Q5SNZ0 (GRDN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Girdin

Alternative name(s):
Akt phosphorylation enhancer
Short name=APE
Coiled-coil domain-containing protein 88A
G alpha-interacting vesicle-associated protein
Short name=GIV
Girders of actin filament
Hook-related protein 1
Short name=HkRP1

Gene names

Name:	Ccdc88a
Synonyms:	Grdn, Kiaa1212

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1873 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome By similarity. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation. Ref.1 Ref.8
Subunit structure	Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi4P] and weakly with phosphatidylinositol 3-phosphate [Pi3P] By similarity. Interacts with microtubules. Interacts AKT1/PKB (via C-terminus). Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Ref.1 Ref.5 Ref.8 UniProtKB Q3V6T2
Subcellular location	Membrane. Cell membrane. Cytoplasm › cytosol. Cytoplasmic vesicle. Cell projection › lamellipodium By similarity. Note: Localizes to the cell membrane through interaction with phosphoinositides By similarity.
Tissue specificity	Expressed in the dentate gyrus, pyramidal cell layer of hippocampal regions CA1 and CA3 at postnatal 15. Expressed highly in neurons. Weakly in neuron progenitors (at protein level). Expressed in the dentate granule cell layer of the hippocampus. Expressed highly in the adult testis, moderately in the brain and at a low level in the spleen, lungs and fat. Ref.1 Ref.5 Ref.8
Developmental stage	Temporally and spatially restricted during embryogenesis. At E10.5, expressed in the branchial arches, nasal processes, limbs, somites and dorsal root ganglia. At E11.5, expression persists at these sites in addition to the eye and fore-, mid- and hindbrain. By E12.5, expressed in the interdigital mesenchyme of the limbs. At E13.5, expression in the limbs flanks the digits and also appears in a subset of tendons in the hind- and forelimbs. Ref.5
Post-translational modification	Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration By similarity. UniProtKB Q3V6T2
Sequence similarities	Belongs to the CCDC88 family.
Sequence caution	The sequence AAH37020.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI24877.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	DNA replication Neurogenesis
Cellular component	Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TOR signaling cascade Inferred from direct assay Ref.8. Source: UniProtKB activation of protein kinase B activity Inferred from direct assay Ref.1. Source: UniProtKB cell migration Inferred from sequence or structural similarity. Source: UniProtKB cellular membrane organization Inferred from sequence or structural similarity. Source: UniProtKB lamellipodium assembly Inferred from sequence or structural similarity. Source: UniProtKB microtubule cytoskeleton organization Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from mutant phenotype Ref.1. Source: UniProtKB regulation of actin cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell proliferation Inferred from mutant phenotype Ref.1. Source: UniProtKB regulation of neuron projection development Inferred from direct assay Ref.8. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic vesicle Inferred from sequence or structural similarity. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum Inferred from sequence or structural similarity. Source: UniProtKB lamellipodium Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB microtubule binding Inferred from direct assay Ref.5. Source: UniProtKB phosphatidylinositol binding Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: Q5SNZ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 Ref.1 (identifier: Q5SNZ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

