Q5SQI0 (ATAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-tubulin N-acetyltransferase
Short name=Alpha-TAT
Short name=TAT
EC=2.3.1.108

Alternative name(s):
Acetyltransferase mec-17 homolog

Gene names

Name:	ATAT1
Synonyms:	C6orf134, MEC17
ORF Names:	Nbla00487

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Ref.7
Catalytic activity	Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine. Ref.7
Sequence similarities	Belongs to the acetyltransferase ATAT1 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	tubulin N-acetyltransferase activity Inferred from mutant phenotype Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5SQI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5SQI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     13-36: ERITVLDQHLRPPARRPGTTTPAR → MWLTWPFCFLTITLREEGVCHLES

Isoform 3 (identifier: Q5SQI0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P

Isoform 4 (identifier: Q5SQI0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     323-333: RGTPPGLVAQS → SSLPRSEESRY
     334-421: Missing.

Isoform 5 (identifier: Q5SQI0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     324-421: Missing.

Isoform 6 (identifier: Q5SQI0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
     323-333: RGTPPGLVAQS → SSLPRSEESRY
     334-421: Missing.

Isoform 7 (identifier: Q5SQI0-7)

The sequence of this isoform differs from the canonical sequence as follows:
     195-218: RPPAPSLRATRHSRAAAVDPTPAA → P
     324-421: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 421

421

Alpha-tubulin N-acetyltransferase HAMAP-Rule MF_03130

PRO_0000348066

Natural variations

Alternative sequence

1 – 12

12

Missing in isoform 2.

VSP_052899

Alternative sequence

13 – 36

24

ERITV…TTPAR → MWLTWPFCFLTITLREEGVC HLES in isoform 2.

VSP_052900

Alternative sequence

195 – 218

24

RPPAP…PTPAA → P in isoform 3, isoform 6 and isoform 7.

VSP_052901

Alternative sequence

323 – 333

11

RGTPPGLVAQS → SSLPRSEESRY in isoform 4 and isoform 6.

VSP_052902

Alternative sequence

324 – 421

98

Missing in isoform 5 and isoform 7.

VSP_052903

Alternative sequence

334 – 421

88

Missing in isoform 4 and isoform 6.

VSP_052904

Secondary structure

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421

Helix Strand Turn

Details...

