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Q5SQI0

- ATAT_HUMAN

UniProt

Q5SQI0 - ATAT_HUMAN

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Protein

Alpha-tubulin N-acetyltransferase 1

Gene
ATAT1, C6orf134, MEC17, Nbla00487
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.3 Publications

Catalytic activityi

Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.1 Publication

Kineticsi

kcat is 2.2 h(-1) for the acetylation of polymerized tubulin (microtubules), 0.35 h(-1) for the acetylation of free tubulin, and 1.47 h(-1)with acetyl-CoA as substrate.

  1. KM=2.0 µM for free alpha-tubulin2 Publications
  2. KM=1.6 µM for polymerized tubulin (microtubules)
  3. KM=2.2 µM for acetyl-CoA

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei58 – 581Crucial for catalytic activity

GO - Molecular functioni

  1. tubulin N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. alpha-tubulin acetylation Source: UniProtKB-HAMAP
  2. neuron development Source: UniProtKB-HAMAP
  3. regulation of microtubule cytoskeleton organization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tubulin N-acetyltransferase 1 (EC:2.3.1.108)
Short name:
Alpha-TAT
Short name:
Alpha-TAT1
Short name:
TAT
Alternative name(s):
Acetyltransferase mec-17 homolog
Gene namesi
Name:ATAT1
Synonyms:C6orf134, MEC17
ORF Names:Nbla00487
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21186. ATAT1.

Subcellular locationi

Cytoplasm. Membraneclathrin-coated pit. Cell junctionfocal adhesion. Cell projectionaxon By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonspindle By similarity 1 Publication

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. coated pit Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB-SubCell
  4. focal adhesion Source: UniProtKB-SubCell
  5. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Coated pit, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi58 – 581Q → A: Loss of acetyltransferase activity. 1 Publication
Mutagenesisi61 – 611S → A: No effect on catalytic activity. 1 Publication
Mutagenesisi64 – 641I → A: Strong reduction in acetyltransferase activity. 2 Publications
Mutagenesisi69 – 691R → A: Strong reduction in acetyltransferase activity. 1 Publication
Mutagenesisi105 – 1051F → A: Reduced activity. 1 Publication
Mutagenesisi106 – 1061V → A: Reduced activity. 1 Publication
Mutagenesisi107 – 1071L → A: Reduced activity. 1 Publication
Mutagenesisi108 – 1081D → A: Reduced activity. 1 Publication
Mutagenesisi109 – 1091D → A: Slight increase in activity. 1 Publication
Mutagenesisi109 – 1091D → R: Marginal increase in activity. 1 Publication
Mutagenesisi111 – 1111E → A: 2-fold increase in activity. 1 Publication
Mutagenesisi111 – 1111E → R: No effect on catalytic activity. 1 Publication
Mutagenesisi115 – 1151E → A: Reduced activity. 1 Publication
Mutagenesisi117 – 1171E → A: Reduced activity. 1 Publication
Mutagenesisi120 – 1201C → A or S: Strong reduction in microtubule acetylation. 1 Publication
Mutagenesisi157 – 1571D → E or N: Strong reduction in microtubule acetylation. 2 Publications
Mutagenesisi158 – 1581R → A: 20% of wild-type acetyltransferase activity. 1 Publication
Mutagenesisi182 – 1821N → A: Strong reduction in activity. 1 Publication
Mutagenesisi183 – 1831F → A: Strong reduction in activity. 1 Publication

Organism-specific databases

PharmGKBiPA134948212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Alpha-tubulin N-acetyltransferase 1UniRule annotationPRO_0000348066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-acetyllysine; by autocatalysis By similarity
Modified residuei146 – 1461N6-acetyllysine; by autocatalysis By similarity
Modified residuei233 – 2331N6-acetyllysine; by autocatalysis By similarity
Modified residuei244 – 2441N6-acetyllysine; by autocatalysis By similarity

Post-translational modificationi

Autoacetylation strongly increases tubulin acetylation By similarity.UniRule annotation

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5SQI0.
PRIDEiQ5SQI0.

