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Q5SNZ0

- GRDN_MOUSE

UniProt

Q5SNZ0 - GRDN_MOUSE

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Protein

Girdin

Gene

Ccdc88a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation.By similarity2 Publications

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. microtubule binding Source: UniProtKB
  3. phosphatidylinositol binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. protein kinase B binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase B activity Source: UniProtKB
  2. cell migration Source: UniProtKB
  3. DNA replication Source: UniProtKB-KW
  4. lamellipodium assembly Source: UniProtKB
  5. membrane organization Source: UniProtKB
  6. regulation of actin cytoskeleton organization Source: UniProtKB
  7. regulation of cell proliferation Source: UniProtKB
  8. regulation of DNA replication Source: UniProtKB
  9. regulation of neuron projection development Source: UniProtKB
  10. regulation of protein phosphorylation Source: UniProtKB
  11. TOR signaling Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA replication, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Girdin
Alternative name(s):
Akt phosphorylation enhancer
Short name:
APE
Coiled-coil domain-containing protein 88A
G alpha-interacting vesicle-associated protein
Short name:
GIV
Girders of actin filament
Hook-related protein 1
Short name:
HkRP1
Gene namesi
Name:Ccdc88a
Synonyms:Grdn, Kiaa1212
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1925177. Ccdc88a.

Subcellular locationi

Membrane By similarity. Cell membrane By similarity. Cytoplasmcytosol. Cytoplasmic vesicle By similarity. Cell projectionlamellipodium By similarity
Note: Localizes to the cell membrane through interaction with phosphoinositides.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. Golgi apparatus Source: UniProtKB
  5. lamellipodium Source: UniProtKB
  6. membrane Source: UniProtKB
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18731873GirdinPRO_0000287430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1387 – 13871PhosphoserineBy similarity
Modified residuei1417 – 14171Phosphoserine; by PKB/AKT1By similarity
Modified residuei1677 – 16771Phosphoserine1 Publication
Modified residuei1839 – 18391PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5SNZ0.
PaxDbiQ5SNZ0.
PRIDEiQ5SNZ0.

PTM databases

PhosphoSiteiQ5SNZ0.

Expressioni

Tissue specificityi

Expressed in the dentate gyrus, pyramidal cell layer of hippocampal regions CA1 and CA3 at postnatal 15. Expressed highly in neurons. Weakly in neuron progenitors (at protein level). Expressed in the dentate granule cell layer of the hippocampus. Expressed highly in the adult testis, moderately in the brain and at a low level in the spleen, lungs and fat.3 Publications

Developmental stagei

Temporally and spatially restricted during embryogenesis. At E10.5, expressed in the branchial arches, nasal processes, limbs, somites and dorsal root ganglia. At E11.5, expression persists at these sites in addition to the eye and fore-, mid- and hindbrain. By E12.5, expressed in the interdigital mesenchyme of the limbs. At E13.5, expression in the limbs flanks the digits and also appears in a subset of tendons in the hind- and forelimbs.1 Publication

Gene expression databases

BgeeiQ5SNZ0.
CleanExiMM_CCDC88A.
ExpressionAtlasiQ5SNZ0. baseline and differential.
GenevestigatoriQ5SNZ0.

Interactioni

Subunit structurei

Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi4P] and weakly with phosphatidylinositol 3-phosphate [Pi3P] (By similarity). Interacts with microtubules. Interacts AKT1/PKB (via C-terminus). Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1.By similarity3 Publications

Protein-protein interaction databases

BioGridi224370. 4 interactions.
IntActiQ5SNZ0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5SNZ0.
SMRiQ5SNZ0. Positions 14-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1390 – 140819Phosphoinositide-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili196 – 425230Sequence AnalysisAdd
BLAST
Coiled coili458 – 1232775Sequence AnalysisAdd
BLAST
Coiled coili1268 – 1385118Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00690000101702.
HOVERGENiHBG057867.
InParanoidiQ5SNZ0.
OMAiCIRLKEL.
OrthoDBiEOG7N0C3V.
PhylomeDBiQ5SNZ0.
TreeFamiTF320231.

