation
    ORF Names:Nbla00487
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21186. ATAT1.

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell junction, Cell projection, Coated pit, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi58Q → A: Loss of acetyltransferase activity. 1 Publication1
    Mutagenesisi61S → A: No effect on catalytic activity. 1 Publication1
    Mutagenesisi64I → A: Strong reduction in acetyltransferase activity. 3 Publications1
    Mutagenesisi69R → A: Strong reduction in acetyltransferase activity. 1 Publication1
    Mutagenesisi102K → A: Strong reduction in acetyltransferase activity. 1 Publication1
    Mutagenesisi105F → A: Reduced activity. 1 Publication1
    Mutagenesisi106V → A: Reduced activity. 1 Publication1
    Mutagenesisi107L → A: Reduced activity. 1 Publication1
    Mutagenesisi108D → A: Reduced activity. 1 Publication1
    Mutagenesisi109D → A: Slight increase in activity. 1 Publication1
    Mutagenesisi109D → R: Marginal increase in activity. 1 Publication1
    Mutagenesisi111E → A: 2-fold increase in activity. 1 Publication1
    Mutagenesisi111E → R: No effect on catalytic activity. 1 Publication1
    Mutagenesisi115E → A: Reduced activity. 1 Publication1
    Mutagenesisi117E → A: Reduced activity. 1 Publication1
    Mutagenesisi120C → A or S: Strong reduction in microtubule acetylation. 1 Publication1
    Mutagenesisi157D → E or N: Strong reduction in microtubule acetylation. 2 Publications1
    Mutagenesisi158R → A: 20% of wild-type acetyltransferase activity. 2 Publications1
    Mutagenesisi182N → A: Strong reduction in activity. 1 Publication1
    Mutagenesisi183F → A: Strong reduction in activity. 1 Publication1

    Organism-specific databases

    DisGeNETi79969.
    OpenTargetsiENSG00000137343.
    ENSG00000206488.
    ENSG00000223752.
    ENSG00000229061.
    ENSG00000231257.
    ENSG00000234549.
    ENSG00000235658.
    PharmGKBiPA134948212.

    Polymorphism and mutation databases

    BioMutaiATAT1.
    DMDMi74743537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003480661 – 421Alpha-tubulin N-acetyltransferase 1Add BLAST421

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei56N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei146N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei233N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei244N6-acetyllysine; by autocatalysisUniRule annotationBy similarity1
    Modified residuei272PhosphoserineBy similarity1
    Modified residuei276PhosphoserineCombined sources1
    Modified residuei305Asymmetric dimethylarginineBy similarity1
    Modified residuei315PhosphoserineCombined sources1
    Modified residuei323Omega-N-methylarginineCombined sources1

    Post-translational modificationi

    Autoacetylation strongly increases tubulin acetylation.UniRule annotation

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    EPDiQ5SQI0.
    PaxDbiQ5SQI0.
    PeptideAtlasiQ5SQI0.
    PRIDEiQ5SQI0.

    PTM databases

    iPTMnetiQ5SQI0.
    PhosphoSitePlusiQ5SQI0.

    Expressioni

    Gene expression databases

    BgeeiENSG00000137343.
    CleanExiHS_C6orf134.
    GenevisibleiQ5SQI0. HS.

    Organism-specific databases

    HPAiHPA046816.
    HPA050999.

    Interactioni

    Subunit structurei

    Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.UniRule annotation4 Publications

    Protein-protein interaction databases

    BioGridi123036. 3 interactors.
    IntActiQ5SQI0. 1 interactor.
    STRINGi9606.ENSP00000327832.

