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Q5SNZ0

- GRDN_MOUSE

UniProt

Q5SNZ0 - GRDN_MOUSE

Protein

Girdin

Gene

Ccdc88a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome By similarity. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation.By similarity2 Publications

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. microtubule binding Source: UniProtKB
    3. phosphatidylinositol binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: UniProtKB
    6. protein kinase B binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. cell migration Source: UniProtKB
    3. DNA replication Source: UniProtKB-KW
    4. lamellipodium assembly Source: UniProtKB
    5. membrane organization Source: UniProtKB
    6. regulation of actin cytoskeleton organization Source: UniProtKB
    7. regulation of cell proliferation Source: UniProtKB
    8. regulation of DNA replication Source: UniProtKB
    9. regulation of neuron projection development Source: UniProtKB
    10. regulation of protein phosphorylation Source: UniProtKB
    11. TOR signaling Source: UniProtKB

    Keywords - Biological processi

    DNA replication, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Girdin
    Alternative name(s):
    Akt phosphorylation enhancer
    Short name:
    APE
    Coiled-coil domain-containing protein 88A
    G alpha-interacting vesicle-associated protein
    Short name:
    GIV
    Girders of actin filament
    Hook-related protein 1
    Short name:
    HkRP1
    Gene namesi
    Name:Ccdc88a
    Synonyms:Grdn, Kiaa1212
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1925177. Ccdc88a.

    Subcellular locationi

    Membrane By similarity. Cell membrane By similarity. Cytoplasmcytosol. Cytoplasmic vesicle By similarity. Cell projectionlamellipodium By similarity
    Note: Localizes to the cell membrane through interaction with phosphoinositides.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. endoplasmic reticulum Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB
    6. lamellipodium Source: UniProtKB
    7. membrane Source: UniProtKB
    8. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18731873GirdinPRO_0000287430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1387 – 13871PhosphoserineBy similarity
    Modified residuei1417 – 14171Phosphoserine; by PKB/AKT1By similarity
    Modified residuei1677 – 16771Phosphoserine1 Publication
    Modified residuei1839 – 18391PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5SNZ0.
    PaxDbiQ5SNZ0.
    PRIDEiQ5SNZ0.

    PTM databases

    PhosphoSiteiQ5SNZ0.

    Expressioni

    Tissue specificityi

    Expressed in the dentate gyrus, pyramidal cell layer of hippocampal regions CA1 and CA3 at postnatal 15. Expressed highly in neurons. Weakly in neuron progenitors (at protein level). Expressed in the dentate granule cell layer of the hippocampus. Expressed highly in the adult testis, moderately in the brain and at a low level in the spleen, lungs and fat.3 Publications

    Developmental stagei

    Temporally and spatially restricted during embryogenesis. At E10.5, expressed in the branchial arches, nasal processes, limbs, somites and dorsal root ganglia. At E11.5, expression persists at these sites in addition to the eye and fore-, mid- and hindbrain. By E12.5, expressed in the interdigital mesenchyme of the limbs. At E13.5, expression in the limbs flanks the digits and also appears in a subset of tendons in the hind- and forelimbs.1 Publication

    Gene expression databases

    BgeeiQ5SNZ0.
    CleanExiMM_CCDC88A.
    GenevestigatoriQ5SNZ0.

    Interactioni

    Subunit structurei

    Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [Pi4P] and weakly with phosphatidylinositol 3-phosphate [Pi3P] By similarity. Interacts with microtubules. Interacts AKT1/PKB (via C-terminus). Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi224370. 2 interactions.
    IntActiQ5SNZ0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SNZ0.
    SMRiQ5SNZ0. Positions 14-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1390 – 140819Phosphoinositide-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili196 – 425230Sequence AnalysisAdd
    BLAST
    Coiled coili458 – 1232775Sequence AnalysisAdd
    BLAST
    Coiled coili1268 – 1385118Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC88 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00690000101702.
    HOVERGENiHBG057867.
    OMAiCIRLKEL.
    OrthoDBiEOG7N0C3V.
    PhylomeDBiQ5SNZ0.
    TreeFamiTF320231.

