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Q5SQG5

- Q5SQG5_MOUSE

UniProt

Q5SQG5 - Q5SQG5_MOUSE

Protein
Submitted name:

Prohibitin

Gene

Phb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    2. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cellular response to interleukin-6 Source: Ensembl
    2. DNA biosynthetic process Source: MGI
    3. histone deacetylation Source: Ensembl
    4. negative regulation of androgen receptor signaling pathway Source: Ensembl
    5. negative regulation of cell growth Source: Ensembl
    6. negative regulation of cell proliferation Source: Ensembl
    7. negative regulation of glucocorticoid receptor signaling pathway Source: Ensembl
    8. negative regulation of transcription by competitive promoter binding Source: Ensembl
    9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    10. positive regulation of transcription, DNA-templated Source: Ensembl
    11. progesterone receptor signaling pathway Source: Ensembl
    12. transcription from RNA polymerase II promoter Source: GOC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ProhibitinImported
    Gene namesi
    Name:PhbImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:97572. Phb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI
    4. nucleoplasm Source: Ensembl
    5. nucleus Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5SQG5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SQG5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074770.
    HOVERGENiHBG004457.
    InParanoidiQ5SQG5.
    PhylomeDBiQ5SQG5.

    Family and domain databases

    InterProiIPR001107. Band_7.
    IPR000163. Prohibitin.
    [Graphical view]
    PANTHERiPTHR23222. PTHR23222. 1 hit.
    PfamiPF01145. Band_7. 1 hit.
    [Graphical view]
    PRINTSiPR00679. PROHIBITIN.
    SMARTiSM00244. PHB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q5SQG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV    50
    GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA 100
    SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV 150
    SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV 200
    EKAEQQK 207
    Length:207
    Mass (Da):22,999
    Last modified:December 21, 2004 - v1
    Checksum:iDAEBDA635E297933
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei207 – 2071Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732490 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000036374; ENSMUSP00000047536; ENSMUSG00000038845.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732490 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5SQG5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5SQG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036374 ; ENSMUSP00000047536 ; ENSMUSG00000038845 .

    Organism-specific databases

    MGIi MGI:97572. Phb.

    Phylogenomic databases

    GeneTreei ENSGT00550000074770.
    HOVERGENi HBG004457.
    InParanoidi Q5SQG5.
    PhylomeDBi Q5SQG5.

    Miscellaneous databases

    SOURCEi Search...

    Family and domain databases

    InterProi IPR001107. Band_7.
    IPR000163. Prohibitin.
    [Graphical view ]
    PANTHERi PTHR23222. PTHR23222. 1 hit.
    Pfami PF01145. Band_7. 1 hit.
    [Graphical view ]
    PRINTSi PR00679. PROHIBITIN.
    SMARTi SM00244. PHB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQ5SQG5_MOUSE
    AccessioniPrimary (citable) accession number: Q5SQG5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3