    Structurei

    Secondary structure

    1421
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi7 – 10Combined sources4
    Beta strandi13 – 18Combined sources6
    Helixi36 – 57Combined sources22
    Helixi67 – 72Combined sources6
    Beta strandi76 – 81Combined sources6
    Beta strandi93 – 101Combined sources9
    Beta strandi104 – 107Combined sources4
    Beta strandi109 – 111Combined sources3
    Beta strandi113 – 116Combined sources4
    Beta strandi119 – 126Combined sources8
    Helixi128 – 130Combined sources3
    Helixi135 – 147Combined sources13
    Helixi151 – 153Combined sources3
    Beta strandi155 – 158Combined sources4
    Helixi161 – 171Combined sources11
    Beta strandi182 – 184Combined sources3
    Turni187 – 190Combined sources4
    Helixi191 – 194Combined sources4

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3VWDX-ray1.25A1-194[»]
    3VWEX-ray1.96A1-194[»]
    4B5OX-ray1.05A1-196[»]
    4B5PX-ray1.60A/B1-196[»]
    4GS4X-ray2.11A2-236[»]
    4IF5X-ray1.70A1-193[»]
    4PK2X-ray1.35A1-194[»]
    4PK3X-ray1.35A1-194[»]
    4U9YX-ray2.20A1-194[»]
    4U9ZX-ray1.80A1-194[»]
    ProteinModelPortaliQ5SQI0.
    SMRiQ5SQI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini1 – 190N-acetyltransferaseUniRule annotationAdd BLAST190

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni124 – 137Acetyl-CoA bindingUniRule annotation3 PublicationsAdd BLAST14
    Regioni160 – 169Acetyl-CoA bindingUniRule annotation3 Publications10

    Sequence similaritiesi

    Belongs to the acetyltransferase ATAT1 family.UniRule annotation
    Contains 1 N-acetyltransferase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiKOG4601. Eukaryota.
    ENOG4111Q8H. LUCA.
    GeneTreeiENSGT00390000008276.
    HOVERGENiHBG055797.
    InParanoidiQ5SQI0.
    KOiK19573.
    OMAiPMHTAPP.
    OrthoDBiEOG091G0F8N.
    PhylomeDBiQ5SQI0.
    TreeFamiTF315643.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    HAMAPiMF_03130. mec17. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR007965. GNAT_ATAT.
    [Graphical view]
    PfamiPF05301. Acetyltransf_16. 1 hit.
    [Graphical view]
    PROSITEiPS51730. GNAT_ATAT. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 11 Publication (identifier: Q5SQI0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL
    60 70 80 90 100
    GKASAKAQNL SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG
    110 120 130 140 150
    YKKLFVLDDR EAHNEVEPLC ILDFYIHESV QRHGHGRELF QYMLQKERVE
    160 170 180 190 200
    PHQLAIDRPS QKLLKFLNKH YNLETTVPQV NNFVIFEGFF AHQHRPPAPS
    210 220 230 240 250
    LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR EFLKVAVEPP
    260 270 280 290 300
    WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP
    310 320 330 340 350
    HPTARLLLAA DPGGSPAQRR RTRGTPPGLV AQSCCYSRHG GVNSSSPNTG
    360 370 380 390 400
    NQDSKQGEQE TKNRSASEEQ ALSQDGSGEK PMHTAPPQAP APPAQSWTVG
    410 420
    GDILNARFIR NLQERRSTRP W
    Length:421
    Mass (Da):46,810
    Last modified:December 21, 2004 - v1
    Checksum:i6CC9B4B844930842
    GO
    Isoform 22 Publications (identifier: Q5SQI0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: Missing.
         13-36: ERITVLDQHLRPPARRPGTTTPAR → MWLTWPFCFLTITLREEGVCHLES

    Show »
    Length:409
    Mass (Da):45,574
    Checksum:iD2D140F7FADEDEEA
    GO
    Isoform 31 Publication (identifier: Q5SQI0-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P

    Show »
    Length:398
    Mass (Da):44,458
    Checksum:i4E53964B391B8C4F
    GO
    Isoform 42 Publications (identifier: Q5SQI0-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         323-333: RGTPPGLVAQS → SSLPRSEESRY
         334-421: Missing.

    Show »
    Length:333
    Mass (Da):37,478
    Checksum:i9AF89C8C2FF122FC
    GO
    Isoform 52 Publications (identifier: Q5SQI0-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         324-421: Missing.

    Show »
    Length:323
    Mass (Da):36,342
    Checksum:iE3D8C0B120A640FB
    GO
    Isoform 61 Publication (identifier: Q5SQI0-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
         323-333: RGTPPGLVAQS → SSLPRSEESRY
         334-421: Missing.