PTM databases

PhosphoSiteiQ5SQI0.

Expressioni

Gene expression databases

BgeeiQ5SQI0.
CleanExiHS_C6orf134.
GenevestigatoriQ5SQI0.

Organism-specific databases

HPAiHPA046816.
HPA050999.

Interactioni

Subunit structurei

Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.2 Publications

Protein-protein interaction databases

BioGridi123036. 3 interactions.
IntActiQ5SQI0. 1 interaction.

Structurei

Secondary structure

1
421
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 104
Beta strandi13 – 186
Helixi36 – 5722
Helixi67 – 726
Beta strandi76 – 816
Beta strandi93 – 1019
Beta strandi104 – 1074
Beta strandi109 – 1113
Beta strandi113 – 1164
Beta strandi119 – 1268
Helixi128 – 1303
Helixi135 – 14713
Helixi151 – 1533
Beta strandi155 – 1584
Helixi161 – 17111
Beta strandi182 – 1843
Turni187 – 1904
Helixi191 – 1944

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VWDX-ray1.25A1-194[»]
3VWEX-ray1.96A1-194[»]
4B5OX-ray1.05A1-196[»]
4B5PX-ray1.60A/B1-196[»]
4GS4X-ray2.11A2-236[»]
4IF5X-ray1.70A1-193[»]
ProteinModelPortaliQ5SQI0.
SMRiQ5SQI0. Positions 1-194.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 13714Acetyl-CoA bindingUniRule annotationAdd
BLAST
Regioni160 – 16910Acetyl-CoA bindingUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG249793.
HOVERGENiHBG055797.
InParanoidiQ5SQI0.
OMAiMFNARFI.
OrthoDBiEOG76739W.
PhylomeDBiQ5SQI0.
TreeFamiTF315643.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
HAMAPiMF_03130. mec17.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR007965. Alpha-TAT.
[Graphical view]
PANTHERiPTHR12327. PTHR12327. 1 hit.
PfamiPF05301. Mec-17. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SQI0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL    50
GKASAKAQNL SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG 100
YKKLFVLDDR EAHNEVEPLC ILDFYIHESV QRHGHGRELF QYMLQKERVE 150
PHQLAIDRPS QKLLKFLNKH YNLETTVPQV NNFVIFEGFF AHQHRPPAPS 200
LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR EFLKVAVEPP 250
WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP 300
HPTARLLLAA DPGGSPAQRR RTRGTPPGLV AQSCCYSRHG GVNSSSPNTG 350
NQDSKQGEQE TKNRSASEEQ ALSQDGSGEK PMHTAPPQAP APPAQSWTVG 400
GDILNARFIR NLQERRSTRP W 421
Length:421
Mass (Da):46,810
Last modified:December 21, 2004 - v1
Checksum:i6CC9B4B844930842
GO
Isoform 2 (identifier: Q5SQI0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     13-36: ERITVLDQHLRPPARRPGTTTPAR → MWLTWPFCFLTITLREEGVCHLES

Show »
Length:409
Mass (Da):45,574
Checksum:iD2D140F7FADEDEEA
GO
Isoform 3 (identifier: Q5SQI0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P

Show »
Length:398
Mass (Da):44,458
Checksum:i4E53964B391B8C4F
GO
Isoform 4 (identifier: Q5SQI0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-333: RGTPPGLVAQS → SSLPRSEESRY
     334-421: Missing.

Show »
Length:333
Mass (Da):37,478
Checksum:i9AF89C8C2FF122FC
GO
Isoform 5 (identifier: Q5SQI0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-421: Missing.

Show »
Length:323
Mass (Da):36,342
Checksum:iE3D8C0B120A640FB
GO
Isoform 6 (identifier: Q5SQI0-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
     323-333: RGTPPGLVAQS → SSLPRSEESRY
     334-421: Missing.

Show »
Length:310
Mass (Da):35,126
Checksum:i1F8BD442CF9A9797
GO
Isoform 7 (identifier: Q5SQI0-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
     324-421: Missing.

