ID   Q5SQG5_MOUSE            Unreviewed;       207 AA.
AC   Q5SQG5;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=Prohibitin {ECO:0000256|RuleBase:RU366048};
DE   Flags: Fragment;
GN   Name=Phb1 {ECO:0000313|Ensembl:ENSMUSP00000047536.6,
GN   ECO:0000313|MGI:MGI:97572}; Synonyms=Phb {ECO:0000313|MGI:MGI:97572};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000047536.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000047536.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047536.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0007829|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [4] {ECO:0007829|PubMed:23576753}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA   Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA   Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT   "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT   identifies substrates of SIRT3 in metabolic pathways.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000047536.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047536.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion inner membrane
CC       {ECO:0000256|ARBA:ARBA00004273, ECO:0000256|RuleBase:RU366048}.
CC   -!- SIMILARITY: Belongs to the prohibitin family.
CC       {ECO:0000256|ARBA:ARBA00009658, ECO:0000256|RuleBase:RU366048}.
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DR   AlphaFoldDB; Q5SQG5; -.
DR   SMR; Q5SQG5; -.
DR   jPOST; Q5SQG5; -.
DR   MaxQB; Q5SQG5; -.
DR   PeptideAtlas; Q5SQG5; -.
DR   ProteomicsDB; 358963; -.
DR   TopDownProteomics; Q5SQG5; -.
DR   Antibodypedia; 1078; 900 antibodies from 43 providers.
DR   Ensembl; ENSMUST00000036374.6; ENSMUSP00000047536.6; ENSMUSG00000038845.12.
DR   AGR; MGI:97572; -.
DR   MGI; MGI:97572; Phb1.
DR   VEuPathDB; HostDB:ENSMUSG00000038845; -.
DR   GeneTree; ENSGT00950000183070; -.
DR   HOGENOM; CLU_047969_5_1_1; -.
DR   OMA; YEFRLVT; -.
DR   PhylomeDB; Q5SQG5; -.
DR   ChiTaRS; Phb; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000038845; Expressed in yolk sac and 261 other cell types or tissues.
DR   ExpressionAtlas; Q5SQG5; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03401; SPFH_prohibitin; 1.
DR   Gene3D; 3.30.479.30; Band 7 domain; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR000163; Prohibitin.
DR   PANTHER; PTHR23222; PROHIBITIN; 1.
DR   PANTHER; PTHR23222:SF0; PROHIBITIN 1; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PRINTS; PR00679; PROHIBITIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|RuleBase:RU366048};
KW   Mitochondrion {ECO:0000256|RuleBase:RU366048};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU366048};
KW   Proteomics identification {ECO:0007829|EPD:Q5SQG5,
KW   ECO:0007829|MaxQB:Q5SQG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          26..187
FT                   /note="Band 7"
FT                   /evidence="ECO:0000259|SMART:SM00244"
FT   NON_TER         207
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000047536.6"
SQ   SEQUENCE   207 AA;  22999 MW;  DAEBDA635E297933 CRC64;
     MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW
     VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP
     SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT
     EAVEAKQVAQ QEAERARFVV EKAEQQK
//