    Show »
    Length:310
    Mass (Da):35,126
    Checksum:i1F8BD442CF9A9797
    GO
    Isoform 72 Publications (identifier: Q5SQI0-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
         324-421: Missing.

    Show »
    Length:300
    Mass (Da):33,990
    Checksum:i359BE466FD5562B1
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0528991 – 12Missing in isoform 2. 2 PublicationsAdd BLAST12
    Alternative sequenceiVSP_05290013 – 36ERITV…TTPAR → MWLTWPFCFLTITLREEGVC HLES in isoform 2. 2 PublicationsAdd BLAST24
    Alternative sequenceiVSP_052901195 – 218RPPAP…PTPAA → P in isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST24
    Alternative sequenceiVSP_052902323 – 333RGTPPGLVAQS → SSLPRSEESRY in isoform 4 and isoform 6. 3 PublicationsAdd BLAST11
    Alternative sequenceiVSP_052903324 – 421Missing in isoform 5 and isoform 7. 3 PublicationsAdd BLAST98
    Alternative sequenceiVSP_052904334 – 421Missing in isoform 4 and isoform 6. 3 PublicationsAdd BLAST88

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB075512 mRNA. Translation: BAE45758.1.
    AK023220 mRNA. Translation: BAB14472.1.
    AL845353 Genomic DNA. Translation: CAI41872.2.
    AL845353 Genomic DNA. Translation: CAI41875.2.
    AL662800 Genomic DNA. Translation: CAI18164.1.
    AL662800 Genomic DNA. Translation: CAI18165.1.
    AL662800 Genomic DNA. Translation: CAI18166.2.
    AL662800 Genomic DNA. Translation: CAI18167.2.
    AL662800 Genomic DNA. Translation: CAI18168.2.
    AL662800 Genomic DNA. Translation: CAM25498.1.
    AL732442 Genomic DNA. Translation: CAI17752.1.
    AL732442 Genomic DNA. Translation: CAI17753.1.
    AL732442 Genomic DNA. Translation: CAI17754.2.
    AL732442 Genomic DNA. Translation: CAI17755.1.
    AL732442 Genomic DNA. Translation: CAM25005.1.
    AL732442 Genomic DNA. Translation: CAM25006.1.
    AL845353 Genomic DNA. Translation: CAI41870.1.
    AL845353 Genomic DNA. Translation: CAI41871.1.
    AL845353 Genomic DNA. Translation: CAI41873.2.
    AL845353 Genomic DNA. Translation: CAI41874.2.
    BX119957 Genomic DNA. Translation: CAM25912.1.
    BX119957 Genomic DNA. Translation: CAM25913.1.
    BX119957 Genomic DNA. Translation: CAM25914.1.
    BX119957 Genomic DNA. Translation: CAM25915.1.
    BX119957 Genomic DNA. Translation: CAM25916.1.
    BX119957 Genomic DNA. Translation: CAM25917.1.
    BX908728 Genomic DNA. Translation: CAQ07413.1.
    BX908728 Genomic DNA. Translation: CAQ07414.1.
    BX908728 Genomic DNA. Translation: CAQ07415.1.
    BX908728 Genomic DNA. Translation: CAQ07416.1.
    BX908728 Genomic DNA. Translation: CAQ07417.1.
    BX908728 Genomic DNA. Translation: CAQ07418.1.
    CR753328 Genomic DNA. Translation: CAP58454.1.
    CR753328 Genomic DNA. Translation: CAP58455.1.
    CR753328 Genomic DNA. Translation: CAP58456.1.
    CR753328 Genomic DNA. Translation: CAP58457.1.
    CR753328 Genomic DNA. Translation: CAP58458.1.
    CR753328 Genomic DNA. Translation: CAP58459.1.
    CR759778 Genomic DNA. Translation: CAQ09406.1.
    CR759778 Genomic DNA. Translation: CAQ09407.1.
    CR759778 Genomic DNA. Translation: CAQ09408.1.
    CR759778 Genomic DNA. Translation: CAQ09409.1.
    CR759778 Genomic DNA. Translation: CAQ09410.1.
    CR759778 Genomic DNA. Translation: CAQ09411.1.
    CH471081 Genomic DNA. Translation: EAX03306.1.
    CH471081 Genomic DNA. Translation: EAX03307.1.
    BC006105 mRNA. Translation: AAH06105.1.
    BC047303 mRNA. Translation: AAH47303.1.
    AL833858 mRNA. Translation: CAD38717.1.
    CCDSiCCDS4683.2. [Q5SQI0-4]
    CCDS54978.1. [Q5SQI0-2]
    CCDS59002.1. [Q5SQI0-6]
    CCDS83072.1. [Q5SQI0-5]
    CCDS83073.1. [Q5SQI0-7]
    RefSeqiNP_001026892.1. NM_001031722.3. [Q5SQI0-2]
    NP_001177653.1. NM_001190724.2.
    NP_001241881.1. NM_001254952.2. [Q5SQI0-6]
    NP_001305691.1. NM_001318762.1. [Q5SQI0-7]
    NP_001305692.1. NM_001318763.1. [Q5SQI0-5]
    NP_079185.2. NM_024909.3. [Q5SQI0-4]
    UniGeneiHs.654798.