Isoform 3 Ref.2 (identifier: Q5SNZ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1054: Missing.
     1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1873	1873	Girdin		PRO_0000287430
Regions
	Region	1390 – 1408	19	Phosphoinositide-binding By similarity UniProtKB Q3V6T2
	Coiled coil	196 – 425	230	Potential
	Coiled coil	458 – 1232	775	Potential
	Coiled coil	1268 – 1385	118	Potential
Amino acid modifications
	Modified residue	1387	1	Phosphoserine By similarity UniProtKB Q3V6T2
	Modified residue	1417	1	Phosphoserine; by PKB/AKT1 By similarity UniProtKB Q3V6T2
	Modified residue	1560	1	Phosphothreonine Ref.6
	Modified residue	1561	1	Phosphothreonine Ref.6
	Modified residue	1562	1	Phosphoserine Ref.6
	Modified residue	1677	1	Phosphoserine Ref.6
	Modified residue	1704	1	Phosphoserine Ref.6
	Modified residue	1839	1	Phosphoserine By similarity
	Modified residue	1840	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1000 – 1054	55	Missing in isoform 3. Ref.2		VSP_052410
	Alternative sequence	1463 – 1491	29	MVALK…RRSMS → T in isoform 2 and isoform 3. Ref.1 Ref.2		VSP_052411
Experimental info
	Sequence conflict	952	1	Missing in CAI35999. Ref.2
	Sequence conflict	1086 – 1089	4	LQRQ → PRVR in AAH37020. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 0E827E3D9336161F	FASTA	1,873	215,918
	10 20 30 40 50 60 MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ VMLQINPKSE 70 80 90 100 110 120 SQRVNKKVNN DASLRIHNLS ILVKQIKFYY QETLQQLIMM PLPDILIIGK NPFSEQGTEE 130 140 150 160 170 180 VKKLLLLLLG CAVQCQKKEE FIEKIQGLDF DTKAAVAAHI QEVTHNQENV FDLQWMEVTD 190 200 210 220 230 240 MSQEDIEPLL KNMVSHLRRL IDERDEHSET IVELSEERDG VHFLPHASSS AQSPCGSPGM 250 260 270 280 290 300 KRTESRQHLS VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQIEVELKR LQQENMNLLS 310 320 330 340 350 360 DARSARMYRD ELDALREKAV RVDKLESELS RYKERLHDIE FYKARVEELK EDNQVLLETK 370 380 390 400 410 420 TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM DRKKIEELME ENMTLEMAQK 430 440 450 460 470 480 QSMDESLHLG WELEQISRTS ELAEAPQKSL GHEVNELTSS KLLKLEMENQ SLTKTVEELR 490 500 510 520 530 540 STADSAAGST SKILKVEKEN QRLNKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK 550 560 570 580 590 600 TIETLRENSE RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETC 610 620 630 640 650 660 GKLSKIEFEK RQMKKELELY KEKGERAEEL ENELNHLGKE NELLQKKITN LKITCEKLET 670 680 690 700 710 720 LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD EENLELRRSV ESLKCASMRM 730 740 750 760 770 780 AQLQLENKEL ESEKEQLRKG LELMRASFKK TERLEVSYQG LDTENQRLQK ALENSNKKIQ 790 800 810 820 830 840 QLESELQDLE MENQTLQKSL EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR 850 860 870 880 890 900 LRQQAEIKDT TLEENNVKIG NLEKENKTLF KEINVYKESC VRLKELEKEN KELVKRATID 910 920 930 940 950 960 IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD DSRYKLLESK 970 980 990 1000 1010 1020 LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRHELKTV KKNYEALKQR QDEERMVQSS 1030 1040 1050 1060 1070 1080 IPVSGEDDKW GRESQEATRE LLKVKDRLIE VERNNATLQA EKQALKTQLK QLETQNNNLQ 1090 1100 1110 1120 1130 1140 AQILALQRQT VSLQEQNTTL QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE 1150 1160 1170 1180 1190 1200 SIMKEREDLK SLYDALIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHKDLED 1210 1220 1230 1240 1250 1260 RYNQLLKQKG QLEDLEKMIK TEQEKMLLES KNHEVVASEY KKLCGENDRL NYTYSQLLKE 1270 1280 1290 1300 1310 