    Family and domain databases

    InterProiIPR027717. Girdin.
    IPR008636. Hook-related_fam.
    [Graphical view]
    PANTHERiPTHR18947. PTHR18947. 1 hit.
    PTHR18947:SF30. PTHR18947:SF30. 1 hit.
    PfamiPF05622. HOOK. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5SNZ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ     50
    VMLQINPKSE SQRVNKKVNN DASLRIHNLS ILVKQIKFYY QETLQQLIMM 100
    PLPDILIIGK NPFSEQGTEE VKKLLLLLLG CAVQCQKKEE FIEKIQGLDF 150
    DTKAAVAAHI QEVTHNQENV FDLQWMEVTD MSQEDIEPLL KNMVSHLRRL 200
    IDERDEHSET IVELSEERDG VHFLPHASSS AQSPCGSPGM KRTESRQHLS 250
    VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQIEVELKR LQQENMNLLS 300
    DARSARMYRD ELDALREKAV RVDKLESELS RYKERLHDIE FYKARVEELK 350
    EDNQVLLETK TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM 400
    DRKKIEELME ENMTLEMAQK QSMDESLHLG WELEQISRTS ELAEAPQKSL 450
    GHEVNELTSS KLLKLEMENQ SLTKTVEELR STADSAAGST SKILKVEKEN 500
    QRLNKKVEIL ENEIIQEKQS LQNCQNLSKD LMKEKAQLEK TIETLRENSE 550
    RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETC 600
    GKLSKIEFEK RQMKKELELY KEKGERAEEL ENELNHLGKE NELLQKKITN 650
    LKITCEKLET LEQENSELER ENRKFKKTLD SFKNLTFQLE SLEKENSQLD 700
    EENLELRRSV ESLKCASMRM AQLQLENKEL ESEKEQLRKG LELMRASFKK 750
    TERLEVSYQG LDTENQRLQK ALENSNKKIQ QLESELQDLE MENQTLQKSL 800
    EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR LRQQAEIKDT 850
    TLEENNVKIG NLEKENKTLF KEINVYKESC VRLKELEKEN KELVKRATID 900
    IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD 950
    DSRYKLLESK LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRHELKTV 1000
    KKNYEALKQR QDEERMVQSS IPVSGEDDKW GRESQEATRE LLKVKDRLIE 1050
    VERNNATLQA EKQALKTQLK QLETQNNNLQ AQILALQRQT VSLQEQNTTL 1100
    QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE SIMKEREDLK 1150
    SLYDALIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHKDLED 1200
    RYNQLLKQKG QLEDLEKMIK TEQEKMLLES KNHEVVASEY KKLCGENDRL 1250
    NYTYSQLLKE TEILQMDHKN LKSVLNNSKL EQTRLEAEFS KLKEQYQQLD 1300
    ITSTKLNNQC ELLSQLKGNL EEENRHLLDQ IQTLMLQNRT LLEQNMESKD 1350
    LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ YKFYDPSPPR RRGNWITLKM 1400
    RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ DSSSVGSNSL 1450
    EDGQTLGTKK SSMVALKRLP FLRNRPKDKD KMKACYRRSM SMNDLVQSMV 1500
    LAGGQWTGST ENLEVPDDIS TGKRRKELGA MAFSTTAINF STVNSSAAFR 1550
    SKQLVNNKDT TSFEDISPQG ISDDSSTGSR VHASRPASLD SGRTSTSNSN 1600
    NNASLHEVKA GAVNIQSRPQ SHSSGDFSLL HDHETWSSSG SSPIQYLKRQ 1650
    TRSSPMLQHK ISETIESRAH HKMKAGSPGS EVVTLQQFLE ESNKLTSIQL 1700
    KSSSQENLLD EVMKSLSVSS DFLGKDKPVS CTLARSVSGK TPGDFYDRRT 1750
    TKPEFLRTGP QKTEDAYTIS SAGKPTPSTQ GKIKLVKETS VSRQSKDSNP 1800
    YATLPRASSV ISTAEGTTRR TSIHDFLSKD SRLPVSVDSS PPTAGSSSTT 1850
    ASNVNKVQES RNSKSRSREQ QSS 1873

    Note: No experimental confirmation available.Curated

    Length:1,873
    Mass (Da):215,918
    Last modified:May 15, 2007 - v2
    Checksum:i0E827E3D9336161F
    GO
    Isoform 21 Publication (identifier: Q5SNZ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

    Show »
    Length:1,845
    Mass (Da):212,497
    Checksum:i87AEDC047EA4A72A
    GO
    Isoform 3 (identifier: Q5SNZ0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1000-1054: Missing.
         1463-1491: MVALKRLPFLRNRPKDKDKMKACYRRSMS → T

    Note: No experimental confirmation available.Curated

    Show »
    Length:1,790
    Mass (Da):205,970
    Checksum:iCD0309B2B554AB94
    GO

