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Q5SQB5

- Q5SQB5_MOUSE

UniProt

Q5SQB5 - Q5SQB5_MOUSE

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Protein
Submitted name:

Nucleophosmin

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ribosomal large subunit binding Source: MGI
  2. ribosomal small subunit binding Source: MGI
  3. RNA binding Source: MGI
  4. rRNA binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cell volume homeostasis Source: MGI
  3. negative regulation of mRNA splicing, via spliceosome Source: MGI
  4. nucleocytoplasmic transport Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. positive regulation of cellular biosynthetic process Source: MGI
  7. positive regulation of centrosome duplication Source: MGI
  8. positive regulation of protein kinase activity Source: MGI
  9. protein localization Source: MGI
  10. protein oligomerization Source: MGI
  11. regulation of cell cycle Source: MGI
  12. regulation of centrosome duplication Source: MGI
  13. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  14. ribosomal large subunit biogenesis Source: MGI
  15. ribosomal large subunit export from nucleus Source: MGI
  16. ribosomal small subunit biogenesis Source: MGI
  17. ribosomal small subunit export from nucleus Source: MGI
  18. rRNA export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NucleophosminImported
Gene namesi
Name:Npm1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. granular component Source: MGI
  5. large ribosomal subunit Source: MGI
  6. nuclear speck Source: MGI
  7. nucleolus Source: MGI
  8. nucleoplasm Source: MGI
  9. nucleus Source: MGI
  10. ribonucleoprotein complex Source: MGI
  11. small ribosomal subunit Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5SQB5.

Expressioni

Gene expression databases

ExpressionAtlasiQ5SQB5. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ5SQB5.
SMRiQ5SQB5. Positions 13-120, 223-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000034554.
HOGENOMiHOG000013061.
HOVERGENiHBG001860.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SQB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK
160 170 180 190 200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA
210 220 230 240 250
KNAQKSNQNG KDLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ
260 270 280
ASIEKFSHGF RRFSSFVQPQ MDWNLALGST FHISY
Length:285
Mass (Da):31,723
Last modified:December 21, 2004 - v1
Checksum:i1F7EC713C23106D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772409 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000101375; ENSMUSP00000098926; ENSMUSG00000057113.
UCSCiuc007ikf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772409 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5SQB5.
SMRi Q5SQB5. Positions 13-120, 223-255.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5SQB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101375 ; ENSMUSP00000098926 ; ENSMUSG00000057113 .
UCSCi uc007ikf.2. mouse.

Organism-specific databases

MGIi MGI:106184. Npm1.

Phylogenomic databases

GeneTreei ENSGT00440000034554.
HOGENOMi HOG000013061.
HOVERGENi HBG001860.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q5SQB5. baseline.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5SQB5_MOUSE
AccessioniPrimary (citable) accession number: Q5SQB5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3