1320 TEILQMDHKN LKSVLNNSKL EQTRLEAEFS KLKEQYQQLD ITSTKLNNQC ELLSQLKGNL 1330 1340 1350 1360 1370 1380 EEENRHLLDQ IQTLMLQNRT LLEQNMESKD LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ 1390 1400 1410 1420 1430 1440 YKFYDPSPPR RRGNWITLKM RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ 1450 1460 1470 1480 1490 1500 DSSSVGSNSL EDGQTLGTKK SSMVALKRLP FLRNRPKDKD KMKACYRRSM SMNDLVQSMV 1510 1520 1530 1540 1550 1560 LAGGQWTGST ENLEVPDDIS TGKRRKELGA MAFSTTAINF STVNSSAAFR SKQLVNNKDT 1570 1580 1590 1600 1610 1620 TSFEDISPQG ISDDSSTGSR VHASRPASLD SGRTSTSNSN NNASLHEVKA GAVNIQSRPQ 1630 1640 1650 1660 1670 1680 SHSSGDFSLL HDHETWSSSG SSPIQYLKRQ TRSSPMLQHK ISETIESRAH HKMKAGSPGS 1690 1700 1710 1720 1730 1740 EVVTLQQFLE ESNKLTSIQL KSSSQENLLD EVMKSLSVSS DFLGKDKPVS CTLARSVSGK 1750 1760 1770 1780 1790 1800 TPGDFYDRRT TKPEFLRTGP QKTEDAYTIS SAGKPTPSTQ GKIKLVKETS VSRQSKDSNP 1810 1820 1830 1840 1850 1860 YATLPRASSV ISTAEGTTRR TSIHDFLSKD SRLPVSVDSS PPTAGSSSTT ASNVNKVQES 1870 RNSKSRSREQ QSS
	Isoform 2 [UniParc]. Checksum: 87AEDC047EA4A72A	FASTA	1,845	212,497
	10 20 30 40 50 60 MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ VMLQINPKSE 70 80 90 100 110 120 SQRVNKKVNN DASLRIHNLS ILVKQIKFYY QETLQQLIMM PLPDILIIGK NPFSEQGTEE 130 140 150 160 170 180 VKKLLLLLLG CAVQCQKKEE FIEKIQGLDF DTKAAVAAHI QEVTHNQENV FDLQWMEVTD 190 200 210 220 230 240 MSQEDIEPLL KNMVSHLRRL IDERDEHSET IVELSEERDG VHFLPHASSS AQSPCGSPGM 250 260 270 280 290 300 KRTESRQHLS VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQIEVELKR LQQENMNLLS 310 320 330 340 350 360 DARSARMYRD ELDALREKAV RVDKLESELS RYKERLHDIE FYKARVEELK EDNQVLLETK 370 380 390 400 410 420 TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM DRKKIEELME ENMTLEMAQK 430 440 450 460 470 480 QSMDESLHLG WELEQISRTS ELAEAPQKSL GHEVNELTSS KLLKLEMENQ SLTKTVEELR 490 500 510 520 530 540 STADSAAGST SKILKVEKEN QRLNKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK 550 560 570 580 590 600 TIETLRENSE RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETC 610 620 630 640 650 660 GKLSKIEFEK RQMKKELELY KEKGERAEEL ENELNHLGKE NELLQKKITN LKITCEKLET 670 680 690 700 710 720 LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD EENLELRRSV ESLKCASMRM 730 740 750 760 770 780 AQLQLENKEL ESEKEQLRKG LELMRASFKK TERLEVSYQG LDTENQRLQK ALENSNKKIQ 790 800 810 820 830 840 QLESELQDLE MENQTLQKSL EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR 850 860 870 880 890 900 LRQQAEIKDT TLEENNVKIG NLEKENKTLF KEINVYKESC VRLKELEKEN KELVKRATID 910 920 930 940 950 960 IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD DSRYKLLESK 970 980 990 1000 1010 1020 LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRHELKTV KKNYEALKQR QDEERMVQSS 1030 1040 1050 1060 1070 1080 IPVSGEDDKW GRESQEATRE LLKVKDRLIE VERNNATLQA EKQALKTQLK QLETQNNNLQ 1090 1100 1110 1120 1130 1140 AQILALQRQT VSLQEQNTTL QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE 1150 1160 1170 1180 1190 1200 SIMKEREDLK SLYDALIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHKDLED 1210 1220 1230 1240 1250 1260 RYNQLLKQKG QLEDLEKMIK TEQEKMLLES KNHEVVASEY KKLCGENDRL NYTYSQLLKE 1270 1280 1290 1300 1310 1320 TEILQMDHKN LKSVLNNSKL EQTRLEAEFS KLKEQYQQLD ITSTKLNNQC ELLSQLKGNL 1330 1340 1350 1360 1370 1380 EEENRHLLDQ IQTLMLQNRT LLEQNMESKD LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ 1390 1400 1410 1420 1430 1440 YKFYDPSPPR RRGNWITLKM RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ 1450 1460 1470 1480 1490 1500 DSSSVGSNSL EDGQTLGTKK SSTMNDLVQS MVLAGGQWTG STENLEVPDD ISTGKRRKEL 1510 1520 1530 1540 1550 1560 GAMAFSTTAI NFSTVNSSAA FRSKQLVNNK DTTSFEDISP QGISDDSSTG SRVHASRPAS 1570 1580 1590 1600 1610 1620 LDSGRTSTSN SNNNASLHEV KAGAVNIQSR PQSHSSGDFS LLHDHETWSS SGSSPIQYLK 1630 1640 1650 1660 1670 1680 RQTRSSPMLQ HKISETIESR AHHKMKAGSP GSEVVTLQQF LEESNKLTSI QLKSSSQENL 1690 1700 1710 1720 1730 1740 LDEVMKSLSV SSDFLGKDKP VSCTLARSVS GKTPGDFYDR RTTKPEFLRT GPQKTEDAYT 1750 1760 1770 1780 1790 1800 ISSAGKPTPS TQGKIKLVKE TSVSRQSKDS NPYATLPRAS SVISTAEGTT RRTSIHDFLS 1810 1820 1830 1840 KDSRLPVSVD SSPPTAGSSS TTASNVNKVQ ESRNSKSRSR EQQSS
	Isoform 3 [UniParc]. Checksum: CD0309B2B554AB94	FASTA	1,790	205,970
	10 20 30 40 50 60 MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ VMLQINPKSE 70 80 90 100 110 120 SQRVNKKVNN DASLRIHNLS ILVKQIKFYY QETLQQLIMM PLPDILIIGK NPFSEQGTEE 130 140 150 160 170 180 VKKLLLLLLG CAVQCQKKEE FIEKIQGLDF DTKAAVAAHI QEVTHNQENV FDLQWMEVTD 190 200 210 220 230 240 MSQEDIEPLL KNMVSHLRRL IDERDEHSET IVELSEERDG VHFLPHASSS AQSPCGSPGM 250 260 270 280 290 300 KRTESRQHLS VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQIEVELKR LQQENMNLLS 310 320 330 340 350 360 DARSARMYRD ELDALREKAV RVDKLESELS RYKERLHDIE FYKARVEELK EDNQVLLETK 370 380 390 400 410 420 TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM DRKKIEELME ENMTLEMAQK 430 440 450 460 470 480 QSMDESLHLG WELEQISRTS ELAEAPQKSL GHEVNELTSS KLLKLEMENQ SLTKTVEELR 490 500 510 520 530 540 STADSAAGST SKILKVEKEN QRLNKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK 550 560 570 580 590 600 TIETLRENSE RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETC 610 620 630 640 650 660 GKLSKIEFEK RQMKKELELY KEKGERAEEL ENELNHLGKE NELLQKKITN LKITCEKLET 670 680 690 700 710 720 LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD EENLELRRSV ESLKCASMRM 730 740 750 760 770 780 AQLQLENKEL ESEKEQLRKG LELMRASFKK TERLEVSYQG LDTENQRLQK ALENSNKKIQ 790 800 810 820 830 840 QLESELQDLE MENQTLQKSL EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR 850 860 870 880 890 900 LRQQAEIKDT TLEENNVKIG NLEKENKTLF KEINVYKESC VRLKELEKEN KELVKRATID 910 920 930 940 950 960 IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD DSRYKLLESK 970 980 990 1000 1010 1020 LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRHELKTN ATLQAEKQAL KTQLKQLETQ 1030 1040 1050 1060 1070 1080 NNNLQAQILA LQRQTVSLQE QNTTLQTQNA KLQVENSTLN SQSTSLMNQN AQLLIQQSSL 1090 1100 1110 1120 1130 1140 ENENESIMKE REDLKSLYDA LIKDHEKLEL LHERQASEYE SLISKHGTLK SAHKNLEVEH 1150 1160 1170 1180 1190 1200 KDLEDRYNQL LKQKGQLEDL EKMIKTEQEK MLLESKNHEV VASEYKKLCG ENDRLNYTYS 1210 1220 1230 1240 1250 1260 QLLKETEILQ MDHKNLKSVL NNSKLEQTRL EAEFSKLKEQ YQQLDITSTK LNNQCELLSQ 1270 1280 1290 1300 1310 1320 LKGNLEEENR HLLDQIQTLM LQNRTLLEQN MESKDLFHVE QRQYIDKLNE LRRQKEKLEE 1330 1340 1350 1360 1370 1380 KIMDQYKFYD PSPPRRRGNW ITLKMRKLIK SKKDINRERQ KSLTLTPTRS DSSEGFLQLP 1390 1400 1410 1420 1430 1440 HQDSQDSSSV GSNSLEDGQT LGTKKSSTMN DLVQSMVLAG GQWTGSTENL EVPDDISTGK 1450 1460 1470 1480 1490 1500 RRKELGAMAF STTAINFSTV NSSAAFRSKQ LVNNKDTTSF EDISPQGISD DSSTGSRVHA 1510 1520 1530 1540 1550 1560 SRPASLDSGR TSTSNSNNNA SLHEVKAGAV NIQSRPQSHS SGDFSLLHDH ETWSSSGSSP 1570 1580 1590 1600 1610 1620 IQYLKRQTRS SPMLQHKISE TIESRAHHKM KAGSPGSEVV TLQQFLEESN KLTSIQLKSS 1630 1640 1650 1660 1670 1680 