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Protein

Uncharacterized protein C6orf136

Gene

C6orf136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf136
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21301. C6orf136.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962744.

Polymorphism and mutation databases

BioMutaiC6orf136.
DMDMi71658797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Uncharacterized protein C6orf136PRO_0000089531Add
BLAST

Proteomic databases

MaxQBiQ5SQH8.
PaxDbiQ5SQH8.
PeptideAtlasiQ5SQH8.
PRIDEiQ5SQH8.

PTM databases

iPTMnetiQ5SQH8.
PhosphoSiteiQ5SQH8.

Expressioni

Gene expression databases

BgeeiENSG00000204564.
CleanExiHS_C6orf136.
ExpressionAtlasiQ5SQH8. baseline and differential.
GenevisibleiQ5SQH8. HS.

Organism-specific databases

HPAiHPA046804.

Interactioni

Protein-protein interaction databases

BioGridi128738. 5 interactions.
IntActiQ5SQH8. 2 interactions.
MINTiMINT-6775723.
STRINGi9606.ENSP00000293604.

Structurei

3D structure databases

ProteinModelPortaliQ5SQH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4457. Eukaryota.
ENOG4111RAP. LUCA.
GeneTreeiENSGT00390000008658.
HOGENOMiHOG000247026.
HOVERGENiHBG056726.
InParanoidiQ5SQH8.
OMAiGRIWYIL.
OrthoDBiEOG091G0SAU.
PhylomeDBiQ5SQH8.
TreeFamiTF313961.

Family and domain databases

InterProiIPR018790. DUF2358.
[Graphical view]
PfamiPF10184. DUF2358. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SQH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQPSRGAAR RLGPCLRAYQ ARPQDQLYPG TLPFPPLWPH STTTTSPSSP
60 70 80 90 100
LFWSPLPPRL PTQRLPQVPP LPLPQIQALS SAWVVLPPGK GEEGPGPELH
110 120 130 140 150
SGCLDGLRSL FEGPPCPYPG AWIPFQVPGT AHPSPATPSG DPSMEEHLSV
160 170 180 190 200
MYERLRQELP KLFLQSHDYS LYSLDVEFIN EILNIRTKGR TWYILSLTLC
210 220 230 240 250
RFLAWNYFAH LRLEVLQLTR HPENWTLQAR WRLVGLPVHL LFLRFYKRDK
260 270 280 290 300
DEHYRTYDAY STFYLNSSGL ICRHRLDKLM PSHSPPTPVK KLLVGALVAL
310
GLSEPEPDLN LCSKP
Note: No experimental confirmation available.
Length:315
Mass (Da):35,794
Last modified:December 21, 2004 - v1
Checksum:i01C9883DA956EB35
GO
Isoform 2 (identifier: Q5SQH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):20,490
Checksum:i157D85CB50329E0F
GO
Isoform 3 (identifier: Q5SQH8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-158: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):21,287
Checksum:iB6B9E76EF32C71CF
GO
Isoform 4 (identifier: Q5SQH8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: Q → QVSGGEEGGR...GASRTPSGTE

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):54,721
Checksum:i5DA16F1C42D72891
GO