Show »
Length:300
Mass (Da):33,990
Checksum:i359BE466FD5562B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform 2. VSP_052899Add
BLAST
Alternative sequencei13 – 3624ERITV…TTPAR → MWLTWPFCFLTITLREEGVC HLES in isoform 2. VSP_052900Add
BLAST
Alternative sequencei195 – 21824RPPAP…PTPAA → P in isoform 3, isoform 6 and isoform 7. VSP_052901Add
BLAST
Alternative sequencei323 – 33311RGTPPGLVAQS → SSLPRSEESRY in isoform 4 and isoform 6. VSP_052902Add
BLAST
Alternative sequencei324 – 42198Missing in isoform 5 and isoform 7. VSP_052903Add
BLAST
Alternative sequencei334 – 42188Missing in isoform 4 and isoform 6. VSP_052904Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075512 mRNA. Translation: BAE45758.1.
AK023220 mRNA. Translation: BAB14472.1.
AL845353 Genomic DNA. Translation: CAI41872.2.
AL845353 Genomic DNA. Translation: CAI41875.2.
AL662800 Genomic DNA. Translation: CAI18164.1.
AL662800 Genomic DNA. Translation: CAI18165.1.
AL662800 Genomic DNA. Translation: CAI18166.2.
AL662800 Genomic DNA. Translation: CAI18167.2.
AL662800 Genomic DNA. Translation: CAI18168.2.
AL662800 Genomic DNA. Translation: CAM25498.1.
AL732442 Genomic DNA. Translation: CAI17752.1.
AL732442 Genomic DNA. Translation: CAI17753.1.
AL732442 Genomic DNA. Translation: CAI17754.2.
AL732442 Genomic DNA. Translation: CAI17755.1.
AL732442 Genomic DNA. Translation: CAM25005.1.
AL732442 Genomic DNA. Translation: CAM25006.1.
AL845353 Genomic DNA. Translation: CAI41870.1.
AL845353 Genomic DNA. Translation: CAI41871.1.
AL845353 Genomic DNA. Translation: CAI41873.2.
AL845353 Genomic DNA. Translation: CAI41874.2.
BX119957 Genomic DNA. Translation: CAM25912.1.
BX119957 Genomic DNA. Translation: CAM25913.1.
BX119957 Genomic DNA. Translation: CAM25914.1.
BX119957 Genomic DNA. Translation: CAM25915.1.
BX119957 Genomic DNA. Translation: CAM25916.1.
BX119957 Genomic DNA. Translation: CAM25917.1.
BX908728 Genomic DNA. Translation: CAQ07413.1.
BX908728 Genomic DNA. Translation: CAQ07414.1.
BX908728 Genomic DNA. Translation: CAQ07415.1.
BX908728 Genomic DNA. Translation: CAQ07416.1.
BX908728 Genomic DNA. Translation: CAQ07417.1.
BX908728 Genomic DNA. Translation: CAQ07418.1.
CR753328 Genomic DNA. Translation: CAP58454.1.
CR753328 Genomic DNA. Translation: CAP58455.1.
CR753328 Genomic DNA. Translation: CAP58456.1.
CR753328 Genomic DNA. Translation: CAP58457.1.
CR753328 Genomic DNA. Translation: CAP58458.1.
CR753328 Genomic DNA. Translation: CAP58459.1.
CR759778 Genomic DNA. Translation: CAQ09406.1.
CR759778 Genomic DNA. Translation: CAQ09407.1.
CR759778 Genomic DNA. Translation: CAQ09408.1.
CR759778 Genomic DNA. Translation: CAQ09409.1.
CR759778 Genomic DNA. Translation: CAQ09410.1.
CR759778 Genomic DNA. Translation: CAQ09411.1.
CH471081 Genomic DNA. Translation: EAX03306.1.
CH471081 Genomic DNA. Translation: EAX03307.1.
BC006105 mRNA. Translation: AAH06105.1.
BC047303 mRNA. Translation: AAH47303.1.
AL833858 mRNA. Translation: CAD38717.1.
CCDSiCCDS4683.2. [Q5SQI0-4]
CCDS54978.1. [Q5SQI0-2]
CCDS59002.1. [Q5SQI0-6]
RefSeqiNP_001026892.1. NM_001031722.2. [Q5SQI0-2]
NP_001241881.1. NM_001254952.1. [Q5SQI0-6]
NP_079185.2. NM_024909.2. [Q5SQI0-4]
XP_005249474.1. XM_005249417.1. [Q5SQI0-1]
XP_005272955.1. XM_005272898.1. [Q5SQI0-1]
XP_005275110.1. XM_005275053.1. [Q5SQI0-1]
XP_005275245.1. XM_005275188.1. [Q5SQI0-1]
XP_005275367.1. XM_005275310.1. [Q5SQI0-1]
XP_005275540.1. XM_005275483.1. [Q5SQI0-1]
XP_005275671.1. XM_005275614.1. [Q5SQI0-1]
UniGeneiHs.654798.

