Q5SQB5 (Q5SQB5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nucleophosmin Ensembl ENSMUSP00000098926

Gene names

Name:

Npm1 Ensembl ENSMUSP00000098926 MGI 106184

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000098926

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000098926

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell growth Inferred from direct assay PubMed 18809582. Source: MGI cell volume homeostasis Inferred from direct assay PubMed 18809582. Source: MGI negative regulation of mRNA splicing, via spliceosome Inferred from direct assay PubMed 16376875. Source: MGI positive regulation of cell proliferation Inferred from direct assay PubMed 18809582. Source: MGI positive regulation of cellular biosynthetic process Inferred from direct assay PubMed 18809582. Source: MGI positive regulation of centrosome duplication Inferred from genetic interaction PubMed 17015463. Source: MGI positive regulation of protein kinase activity Inferred from direct assay PubMed 17015463. Source: MGI protein localization Inferred from mutant phenotype PubMed 16199867. Source: MGI protein oligomerization Inferred from sequence orthology PubMed 18809582. Source: MGI rRNA export from nucleus Inferred from direct assay PubMed 18809582. Source: MGI regulation of DNA damage response, signal transduction by p53 class mediator Inferred from genetic interaction PubMed 16199867. Source: MGI ribosomal large subunit biogenesis Inferred from mutant phenotype PubMed 18809582. Source: MGI ribosomal large subunit export from nucleus Inferred from mutant phenotype PubMed 18809582. Source: MGI ribosomal small subunit biogenesis Inferred from mutant phenotype PubMed 18809582. Source: MGI ribosomal small subunit export from nucleus Inferred from direct assay PubMed 18809582. Source: MGI
Cellular_component	centrosome Inferred from direct assay PubMed 16297385. Source: MGI cytosol Inferred from direct assay PubMed 18809582. Source: MGI granular component Inferred from direct assay PubMed 15485902. Source: MGI large ribosomal subunit Inferred from direct assay PubMed 18809582. Source: MGI nuclear speck Inferred from direct assay PubMed 16376875. Source: MGI small ribosomal subunit Inferred from direct assay PubMed 18809582. Source: MGI
Molecular_function	rRNA binding Inferred from direct assay PubMed 15596447PubMed 18809582. Source: MGI ribosomal large subunit binding Inferred from sequence orthology PubMed 18809582. Source: MGI ribosomal small subunit binding Inferred from sequence orthology PubMed 18809582. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5SQB5 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 1F7EC713C23106D3	FASTA	285	31,723
	10 20 30 40 50 60 MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 70 80 90 100 110 120 EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 130 140 150 160 170 180 EDAESEDEDE EDVKLLGMSG KRSAPGGGNK VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF 190 200 210 220 230 240 DEEETEEKVP VKKSVRDTPA KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS 250 260 270 280 SVEDIKAKMQ ASIEKFSHGF RRFSSFVQPQ MDWNLALGST FHISY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000098926.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000098926.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL772409 Genomic DNA. No translation available.
IPI	IPI00649841.
3D structure databases
ProteinModelPortal	Q5SQB5.
SMR	Q5SQB5. Positions 15-118, 223-255.
ModBase	Search...
Proteomic databases
PRIDE	Q5SQB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
UCSC	uc007ikf.2. mouse.
Organism-specific databases
MGI	MGI:106184. Npm1.
Phylogenomic databases
GeneTree	ENSGT00440000034554.
HOGENOM	HOG000013061.
HOVERGEN	HBG001860.
Gene expression databases
ArrayExpress	Q5SQB5.
Family and domain databases
Gene3D	2.60.120.340. 1 hit.
InterPro	IPR004301. Nucleoplasmin. IPR024057. Nucleoplasmin_core_dom. [Graphical view]
PANTHER	PTHR22747. PTHR22747. 1 hit.
SUPFAM	SSF69203. Nucleoplasmin. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q5SQB5_MOUSE

Accession

Primary (citable) accession number: Q5SQB5

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)