Q5SPD7 (P5CR3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase 3
Short name=P5C reductase 3
Short name=P5CR 3
EC=1.5.1.2

Alternative name(s):
Pyrroline-5-carboxylate reductase-like protein

Gene names

Name:	pycrl
ORF Names:	si:dkey-235d18.3

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Pyrroline-5-carboxylate reductase 3		PRO_0000324565

Sequences

	Sequence		Length	Mass (Da)
	Q5SPD7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 31A523F549C35D60	FASTA	288	29,922
	10 20 30 40 50 60 MSLSGASDKT SDSPDVFQIK IGFIGAGNMA FGVAQGIIAS GKVPPSNIII SAPSMNNLPR 70 80 90 100 110 120 FKEKGVSVTH SNHEVVGGSR LIFLAVKPHI IPQVLKEISQ EVTKEHIIVS MAAGITIATL 130 140 150 160 170 180 EELLPAGTHV IRIMPNLPCM LLEGALLLSC GSHAGEQEET LLKTLLGPCG LVEFGPESWI 190 200 210 220 230 240 DAHVGLSGSG VAFVYVFAEA LADGAVKMGM PSTLARRIAA QTILGAGVLL RDSGKLPAEL 250 260 270 280 KAEVCTPGGT TIHGIHALEK GGFRAAAIGA VEAASERARE LGNKQKKN

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL929003 Genomic DNA. Translation: CAI21008.1. BC124544 mRNA. Translation: AAI24545.1.
IPI	IPI00503414.
RefSeq	NP_001038403.1. NM_001044938.1.
UniGene	Dr.81533.
3D structure databases
HSSP	HSSP built from PDB template 2AMF based on UniProtKB Q9A1S9.
ProteinModelPortal	Q5SPD7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5SPD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000002787; ENSDARP00000011713; ENSDARG00000015236.
GeneID	560682.
KEGG	dre:560682.
Organism-specific databases
CTD	65263.
ZFIN	ZDB-GENE-041014-244. pycrl.
Phylogenomic databases
eggNOG	fiNOG09116.
GeneTree	ENSGT00390000007443.
HOGENOM	HBG726602.
HOVERGEN	HBG053399.
InParanoid	Q5SPD7.
OMA	YINIHTG.
PhylomeDB	Q5SPD7.
Gene expression databases
ArrayExpress	Q5SPD7.
Bgee	Q5SPD7.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR3_DANRE

Accession

Primary (citable) accession number: Q5SPD7
Secondary accession number(s): Q05AI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 21, 2004
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program