Helix

7 – 10

4

Beta strand

13 – 18

6

Helix

36 – 57

22

Helix

67 – 72

6

Beta strand

76 – 81

6

Beta strand

93 – 101

9

Beta strand

104 – 107

4

Beta strand

113 – 116

4

Beta strand

119 – 126

8

Helix

128 – 130

3

Helix

135 – 147

13

Helix

151 – 153

3

Beta strand

155 – 158

4

Helix

161 – 171

11

Beta strand

182 – 184

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 6CC9B4B844930842	FASTA	421	46,810
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHRPPAPS LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR 250 260 270 280 290 300 EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP 310 320 330 340 350 360 HPTARLLLAA DPGGSPAQRR RTRGTPPGLV AQSCCYSRHG GVNSSSPNTG NQDSKQGEQE 370 380 390 400 410 420 TKNRSASEEQ ALSQDGSGEK PMHTAPPQAP APPAQSWTVG GDILNARFIR NLQERRSTRP W
	Isoform 2 [UniParc]. Checksum: D2D140F7FADEDEEA	FASTA	409	45,574
	10 20 30 40 50 60 MWLTWPFCFL TITLREEGVC HLESVDLQQQ IMTIIDELGK ASAKAQNLSA PITSASRMQS 70 80 90 100 110 120 NRHVVYILKD SSARPAGKGA IIGFIKVGYK KLFVLDDREA HNEVEPLCIL DFYIHESVQR 130 140 150 160 170 180 HGHGRELFQY MLQKERVEPH QLAIDRPSQK LLKFLNKHYN LETTVPQVNN FVIFEGFFAH 190 200 210 220 230 240 QHRPPAPSLR ATRHSRAAAV DPTPAAPARK LPPKRAEGDI KPYSSSDREF LKVAVEPPWP 250 260 270 280 290 300 LNRAPRRATP PAHPPPRSSS LGNSPERGPL RPFVPEQELL RSLRLCPPHP TARLLLAADP 310 320 330 340 350 360 GGSPAQRRRT RGTPPGLVAQ SCCYSRHGGV NSSSPNTGNQ DSKQGEQETK NRSASEEQAL 370 380 390 400 SQDGSGEKPM HTAPPQAPAP PAQSWTVGGD ILNARFIRNL QERRSTRPW
	Isoform 3 [UniParc]. Checksum: 4E53964B391B8C4F	FASTA	398	44,458
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHPPARKL PPKRAEGDIK PYSSSDREFL KVAVEPPWPL NRAPRRATPP 250 260 270 280 290 300 AHPPPRSSSL GNSPERGPLR PFVPEQELLR SLRLCPPHPT ARLLLAADPG GSPAQRRRTR 310 320 330 340 350 360 GTPPGLVAQS CCYSRHGGVN SSSPNTGNQD SKQGEQETKN RSASEEQALS QDGSGEKPMH 370 380 390 TAPPQAPAPP AQSWTVGGDI LNARFIRNLQ ERRSTRPW
	Isoform 4 [UniParc]. Checksum: 9AF89C8C2FF122FC	FASTA	333	37,478
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHRPPAPS LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR 250 260 270 280 290 300 EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP 310 320 330 HPTARLLLAA DPGGSPAQRR RTSSLPRSEE SRY
	Isoform 5 [UniParc]. Checksum: E3D8C0B120A640FB	FASTA	323	36,342
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHRPPAPS LRATRHSRAA AVDPTPAAPA RKLPPKRAEG DIKPYSSSDR 250 260 270 280 290 300 EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPERG PLRPFVPEQE LLRSLRLCPP 310 320 HPTARLLLAA DPGGSPAQRR RTR
	Isoform 6 [UniParc]. Checksum: 1F8BD442CF9A9797	FASTA	310	35,126
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHPPARKL PPKRAEGDIK PYSSSDREFL KVAVEPPWPL NRAPRRATPP 250 260 270 280 290 300 AHPPPRSSSL GNSPERGPLR PFVPEQELLR SLRLCPPHPT ARLLLAADPG GSPAQRRRTS 310 SLPRSEESRY
	Isoform 7 [UniParc]. Checksum: 359BE466FD5562B1	FASTA	300	33,990