    Genome annotation databases

    EnsembliENST00000318999; ENSP00000324222; ENSG00000137343. [Q5SQI0-7]
    ENST00000319027; ENSP00000324459; ENSG00000137343. [Q5SQI0-6]
    ENST00000329992; ENSP00000332374; ENSG00000137343. [Q5SQI0-4]
    ENST00000330083; ENSP00000327832; ENSG00000137343. [Q5SQI0-2]
    ENST00000376483; ENSP00000365666; ENSG00000137343. [Q5SQI0-5]
    ENST00000376485; ENSP00000365668; ENSG00000137343. [Q5SQI0-1]
    ENST00000383582; ENSP00000373076; ENSG00000206488. [Q5SQI0-2]
    ENST00000383583; ENSP00000373077; ENSG00000206488. [Q5SQI0-4]
    ENST00000383584; ENSP00000373078; ENSG00000206488. [Q5SQI0-7]
    ENST00000383585; ENSP00000373079; ENSG00000206488. [Q5SQI0-1]
    ENST00000400575; ENSP00000383419; ENSG00000206488. [Q5SQI0-5]
    ENST00000400576; ENSP00000383420; ENSG00000206488. [Q5SQI0-6]
    ENST00000411724; ENSP00000388617; ENSG00000234549. [Q5SQI0-5]
    ENST00000416435; ENSP00000412993; ENSG00000235658. [Q5SQI0-2]
    ENST00000416917; ENSP00000402998; ENSG00000234549. [Q5SQI0-7]
    ENST00000417183; ENSP00000393868; ENSG00000231257. [Q5SQI0-7]
    ENST00000418248; ENSP00000411362; ENSG00000231257. [Q5SQI0-5]
    ENST00000420586; ENSP00000411050; ENSG00000231257. [Q5SQI0-1]
    ENST00000423338; ENSP00000415000; ENSG00000223752. [Q5SQI0-7]
    ENST00000423654; ENSP00000403142; ENSG00000235658. [Q5SQI0-5]
    ENST00000424121; ENSP00000412198; ENSG00000223752. [Q5SQI0-6]
    ENST00000425448; ENSP00000391244; ENSG00000223752. [Q5SQI0-2]
    ENST00000428764; ENSP00000399509; ENSG00000235658. [Q5SQI0-4]
    ENST00000430611; ENSP00000409296; ENSG00000235658. [Q5SQI0-6]
    ENST00000432356; ENSP00000416994; ENSG00000234549. [Q5SQI0-1]
    ENST00000432643; ENSP00000416925; ENSG00000231257. [Q5SQI0-2]
    ENST00000442844; ENSP00000394914; ENSG00000235658. [Q5SQI0-1]
    ENST00000443114; ENSP00000405656; ENSG00000229061. [Q5SQI0-7]
    ENST00000443391; ENSP00000406071; ENSG00000229061. [Q5SQI0-6]
    ENST00000445486; ENSP00000398422; ENSG00000223752. [Q5SQI0-1]
    ENST00000445973; ENSP00000415408; ENSG00000231257. [Q5SQI0-6]
    ENST00000446100; ENSP00000393269; ENSG00000229061. [Q5SQI0-5]
    ENST00000448670; ENSP00000389129; ENSG00000229061. [Q5SQI0-2]
    ENST00000449905; ENSP00000399529; ENSG00000235658. [Q5SQI0-7]
    ENST00000450003; ENSP00000406421; ENSG00000223752. [Q5SQI0-4]
    ENST00000450220; ENSP00000405036; ENSG00000231257. [Q5SQI0-4]
    ENST00000454794; ENSP00000409067; ENSG00000229061. [Q5SQI0-1]
    ENST00000454987; ENSP00000410415; ENSG00000234549. [Q5SQI0-6]
    ENST00000456215; ENSP00000399452; ENSG00000234549. [Q5SQI0-4]
    ENST00000456704; ENSP00000394357; ENSG00000229061. [Q5SQI0-4]
    ENST00000457161; ENSP00000388171; ENSG00000223752. [Q5SQI0-5]
    ENST00000457334; ENSP00000398374; ENSG00000234549. [Q5SQI0-2]
    GeneIDi79969.
    KEGGihsa:79969.
    UCSCiuc003nqr.5. human. [Q5SQI0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB075512 mRNA. Translation: BAE45758.1.
    AK023220 mRNA. Translation: BAB14472.1.
    AL845353 Genomic DNA. Translation: CAI41872.2.
    AL845353 Genomic DNA. Translation: CAI41875.2.
    AL662800 Genomic DNA. Translation: CAI18164.1.
