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Protein

Uncharacterized protein C6orf136

Gene

C6orf136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf136
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204564.11
HGNCiHGNC:21301 C6orf136
neXtProtiNX_Q5SQH8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204564
PharmGKBiPA134962744

Polymorphism and mutation databases

BioMutaiC6orf136
DMDMi71658797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895311 – 315Uncharacterized protein C6orf136Add BLAST315

Proteomic databases

MaxQBiQ5SQH8
PaxDbiQ5SQH8
PeptideAtlasiQ5SQH8
PRIDEiQ5SQH8

PTM databases

iPTMnetiQ5SQH8
PhosphoSitePlusiQ5SQH8

Expressioni

Gene expression databases

BgeeiENSG00000204564
CleanExiHS_C6orf136
ExpressionAtlasiQ5SQH8 baseline and differential
GenevisibleiQ5SQH8 HS

Organism-specific databases

HPAiHPA046804

Interactioni

Protein-protein interaction databases

BioGridi128738, 8 interactors
IntActiQ5SQH8, 2 interactors
MINTiQ5SQH8
STRINGi9606.ENSP00000293604

Structurei

3D structure databases

ProteinModelPortaliQ5SQH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4457 Eukaryota
ENOG4111RAP LUCA
GeneTreeiENSGT00390000008658
HOGENOMiHOG000247026
HOVERGENiHBG056726
InParanoidiQ5SQH8
OMAiTWYILSL
OrthoDBiEOG091G0SAU
PhylomeDBiQ5SQH8
TreeFamiTF313961

Family and domain databases

InterProiView protein in InterPro
IPR018790 DUF2358
PfamiView protein in Pfam
PF10184 DUF2358, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SQH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQPSRGAAR RLGPCLRAYQ ARPQDQLYPG TLPFPPLWPH STTTTSPSSP
60 70 80 90 100
LFWSPLPPRL PTQRLPQVPP LPLPQIQALS SAWVVLPPGK GEEGPGPELH
110 120 130 140 150
SGCLDGLRSL FEGPPCPYPG AWIPFQVPGT AHPSPATPSG DPSMEEHLSV
160 170 180 190 200
MYERLRQELP KLFLQSHDYS LYSLDVEFIN EILNIRTKGR TWYILSLTLC
210 220 230 240 250
RFLAWNYFAH LRLEVLQLTR HPENWTLQAR WRLVGLPVHL LFLRFYKRDK
260 270 280 290 300
DEHYRTYDAY STFYLNSSGL ICRHRLDKLM PSHSPPTPVK KLLVGALVAL
310
GLSEPEPDLN LCSKP
Note: No experimental confirmation available.
Length:315
Mass (Da):35,794
Last modified:December 21, 2004 - v1
Checksum:i01C9883DA956EB35
GO
Isoform 2 (identifier: Q5SQH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):20,490
Checksum:i157D85CB50329E0F
GO
Isoform 3 (identifier: Q5SQH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-158: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):21,287
Checksum:iB6B9E76EF32C71CF
GO
Isoform 4 (identifier: Q5SQH8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: Q → QVSGGEEGGR...GASRTPSGTE

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):54,721
Checksum:i5DA16F1C42D72891
GO

Sequence cautioni

The sequence CAI17760 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41881 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95540 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95541 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187T → S in BAC87037 (PubMed:14702039).Curated1
Sequence conflicti283H → P in BAC87037 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146181 – 143Missing in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_04664024Q → QVSGGEEGGRRGGGERPSSK PVRGAERALGSAQAQRHPPP LPTCALQRVDRLGVAGAGGR RCRACRARTSVLPGLRAVRR GQGQAAGRVCVAPDSPRLPV PRGDLKGRGREIRSPAAAPS RSSPAQTRPAGRPQQPARLA LGERSWQEGRPVCTRFGPLR PGWQDGHAPSRDGASRTPSG TE in isoform 4. Curated1
Alternative sequenceiVSP_01461925 – 158Missing in isoform 3. CuratedAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127564 mRNA Translation: BAC87037.1
AL662800, AL662798 Genomic DNA Translation: CAI18171.1
AL662800, AL662798 Genomic DNA Translation: CAI18172.2
AL662800, AL662798 Genomic DNA Translation: CAI95540.2 Sequence problems.
AL662798, AL662800 Genomic DNA Translation: CAI18249.1
AL662798, AL662800 Genomic DNA Translation: CAI18250.2
AL662798, AL662800 Genomic DNA Translation: CAI95541.2 Sequence problems.
AL732442 Genomic DNA Translation: CAI17758.1
AL732442 Genomic DNA Translation: CAI17759.1
AL732442 Genomic DNA Translation: CAI17760.2 Sequence problems.
AL845353 Genomic DNA Translation: CAI41879.1
AL845353 Genomic DNA Translation: CAI41880.1
AL845353 Genomic DNA Translation: CAI41881.2 Sequence problems.
BX119957 Genomic DNA Translation: CAM25920.1
CR753328 Genomic DNA Translation: CAP58461.1
BX908728 Genomic DNA Translation: CAQ07421.1
CR759778 Genomic DNA Translation: CAQ09414.1
BC016167 mRNA Translation: AAH16167.1
CCDSiCCDS43443.1 [Q5SQH8-1]
CCDS4684.2 [Q5SQH8-3]
CCDS54979.1 [Q5SQH8-4]
RefSeqiNP_001103408.1, NM_001109938.2 [Q5SQH8-1]
NP_659466.2, NM_145029.3 [Q5SQH8-3]
XP_011512686.1, XM_011514384.1 [Q5SQH8-2]
UniGeneiHs.591787

Genome annotation databases

EnsembliENST00000293604; ENSP00000293604; ENSG00000204564 [Q5SQH8-4]
ENST00000376471; ENSP00000365654; ENSG00000204564 [Q5SQH8-3]
ENST00000376473; ENSP00000365656; ENSG00000204564 [Q5SQH8-1]
ENST00000383580; ENSP00000373074; ENSG00000206487 [Q5SQH8-3]
ENST00000383581; ENSP00000373075; ENSG00000206487 [Q5SQH8-1]
ENST00000415931; ENSP00000402805; ENSG00000233164 [Q5SQH8-3]
ENST00000417076; ENSP00000405594; ENSG00000237100 [Q5SQH8-3]
ENST00000417649; ENSP00000395979; ENSG00000233641 [Q5SQH8-3]
ENST00000419321; ENSP00000398769; ENSG00000237100 [Q5SQH8-1]
ENST00000422530; ENSP00000390275; ENSG00000237012 [Q5SQH8-1]
ENST00000425581; ENSP00000404588; ENSG00000233641 [Q5SQH8-1]
ENST00000430141; ENSP00000396916; ENSG00000224120 [Q5SQH8-1]
ENST00000447505; ENSP00000415915; ENSG00000233164 [Q5SQH8-1]
ENST00000455682; ENSP00000391657; ENSG00000224120 [Q5SQH8-3]
ENST00000456444; ENSP00000387592; ENSG00000237012 [Q5SQH8-3]
GeneIDi221545
KEGGihsa:221545
UCSCiuc003nqw.5 human [Q5SQH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCF136_HUMAN
AccessioniPrimary (citable) accession number: Q5SQH8
Secondary accession number(s): A9R9P9
, F8VX15, Q5SU01, Q6ZSB7, Q8TB84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM

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