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Q5SQB7 (Q5SQB7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Nucleophosmin 1 EMBL AAH89546.1
Gene names
Name:Npm1 MGI 106184 EMBL AAH89546.1
ORF Names:mCG_68069 EMBL EDL23744.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processcell growth

Inferred from direct assay PubMed 18809582. Source: MGI

cell volume homeostasis

Inferred from direct assay PubMed 18809582. Source: MGI

negative regulation of mRNA splicing, via spliceosome

Inferred from direct assay PubMed 16376875. Source: MGI

nucleocytoplasmic transport

Inferred from direct assay PubMed 15485902. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 18809582. Source: MGI

positive regulation of cellular biosynthetic process

Inferred from direct assay PubMed 18809582. Source: MGI

positive regulation of centrosome duplication

Inferred from genetic interaction PubMed 17015463. Source: MGI

positive regulation of protein kinase activity

Inferred from direct assay PubMed 17015463. Source: MGI

protein localization

Inferred from mutant phenotype PubMed 16199867. Source: MGI

protein oligomerization

Inferred from sequence orthology PubMed 18809582. Source: MGI

rRNA export from nucleus

Inferred from direct assay PubMed 18809582. Source: MGI

regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from genetic interaction PubMed 16199867. Source: MGI

regulation of cell cycle

Inferred from mutant phenotype PubMed 15485902. Source: MGI

regulation of centrosome duplication

Inferred from mutant phenotype PubMed 16007073. Source: MGI

ribosomal large subunit biogenesis

Inferred from direct assay PubMed 18809582. Source: MGI

ribosomal large subunit export from nucleus

Inferred from mutant phenotype PubMed 18809582. Source: MGI

ribosomal small subunit biogenesis

Inferred from direct assay PubMed 18809582. Source: MGI

ribosomal small subunit export from nucleus

Inferred from direct assay PubMed 18809582. Source: MGI

   Cellular_componentcentrosome

Inferred from direct assay PubMed 16297385. Source: MGI

cytoplasm

Inferred from direct assay PubMed 16648475. Source: MGI

cytosol

Inferred from direct assay PubMed 18809582. Source: MGI

granular component

Inferred from direct assay PubMed 15485902. Source: MGI

large ribosomal subunit

Inferred from direct assay PubMed 18809582. Source: MGI

nuclear speck

Inferred from direct assay PubMed 16376875. Source: MGI

nucleolus

Inferred from direct assay PubMed 10716735PubMed 12374805PubMed 15485902PubMed 15596447PubMed 15615785PubMed 15989966PubMed 16027046PubMed 16297385PubMed 16648475PubMed 16855206PubMed 18023416PubMed 18809582PubMed 2100262. Source: MGI

nucleoplasm

Inferred from direct assay PubMed 12374805PubMed 16297385PubMed 18809582. Source: MGI

nucleus

Inferred from direct assay PubMed 16648475. Source: MGI

ribonucleoprotein complex

Inferred from sequence orthology PubMed 18809582. Source: MGI

small ribosomal subunit

Inferred from direct assay PubMed 18809582. Source: MGI

   Molecular_functionRNA binding

Inferred from direct assay PubMed 16376875. Source: MGI

rRNA binding

Inferred from direct assay PubMed 15596447PubMed 18809582. Source: MGI

ribosomal large subunit binding

Inferred from sequence orthology PubMed 18809582. Source: MGI

ribosomal small subunit binding

Inferred from sequence orthology PubMed 18809582. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5SQB7 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: E68750C549ED25E6

FASTA29232,560
        10         20         30         40         50         60 
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 

        70         80         90        100        110        120 
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 

       130        140        150        160        170        180 
EDAESEDEDE EDVKLLGMSG KRSAPGGGNK VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF 

       190        200        210        220        230        240 
DEEETEEKVP VKKSVRDTPA KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS 

       250        260        270        280        290 
SVEDIKAKMQ ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL23744.1.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH92378.1.
Tissue: Brain EMBL AAH92378.1 and Molar EMBL AAH89546.1.
[8]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[9]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung EMBL BAE38420.1.
[10]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[11]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE26667.1.
Tissue: Lung EMBL BAE38420.1, Mammary gland EMBL BAE26248.1 and Mullerian duct includes surrounding region EMBL BAE22562.1.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL23744.1.
[13]"Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation."
Olanich M.E., Moss B.L., Piwnica-Worms D., Townsend R.R., Weber J.D.
Oncogene 30:77-86(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6 EMBL ADA57701.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089546 mRNA. Translation: AAH89546.1.
BC092378 mRNA. Translation: AAH92378.1.
GU214027 mRNA. Translation: ADA57701.1.
AK135517 mRNA. Translation: BAE22562.1.
AK145124 mRNA. Translation: BAE26248.1.
AK145813 mRNA. Translation: BAE26667.1.
AK165860 mRNA. Translation: BAE38420.1.
CH466604 Genomic DNA. Translation: EDL23744.1.
RefSeqNP_001239189.1. NM_001252260.1.
NP_032748.1. NM_008722.3.
UniGeneMm.485384.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18148.
KEGGmmu:18148.

Organism-specific databases

CTD4869.
MGIMGI:106184. Npm1.

Phylogenomic databases

HOVERGENHBG001860.
InParanoidQ5SQB7.
KOK11276.
OMANCFRTED.

Gene expression databases

GenevestigatorQ5SQB7.

Family and domain databases

Gene3D2.60.120.340. 1 hit.
InterProIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERPTHR22747. PTHR22747. 1 hit.
SUPFAMSSF69203. SSF69203. 1 hit.
ProtoNetSearch...

Other

NextBio293410.
SOURCESearch...

Entry information

Entry nameQ5SQB7_MOUSE
AccessionPrimary (citable) accession number: Q5SQB7
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)