    AL662800 Genomic DNA. Translation: CAI18165.1.
    AL662800 Genomic DNA. Translation: CAI18166.2.
    AL662800 Genomic DNA. Translation: CAI18167.2.
    AL662800 Genomic DNA. Translation: CAI18168.2.
    AL662800 Genomic DNA. Translation: CAM25498.1.
    AL732442 Genomic DNA. Translation: CAI17752.1.
    AL732442 Genomic DNA. Translation: CAI17753.1.
    AL732442 Genomic DNA. Translation: CAI17754.2.
    AL732442 Genomic DNA. Translation: CAI17755.1.
    AL732442 Genomic DNA. Translation: CAM25005.1.
    AL732442 Genomic DNA. Translation: CAM25006.1.
    AL845353 Genomic DNA. Translation: CAI41870.1.
    AL845353 Genomic DNA. Translation: CAI41871.1.
    AL845353 Genomic DNA. Translation: CAI41873.2.
    AL845353 Genomic DNA. Translation: CAI41874.2.
    BX119957 Genomic DNA. Translation: CAM25912.1.
    BX119957 Genomic DNA. Translation: CAM25913.1.
    BX119957 Genomic DNA. Translation: CAM25914.1.
    BX119957 Genomic DNA. Translation: CAM25915.1.
    BX119957 Genomic DNA. Translation: CAM25916.1.
    BX119957 Genomic DNA. Translation: CAM25917.1.
    BX908728 Genomic DNA. Translation: CAQ07413.1.
    BX908728 Genomic DNA. Translation: CAQ07414.1.
    BX908728 Genomic DNA. Translation: CAQ07415.1.
    BX908728 Genomic DNA. Translation: CAQ07416.1.
    BX908728 Genomic DNA. Translation: CAQ07417.1.
    BX908728 Genomic DNA. Translation: CAQ07418.1.
    CR753328 Genomic DNA. Translation: CAP58454.1.
    CR753328 Genomic DNA. Translation: CAP58455.1.
    CR753328 Genomic DNA. Translation: CAP58456.1.
    CR753328 Genomic DNA. Translation: CAP58457.1.
    CR753328 Genomic DNA. Translation: CAP58458.1.
    CR753328 Genomic DNA. Translation: CAP58459.1.
    CR759778 Genomic DNA. Translation: CAQ09406.1.
    CR759778 Genomic DNA. Translation: CAQ09407.1.
    CR759778 Genomic DNA. Translation: CAQ09408.1.
    CR759778 Genomic DNA. Translation: CAQ09409.1.
    CR759778 Genomic DNA. Translation: CAQ09410.1.
    CR759778 Genomic DNA. Translation: CAQ09411.1.
    CH471081 Genomic DNA. Translation: EAX03306.1.
    CH471081 Genomic DNA. Translation: EAX03307.1.
    BC006105 mRNA. Translation: AAH06105.1.
    BC047303 mRNA. Translation: AAH47303.1.
    AL833858 mRNA. Translation: CAD38717.1.
    CCDSiCCDS4683.2. [Q5SQI0-4]
    CCDS54978.1. [Q5SQI0-2]
    CCDS59002.1. [Q5SQI0-6]
    CCDS83072.1. [Q5SQI0-5]
    CCDS83073.1. [Q5SQI0-7]
    RefSeqiNP_001026892.1. NM_001031722.3. [Q5SQI0-2]
    NP_001177653.1. NM_001190724.2.
    NP_001241881.1. NM_001254952.2. [Q5SQI0-6]
    NP_001305691.1. NM_001318762.1. [Q5SQI0-7]
    NP_001305692.1. NM_001318763.1. [Q5SQI0-5]
    NP_079185.2. NM_024909.3. [Q5SQI0-4]
    UniGeneiHs.654798.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3VWDX-ray1.25A1-194[»]
    3VWEX-ray1.96A1-194[»]
    4B5OX-ray1.05A1-196[»]
    4B5PX-ray1.60A/B1-196[»]
    4GS4X-ray2.11A2-236[»]
    4IF5X-ray1.70A1-193[»]
    4PK2X-ray1.35A1-194[»]
    4PK3X-ray1.35A1-194[»]
    4U9YX-ray2.20A1-194[»]
    4U9ZX-ray1.80A1-194[»]
    ProteinModelPortaliQ5SQI0.
    SMRiQ5SQI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123036. 3 interactors.
    IntActiQ5SQI0. 1 interactor.
    STRINGi9606.ENSP00000327832.

