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Q5SQB5 (Q5SQB5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000098926

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell growth

Inferred from direct assay PubMed 18809582. Source: MGI

cell volume homeostasis

Inferred from direct assay PubMed 18809582. Source: MGI

negative regulation of mRNA splicing, via spliceosome

Inferred from direct assay PubMed 16376875. Source: MGI

nucleocytoplasmic transport

Inferred from direct assay PubMed 15485902. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 18809582. Source: MGI

positive regulation of cellular biosynthetic process

Inferred from direct assay PubMed 18809582. Source: MGI

positive regulation of centrosome duplication

Inferred from genetic interaction PubMed 17015463. Source: MGI

positive regulation of protein kinase activity

Inferred from direct assay PubMed 17015463. Source: MGI

protein localization

Inferred from mutant phenotype PubMed 16199867. Source: MGI

protein oligomerization

Inferred from sequence orthology PubMed 18809582. Source: MGI

rRNA export from nucleus

Inferred from direct assay PubMed 18809582. Source: MGI

regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from genetic interaction PubMed 16199867. Source: MGI

regulation of cell cycle

Inferred from mutant phenotype PubMed 15485902. Source: MGI

regulation of centrosome duplication

Inferred from mutant phenotype PubMed 16007073. Source: MGI

ribosomal large subunit biogenesis

Inferred from direct assay PubMed 18809582. Source: MGI

ribosomal large subunit export from nucleus

Inferred from mutant phenotype PubMed 18809582. Source: MGI

ribosomal small subunit biogenesis

Inferred from direct assay PubMed 18809582. Source: MGI

ribosomal small subunit export from nucleus

Inferred from direct assay PubMed 18809582. Source: MGI

   Cellular_componentcentrosome

Inferred from direct assay PubMed 16297385. Source: MGI

cytoplasm

Inferred from direct assay PubMed 16648475. Source: MGI

cytosol

Inferred from direct assay PubMed 18809582. Source: MGI

granular component

Inferred from direct assay PubMed 15485902. Source: MGI

large ribosomal subunit

Inferred from direct assay PubMed 18809582. Source: MGI

nuclear speck

Inferred from direct assay PubMed 16376875. Source: MGI

nucleolus

Inferred from direct assay PubMed 10716735PubMed 12374805PubMed 15485902PubMed 15596447PubMed 15615785PubMed 15989966PubMed 16027046PubMed 16297385PubMed 16648475PubMed 16855206PubMed 18023416PubMed 18809582PubMed 2100262. Source: MGI

nucleoplasm

Inferred from direct assay PubMed 12374805PubMed 16297385PubMed 18809582. Source: MGI

nucleus

Inferred from direct assay PubMed 16648475. Source: MGI

ribonucleoprotein complex

Inferred from sequence orthology PubMed 18809582. Source: MGI

small ribosomal subunit

Inferred from direct assay PubMed 18809582. Source: MGI

   Molecular_functionRNA binding

Inferred from direct assay PubMed 16376875. Source: MGI

protein binding

Inferred from physical interaction PubMed 15485902PubMed 15596447PubMed 16648475PubMed 17015463PubMed 19710015. Source: MGI

rRNA binding

Inferred from direct assay PubMed 15596447PubMed 18809582. Source: MGI

ribosomal large subunit binding

Inferred from sequence orthology PubMed 18809582. Source: MGI

ribosomal small subunit binding

Inferred from sequence orthology PubMed 18809582. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5SQB5 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 1F7EC713C23106D3

FASTA28531,723
        10         20         30         40         50         60 
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV 

        70         80         90        100        110        120 
EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE 

       130        140        150        160        170        180 
EDAESEDEDE EDVKLLGMSG KRSAPGGGNK VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF 

       190        200        210        220        230        240 
DEEETEEKVP VKKSVRDTPA KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS 

       250        260        270        280 
SVEDIKAKMQ ASIEKFSHGF RRFSSFVQPQ MDWNLALGST FHISY 

« Hide

References

« Hide 'large scale' references
[1]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000098926.
[7]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000098926.
[8]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772409 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalQ5SQB5.
SMRQ5SQB5. Positions 13-120, 223-255.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5SQB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
UCSCuc007ikf.2. mouse.

Organism-specific databases

MGIMGI:106184. Npm1.

Phylogenomic databases

GeneTreeENSGT00440000034554.
HOGENOMHOG000013061.
HOVERGENHBG001860.

Gene expression databases

ArrayExpressQ5SQB5.

Family and domain databases

Gene3D2.60.120.340. 1 hit.
InterProIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERPTHR22747. PTHR22747. 1 hit.
SUPFAMSSF69203. SSF69203. 1 hit.
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ5SQB5_MOUSE
AccessionPrimary (citable) accession number: Q5SQB5
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)