Family and domain databases

InterProiIPR027717. Girdin.
IPR008636. Hook-related_fam.
[Graphical view]
PANTHERiPTHR18947. PTHR18947. 1 hit.
PTHR18947:SF30. PTHR18947:SF30. 1 hit.
PfamiPF05622. HOOK. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SNZ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ
60 70 80 90 100
VMLQINPKSE SQRVNKKVNN DASLRIHNLS ILVKQIKFYY QETLQQLIMM
110 120 130 140 150
PLPDILIIGK NPFSEQGTEE VKKLLLLLLG CAVQCQKKEE FIEKIQGLDF
160 170 180 190 200
DTKAAVAAHI QEVTHNQENV FDLQWMEVTD MSQEDIEPLL KNMVSHLRRL
210 220 230 240 250
IDERDEHSET IVELSEERDG VHFLPHASSS AQSPCGSPGM KRTESRQHLS
260 270 280 290 300
VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQIEVELKR LQQENMNLLS
310 320 330 340 350
DARSARMYRD ELDALREKAV RVDKLESELS RYKERLHDIE FYKARVEELK
360 370 380 390 400
EDNQVLLETK TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM
410 420 430 440 450
DRKKIEELME ENMTLEMAQK QSMDESLHLG WELEQISRTS ELAEAPQKSL
460 470 480 490 500
GHEVNELTSS KLLKLEMENQ SLTKTVEELR STADSAAGST SKILKVEKEN
510 520 530 540 550
QRLNKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK TIETLRENSE
560 570 580 590 600
RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETC
610 620 630 640 650
GKLSKIEFEK RQMKKELELY KEKGERAEEL ENELNHLGKE NELLQKKITN
660 670 680 690 700
LKITCEKLET LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD
710 720 730 740 750
EENLELRRSV ESLKCASMRM AQLQLENKEL ESEKEQLRKG LELMRASFKK
760 770 780 790 800
TERLEVSYQG LDTENQRLQK ALENSNKKIQ QLESELQDLE MENQTLQKSL
810 820 830 840 850
EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR LRQQAEIKDT
860 870 880 890 900
TLEENNVKIG NLEKENKTLF KEINVYKESC VRLKELEKEN KELVKRATID
910 920 930 940 950
IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD
960 970 980 990 1000
DSRYKLLESK LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRHELKTV
1010 1020 1030 1040 1050
KKNYEALKQR QDEERMVQSS IPVSGEDDKW GRESQEATRE LLKVKDRLIE
1060 1070 1080 1090 1100
VERNNATLQA EKQALKTQLK QLETQNNNLQ AQILALQRQT VSLQEQNTTL
1110 1120 1130 1140 1150
QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE SIMKEREDLK
1160 1170 1180 1190 1200
SLYDALIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHKDLED
1210 1220 1230 1240 1250
RYNQLLKQKG QLEDLEKMIK TEQEKMLLES KNHEVVASEY KKLCGENDRL
1260 1270 1280 1290 1300
NYTYSQLLKE TEILQMDHKN LKSVLNNSKL EQTRLEAEFS KLKEQYQQLD
1310 1320 1330 1340 1350
ITSTKLNNQC ELLSQLKGNL EEENRHLLDQ IQTLMLQNRT LLEQNMESKD
1360 1370 1380 1390 1400
LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ YKFYDPSPPR RRGNWITLKM
1410 1420 1430 1440 1450
RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ DSSSVGSNSL
1460 1470 1480 1490 1500
EDGQTLGTKK SSMVALKRLP FLRNRPKDKD KMKACYRRSM SMNDLVQSMV
1510 1520 1530 1540 1550
LAGGQWTGST ENLEVPDDIS TGKRRKELGA MAFSTTAINF STVNSSAAFR
1560 1570 1580 1590 1600
SKQLVNNKDT TSFEDISPQG ISDDSSTGSR VHASRPASLD SGRTSTSNSN
1610 1620 1630 1640 1650
NNASLHEVKA GAVNIQSRPQ SHSSGDFSLL HDHETWSSSG SSPIQYLKRQ
1660 1670 1680 1690 1700
TRSSPMLQHK ISETIESRAH HKMKAGSPGS EVVTLQQFLE ESNKLTSIQL
1710 1720 1730 1740 1750
KSSSQENLLD EVMKSLSVSS DFLGKDKPVS CTLARSVSGK TPGDFYDRRT
1760 1770 1780 1790 1800
TKPEFLRTGP QKTEDAYTIS SAGKPTPSTQ GKIKLVKETS VSRQSKDSNP
1810 1820 1830 1840 1850
YATLPRASSV ISTAEGTTRR TSIHDFLSKD SRLPVSVDSS PPTAGSSSTT
1860 1870
ASNVNKVQES RNSKSRSREQ QSS

Note: No experimental confirmation available.Curated

Length:1,873
Mass (Da):215,918
Last modified:May 15, 2007 - v2
Checksum:i0E827E3D9336161F
GO
Isoform 21 Publication (identifier: Q5SNZ0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

Show »
Length:1,845
Mass (Da):212,497
Checksum:i87AEDC047EA4A72A
GO
Isoform 3 (identifier: Q5SNZ0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1054: Missing.
     1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

