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Protein
Submitted name:

Transducin-like enhancer protein 1

Gene

Tle1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transducin-like enhancer protein 1Imported
Gene namesi
Name:Tle1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104636 Tle1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ5SQA3

Expressioni

Gene expression databases

BgeeiENSMUSG00000008305
ExpressionAtlasiQ5SQA3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SQA3
SMRiQ5SQA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini490 – 663WD_REPEATS_REGIONInterPro annotationAdd BLAST174
Repeati580 – 621WDPROSITE-ProRule annotationAdd BLAST42
Repeati622 – 663WDPROSITE-ProRule annotationAdd BLAST42
Domaini704 – 780WD_REPEATS_REGIONInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 53Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
HOVERGENiHBG004689
OMAiKRRNGPD
OrthoDBiEOG091G181Y
PhylomeDBiQ5SQA3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q5SQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL
60 70 80 90 100
ASEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMAELN AIIGVRGLPG LPPTQQQLQA QHLSHGHGPP
160 170 180 190 200
VPLTPHPSGL QPPGIPPLGG SASLLALSSA LSGQSHLAIK DDKKHHDAER
210 220 230 240 250
HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD
260 270 280 290 300
KSDDNLVVDV SNEDPSSPHA SPTHSPRENG IDKNRLLKKD ASGSPASTAS
310 320 330 340 350
SGSSSSLKSK EVSLHEKANT PVLKSSTPTP RSDMPTPGTS ATPGLRPGLG
360 370 380 390 400
KPPAMEPLVN QAAAGLRTPL AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA
410 420 430 440 450
GLHSMSPQMS AAAAAAAAAV VAYGRSPMVG FDPPPHMRVP SIPPNLAGIP
460 470 480 490 500
GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT LNHGEVVCAV
510 520 530 540 550
TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP
560 570 580 590 600
DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF
610 620 630 640 650
SCCSDGNIAV WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV
660 670 680 690 700
RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE WLAVGMESSN VEVLHVNKPD
710 720 730 740 750
KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG ASIFQSKESS
760 770 780
SVLSCDISVD DKYIVTGSGD KKATVYEVIY
Length:780
Mass (Da):84,065
Last modified:December 21, 2004 - v1
Checksum:iD469EFC30529EFE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773513 Genomic DNA No translation available.
BX640475 Genomic DNA No translation available.
RefSeqiXP_006537821.1, XM_006537758.2
UniGeneiMm.278444
Mm.388819
Mm.399716

Genome annotation databases

EnsembliENSMUST00000030095; ENSMUSP00000030095; ENSMUSG00000008305
GeneIDi21885

Similar proteinsi

Entry informationi

Entry nameiQ5SQA3_MOUSE
AccessioniPrimary (citable) accession number: Q5SQA3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health