Sequence cautioni

The sequence CAI17760 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41881 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI95540 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI95541 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871T → S in BAC87037 (PubMed:14702039).Curated
Sequence conflicti283 – 2831H → P in BAC87037 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 143143Missing in isoform 2. 1 PublicationVSP_014618Add
BLAST
Alternative sequencei24 – 241Q → QVSGGEEGGRRGGGERPSSK PVRGAERALGSAQAQRHPPP LPTCALQRVDRLGVAGAGGR RCRACRARTSVLPGLRAVRR GQGQAAGRVCVAPDSPRLPV PRGDLKGRGREIRSPAAAPS RSSPAQTRPAGRPQQPARLA LGERSWQEGRPVCTRFGPLR PGWQDGHAPSRDGASRTPSG TE in isoform 4. CuratedVSP_046640
Alternative sequencei25 – 158134Missing in isoform 3. CuratedVSP_014619Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127564 mRNA. Translation: BAC87037.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18171.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18172.2.
AL662800, AL662798 Genomic DNA. Translation: CAI95540.2. Sequence problems.
AL662798, AL662800 Genomic DNA. Translation: CAI18249.1.
AL662798, AL662800 Genomic DNA. Translation: CAI18250.2.
AL662798, AL662800 Genomic DNA. Translation: CAI95541.2. Sequence problems.
AL732442 Genomic DNA. Translation: CAI17758.1.
AL732442 Genomic DNA. Translation: CAI17759.1.
AL732442 Genomic DNA. Translation: CAI17760.2. Sequence problems.
AL845353 Genomic DNA. Translation: CAI41879.1.
AL845353 Genomic DNA. Translation: CAI41880.1.
AL845353 Genomic DNA. Translation: CAI41881.2. Sequence problems.
BX119957 Genomic DNA. Translation: CAM25920.1.
CR753328 Genomic DNA. Translation: CAP58461.1.
BX908728 Genomic DNA. Translation: CAQ07421.1.
CR759778 Genomic DNA. Translation: CAQ09414.1.
BC016167 mRNA. Translation: AAH16167.1.
CCDSiCCDS43443.1. [Q5SQH8-1]
CCDS4684.2. [Q5SQH8-3]
CCDS54979.1. [Q5SQH8-4]
RefSeqiNP_001103408.1. NM_001109938.2. [Q5SQH8-1]
NP_659466.2. NM_145029.3. [Q5SQH8-3]
XP_011512686.1. XM_011514384.1. [Q5SQH8-2]
UniGeneiHs.591787.

Genome annotation databases

EnsembliENST00000293604; ENSP00000293604; ENSG00000204564. [Q5SQH8-4]
ENST00000376471; ENSP00000365654; ENSG00000204564. [Q5SQH8-3]
ENST00000376473; ENSP00000365656; ENSG00000204564. [Q5SQH8-1]
ENST00000383580; ENSP00000373074; ENSG00000206487. [Q5SQH8-3]
ENST00000383581; ENSP00000373075; ENSG00000206487. [Q5SQH8-1]
ENST00000415931; ENSP00000402805; ENSG00000233164. [Q5SQH8-3]
ENST00000417076; ENSP00000405594; ENSG00000237100. [Q5SQH8-3]
ENST00000417649; ENSP00000395979; ENSG00000233641. [Q5SQH8-3]
ENST00000419321; ENSP00000398769; ENSG00000237100. [Q5SQH8-1]
ENST00000422530; ENSP00000390275; ENSG00000237012. [Q5SQH8-1]
ENST00000425581; ENSP00000404588; ENSG00000233641. [Q5SQH8-1]
ENST00000430141; ENSP00000396916; ENSG00000224120. [Q5SQH8-1]
ENST00000447505; ENSP00000415915; ENSG00000233164. [Q5SQH8-1]
ENST00000455682; ENSP00000391657; ENSG00000224120. [Q5SQH8-3]
ENST00000456444; ENSP00000387592; ENSG00000237012. [Q5SQH8-3]
GeneIDi221545.
KEGGihsa:221545.
UCSCiuc003nqw.5. human. [Q5SQH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127564 mRNA. Translation: BAC87037.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18171.1.
AL662800, AL662798 Genomic DNA. Translation: CAI18172.2.
AL662800, AL662798 Genomic DNA. Translation: CAI95540.2. Sequence problems.
AL662798, AL662800 Genomic DNA. Translation: CAI18249.1.
AL662798, AL662800 Genomic DNA. Translation: CAI18250.2.
AL662798, AL662800 Genomic DNA. Translation: CAI95541.2. Sequence problems.
AL732442 Genomic DNA. Translation: CAI17758.1.
AL732442 Genomic DNA. Translation: CAI17759.1.
AL732442 Genomic DNA. Translation: CAI17760.2. Sequence problems.
AL845353 Genomic DNA. Translation: CAI41879.1.
AL845353 Genomic DNA. Translation: CAI41880.1.
AL845353 Genomic DNA. Translation: CAI41881.2. Sequence problems.
BX119957 Genomic DNA. Translation: CAM25920.1.
CR753328 Genomic DNA. Translation: CAP58461.1.
BX908728 Genomic DNA. Translation: CAQ07421.1.
CR759778 Genomic DNA. Translation: CAQ09414.1.
BC016167 mRNA. Translation: AAH16167.1.
CCDSiCCDS43443.1. [Q5SQH8-1]
CCDS4684.2. [Q5SQH8-3]
CCDS54979.1. [Q5SQH8-4]
RefSeqiNP_001103408.1. NM_001109938.2. [Q5SQH8-1]
NP_659466.2. NM_145029.3. [Q5SQH8-3]
XP_011512686.1. XM_011514384.1. [Q5SQH8-2]
UniGeneiHs.591787.