Note: No experimental confirmation available.Curated

Show »
Length:1,790
Mass (Da):205,970
Checksum:iCD0309B2B554AB94
GO

Sequence cautioni

The sequence AAH37020.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI24877.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti952 – 9521Missing in CAI35999. (PubMed:19468303)Curated
Sequence conflicti1086 – 10894LQRQ → PRVR in AAH37020. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1000 – 105455Missing in isoform 3. CuratedVSP_052410Add
BLAST
Alternative sequencei1463 – 149129MVALK…RRSMS → T in isoform 2 and isoform 3. 1 PublicationVSP_052411Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB087827 mRNA. Translation: BAD98263.1.
AL935054 Genomic DNA. Translation: CAI24877.1. Sequence problems.
AL935054, BX284634 Genomic DNA. Translation: CAI24878.1.
BX284634 Genomic DNA. Translation: CAI35999.1.
BX284634 Genomic DNA. Translation: CAI36000.1.
BX284634, AL935054 Genomic DNA. Translation: CAI36001.1.
BX284634 Genomic DNA. Translation: CAI36002.1.
BC037020 mRNA. Translation: AAH37020.1. Different initiation.
AK082771 mRNA. Translation: BAC38612.1.
CCDSiCCDS24494.1. [Q5SNZ0-2]
RefSeqiNP_789811.2. NM_176841.4. [Q5SNZ0-2]
XP_006514518.1. XM_006514455.1. [Q5SNZ0-1]
UniGeneiMm.338284.
Mm.441367.

Genome annotation databases

EnsembliENSMUST00000040182; ENSMUSP00000048978; ENSMUSG00000032740. [Q5SNZ0-2]
GeneIDi108686.
KEGGimmu:108686.
UCSCiuc007igw.1. mouse. [Q5SNZ0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB087827 mRNA. Translation: BAD98263.1 .
AL935054 Genomic DNA. Translation: CAI24877.1 . Sequence problems.
AL935054 , BX284634 Genomic DNA. Translation: CAI24878.1 .
BX284634 Genomic DNA. Translation: CAI35999.1 .
BX284634 Genomic DNA. Translation: CAI36000.1 .
BX284634 , AL935054 Genomic DNA. Translation: CAI36001.1 .
BX284634 Genomic DNA. Translation: CAI36002.1 .
BC037020 mRNA. Translation: AAH37020.1 . Different initiation.
AK082771 mRNA. Translation: BAC38612.1 .
CCDSi CCDS24494.1. [Q5SNZ0-2 ]
RefSeqi NP_789811.2. NM_176841.4. [Q5SNZ0-2 ]
XP_006514518.1. XM_006514455.1. [Q5SNZ0-1 ]
UniGenei Mm.338284.
Mm.441367.

3D structure databases

ProteinModelPortali Q5SNZ0.
SMRi Q5SNZ0. Positions 14-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224370. 4 interactions.
IntActi Q5SNZ0. 1 interaction.

PTM databases

PhosphoSitei Q5SNZ0.

Proteomic databases

MaxQBi Q5SNZ0.
PaxDbi Q5SNZ0.
PRIDEi Q5SNZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040182 ; ENSMUSP00000048978 ; ENSMUSG00000032740 . [Q5SNZ0-2 ]
GeneIDi 108686.
KEGGi mmu:108686.
UCSCi uc007igw.1. mouse. [Q5SNZ0-2 ]

Organism-specific databases

CTDi 55704.
MGIi MGI:1925177. Ccdc88a.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00690000101702.
HOVERGENi HBG057867.
InParanoidi Q5SNZ0.
OMAi CIRLKEL.
OrthoDBi EOG7N0C3V.
PhylomeDBi Q5SNZ0.
TreeFami TF320231.

Miscellaneous databases

ChiTaRSi Ccdc88a. mouse.
NextBioi 361223.
PROi Q5SNZ0.
SOURCEi Search...

Gene expression databases

Bgeei Q5SNZ0.
CleanExi MM_CCDC88A.
ExpressionAtlasi Q5SNZ0. baseline and differential.
Genevestigatori Q5SNZ0.

Family and domain databases

InterProi IPR027717. Girdin.
IPR008636. Hook-related_fam.
[Graphical view ]
PANTHERi PTHR18947. PTHR18947. 1 hit.
PTHR18947:SF30. PTHR18947:SF30. 1 hit.
Pfami PF05622. HOOK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH AKT1, TISSUE SPECIFICITY.
    Tissue: Embryo1 Publication.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1086-1873 (ISOFORMS 2/3).
    Strain: C57BL/6Imported.
    Tissue: RetinaImported.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1623-1873.
    Strain: C57BL/6JImported.
    Tissue: Embryonic stem cellImported.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A novel hook-related protein family and the characterization of hook-related protein 1."
    Simpson F., Martin S., Evans T.M., Kerr M., James D.E., Parton R.G., Teasdale R.D., Wicking C.
    Traffic 6:442-458(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways."
    Enomoto A., Ping J., Takahashi M.
    Ann. N. Y. Acad. Sci. 1086:169-184(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212."
    Kim J.Y., Duan X., Liu C.Y., Jang M.H., Guo J.U., Pow-anpongkul N., Kang E., Song H., Ming G.L.
    Neuron 63:761-773(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DISC1 AND AKT PROTEINS, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGRDN_MOUSE
AccessioniPrimary (citable) accession number: Q5SNZ0
Secondary accession number(s): Q5M6X2
, Q5M6X4, Q5M6X5, Q5SNZ1, Q8C486, Q8CFU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3