MCG68069

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: Ensembl
• DNA binding Source: Ensembl
• p53 binding Source: Ensembl
• phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
• protein kinase B binding Source: Ensembl
• protein N-terminus binding Source: Ensembl
• rRNA binding Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cardiac muscle hypertrophy Source: Ensembl
• cell growth Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to testosterone stimulus Source: Ensembl
• cell volume homeostasis Source: Ensembl
• cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
• liver regeneration Source: Ensembl
• negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of mRNA splicing, via spliceosome Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• positive regulation of cell proliferation Source: Ensembl
• positive regulation of centrosome duplication Source: Ensembl
• positive regulation of DNA-directed DNA polymerase activity Source: Ensembl
• positive regulation of DNA replication Source: Ensembl
• positive regulation of protein kinase activity Source: Ensembl
• positive regulation of protein localization to nucleolus Source: Ensembl
• positive regulation of protein ubiquitination Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• posttranscriptional regulation of gene expression Source: Ensembl
• protein homooligomerization Source: Ensembl
• protein stabilization Source: Ensembl
• regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
• ribosomal large subunit export from nucleus Source: Ensembl
• ribosomal small subunit biogenesis Source: Ensembl
• ribosomal small subunit export from nucleus Source: Ensembl
• rRNA export from nucleus Source: Ensembl
• rRNA transcription Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• p53 binding Source: Ensembl
• protein kinase B binding Source: Ensembl
• protein N-terminus binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG 
        60         70         80         90        100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 
       110        120        130        140        150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 
       160        170        180        190        200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 
       210        220        230        240        250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 
       260        270        280        290 
ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