Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein C6orf136

Gene

C6orf136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf136
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21301. C6orf136.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204564.
PharmGKBiPA134962744.

Polymorphism and mutation databases

BioMutaiC6orf136.
DMDMi71658797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895311 – 315Uncharacterized protein C6orf136Add BLAST315

Proteomic databases

MaxQBiQ5SQH8.
PaxDbiQ5SQH8.
PeptideAtlasiQ5SQH8.
PRIDEiQ5SQH8.

PTM databases

iPTMnetiQ5SQH8.
PhosphoSitePlusiQ5SQH8.

Expressioni

Gene expression databases

BgeeiENSG00000204564.
CleanExiHS_C6orf136.
ExpressionAtlasiQ5SQH8. baseline and differential.
GenevisibleiQ5SQH8. HS.

Organism-specific databases

HPAiHPA046804.

Interactioni

Protein-protein interaction databases

BioGridi128738. 8 interactors.
IntActiQ5SQH8. 2 interactors.
MINTiMINT-6775723.
STRINGi9606.ENSP00000293604.

Structurei

3D structure databases

ProteinModelPortaliQ5SQH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4457. Eukaryota.
ENOG4111RAP. LUCA.
GeneTreeiENSGT00390000008658.
HOGENOMiHOG000247026.
HOVERGENiHBG056726.
InParanoidiQ5SQH8.
OMAiTWYILSL.
OrthoDBiEOG091G0SAU.
PhylomeDBiQ5SQH8.
TreeFamiTF313961.

Family and domain databases

InterProiView protein in InterPro
IPR018790. DUF2358.
PfamiView protein in Pfam
PF10184. DUF2358. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SQH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQPSRGAAR RLGPCLRAYQ ARPQDQLYPG TLPFPPLWPH STTTTSPSSP
60 70 80 90 100
LFWSPLPPRL PTQRLPQVPP LPLPQIQALS SAWVVLPPGK GEEGPGPELH
110 120 130 140 150
SGCLDGLRSL FEGPPCPYPG AWIPFQVPGT AHPSPATPSG DPSMEEHLSV
160 170 180 190 200
MYERLRQELP KLFLQSHDYS LYSLDVEFIN EILNIRTKGR TWYILSLTLC
210 220 230 240 250
RFLAWNYFAH LRLEVLQLTR HPENWTLQAR WRLVGLPVHL LFLRFYKRDK
260 270 280 290 300
DEHYRTYDAY STFYLNSSGL ICRHRLDKLM PSHSPPTPVK KLLVGALVAL
310
GLSEPEPDLN LCSKP
Note: No experimental confirmation available.
Length:315
Mass (Da):35,794
Last modified:December 21, 2004 - v1
Checksum:i01C9883DA956EB35
GO
Isoform 2 (identifier: Q5SQH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):20,490
Checksum:i157D85CB50329E0F
GO
Isoform 3 (identifier: Q5SQH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-158: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):21,287
Checksum:iB6B9E76EF32C71CF
GO
Isoform 4 (identifier: Q5SQH8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: Q → QVSGGEEGGR...GASRTPSGTE

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):54,721
Checksum:i5DA16F1C42D72891
GO

Sequence cautioni

The sequence CAI17760 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41881 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95540 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95541 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187T → S in BAC87037 (PubMed:14702039).Curated1
Sequence conflicti283H → P in BAC87037 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146181 – 143Missing in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_04664024Q → QVSGGEEGGRRGGGERPSSK PVRGAERALGSAQAQRHPPP LPTCALQRVDRLGVAGAGGR RCRACRARTSVLPGLRAVRR GQGQAAGRVCVAPDSPRLPV PRGDLKGRGREIRSPAAAPS RSSPAQTRPAGRPQQPARLA LGERSWQEGRPVCTRFGPLR PGWQDGHAPSRDGASRTPSG TE in isoform 4. Curated1
Alternative sequenceiVSP_01461925 – 158Missing in isoform 3. CuratedAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127564 mRNA. Translation: BAC87037.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18171.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18172.2.
AL662800, AL662798 Genomic DNA. Translation: CAI95540.2. Sequence problems.
AL662798, AL662800 Genomic DNA. Translation: CAI18249.1.
AL662798, AL662800 Genomic DNA. Translation: CAI18250.2.
AL662798, AL662800 Genomic DNA. Translation: CAI95541.2. Sequence problems.
AL732442 Genomic DNA. Translation: CAI17758.1.
AL732442 Genomic DNA. Translation: CAI17759.1.
AL732442 Genomic DNA. Translation: CAI17760.2. Sequence problems.
AL845353 Genomic DNA. Translation: CAI41879.1.
AL845353 Genomic DNA. Translation: CAI41880.1.
AL845353 Genomic DNA. Translation: CAI41881.2. Sequence problems.
BX119957 Genomic DNA. Translation: CAM25920.1.
CR753328 Genomic DNA. Translation: CAP58461.1.
BX908728 Genomic DNA. Translation: CAQ07421.1.
CR759778 Genomic DNA. Translation: CAQ09414.1.
BC016167 mRNA. Translation: AAH16167.1.
CCDSiCCDS43443.1. [Q5SQH8-1]
CCDS4684.2. [Q5SQH8-3]
CCDS54979.1. [Q5SQH8-4]
RefSeqiNP_001103408.1. NM_001109938.2. [Q5SQH8-1]
NP_659466.2. NM_145029.3. [Q5SQH8-3]
XP_011512686.1. XM_011514384.1. [Q5SQH8-2]
UniGeneiHs.591787.

Genome annotation databases

EnsembliENST00000293604; ENSP00000293604; ENSG00000204564. [Q5SQH8-4]
ENST00000376471; ENSP00000365654; ENSG00000204564. [Q5SQH8-3]
ENST00000376473; ENSP00000365656; ENSG00000204564. [Q5SQH8-1]
ENST00000383580; ENSP00000373074; ENSG00000206487. [Q5SQH8-3]
ENST00000383581; ENSP00000373075; ENSG00000206487. [Q5SQH8-1]
ENST00000415931; ENSP00000402805; ENSG00000233164. [Q5SQH8-3]
ENST00000417076; ENSP00000405594; ENSG00000237100. [Q5SQH8-3]
ENST00000417649; ENSP00000395979; ENSG00000233641. [Q5SQH8-3]
ENST00000419321; ENSP00000398769; ENSG00000237100. [Q5SQH8-1]
ENST00000422530; ENSP00000390275; ENSG00000237012. [Q5SQH8-1]
ENST00000425581; ENSP00000404588; ENSG00000233641. [Q5SQH8-1]
ENST00000430141; ENSP00000396916; ENSG00000224120. [Q5SQH8-1]
ENST00000447505; ENSP00000415915; ENSG00000233164. [Q5SQH8-1]
ENST00000455682; ENSP00000391657; ENSG00000224120. [Q5SQH8-3]
ENST00000456444; ENSP00000387592; ENSG00000237012. [Q5SQH8-3]
GeneIDi221545.
KEGGihsa:221545.
UCSCiuc003nqw.5. human. [Q5SQH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCF136_HUMAN
AccessioniPrimary (citable) accession number: Q5SQH8
Secondary accession number(s): A9R9P9
, F8VX15, Q5SU01, Q6ZSB7, Q8TB84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 21, 2004
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM