Npm1

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: Ensembl
DNA binding Source: Ensembl
p53 binding Source: Ensembl
phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
protein kinase B binding Source: Ensembl
protein N-terminus binding Source: Ensembl
rRNA binding Source: Ensembl

GO - Biological processⁱ

cardiac muscle hypertrophy Source: Ensembl
cell growth Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to testosterone stimulus Source: Ensembl
cell volume homeostasis Source: Ensembl
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
liver regeneration Source: Ensembl
negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
negative regulation of epithelial cell proliferation Source: Ensembl
negative regulation of mRNA splicing, via spliceosome Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of centrosome duplication Source: Ensembl
positive regulation of DNA-directed DNA polymerase activity Source: Ensembl
positive regulation of DNA replication Source: Ensembl
positive regulation of protein kinase activity Source: Ensembl
positive regulation of protein localization to nucleolus Source: Ensembl
positive regulation of protein ubiquitination Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
posttranscriptional regulation of gene expression Source: Ensembl
protein homooligomerization Source: Ensembl
protein stabilization Source: Ensembl
regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
ribosomal large subunit export from nucleus Source: Ensembl
ribosomal small subunit biogenesis Source: Ensembl
ribosomal small subunit export from nucleus Source: Ensembl
rRNA export from nucleus Source: Ensembl
rRNA transcription Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MCG68069Imported Submitted name: Nucleophosmin 1Imported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Npm1Imported ORF Names:mCG_68069Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:106184. Npm1.

Subcellular locationⁱ

GO - Cellular componentⁱ

centrosome Source: Ensembl
cytosol Source: Ensembl
granular component Source: Ensembl
large ribosomal subunit Source: Ensembl
nuclear matrix Source: Ensembl
nuclear speck Source: Ensembl
small ribosomal subunit Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

TopDownProteomicsⁱ	Q5SQB7.

TopDownProteomicsⁱ

Q5SQB7.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000057113.
ExpressionAtlasⁱ	Q5SQB7. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

p53 binding Source: Ensembl
protein kinase B binding Source: Ensembl
protein N-terminus binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q5SQB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 117	NucleoplasminInterPro annotationAdd BLAST		101
Domainⁱ	243 – 291	NPM1-CInterPro annotationAdd BLAST		49

Phylogenomic databases

eggNOGⁱ	ENOG410IHZM. Eukaryota. ENOG4111IKX. LUCA.
HOVERGENⁱ	HBG001860.
KEGG Orthology (KO) More...KOⁱ	K11276.
OMAⁱ	KMQASVD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NLY.

Family and domain databases

InterProⁱ	View protein in InterPro IPR032569. NPM1_C. IPR004301. Nucleoplasmin. IPR024057. Nucleoplasmin_core_dom.
PANTHERⁱ	PTHR22747. PTHR22747. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16276. NPM1-C. 1 hit. PF03066. Nucleoplasmin. 1 hit.
SUPFAMⁱ	SSF69203. SSF69203. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5SQB7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG 
        60         70         80         90        100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 
       110        120        130        140        150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 
       160        170        180        190        200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 
       210        220        230        240        250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 
       260        270        280        290 
ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL

Length:292

Mass (Da):32,560

Last modified:May 10, 2005 - v1

Checksum:ⁱE68750C549ED25E6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC089546 mRNA. Translation: AAH89546.1. BC092378 mRNA. Translation: AAH92378.1. GU214027 mRNA. Translation: ADA57701.1. AK135517 mRNA. Translation: BAE22562.1. AK145124 mRNA. Translation: BAE26248.1. AK145813 mRNA. Translation: BAE26667.1. AK165860 mRNA. Translation: BAE38420.1. CH466604 Genomic DNA. Translation: EDL23744.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001239189.1. NM_001252260.1. NP_032748.1. NM_008722.3.
UniGeneⁱ	Mm.485384.

Genome annotation databases

GeneIDⁱ	18148.
KEGGⁱ	mmu:18148.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC089546 mRNA. Translation: AAH89546.1. BC092378 mRNA. Translation: AAH92378.1. GU214027 mRNA. Translation: ADA57701.1. AK135517 mRNA. Translation: BAE22562.1. AK145124 mRNA. Translation: BAE26248.1. AK145813 mRNA. Translation: BAE26667.1. AK165860 mRNA. Translation: BAE38420.1. CH466604 Genomic DNA. Translation: EDL23744.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001239189.1. NM_001252260.1. NP_032748.1. NM_008722.3.
UniGeneⁱ	Mm.485384.

3D structure databases

SMRⁱ	Q5SQB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

TopDownProteomicsⁱ	Q5SQB7.

TopDownProteomicsⁱ

Q5SQB7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	18148.
KEGGⁱ	mmu:18148.

Organism-specific databases

CTDⁱ	4869.
MGIⁱ	MGI:106184. Npm1.

Phylogenomic databases

eggNOGⁱ	ENOG410IHZM. Eukaryota. ENOG4111IKX. LUCA.
HOVERGENⁱ	HBG001860.
KEGG Orthology (KO) More...KOⁱ	K11276.
OMAⁱ	KMQASVD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NLY.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000057113.
ExpressionAtlasⁱ	Q5SQB7. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR032569. NPM1_C. IPR004301. Nucleoplasmin. IPR024057. Nucleoplasmin_core_dom.
PANTHERⁱ	PTHR22747. PTHR22747. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16276. NPM1-C. 1 hit. PF03066. Nucleoplasmin. 1 hit.
SUPFAMⁱ	SSF69203. SSF69203. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SQB7_MOUSE
Accessionⁱ	Q5SQB7Primary (citable) accession number: Q5SQB7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	July 5, 2017
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q5SQB7 (Q5SQB7_MOUSE)

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MCG68069

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SQB7 (Q5SQB7_MOUSE)

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MCG68069

Npm1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