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Q5SQB0

- Q5SQB0_MOUSE

UniProt

Q5SQB0 - Q5SQB0_MOUSE

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Protein
Submitted name:

Nucleophosmin

Gene
Npm1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. ribosomal large subunit binding Source: MGI
  3. ribosomal small subunit binding Source: MGI
  4. RNA binding Source: MGI
  5. rRNA binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cell volume homeostasis Source: MGI
  3. negative regulation of mRNA splicing, via spliceosome Source: MGI
  4. nucleocytoplasmic transport Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. positive regulation of cellular biosynthetic process Source: MGI
  7. positive regulation of centrosome duplication Source: MGI
  8. positive regulation of protein kinase activity Source: MGI
  9. protein localization Source: MGI
  10. protein oligomerization Source: MGI
  11. regulation of cell cycle Source: MGI
  12. regulation of centrosome duplication Source: MGI
  13. regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  14. ribosomal large subunit biogenesis Source: MGI
  15. ribosomal large subunit export from nucleus Source: MGI
  16. ribosomal small subunit biogenesis Source: MGI
  17. ribosomal small subunit export from nucleus Source: MGI
  18. rRNA export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NucleophosminImported
Gene namesi
Name:Npm1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. granular component Source: MGI
  5. large ribosomal subunit Source: MGI
  6. nuclear speck Source: MGI
  7. nucleolus Source: MGI
  8. nucleoplasm Source: MGI
  9. nucleus Source: MGI
  10. ribonucleoprotein complex Source: MGI
  11. small ribosomal subunit Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5SQB0.

Expressioni

Gene expression databases

ArrayExpressiQ5SQB0.

Structurei

3D structure databases

ProteinModelPortaliQ5SQB0.
SMRiQ5SQB0. Positions 13-120, 195-264.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00440000034554.
HOGENOMiHOG000013061.
HOVERGENiHBG001860.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SQB0-1 [UniParc]FASTAAdd to Basket

« Hide

MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG    50
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL 100
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK 150
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKGQESFKK 200
QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD 250
QEAIQDLWQW RKSL 264
Length:264
Mass (Da):29,525
Last modified:December 21, 2004 - v1
Checksum:i87C12DB1C92DAF58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772409 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000093201; ENSMUSP00000090891; ENSMUSG00000057113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772409 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5SQB0.
SMRi Q5SQB0. Positions 13-120, 195-264.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5SQB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000093201 ; ENSMUSP00000090891 ; ENSMUSG00000057113 .

Organism-specific databases

MGIi MGI:106184. Npm1.

Phylogenomic databases

GeneTreei ENSGT00440000034554.
HOGENOMi HOG000013061.
HOVERGENi HBG001860.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q5SQB0.

Family and domain databases

Gene3Di 2.60.120.340. 1 hit.
InterProi IPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view ]
PANTHERi PTHR22747. PTHR22747. 1 hit.
SUPFAMi SSF69203. SSF69203. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5SQB0_MOUSE
AccessioniPrimary (citable) accession number: Q5SQB0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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