Genome annotation databases

EnsembliENST00000318999; ENSP00000324222; ENSG00000137343. [Q5SQI0-7]
ENST00000319027; ENSP00000324459; ENSG00000137343. [Q5SQI0-6]
ENST00000329992; ENSP00000332374; ENSG00000137343. [Q5SQI0-4]
ENST00000330083; ENSP00000327832; ENSG00000137343. [Q5SQI0-2]
ENST00000376478; ENSP00000365661; ENSG00000137343. [Q5SQI0-3]
ENST00000376483; ENSP00000365666; ENSG00000137343. [Q5SQI0-5]
ENST00000376485; ENSP00000365668; ENSG00000137343. [Q5SQI0-1]
ENST00000383582; ENSP00000373076; ENSG00000206488. [Q5SQI0-2]
ENST00000383583; ENSP00000373077; ENSG00000206488. [Q5SQI0-4]
ENST00000383584; ENSP00000373078; ENSG00000206488. [Q5SQI0-7]
ENST00000383585; ENSP00000373079; ENSG00000206488. [Q5SQI0-1]
ENST00000400575; ENSP00000383419; ENSG00000206488. [Q5SQI0-5]
ENST00000400576; ENSP00000383420; ENSG00000206488. [Q5SQI0-6]
ENST00000411724; ENSP00000388617; ENSG00000234549. [Q5SQI0-5]
ENST00000416435; ENSP00000412993; ENSG00000235658. [Q5SQI0-2]
ENST00000416917; ENSP00000402998; ENSG00000234549. [Q5SQI0-7]
ENST00000417183; ENSP00000393868; ENSG00000231257. [Q5SQI0-7]
ENST00000418248; ENSP00000411362; ENSG00000231257. [Q5SQI0-5]
ENST00000420586; ENSP00000411050; ENSG00000231257. [Q5SQI0-1]
ENST00000423338; ENSP00000415000; ENSG00000223752. [Q5SQI0-7]
ENST00000423654; ENSP00000403142; ENSG00000235658. [Q5SQI0-5]
ENST00000424121; ENSP00000412198; ENSG00000223752. [Q5SQI0-6]
ENST00000425448; ENSP00000391244; ENSG00000223752. [Q5SQI0-2]
ENST00000428764; ENSP00000399509; ENSG00000235658. [Q5SQI0-4]
ENST00000430611; ENSP00000409296; ENSG00000235658. [Q5SQI0-6]
ENST00000432356; ENSP00000416994; ENSG00000234549. [Q5SQI0-1]
ENST00000432643; ENSP00000416925; ENSG00000231257. [Q5SQI0-2]
ENST00000442844; ENSP00000394914; ENSG00000235658. [Q5SQI0-1]
ENST00000443114; ENSP00000405656; ENSG00000229061. [Q5SQI0-7]
ENST00000443391; ENSP00000406071; ENSG00000229061. [Q5SQI0-6]
ENST00000445486; ENSP00000398422; ENSG00000223752. [Q5SQI0-1]
ENST00000445973; ENSP00000415408; ENSG00000231257. [Q5SQI0-6]
ENST00000446100; ENSP00000393269; ENSG00000229061. [Q5SQI0-5]
ENST00000448670; ENSP00000389129; ENSG00000229061. [Q5SQI0-2]
ENST00000449905; ENSP00000399529; ENSG00000235658. [Q5SQI0-7]
ENST00000450003; ENSP00000406421; ENSG00000223752. [Q5SQI0-4]
ENST00000450220; ENSP00000405036; ENSG00000231257. [Q5SQI0-4]
ENST00000454794; ENSP00000409067; ENSG00000229061. [Q5SQI0-1]
ENST00000454987; ENSP00000410415; ENSG00000234549. [Q5SQI0-6]
ENST00000456215; ENSP00000399452; ENSG00000234549. [Q5SQI0-4]
ENST00000456704; ENSP00000394357; ENSG00000229061. [Q5SQI0-4]
ENST00000457161; ENSP00000388171; ENSG00000223752. [Q5SQI0-5]
ENST00000457334; ENSP00000398374; ENSG00000234549. [Q5SQI0-2]
ENST00000546440; ENSP00000449304; ENSG00000231257. [Q5SQI0-3]
ENST00000547124; ENSP00000449503; ENSG00000235658. [Q5SQI0-3]
ENST00000550031; ENSP00000449729; ENSG00000234549. [Q5SQI0-3]
ENST00000551737; ENSP00000448247; ENSG00000206488. [Q5SQI0-3]
ENST00000553018; ENSP00000448905; ENSG00000229061. [Q5SQI0-3]
ENST00000553093; ENSP00000449160; ENSG00000223752. [Q5SQI0-3]
GeneIDi79969.
KEGGihsa:79969.
UCSCiuc003nqr.4. human. [Q5SQI0-4]
uc003nqs.4. human. [Q5SQI0-6]
uc003nqv.3. human. [Q5SQI0-2]
uc003rdc.3. human. [Q5SQI0-1]
uc003rdd.3. human. [Q5SQI0-7]

