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Q5SNT6

- FA21B_HUMAN

UniProt

Q5SNT6 - FA21B_HUMAN

Protein

WASH complex subunit FAM21B

Gene

FAM21B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.By similarity

    GO - Biological processi

    1. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WASH complex subunit FAM21B
    Gene namesi
    Name:FAM21B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23417. FAM21B.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell
    3. WASH complex Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134877872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12531253WASH complex subunit FAM21BPRO_0000317300Add
    BLAST

    Proteomic databases

    MaxQBiQ5SNT6.
    PaxDbiQ5SNT6.
    PRIDEiQ5SNT6.

    PTM databases

    PhosphoSiteiQ5SNT6.

    Expressioni

    Gene expression databases

    BgeeiQ5SNT6.
    CleanExiHS_FAM21B.
    GenevestigatoriQ5SNT6.

    Organism-specific databases

    HPAiHPA047844.

    Interactioni

    Subunit structurei

    Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120865. 7 interactions.
    IntActiQ5SNT6. 2 interactions.
    STRINGi9606.ENSP00000351259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SNT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM21 family.Curated

    Phylogenomic databases

    eggNOGiNOG76301.
    HOGENOMiHOG000112469.
    HOVERGENiHBG055529.
    InParanoidiQ5SNT6.
    OMAiYFRITEN.
    OrthoDBiEOG7GBFWP.
    PhylomeDBiQ5SNT6.
    TreeFamiTF329309.

    Family and domain databases

    InterProiIPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view]
    PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
    PfamiPF15255. CAP-ZIP_m. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SNT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN     50
    YGLQVLDSAF EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI 100
    GSKLFMEQED VGLGELSSEE GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS 150
    DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE EEDIEDIEEN TRPKRSRPTS 200
    FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE RRTPSDDEED 250
    NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG 300
    ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP 350
    RKSPYGPPPT GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG 400
    DLFKEKAVAS PEATVSQTDE NKARAEKKVT LSSSKNLKPS SETKTQKGLF 450
    SDEEDSEDLF SSQSASKLKG ASLLPGKLPT SVSLFDDEDE EDNLFGGTAA 500
    KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI PASQTHLASD 550
    SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS 600
    LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG 650
    VKSVDKKVES AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP 700
    WDKGTKPRTK TVLSLFDEEE DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG 750
    VFQDEELLFS HKLQKDNDPD VDLFAGTKKT KLLEPSVGSL FGDDEDDDLF 800
    SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK GIWKPETPQD 850
    SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF 900
    PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR 950
    RPQTRAARRL AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG 1000
    EDSTEEALAA AAAPWEGGPV PGVDRSPFAK SLGHSRGEAD LFDSGDIFST 1050
    GTGSQSVERT KPKAKIAENP ANPPVGGKAK SPMFPALGEA SSDDDLFQSA 1100
    KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI LTTQDIFEDD 1150
    IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK 1200
    SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF 1250
    GGQ 1253
    Length:1,253
    Mass (Da):136,969
    Last modified:February 5, 2008 - v2
    Checksum:iC41DE76CC1BBFF3F
    GO

    Sequence cautioni

    The sequence CAI17187.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954360 Genomic DNA. Translation: CAI17187.1. Sequence problems.
    UniGeneiHs.365286.
    Hs.449662.
    Hs.645272.

    Genome annotation databases

    KEGGihsa:55747.
    UCSCiuc001jep.4. human.

    Polymorphism databases

    DMDMi166971548.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954360 Genomic DNA. Translation: CAI17187.1 . Sequence problems.
    UniGenei Hs.365286.
    Hs.449662.
    Hs.645272.

    3D structure databases

    ProteinModelPortali Q5SNT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120865. 7 interactions.
    IntActi Q5SNT6. 2 interactions.
    STRINGi 9606.ENSP00000351259.

    PTM databases

    PhosphoSitei Q5SNT6.

    Polymorphism databases

    DMDMi 166971548.

    Proteomic databases

    MaxQBi Q5SNT6.
    PaxDbi Q5SNT6.
    PRIDEi Q5SNT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    KEGGi hsa:55747.
    UCSCi uc001jep.4. human.

    Organism-specific databases

    GeneCardsi GC10P047894.
    H-InvDB HIX0025987.
    HGNCi HGNC:23417. FAM21B.
    HPAi HPA047844.
    neXtProti NX_Q5SNT6.
    PharmGKBi PA134877872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76301.
    HOGENOMi HOG000112469.
    HOVERGENi HBG055529.
    InParanoidi Q5SNT6.
    OMAi YFRITEN.
    OrthoDBi EOG7GBFWP.
    PhylomeDBi Q5SNT6.
    TreeFami TF329309.

    Miscellaneous databases

    GenomeRNAii 55747.
    NextBioi 60723.
    PROi Q5SNT6.

    Gene expression databases

    Bgeei Q5SNT6.
    CleanExi HS_FAM21B.
    Genevestigatori Q5SNT6.

    Family and domain databases

    InterProi IPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view ]
    PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
    Pfami PF15255. CAP-ZIP_m. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFA21B_HUMAN
    AccessioniPrimary (citable) accession number: Q5SNT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3