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Protein
Submitted name:

Nucleophosmin

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: MGI
  • cell growth Source: MGI
  • cell volume homeostasis Source: MGI
  • centrosome cycle Source: MGI
  • DNA repair Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of centrosome duplication Source: MGI
  • negative regulation of mRNA splicing, via spliceosome Source: MGI
  • negative regulation of protein kinase activity by regulation of protein phosphorylation Source: MGI
  • nucleocytoplasmic transport Source: MGI
  • nucleosome assembly Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cellular biosynthetic process Source: MGI
  • positive regulation of centrosome duplication Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of translation Source: MGI
  • protein homooligomerization Source: MGI
  • protein localization Source: MGI
  • protein oligomerization Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of centriole replication Source: MGI
  • regulation of centrosome duplication Source: MGI
  • regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  • regulation of eIF2 alpha phosphorylation by dsRNA Source: MGI
  • regulation of endodeoxyribonuclease activity Source: MGI
  • regulation of endoribonuclease activity Source: MGI
  • ribosomal large subunit biogenesis Source: MGI
  • ribosomal large subunit export from nucleus Source: MGI
  • ribosomal small subunit biogenesis Source: MGI
  • ribosomal small subunit export from nucleus Source: MGI
  • rRNA export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NucleophosminImported
Gene namesi
Name:Npm1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • focal adhesion Source: MGI
  • granular component Source: MGI
  • large ribosomal subunit Source: MGI
  • membrane Source: MGI
  • nuclear speck Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • ribonucleoprotein complex Source: MGI
  • small ribosomal subunit Source: MGI
  • spindle pole centrosome Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5SQB5.

Expressioni

Gene expression databases

BgeeiQ5SQB5.
ExpressionAtlasiQ5SQB5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075067.

Structurei

3D structure databases

ProteinModelPortaliQ5SQB5.
SMRiQ5SQB5. Positions 13-120, 223-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000034554.
HOGENOMiHOG000013061.
HOVERGENiHBG001860.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SQB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK
160 170 180 190 200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA
210 220 230 240 250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ
260 270 280
ASIEKFSHGF RRFSSFVQPQ MDWNLALGST FHISY
Length:285
Mass (Da):31,723
Last modified:December 21, 2004 - v1
Checksum:i1F7EC713C23106D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772409 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
UCSCiuc007ikf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772409 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5SQB5.
SMRiQ5SQB5. Positions 13-120, 223-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075067.

Proteomic databases

PRIDEiQ5SQB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
UCSCiuc007ikf.2. mouse.

Organism-specific databases

MGIiMGI:106184. Npm1.

Phylogenomic databases

GeneTreeiENSGT00440000034554.
HOGENOMiHOG000013061.
HOVERGENiHBG001860.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ5SQB5.
ExpressionAtlasiQ5SQB5. baseline.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5SQB5_MOUSE
AccessioniPrimary (citable) accession number: Q5SQB5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.