Polymorphism databases

DMDMi74743537.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075512 mRNA. Translation: BAE45758.1 .
AK023220 mRNA. Translation: BAB14472.1 .
AL845353 Genomic DNA. Translation: CAI41872.2 .
AL845353 Genomic DNA. Translation: CAI41875.2 .
AL662800 Genomic DNA. Translation: CAI18164.1 .
AL662800 Genomic DNA. Translation: CAI18165.1 .
AL662800 Genomic DNA. Translation: CAI18166.2 .
AL662800 Genomic DNA. Translation: CAI18167.2 .
AL662800 Genomic DNA. Translation: CAI18168.2 .
AL662800 Genomic DNA. Translation: CAM25498.1 .
AL732442 Genomic DNA. Translation: CAI17752.1 .
AL732442 Genomic DNA. Translation: CAI17753.1 .
AL732442 Genomic DNA. Translation: CAI17754.2 .
AL732442 Genomic DNA. Translation: CAI17755.1 .
AL732442 Genomic DNA. Translation: CAM25005.1 .
AL732442 Genomic DNA. Translation: CAM25006.1 .
AL845353 Genomic DNA. Translation: CAI41870.1 .
AL845353 Genomic DNA. Translation: CAI41871.1 .
AL845353 Genomic DNA. Translation: CAI41873.2 .
AL845353 Genomic DNA. Translation: CAI41874.2 .
BX119957 Genomic DNA. Translation: CAM25912.1 .
BX119957 Genomic DNA. Translation: CAM25913.1 .
BX119957 Genomic DNA. Translation: CAM25914.1 .
BX119957 Genomic DNA. Translation: CAM25915.1 .
BX119957 Genomic DNA. Translation: CAM25916.1 .
BX119957 Genomic DNA. Translation: CAM25917.1 .
BX908728 Genomic DNA. Translation: CAQ07413.1 .
BX908728 Genomic DNA. Translation: CAQ07414.1 .
BX908728 Genomic DNA. Translation: CAQ07415.1 .
BX908728 Genomic DNA. Translation: CAQ07416.1 .
BX908728 Genomic DNA. Translation: CAQ07417.1 .
BX908728 Genomic DNA. Translation: CAQ07418.1 .
CR753328 Genomic DNA. Translation: CAP58454.1 .
CR753328 Genomic DNA. Translation: CAP58455.1 .
CR753328 Genomic DNA. Translation: CAP58456.1 .
CR753328 Genomic DNA. Translation: CAP58457.1 .
CR753328 Genomic DNA. Translation: CAP58458.1 .
CR753328 Genomic DNA. Translation: CAP58459.1 .
CR759778 Genomic DNA. Translation: CAQ09406.1 .
CR759778 Genomic DNA. Translation: CAQ09407.1 .
CR759778 Genomic DNA. Translation: CAQ09408.1 .
CR759778 Genomic DNA. Translation: CAQ09409.1 .
CR759778 Genomic DNA. Translation: CAQ09410.1 .
CR759778 Genomic DNA. Translation: CAQ09411.1 .
CH471081 Genomic DNA. Translation: EAX03306.1 .
CH471081 Genomic DNA. Translation: EAX03307.1 .
BC006105 mRNA. Translation: AAH06105.1 .
BC047303 mRNA. Translation: AAH47303.1 .
AL833858 mRNA. Translation: CAD38717.1 .
CCDSi CCDS4683.2. [Q5SQI0-4 ]
CCDS54978.1. [Q5SQI0-2 ]
CCDS59002.1. [Q5SQI0-6 ]
RefSeqi NP_001026892.1. NM_001031722.2. [Q5SQI0-2 ]
NP_001241881.1. NM_001254952.1. [Q5SQI0-6 ]
NP_079185.2. NM_024909.2. [Q5SQI0-4 ]
XP_005249474.1. XM_005249417.1. [Q5SQI0-1 ]
XP_005272955.1. XM_005272898.1. [Q5SQI0-1 ]
XP_005275110.1. XM_005275053.1. [Q5SQI0-1 ]
XP_005275245.1. XM_005275188.1. [Q5SQI0-1 ]
XP_005275367.1. XM_005275310.1. [Q5SQI0-1 ]
XP_005275540.1. XM_005275483.1. [Q5SQI0-1 ]
XP_005275671.1. XM_005275614.1. [Q5SQI0-1 ]
UniGenei Hs.654798.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VWD X-ray 1.25 A 1-194 [» ]
3VWE X-ray 1.96 A 1-194 [» ]
4B5O X-ray 1.05 A 1-196 [» ]
4B5P X-ray 1.60 A/B 1-196 [» ]
4GS4 X-ray 2.11 A 2-236 [» ]
4IF5 X-ray 1.70 A 1-193 [» ]
ProteinModelPortali Q5SQI0.
SMRi Q5SQI0. Positions 1-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123036. 3 interactions.
IntActi Q5SQI0. 1 interaction.

PTM databases

PhosphoSitei Q5SQI0.

Polymorphism databases

DMDMi 74743537.

Proteomic databases

PaxDbi Q5SQI0.
PRIDEi Q5SQI0.

Protocols and materials databases

DNASUi 79969.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318999 ; ENSP00000324222 ; ENSG00000137343 . [Q5SQI0-7 ]
ENST00000319027 ; ENSP00000324459 ; ENSG00000137343 . [Q5SQI0-6 ]
ENST00000329992 ; ENSP00000332374 ; ENSG00000137343 . [Q5SQI0-4 ]
ENST00000330083 ; ENSP00000327832 ; ENSG00000137343 . [Q5SQI0-2 ]
ENST00000376478 ; ENSP00000365661 ; ENSG00000137343 . [Q5SQI0-3 ]
ENST00000376483 ; ENSP00000365666 ; ENSG00000137343 . [Q5SQI0-5 ]
ENST00000376485 ; ENSP00000365668 ; ENSG00000137343 . [Q5SQI0-1 ]
ENST00000383582 ; ENSP00000373076 ; ENSG00000206488 . [Q5SQI0-2 ]
ENST00000383583 ; ENSP00000373077 ; ENSG00000206488 . [Q5SQI0-4 ]
ENST00000383584 ; ENSP00000373078 ; ENSG00000206488 . [Q5SQI0-7 ]
ENST00000383585 ; ENSP00000373079 ; ENSG00000206488 . [Q5SQI0-1 ]
ENST00000400575 ; ENSP00000383419 ; ENSG00000206488 . [Q5SQI0-5 ]
ENST00000400576 ; ENSP00000383420 ; ENSG00000206488 . [Q5SQI0-6 ]
ENST00000411724 ; ENSP00000388617 ; ENSG00000234549 . [Q5SQI0-5 ]
ENST00000416435 ; ENSP00000412993 ; ENSG00000235658 . [Q5SQI0-2 ]
ENST00000416917 ; ENSP00000402998 ; ENSG00000234549 . [Q5SQI0-7 ]
ENST00000417183 ; ENSP00000393868 ; ENSG00000231257 . [Q5SQI0-7 ]
ENST00000418248 ; ENSP00000411362 ; ENSG00000231257 . [Q5SQI0-5 ]
ENST00000420586 ; ENSP00000411050 ; ENSG00000231257 . [Q5SQI0-1 ]
ENST00000423338 ; ENSP00000415000 ; ENSG00000223752 . [Q5SQI0-7 ]
ENST00000423654 ; ENSP00000403142 ; ENSG00000235658 . [Q5SQI0-5 ]
ENST00000424121 ; ENSP00000412198 ; ENSG00000223752 . [Q5SQI0-6 ]
ENST00000425448 ; ENSP00000391244 ; ENSG00000223752 . [Q5SQI0-2 ]
ENST00000428764 ; ENSP00000399509 ; ENSG00000235658 . [Q5SQI0-4 ]
ENST00000430611 ; ENSP00000409296 ; ENSG00000235658 . [Q5SQI0-6 ]
ENST00000432356 ; ENSP00000416994 ; ENSG00000234549 . [Q5SQI0-1 ]
ENST00000432643 ; ENSP00000416925 ; ENSG00000231257 . [Q5SQI0-2 ]
ENST00000442844 ; ENSP00000394914 ; ENSG00000235658 . [Q5SQI0-1 ]
ENST00000443114 ; ENSP00000405656 ; ENSG00000229061 . [Q5SQI0-7 ]
ENST00000443391 ; ENSP00000406071 ; ENSG00000229061 . [Q5SQI0-6 ]
ENST00000445486 ; ENSP00000398422 ; ENSG00000223752 . [Q5SQI0-1 ]
ENST00000445973 ; ENSP00000415408 ; ENSG00000231257 . [Q5SQI0-6 ]
ENST00000446100 ; ENSP00000393269 ; ENSG00000229061 . [Q5SQI0-5 ]
ENST00000448670 ; ENSP00000389129 ; ENSG00000229061 . [Q5SQI0-2 ]
ENST00000449905 ; ENSP00000399529 ; ENSG00000235658 . [Q5SQI0-7 ]
ENST00000450003 ; ENSP00000406421 ; ENSG00000223752 . [Q5SQI0-4 ]
ENST00000450220 ; ENSP00000405036 ; ENSG00000231257 . [Q5SQI0-4 ]
ENST00000454794 ; ENSP00000409067 ; ENSG00000229061 . [Q5SQI0-1 ]
ENST00000454987 ; ENSP00000410415 ; ENSG00000234549 . [Q5SQI0-6 ]
ENST00000456215 ; ENSP00000399452 ; ENSG00000234549 . [Q5SQI0-4 ]
ENST00000456704 ; ENSP00000394357 ; ENSG00000229061 . [Q5SQI0-4 ]
ENST00000457161 ; ENSP00000388171 ; ENSG00000223752 . [Q5SQI0-5 ]
ENST00000457334 ; ENSP00000398374 ; ENSG00000234549 . [Q5SQI0-2 ]
ENST00000546440 ; ENSP00000449304 ; ENSG00000231257 . [Q5SQI0-3 ]
ENST00000547124 ; ENSP00000449503 ; ENSG00000235658 . [Q5SQI0-3 ]
ENST00000550031 ; ENSP00000449729 ; ENSG00000234549 . [Q5SQI0-3 ]
ENST00000551737 ; ENSP00000448247 ; ENSG00000206488 . [Q5SQI0-3 ]
ENST00000553018 ; ENSP00000448905 ; ENSG00000229061 . [Q5SQI0-3 ]
ENST00000553093 ; ENSP00000449160 ; ENSG00000223752 . [Q5SQI0-3 ]
GeneIDi 79969.
KEGGi hsa:79969.
UCSCi uc003nqr.4. human. [Q5SQI0-4 ]
uc003nqs.4. human. [Q5SQI0-6 ]
uc003nqv.3. human. [Q5SQI0-2 ]
uc003rdc.3. human. [Q5SQI0-1 ]
uc003rdd.3. human. [Q5SQI0-7 ]