SQENLLDEVM KSLSVSSDFL GKDKPVSCTL ARSVSGKTPG DFYDRRTTKP EFLRTGPQKT 1690 1700 1710 1720 1730 1740 EDAYTISSAG KPTPSTQGKI KLVKETSVSR QSKDSNPYAT LPRASSVIST AEGTTRRTSI 1750 1760 1770 1780 1790 HDFLSKDSRL PVSVDSSPPT AGSSSTTASN VNKVQESRNS KSRSREQQSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis." Anai M., Shojima N., Katagiri H., Ogihara T., Sakoda H., Onishi Y., Ono H., Fujishiro M., Fukushima Y., Horike N., Viana A., Kikuchi M., Noguchi N., Takahashi S., Takata K., Oka Y., Uchijima Y., Kurihara H., Asano T. J. Biol. Chem. 280:18525-18535(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH AKT1, TISSUE SPECIFICITY. Tissue: Embryo.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1086-1873 (ISOFORMS 2/3). Strain: C57BL/6. Tissue: Retina.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1623-1873. Strain: C57BL/6J. Tissue: Embryonic stem cell.
[5]	"A novel hook-related protein family and the characterization of hook-related protein 1." Simpson F., Martin S., Evans T.M., Kerr M., James D.E., Parton R.G., Teasdale R.D., Wicking C. Traffic 6:442-458(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1560; THR-1561; SER-1562; SER-1677; SER-1704 AND SER-1840, MASS SPECTROMETRY. Tissue: Embryonic brain.
[7]	"Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways." Enomoto A., Ping J., Takahashi M. Ann. N. Y. Acad. Sci. 1086:169-184(2006) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212." Kim J.Y., Duan X., Liu C.Y., Jang M.H., Guo J.U., Pow-anpongkul N., Kang E., Song H., Ming G.L. Neuron 63:761-773(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DISC1 AND AKT PROTEINS, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB087827 mRNA. Translation: BAD98263.1. AL935054 Genomic DNA. Translation: CAI24877.1. Sequence problems. AL935054, BX284634 Genomic DNA. Translation: CAI24878.1. BX284634 Genomic DNA. Translation: CAI35999.1. BX284634 Genomic DNA. Translation: CAI36000.1. BX284634, AL935054 Genomic DNA. Translation: CAI36001.1. BX284634 Genomic DNA. Translation: CAI36002.1. BC037020 mRNA. Translation: AAH37020.1. Different initiation. AK082771 mRNA. Translation: BAC38612.1.
IPI	IPI00461244. IPI00551498. IPI00648605.
RefSeq	NP_789811.2. NM_176841.4.
UniGene	Mm.338284. Mm.441367.
3D structure databases
ProteinModelPortal	Q5SNZ0.
SMR	Q5SNZ0. Positions 14-163.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SNZ0. 1 interaction.
PTM databases
PhosphoSite	Q5SNZ0.
Proteomic databases
PaxDb	Q5SNZ0.
PRIDE	Q5SNZ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000040182; ENSMUSP00000048978; ENSMUSG00000032740.
GeneID	108686.
KEGG	mmu:108686.
UCSC	uc007igw.1. mouse.
Organism-specific databases
CTD	55704.
MGI	MGI:1925177. Ccdc88a.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00690000101702.
HOVERGEN	HBG057867.
OMA	TGFRSKQ.
OrthoDB	EOG4W6NV4.
Gene expression databases
Bgee	Q5SNZ0.
CleanEx	MM_CCDC88A.
Genevestigator	Q5SNZ0.
Family and domain databases
InterPro	IPR008636. HOOK/CCDC88. [Graphical view]
Pfam	PF05622. HOOK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	361223.
SOURCE	Search...

Entry information

Entry name

GRDN_MOUSE

Accession

Primary (citable) accession number: Q5SNZ0
Secondary accession number(s): Q5M6X2 , Q5M6X4, Q5M6X5, Q5SNZ1, Q8C486, Q8CFU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 29, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program