3D structure databases

ProteinModelPortaliQ5SQH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128738. 5 interactions.
IntActiQ5SQH8. 2 interactions.
MINTiMINT-6775723.
STRINGi9606.ENSP00000293604.

PTM databases

iPTMnetiQ5SQH8.
PhosphoSiteiQ5SQH8.

Polymorphism and mutation databases

BioMutaiC6orf136.
DMDMi71658797.

Proteomic databases

MaxQBiQ5SQH8.
PaxDbiQ5SQH8.
PeptideAtlasiQ5SQH8.
PRIDEiQ5SQH8.

Protocols and materials databases

DNASUi221545.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293604; ENSP00000293604; ENSG00000204564. [Q5SQH8-4]
ENST00000376471; ENSP00000365654; ENSG00000204564. [Q5SQH8-3]
ENST00000376473; ENSP00000365656; ENSG00000204564. [Q5SQH8-1]
ENST00000383580; ENSP00000373074; ENSG00000206487. [Q5SQH8-3]
ENST00000383581; ENSP00000373075; ENSG00000206487. [Q5SQH8-1]
ENST00000415931; ENSP00000402805; ENSG00000233164. [Q5SQH8-3]
ENST00000417076; ENSP00000405594; ENSG00000237100. [Q5SQH8-3]
ENST00000417649; ENSP00000395979; ENSG00000233641. [Q5SQH8-3]
ENST00000419321; ENSP00000398769; ENSG00000237100. [Q5SQH8-1]
ENST00000422530; ENSP00000390275; ENSG00000237012. [Q5SQH8-1]
ENST00000425581; ENSP00000404588; ENSG00000233641. [Q5SQH8-1]
ENST00000430141; ENSP00000396916; ENSG00000224120. [Q5SQH8-1]
ENST00000447505; ENSP00000415915; ENSG00000233164. [Q5SQH8-1]
ENST00000455682; ENSP00000391657; ENSG00000224120. [Q5SQH8-3]
ENST00000456444; ENSP00000387592; ENSG00000237012. [Q5SQH8-3]
GeneIDi221545.
KEGGihsa:221545.
UCSCiuc003nqw.5. human. [Q5SQH8-1]

Organism-specific databases

CTDi221545.
GeneCardsiC6orf136.
HGNCiHGNC:21301. C6orf136.
HPAiHPA046804.
neXtProtiNX_Q5SQH8.
PharmGKBiPA134962744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4457. Eukaryota.
ENOG4111RAP. LUCA.
GeneTreeiENSGT00390000008658.
HOGENOMiHOG000247026.
HOVERGENiHBG056726.
InParanoidiQ5SQH8.
OMAiGRIWYIL.
OrthoDBiEOG091G0SAU.
PhylomeDBiQ5SQH8.
TreeFamiTF313961.

Miscellaneous databases

GenomeRNAii221545.
PROiQ5SQH8.

Gene expression databases

BgeeiENSG00000204564.
CleanExiHS_C6orf136.
ExpressionAtlasiQ5SQH8. baseline and differential.
GenevisibleiQ5SQH8. HS.

Family and domain databases

InterProiIPR018790. DUF2358.
[Graphical view]
PfamiPF10184. DUF2358. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCF136_HUMAN
AccessioniPrimary (citable) accession number: Q5SQH8
Secondary accession number(s): A9R9P9
, F8VX15, Q5SU01, Q6ZSB7, Q8TB84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.