	10 20 30 40 50 60 MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIIDEL GKASAKAQNL 70 80 90 100 110 120 SAPITSASRM QSNRHVVYIL KDSSARPAGK GAIIGFIKVG YKKLFVLDDR EAHNEVEPLC 130 140 150 160 170 180 ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 190 200 210 220 230 240 NNFVIFEGFF AHQHPPARKL PPKRAEGDIK PYSSSDREFL KVAVEPPWPL NRAPRRATPP 250 260 270 280 290 300 AHPPPRSSSL GNSPERGPLR PFVPEQELLR SLRLCPPHPT ARLLLAADPG GSPAQRRRTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma." Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A. Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Neuroblastoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7). Tissue: Brain and Lung.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-421 (ISOFORM 4). Tissue: Brain.
[7]	"MEC-17 is an alpha-tubulin acetyltransferase." Akella J.S., Wloga D., Kim J., Starostina N.G., Lyons-Abbott S., Morrissette N.S., Dougan S.T., Kipreos E.T., Gaertig J. Nature 467:218-222(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB075512 mRNA. Translation: BAE45758.1.
AK023220 mRNA. Translation: BAB14472.1.
AL845353 Genomic DNA. Translation: CAI41872.2.
AL845353 Genomic DNA. Translation: CAI41875.2.
AL662800 Genomic DNA. Translation: CAI18164.1.
AL662800 Genomic DNA. Translation: CAI18165.1.
AL662800 Genomic DNA. Translation: CAI18166.2.
AL662800 Genomic DNA. Translation: CAI18167.2.
AL662800 Genomic DNA. Translation: CAI18168.2.
AL662800 Genomic DNA. Translation: CAM25498.1.
AL732442 Genomic DNA. Translation: CAI17752.1.
AL732442 Genomic DNA. Translation: CAI17753.1.
AL732442 Genomic DNA. Translation: CAI17754.2.
AL732442 Genomic DNA. Translation: CAI17755.1.
AL732442 Genomic DNA. Translation: CAM25005.1.
AL732442 Genomic DNA. Translation: CAM25006.1.
AL845353 Genomic DNA. Translation: CAI41870.1.
AL845353 Genomic DNA. Translation: CAI41871.1.
AL845353 Genomic DNA. Translation: CAI41873.2.
AL845353 Genomic DNA. Translation: CAI41874.2.
BX119957 Genomic DNA. Translation: CAM25912.1.
BX119957 Genomic DNA. Translation: CAM25913.1.
BX119957 Genomic DNA. Translation: CAM25914.1.
BX119957 Genomic DNA. Translation: CAM25915.1.
BX119957 Genomic DNA. Translation: CAM25916.1.
BX119957 Genomic DNA. Translation: CAM25917.1.
BX908728 Genomic DNA. Translation: CAQ07413.1.
BX908728 Genomic DNA. Translation: CAQ07414.1.
BX908728 Genomic DNA. Translation: CAQ07415.1.
BX908728 Genomic DNA. Translation: CAQ07416.1.
BX908728 Genomic DNA. Translation: CAQ07417.1.
BX908728 Genomic DNA. Translation: CAQ07418.1.
CR753328 Genomic DNA. Translation: CAP58454.1.
CR753328 Genomic DNA. Translation: CAP58455.1.
CR753328 Genomic DNA. Translation: CAP58456.1.
CR753328 Genomic DNA. Translation: CAP58457.1.
CR753328 Genomic DNA. Translation: CAP58458.1.
CR753328 Genomic DNA. Translation: CAP58459.1.
CR759778 Genomic DNA. Translation: CAQ09406.1.
CR759778 Genomic DNA. Translation: CAQ09407.1.
CR759778 Genomic DNA. Translation: CAQ09408.1.
CR759778 Genomic DNA. Translation: CAQ09409.1.
CR759778 Genomic DNA. Translation: CAQ09410.1.
CR759778 Genomic DNA. Translation: CAQ09411.1.
CH471081 Genomic DNA. Translation: EAX03306.1.
CH471081 Genomic DNA. Translation: EAX03307.1.
BC006105 mRNA. Translation: AAH06105.1.
BC047303 mRNA. Translation: AAH47303.1.
AL833858 mRNA. Translation: CAD38717.1.