    PTM databases

    iPTMnetiQ5SQI0.
    PhosphoSitePlusiQ5SQI0.

    Polymorphism and mutation databases

    BioMutaiATAT1.
    DMDMi74743537.

    Proteomic databases

    EPDiQ5SQI0.
    PaxDbiQ5SQI0.
    PeptideAtlasiQ5SQI0.
    PRIDEiQ5SQI0.

    Protocols and materials databases

    DNASUi79969.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000318999; ENSP00000324222; ENSG00000137343. [Q5SQI0-7]
    ENST00000319027; ENSP00000324459; ENSG00000137343. [Q5SQI0-6]
    ENST00000329992; ENSP00000332374; ENSG00000137343. [Q5SQI0-4]
    ENST00000330083; ENSP00000327832; ENSG00000137343. [Q5SQI0-2]
    ENST00000376483; ENSP00000365666; ENSG00000137343. [Q5SQI0-5]
    ENST00000376485; ENSP00000365668; ENSG00000137343. [Q5SQI0-1]
    ENST00000383582; ENSP00000373076; ENSG00000206488. [Q5SQI0-2]
    ENST00000383583; ENSP00000373077; ENSG00000206488. [Q5SQI0-4]
    ENST00000383584; ENSP00000373078; ENSG00000206488. [Q5SQI0-7]
    ENST00000383585; ENSP00000373079; ENSG00000206488. [Q5SQI0-1]
    ENST00000400575; ENSP00000383419; ENSG00000206488. [Q5SQI0-5]
    ENST00000400576; ENSP00000383420; ENSG00000206488. [Q5SQI0-6]
    ENST00000411724; ENSP00000388617; ENSG00000234549. [Q5SQI0-5]
    ENST00000416435; ENSP00000412993; ENSG00000235658. [Q5SQI0-2]
    ENST00000416917; ENSP00000402998; ENSG00000234549. [Q5SQI0-7]
    ENST00000417183; ENSP00000393868; ENSG00000231257. [Q5SQI0-7]
    ENST00000418248; ENSP00000411362; ENSG00000231257. [Q5SQI0-5]
    ENST00000420586; ENSP00000411050; ENSG00000231257. [Q5SQI0-1]
    ENST00000423338; ENSP00000415000; ENSG00000223752. [Q5SQI0-7]
    ENST00000423654; ENSP00000403142; ENSG00000235658. [Q5SQI0-5]
    ENST00000424121; ENSP00000412198; ENSG00000223752. [Q5SQI0-6]
    ENST00000425448; ENSP00000391244; ENSG00000223752. [Q5SQI0-2]
    ENST00000428764; ENSP00000399509; ENSG00000235658. [Q5SQI0-4]
    ENST00000430611; ENSP00000409296; ENSG00000235658. [Q5SQI0-6]
    ENST00000432356; ENSP00000416994; ENSG00000234549. [Q5SQI0-1]
    ENST00000432643; ENSP00000416925; ENSG00000231257. [Q5SQI0-2]
    ENST00000442844; ENSP00000394914; ENSG00000235658. [Q5SQI0-1]
    ENST00000443114; ENSP00000405656; ENSG00000229061. [Q5SQI0-7]
    ENST00000443391; ENSP00000406071; ENSG00000229061. [Q5SQI0-6]
    ENST00000445486; ENSP00000398422; ENSG00000223752. [Q5SQI0-1]
    ENST00000445973; ENSP00000415408; ENSG00000231257. [Q5SQI0-6]
    ENST00000446100; ENSP00000393269; ENSG00000229061. [Q5SQI0-5]
