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Q5SQB5

- Q5SQB5_MOUSE

UniProt

Q5SQB5 - Q5SQB5_MOUSE

Protein
Submitted name:

Nucleophosmin

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. ribosomal large subunit binding Source: MGI
    3. ribosomal small subunit binding Source: MGI
    4. RNA binding Source: MGI
    5. rRNA binding Source: MGI

    GO - Biological processi

    1. cell growth Source: MGI
    2. cell volume homeostasis Source: MGI
    3. negative regulation of mRNA splicing, via spliceosome Source: MGI
    4. nucleocytoplasmic transport Source: MGI
    5. positive regulation of cell proliferation Source: MGI
    6. positive regulation of cellular biosynthetic process Source: MGI
    7. positive regulation of centrosome duplication Source: MGI
    8. positive regulation of protein kinase activity Source: MGI
    9. protein localization Source: MGI
    10. protein oligomerization Source: MGI
    11. regulation of cell cycle Source: MGI
    12. regulation of centrosome duplication Source: MGI
    13. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
    14. ribosomal large subunit biogenesis Source: MGI
    15. ribosomal large subunit export from nucleus Source: MGI
    16. ribosomal small subunit biogenesis Source: MGI
    17. ribosomal small subunit export from nucleus Source: MGI
    18. rRNA export from nucleus Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NucleophosminImported
    Gene namesi
    Name:Npm1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:106184. Npm1.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: MGI
    2. cytoplasm Source: MGI
    3. cytosol Source: MGI
    4. granular component Source: MGI
    5. large ribosomal subunit Source: MGI
    6. nuclear speck Source: MGI
    7. nucleolus Source: MGI
    8. nucleoplasm Source: MGI
    9. nucleus Source: MGI
    10. ribonucleoprotein complex Source: MGI
    11. small ribosomal subunit Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5SQB5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SQB5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SQB5.
    SMRiQ5SQB5. Positions 13-120, 223-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00440000034554.
    HOGENOMiHOG000013061.
    HOVERGENiHBG001860.

    Family and domain databases

    Gene3Di2.60.120.340. 1 hit.
    InterProiIPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view]
    PANTHERiPTHR22747. PTHR22747. 1 hit.
    SUPFAMiSSF69203. SSF69203. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SQB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG    50
    AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 100
    RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 150
    VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA 200
    KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ 250
    ASIEKFSHGF RRFSSFVQPQ MDWNLALGST FHISY 285
    Length:285
    Mass (Da):31,723
    Last modified:December 21, 2004 - v1
    Checksum:i1F7EC713C23106D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772409 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
    UCSCiuc007ikf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772409 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5SQB5.
    SMRi Q5SQB5. Positions 13-120, 223-255.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5SQB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101375 ; ENSMUSP00000098926 ; ENSMUSG00000057113 .
    UCSCi uc007ikf.2. mouse.

    Organism-specific databases

    MGIi MGI:106184. Npm1.

    Phylogenomic databases

    GeneTreei ENSGT00440000034554.
    HOGENOMi HOG000013061.
    HOVERGENi HBG001860.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5SQB5.

    Family and domain databases

    Gene3Di 2.60.120.340. 1 hit.
    InterProi IPR004301. Nucleoplasmin.
    IPR024057. Nucleoplasmin_core_dom.
    [Graphical view ]
    PANTHERi PTHR22747. PTHR22747. 1 hit.
    SUPFAMi SSF69203. SSF69203. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQ5SQB5_MOUSE
    AccessioniPrimary (citable) accession number: Q5SQB5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3