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Q5SQB7

- Q5SQB7_MOUSE

UniProt

Q5SQB7 - Q5SQB7_MOUSE

Protein
Submitted name:

MCG68069

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. ribosomal large subunit binding Source: MGI
    3. ribosomal small subunit binding Source: MGI
    4. RNA binding Source: MGI
    5. rRNA binding Source: MGI

    GO - Biological processi

    1. cell growth Source: MGI
    2. cell volume homeostasis Source: MGI
    3. negative regulation of mRNA splicing, via spliceosome Source: MGI
    4. nucleocytoplasmic transport Source: MGI
    5. positive regulation of cell proliferation Source: MGI
    6. positive regulation of cellular biosynthetic process Source: MGI
    7. positive regulation of centrosome duplication Source: MGI
    8. positive regulation of protein kinase activity Source: MGI
    9. protein localization Source: MGI
    10. protein oligomerization Source: MGI
    11. regulation of cell cycle Source: MGI
    12. regulation of centrosome duplication Source: MGI
    13. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
    14. ribosomal large subunit biogenesis Source: MGI
    15. ribosomal large subunit export from nucleus Source: MGI
    16. ribosomal small subunit biogenesis Source: MGI
    17. ribosomal small subunit export from nucleus Source: MGI
    18. rRNA export from nucleus Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MCG68069Imported
    Submitted name:
    Nucleophosmin 1Imported
    Gene namesi
    Name:Npm1Imported
    ORF Names:mCG_68069Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:106184. Npm1.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: MGI
    2. cytoplasm Source: MGI
    3. cytosol Source: MGI
    4. granular component Source: MGI
    5. large ribosomal subunit Source: MGI
    6. nuclear speck Source: MGI
    7. nucleolus Source: MGI
    8. nucleoplasm Source: MGI
    9. nucleus Source: MGI
    10. ribonucleoprotein complex Source: MGI
    11. small ribosomal subunit Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ5SQB7.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG001860.
    InParanoidiQ5SQB7.
    KOiK11276.
    OMAiNCFRTED.

    Family and domain databases

    Gene3Di2.60.120.340. 1 hit.
    InterProiIPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view]
    PANTHERiPTHR22747. PTHR22747. 1 hit.
    SUPFAMiSSF69203. SSF69203. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SQB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG    50
    AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 100
    RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 150
    VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 200
    KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 250
    ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL 292
    Length:292
    Mass (Da):32,560
    Last modified:May 10, 2005 - v1
    Checksum:iE68750C549ED25E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089546 mRNA. Translation: AAH89546.1.
    BC092378 mRNA. Translation: AAH92378.1.
    GU214027 mRNA. Translation: ADA57701.1.
    AK135517 mRNA. Translation: BAE22562.1.
    AK145124 mRNA. Translation: BAE26248.1.
    AK145813 mRNA. Translation: BAE26667.1.
    AK165860 mRNA. Translation: BAE38420.1.
    CH466604 Genomic DNA. Translation: EDL23744.1.
    RefSeqiNP_001239189.1. NM_001252260.1.
    NP_032748.1. NM_008722.3.
    UniGeneiMm.485384.

    Genome annotation databases

    GeneIDi18148.
    KEGGimmu:18148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089546 mRNA. Translation: AAH89546.1 .
    BC092378 mRNA. Translation: AAH92378.1 .
    GU214027 mRNA. Translation: ADA57701.1 .
    AK135517 mRNA. Translation: BAE22562.1 .
    AK145124 mRNA. Translation: BAE26248.1 .
    AK145813 mRNA. Translation: BAE26667.1 .
    AK165860 mRNA. Translation: BAE38420.1 .
    CH466604 Genomic DNA. Translation: EDL23744.1 .
    RefSeqi NP_001239189.1. NM_001252260.1.
    NP_032748.1. NM_008722.3.
    UniGenei Mm.485384.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18148.
    KEGGi mmu:18148.

    Organism-specific databases

    CTDi 4869.
    MGIi MGI:106184. Npm1.

    Phylogenomic databases

    HOVERGENi HBG001860.
    InParanoidi Q5SQB7.
    KOi K11276.
    OMAi NCFRTED.

    Miscellaneous databases

    NextBioi 293410.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5SQB7.

    Family and domain databases

    Gene3Di 2.60.120.340. 1 hit.
    InterProi IPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view ]
    PANTHERi PTHR22747. PTHR22747. 1 hit.
    SUPFAMi SSF69203. SSF69203. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported and MolarImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Mammary glandImported and Mullerian duct includes surrounding regionImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LungImported.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    13. "Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation."
      Olanich M.E., Moss B.L., Piwnica-Worms D., Townsend R.R., Weber J.D.
      Oncogene 30:77-86(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.

    Entry informationi

    Entry nameiQ5SQB7_MOUSE
    AccessioniPrimary (citable) accession number: Q5SQB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)