Organism-specific databases

CTDi 79969.
GeneCardsi GC06P030605.
GC06Pj30584.
GC06Pk30584.
GC06Pl30639.
GC06Pm30673.
GC06Pn30584.
GC06Po30586.
H-InvDB HIX0166068.
HIX0166337.
HIX0166615.
HIX0166865.
HIX0167123.
HIX0167356.
HIX0184148.
HGNCi HGNC:21186. ATAT1.
HPAi HPA046816.
HPA050999.
MIMi 615556. gene.
neXtProti NX_Q5SQI0.
PharmGKBi PA134948212.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249793.
HOVERGENi HBG055797.
InParanoidi Q5SQI0.
OMAi MFNARFI.
OrthoDBi EOG76739W.
PhylomeDBi Q5SQI0.
TreeFami TF315643.

Miscellaneous databases

GenomeRNAii 79969.
NextBioi 69981.
PROi Q5SQI0.
SOURCEi Search...

Gene expression databases

Bgeei Q5SQI0.
CleanExi HS_C6orf134.
Genevestigatori Q5SQI0.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
HAMAPi MF_03130. mec17.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR007965. Alpha-TAT.
[Graphical view ]
PANTHERi PTHR12327. PTHR12327. 1 hit.
Pfami PF05301. Mec-17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Neuroblastoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7).
    Tissue: Brain and Lung.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-421 (ISOFORM 4).
    Tissue: Brain.
  7. Cited for: FUNCTION, CATALYTIC ACTIVITY.
  8. "The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation."
    Shida T., Cueva J.G., Xu Z., Goodman M.B., Nachury M.V.
    Proc. Natl. Acad. Sci. U.S.A. 107:21517-21522(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH THE BBSOME COMPLEX, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ASP-157.
  9. Cited for: FUNCTION, INTERACTION WITH AP2A2, SUBCELLULAR LOCATION.
  10. "Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA."
    Taschner M., Vetter M., Lorentzen E.
    Proc. Natl. Acad. Sci. U.S.A. 109:19649-19654(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF 1-196 IN COMPLEX WITH ACETYL-COA, MUTAGENESIS OF GLN-58; SER-61; ILE-64 AND ARG-158.
  11. "Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation."
    Friedmann D.R., Aguilar A., Fan J., Nachury M.V., Marmorstein R.
    Proc. Natl. Acad. Sci. U.S.A. 109:19655-19660(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 2-236 IN COMPLEX WITH ACETYL-COA, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ILE-64; ARG-69; PHE-105; VAL-106; LEU-107; ASP-108; ASP-109; GLU-111; GLU-115; GLU-117; CYS-120; ASP-157; ASN-182 AND PHE-183.

Entry informationi

Entry nameiATAT_HUMAN
AccessioniPrimary (citable) accession number: Q5SQI0
Secondary accession number(s): A2AB28
, Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI1, Q5SU03, Q86X42, Q8NDK9, Q9BRS1, Q9H8X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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