    ENST00000448670; ENSP00000389129; ENSG00000229061. [Q5SQI0-2]
    ENST00000449905; ENSP00000399529; ENSG00000235658. [Q5SQI0-7]
    ENST00000450003; ENSP00000406421; ENSG00000223752. [Q5SQI0-4]
    ENST00000450220; ENSP00000405036; ENSG00000231257. [Q5SQI0-4]
    ENST00000454794; ENSP00000409067; ENSG00000229061. [Q5SQI0-1]
    ENST00000454987; ENSP00000410415; ENSG00000234549. [Q5SQI0-6]
    ENST00000456215; ENSP00000399452; ENSG00000234549. [Q5SQI0-4]
    ENST00000456704; ENSP00000394357; ENSG00000229061. [Q5SQI0-4]
    ENST00000457161; ENSP00000388171; ENSG00000223752. [Q5SQI0-5]
    ENST00000457334; ENSP00000398374; ENSG00000234549. [Q5SQI0-2]
    GeneIDi79969.
    KEGGihsa:79969.
    UCSCiuc003nqr.5. human. [Q5SQI0-1]

    Organism-specific databases

    CTDi79969.
    DisGeNETi79969.
    GeneCardsiATAT1.
    H-InvDBHIX0166068.
    HIX0166337.
    HIX0166615.
    HIX0166865.
    HIX0167123.
    HIX0167356.
    HIX0184148.
    HGNCiHGNC:21186. ATAT1.
    HPAiHPA046816.
    HPA050999.
    MIMi615556. gene.
    neXtProtiNX_Q5SQI0.
    OpenTargetsiENSG00000137343.
    ENSG00000206488.
    ENSG00000223752.
    ENSG00000229061.
    ENSG00000231257.
    ENSG00000234549.
    ENSG00000235658.
    PharmGKBiPA134948212.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG4601. Eukaryota.
    ENOG4111Q8H. LUCA.
    GeneTreeiENSGT00390000008276.
    HOVERGENiHBG055797.
    InParanoidiQ5SQI0.
    KOiK19573.
    OMAiPMHTAPP.
    OrthoDBiEOG091G0F8N.
    PhylomeDBiQ5SQI0.
    TreeFamiTF315643.

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000137343-MONOMER.
    ReactomeiR-HSA-5617833. Assembly of the primary cilium.

    Miscellaneous databases

    GenomeRNAii79969.
    PROiQ5SQI0.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000137343.
    CleanExiHS_C6orf134.
    GenevisibleiQ5SQI0. HS.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    HAMAPiMF_03130. mec17. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR007965. GNAT_ATAT.
    [Graphical view]
    PfamiPF05301. Acetyltransf_16. 1 hit.
    [Graphical view]
    PROSITEiPS51730. GNAT_ATAT. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiATAT_HUMAN
    AccessioniPrimary (citable) accession number: Q5SQI0
    Secondary accession number(s): A2AB28
    , Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI1, Q5SU03, Q86X42, Q8NDK9, Q9BRS1, Q9H8X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: December 21, 2004
    Last modified: November 2, 2016
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.