    Sequence cautioni

    The sequence AAH37020.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI24877.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti952 – 9521Missing in CAI35999. (PubMed:19468303)Curated
    Sequence conflicti1086 – 10894LQRQ → PRVR in AAH37020. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1000 – 105455Missing in isoform 3. CuratedVSP_052410Add
    BLAST
    Alternative sequencei1463 – 149129MVALK…RRSMS → T in isoform 2 and isoform 3. 1 PublicationVSP_052411Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087827 mRNA. Translation: BAD98263.1.
    AL935054 Genomic DNA. Translation: CAI24877.1. Sequence problems.
    AL935054, BX284634 Genomic DNA. Translation: CAI24878.1.
    BX284634 Genomic DNA. Translation: CAI35999.1.
    BX284634 Genomic DNA. Translation: CAI36000.1.
    BX284634, AL935054 Genomic DNA. Translation: CAI36001.1.
    BX284634 Genomic DNA. Translation: CAI36002.1.
    BC037020 mRNA. Translation: AAH37020.1. Different initiation.
    AK082771 mRNA. Translation: BAC38612.1.
    CCDSiCCDS24494.1. [Q5SNZ0-2]
    RefSeqiNP_789811.2. NM_176841.4. [Q5SNZ0-2]
    XP_006514518.1. XM_006514455.1. [Q5SNZ0-1]
    UniGeneiMm.338284.
    Mm.441367.

    Genome annotation databases

    EnsembliENSMUST00000040182; ENSMUSP00000048978; ENSMUSG00000032740. [Q5SNZ0-2]
    GeneIDi108686.
    KEGGimmu:108686.
    UCSCiuc007igw.1. mouse. [Q5SNZ0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB087827 mRNA. Translation: BAD98263.1 .
    AL935054 Genomic DNA. Translation: CAI24877.1 . Sequence problems.
    AL935054 , BX284634 Genomic DNA. Translation: CAI24878.1 .
    BX284634 Genomic DNA. Translation: CAI35999.1 .
    BX284634 Genomic DNA. Translation: CAI36000.1 .
    BX284634 , AL935054 Genomic DNA. Translation: CAI36001.1 .
    BX284634 Genomic DNA. Translation: CAI36002.1 .
    BC037020 mRNA. Translation: AAH37020.1 . Different initiation.
    AK082771 mRNA. Translation: BAC38612.1 .
    CCDSi CCDS24494.1. [Q5SNZ0-2 ]
    RefSeqi NP_789811.2. NM_176841.4. [Q5SNZ0-2 ]
    XP_006514518.1. XM_006514455.1. [Q5SNZ0-1 ]
    UniGenei Mm.338284.
    Mm.441367.

    3D structure databases

    ProteinModelPortali Q5SNZ0.
    SMRi Q5SNZ0. Positions 14-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224370. 2 interactions.
    IntActi Q5SNZ0. 1 interaction.

    PTM databases

    PhosphoSitei Q5SNZ0.

    Proteomic databases

    MaxQBi Q5SNZ0.
    PaxDbi Q5SNZ0.
    PRIDEi Q5SNZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040182 ; ENSMUSP00000048978 ; ENSMUSG00000032740 . [Q5SNZ0-2 ]
    GeneIDi 108686.
    KEGGi mmu:108686.
    UCSCi uc007igw.1. mouse. [Q5SNZ0-2 ]

    Organism-specific databases

    CTDi 55704.
    MGIi MGI:1925177. Ccdc88a.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00690000101702.
    HOVERGENi HBG057867.
    OMAi CIRLKEL.
    OrthoDBi EOG7N0C3V.
    PhylomeDBi Q5SNZ0.
    TreeFami TF320231.

    Miscellaneous databases

    NextBioi 361223.
    PROi Q5SNZ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5SNZ0.
    CleanExi MM_CCDC88A.
    Genevestigatori Q5SNZ0.

    Family and domain databases

    InterProi IPR027717. Girdin.
    IPR008636. Hook-related_fam.
    [Graphical view ]
    PANTHERi PTHR18947. PTHR18947. 1 hit.
    PTHR18947:SF30. PTHR18947:SF30. 1 hit.
    Pfami PF05622. HOOK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH AKT1, TISSUE SPECIFICITY.
      Tissue: Embryo1 Publication.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1086-1873 (ISOFORMS 2/3).
      Strain: C57BL/6Imported.
      Tissue: RetinaImported.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1623-1873.
      Strain: C57BL/6JImported.
      Tissue: Embryonic stem cellImported.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1677, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A novel hook-related protein family and the characterization of hook-related protein 1."
      Simpson F., Martin S., Evans T.M., Kerr M., James D.E., Parton R.G., Teasdale R.D., Wicking C.
      Traffic 6:442-458(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    8. "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways."
      Enomoto A., Ping J., Takahashi M.
      Ann. N. Y. Acad. Sci. 1086:169-184(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212."
      Kim J.Y., Duan X., Liu C.Y., Jang M.H., Guo J.U., Pow-anpongkul N., Kang E., Song H., Ming G.L.
      Neuron 63:761-773(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DISC1 AND AKT PROTEINS, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGRDN_MOUSE
    AccessioniPrimary (citable) accession number: Q5SNZ0
    Secondary accession number(s): Q5M6X2
    , Q5M6X4, Q5M6X5, Q5SNZ1, Q8C486, Q8CFU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3