IPI

IPI00026795.
IPI00329132.
IPI00789297.
IPI00794859.
IPI00844295.
IPI00848136.
IPI00903142.

RefSeq

NP_001026892.1. NM_001031722.2.
NP_001241881.1. NM_001254952.1.
NP_079185.2. NM_024909.2.

UniGene

Hs.654798.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B5O	X-ray	1.05	A	1-196	[»]
4B5P	X-ray	1.60	A/B	1-196	[»]
4GS4	X-ray	2.11	A	2-236	[»]

ProteinModelPortal

Q5SQI0.

ModBase

Search...

PTM databases

PhosphoSite

Q5SQI0.

Polymorphism databases

DMDM

74743537.

Proteomic databases

PaxDb

Q5SQI0.

PRIDE

Q5SQI0.

Protocols and materials databases

DNASU

79969.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000318999; ENSP00000324222; ENSG00000137343.
ENST00000319027; ENSP00000324459; ENSG00000137343.
ENST00000329992; ENSP00000332374; ENSG00000137343.
ENST00000330083; ENSP00000327832; ENSG00000137343.
ENST00000376478; ENSP00000365661; ENSG00000137343.
ENST00000376483; ENSP00000365666; ENSG00000137343.
ENST00000376485; ENSP00000365668; ENSG00000137343.
ENST00000383582; ENSP00000373076; ENSG00000206488.
ENST00000383583; ENSP00000373077; ENSG00000206488.
ENST00000383584; ENSP00000373078; ENSG00000206488.
ENST00000383585; ENSP00000373079; ENSG00000206488.
ENST00000400575; ENSP00000383419; ENSG00000206488.
ENST00000400576; ENSP00000383420; ENSG00000206488.
ENST00000411724; ENSP00000388617; ENSG00000234549.
ENST00000416435; ENSP00000412993; ENSG00000235658.
ENST00000416917; ENSP00000402998; ENSG00000234549.
ENST00000417183; ENSP00000393868; ENSG00000231257.
ENST00000418248; ENSP00000411362; ENSG00000231257.
ENST00000420586; ENSP00000411050; ENSG00000231257.
ENST00000423338; ENSP00000415000; ENSG00000223752.
ENST00000423654; ENSP00000403142; ENSG00000235658.
ENST00000424121; ENSP00000412198; ENSG00000223752.
ENST00000425448; ENSP00000391244; ENSG00000223752.
ENST00000428764; ENSP00000399509; ENSG00000235658.
ENST00000430611; ENSP00000409296; ENSG00000235658.
ENST00000432356; ENSP00000416994; ENSG00000234549.
ENST00000432643; ENSP00000416925; ENSG00000231257.
ENST00000442844; ENSP00000394914; ENSG00000235658.
ENST00000443114; ENSP00000405656; ENSG00000229061.
ENST00000443391; ENSP00000406071; ENSG00000229061.
ENST00000445486; ENSP00000398422; ENSG00000223752.
ENST00000445973; ENSP00000415408; ENSG00000231257.
ENST00000446100; ENSP00000393269; ENSG00000229061.
ENST00000448670; ENSP00000389129; ENSG00000229061.
ENST00000449905; ENSP00000399529; ENSG00000235658.
ENST00000450003; ENSP00000406421; ENSG00000223752.
ENST00000450220; ENSP00000405036; ENSG00000231257.
ENST00000454794; ENSP00000409067; ENSG00000229061.
ENST00000454987; ENSP00000410415; ENSG00000234549.
ENST00000456215; ENSP00000399452; ENSG00000234549.
ENST00000456704; ENSP00000394357; ENSG00000229061.
ENST00000457161; ENSP00000388171; ENSG00000223752.
ENST00000457334; ENSP00000398374; ENSG00000234549.
ENST00000546440; ENSP00000449304; ENSG00000231257.
ENST00000547124; ENSP00000449503; ENSG00000235658.
ENST00000550031; ENSP00000449729; ENSG00000234549.
ENST00000551737; ENSP00000448247; ENSG00000206488.
ENST00000553018; ENSP00000448905; ENSG00000229061.
ENST00000553093; ENSP00000449160; ENSG00000223752.

GeneID

79969.

KEGG

hsa:79969.

UCSC

uc003nqr.4. human.
uc003nqs.4. human.
uc003nqv.3. human.
uc003rdc.3. human.
uc003rdd.3. human.

Organism-specific databases

CTD

79969.

GeneCards

GC06P030598.

H-InvDB

HIX0166068.
HIX0166337.
HIX0166615.
HIX0166865.
HIX0167123.
HIX0167356.
HIX0184148.

HGNC

HGNC:21186. ATAT1.

HPA

HPA046816.
HPA050999.

neXtProt

NX_Q5SQI0.

PharmGKB

PA134948212.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG249793.

HOVERGEN

HBG055797.

InParanoid

Q5SQI0.

OMA

MHTAPPQ.

Gene expression databases

Bgee

Q5SQI0.

CleanEx

HS_C6orf134.

Genevestigator

Q5SQI0.

Family and domain databases

Gene3D

3.40.630.30. 1 hit.

HAMAP

MF_03130. mec17.

InterPro

IPR016181. Acyl_CoA_acyltransferase.
IPR007965. Touch_recpt_neuron_Mec-17.
[Graphical view]

PANTHER

PTHR12327. PTHR12327. 1 hit.

Pfam

PF05301. Mec-17. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

79969.

NextBio

69981.

Entry information

Entry name

ATAT_HUMAN

Accession

Primary (citable) accession number: Q5SQI0
Secondary accession number(s): A2AB28 , Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI1, Q5SU03, Q86X42, Q8NDK9, Q9BRS1, Q9H8X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.