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Q5SQB7

- Q5SQB7_MOUSE

UniProt

Q5SQB7 - Q5SQB7_MOUSE

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Protein
Submitted name:

MCG68069

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
  3. ribosomal large subunit binding Source: MGI
  4. ribosomal small subunit binding Source: MGI
  5. RNA binding Source: MGI
  6. rRNA binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cell volume homeostasis Source: MGI
  3. negative regulation of mRNA splicing, via spliceosome Source: MGI
  4. nucleocytoplasmic transport Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. positive regulation of cellular biosynthetic process Source: MGI
  7. positive regulation of centrosome duplication Source: MGI
  8. positive regulation of DNA replication Source: Ensembl
  9. positive regulation of protein kinase activity Source: MGI
  10. protein homooligomerization Source: Ensembl
  11. protein localization Source: MGI
  12. protein oligomerization Source: MGI
  13. regulation of cell cycle Source: MGI
  14. regulation of centrosome duplication Source: MGI
  15. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  16. regulation of neuron apoptotic process Source: Ensembl
  17. ribosomal large subunit biogenesis Source: MGI
  18. ribosomal large subunit export from nucleus Source: MGI
  19. ribosomal small subunit biogenesis Source: MGI
  20. ribosomal small subunit export from nucleus Source: MGI
  21. rRNA export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MCG68069Imported
Submitted name:
Nucleophosmin 1Imported
Gene namesi
Name:Npm1Imported
ORF Names:mCG_68069Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. granular component Source: MGI
  5. large ribosomal subunit Source: MGI
  6. nuclear speck Source: MGI
  7. nucleolus Source: MGI
  8. nucleoplasm Source: MGI
  9. nucleus Source: MGI
  10. ribonucleoprotein complex Source: MGI
  11. small ribosomal subunit Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5SQB7.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG001860.
KOiK11276.
OMAiNCFRTED.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SQB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK
160 170 180 190 200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA
210 220 230 240 250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ
260 270 280 290
ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL
Length:292
Mass (Da):32,560
Last modified:May 10, 2005 - v1
Checksum:iE68750C549ED25E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089546 mRNA. Translation: AAH89546.1.
BC092378 mRNA. Translation: AAH92378.1.
GU214027 mRNA. Translation: ADA57701.1.
AK135517 mRNA. Translation: BAE22562.1.
AK145124 mRNA. Translation: BAE26248.1.
AK145813 mRNA. Translation: BAE26667.1.
AK165860 mRNA. Translation: BAE38420.1.
CH466604 Genomic DNA. Translation: EDL23744.1.
RefSeqiNP_001239189.1. NM_001252260.1.
NP_032748.1. NM_008722.3.
UniGeneiMm.485384.

Genome annotation databases

GeneIDi18148.
KEGGimmu:18148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089546 mRNA. Translation: AAH89546.1 .
BC092378 mRNA. Translation: AAH92378.1 .
GU214027 mRNA. Translation: ADA57701.1 .
AK135517 mRNA. Translation: BAE22562.1 .
AK145124 mRNA. Translation: BAE26248.1 .
AK145813 mRNA. Translation: BAE26667.1 .
AK165860 mRNA. Translation: BAE38420.1 .
CH466604 Genomic DNA. Translation: EDL23744.1 .
RefSeqi NP_001239189.1. NM_001252260.1.
NP_032748.1. NM_008722.3.
UniGenei Mm.485384.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 18148.
KEGGi mmu:18148.

Organism-specific databases

CTDi 4869.
MGIi MGI:106184. Npm1.

Phylogenomic databases

HOVERGENi HBG001860.
KOi K11276.
OMAi NCFRTED.

Miscellaneous databases

NextBioi 293410.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5SQB7.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported and MolarImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Mammary glandImported and Mullerian duct includes surrounding regionImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LungImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported, Mammary glandImported and Mullerian duct includes surrounding regionImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. "Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation."
    Olanich M.E., Moss B.L., Piwnica-Worms D., Townsend R.R., Weber J.D.
    Oncogene 30:77-86(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiQ5SQB7_MOUSE
AccessioniPrimary (citable) accession number: Q5SQB7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)