UniProtKB - Q5SQB7 (Q5SQB7_MOUSE)
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Protein
Submitted name:
MCG68069
Gene
Npm1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: Ensembl
- DNA binding Source: Ensembl
- p53 binding Source: Ensembl
- phosphatidylinositol-3,4,5-trisphosphate binding Source: Ensembl
- protein kinase B binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- rRNA binding Source: Ensembl
GO - Biological processi
- cardiac muscle hypertrophy Source: Ensembl
- cell growth Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to testosterone stimulus Source: Ensembl
- cell volume homeostasis Source: Ensembl
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
- liver regeneration Source: Ensembl
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of mRNA splicing, via spliceosome Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- positive regulation of cell proliferation Source: Ensembl
- positive regulation of centrosome duplication Source: Ensembl
- positive regulation of DNA-directed DNA polymerase activity Source: Ensembl
- positive regulation of DNA replication Source: Ensembl
- positive regulation of protein kinase activity Source: Ensembl
- positive regulation of protein localization to nucleolus Source: Ensembl
- positive regulation of protein ubiquitination Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- posttranscriptional regulation of gene expression Source: Ensembl
- protein homooligomerization Source: Ensembl
- protein stabilization Source: Ensembl
- regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
- ribosomal large subunit export from nucleus Source: Ensembl
- ribosomal small subunit biogenesis Source: Ensembl
- ribosomal small subunit export from nucleus Source: Ensembl
- rRNA export from nucleus Source: Ensembl
- rRNA transcription Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: MCG68069ImportedSubmitted name: Nucleophosmin 1Imported |
Gene namesi | Name:Npm1Imported ORF Names:mCG_68069Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:106184. Npm1. |
Subcellular locationi
Interactioni
GO - Molecular functioni
- p53 binding Source: Ensembl
- protein kinase B binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 117 | NucleoplasminInterPro annotationAdd BLAST | 101 | |
Domaini | 243 – 291 | NPM1-CInterPro annotationAdd BLAST | 49 |
Phylogenomic databases
eggNOGi | ENOG410IHZM. Eukaryota. ENOG4111IKX. LUCA. |
HOVERGENi | HBG001860. |
KOi | K11276. |
OMAi | KMQASVD. |
OrthoDBi | EOG091G0NLY. |
Family and domain databases
Gene3Di | 1.10.10.2100. 1 hit. |
InterProi | View protein in InterPro IPR032569. NPM1_C. IPR038101. NPM1_C_sf. IPR004301. Nucleoplasmin. IPR024057. Nucleoplasmin_core_dom. IPR036824. Nucleoplasmin_core_dom_sf. |
PANTHERi | PTHR22747. PTHR22747. 1 hit. |
Pfami | View protein in Pfam PF16276. NPM1-C. 1 hit. PF03066. Nucleoplasmin. 1 hit. |
SUPFAMi | SSF69203. SSF69203. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5SQB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK
160 170 180 190 200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA
210 220 230 240 250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ
260 270 280 290
ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC089546 mRNA. Translation: AAH89546.1. BC092378 mRNA. Translation: AAH92378.1. GU214027 mRNA. Translation: ADA57701.1. AK135517 mRNA. Translation: BAE22562.1. AK145124 mRNA. Translation: BAE26248.1. AK145813 mRNA. Translation: BAE26667.1. AK165860 mRNA. Translation: BAE38420.1. CH466604 Genomic DNA. Translation: EDL23744.1. |
RefSeqi | NP_001239189.1. NM_001252260.1. NP_032748.1. NM_008722.3. |
UniGenei | Mm.485384. |
Genome annotation databases
GeneIDi | 18148. |
KEGGi | mmu:18148. |
Similar proteinsi
Entry informationi
Entry namei | Q5SQB7_MOUSE | |
Accessioni | Q5SQB7Primary (citable) accession number: Q5SQB7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | March 28, 2018 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |