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Q5SQG5

- Q5SQG5_MOUSE

UniProt

Q5SQG5 - Q5SQG5_MOUSE

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Protein
Submitted name:

Prohibitin

Gene

Phb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  2. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to interleukin-6 Source: Ensembl
  2. DNA biosynthetic process Source: MGI
  3. histone deacetylation Source: Ensembl
  4. negative regulation of androgen receptor signaling pathway Source: Ensembl
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of cell growth Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of glucocorticoid receptor signaling pathway Source: Ensembl
  9. negative regulation of transcription by competitive promoter binding Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. organ regeneration Source: Ensembl
  12. osteoblast differentiation Source: Ensembl
  13. ovarian follicle atresia Source: Ensembl
  14. ovarian follicle development Source: Ensembl
  15. positive regulation of transcription, DNA-templated Source: Ensembl
  16. progesterone receptor signaling pathway Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to ethanol Source: Ensembl
  19. response to immobilization stress Source: Ensembl
  20. response to peptide hormone Source: Ensembl
  21. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ProhibitinImported
Gene namesi
Name:PhbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97572. Phb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. extrinsic component of mitochondrial outer membrane Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
  4. mitochondrial crista Source: Ensembl
  5. mitochondrial inner membrane Source: MGI
  6. mitochondrion Source: MGI
  7. nucleoplasm Source: Ensembl
  8. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5SQG5.

Expressioni

Gene expression databases

ExpressionAtlasiQ5SQG5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5SQG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074770.
HOVERGENiHBG004457.
PhylomeDBiQ5SQG5.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5SQG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA
110 120 130 140 150
SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV

EKAEQQK
Length:207
Mass (Da):22,999
Last modified:December 21, 2004 - v1
Checksum:iDAEBDA635E297933
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei207 – 2071Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732490 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000036374; ENSMUSP00000047536; ENSMUSG00000038845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732490 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5SQG5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5SQG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036374 ; ENSMUSP00000047536 ; ENSMUSG00000038845 .

Organism-specific databases

MGIi MGI:97572. Phb.

Phylogenomic databases

GeneTreei ENSGT00550000074770.
HOVERGENi HBG004457.
PhylomeDBi Q5SQG5.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q5SQG5. baseline and differential.

Family and domain databases

InterProi IPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view ]
PANTHERi PTHR23222. PTHR23222. 1 hit.
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
PRINTSi PR00679. PROHIBITIN.
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5SQG5_MOUSE
AccessioniPrimary (citable) accession number: Q5SQG5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3