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Q5SNT6 (FA21B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WASH complex subunit FAM21B
Gene names
Name:FAM21B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1253 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.

Subunit structure

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.

Subcellular location

Early endosome membrane By similarity.

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Sequence similarities

Belongs to the FAM21 family.

Sequence caution

The sequence CAI17187.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12531253WASH complex subunit FAM21B
PRO_0000317300

Sequences

Sequence LengthMass (Da)Tools
Q5SNT6 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: C41DE76CC1BBFF3F

FASTA1,253136,969
        10         20         30         40         50         60 
MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN YGLQVLDSAF 

        70         80         90        100        110        120 
EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI GSKLFMEQED VGLGELSSEE 

       130        140        150        160        170        180 
GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE 

       190        200        210        220        230        240 
EEDIEDIEEN TRPKRSRPTS FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE 

       250        260        270        280        290        300 
RRTPSDDEED NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG 

       310        320        330        340        350        360 
ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP RKSPYGPPPT 

       370        380        390        400        410        420 
GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG DLFKEKAVAS PEATVSQTDE 

       430        440        450        460        470        480 
NKARAEKKVT LSSSKNLKPS SETKTQKGLF SDEEDSEDLF SSQSASKLKG ASLLPGKLPT 

       490        500        510        520        530        540 
SVSLFDDEDE EDNLFGGTAA KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI 

       550        560        570        580        590        600 
PASQTHLASD SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS 

       610        620        630        640        650        660 
LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG VKSVDKKVES 

       670        680        690        700        710        720 
AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP WDKGTKPRTK TVLSLFDEEE 

       730        740        750        760        770        780 
DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG VFQDEELLFS HKLQKDNDPD VDLFAGTKKT 

       790        800        810        820        830        840 
KLLEPSVGSL FGDDEDDDLF SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK 

       850        860        870        880        890        900 
GIWKPETPQD SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF 

       910        920        930        940        950        960 
PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR RPQTRAARRL 

       970        980        990       1000       1010       1020 
AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG EDSTEEALAA AAAPWEGGPV 

      1030       1040       1050       1060       1070       1080 
PGVDRSPFAK SLGHSRGEAD LFDSGDIFST GTGSQSVERT KPKAKIAENP ANPPVGGKAK 

      1090       1100       1110       1120       1130       1140 
SPMFPALGEA SSDDDLFQSA KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI 

      1150       1160       1170       1180       1190       1200 
LTTQDIFEDD IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK 

      1210       1220       1230       1240       1250 
SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF GGQ 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954360 Genomic DNA. Translation: CAI17187.1. Sequence problems.
RefSeqNP_060702.1. NM_018232.1.
UniGeneHs.365286.
Hs.449662.

3D structure databases

ProteinModelPortalQ5SNT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120865. 7 interactions.
IntActQ5SNT6. 2 interactions.
STRING9606.ENSP00000351259.

PTM databases

PhosphoSiteQ5SNT6.

Polymorphism databases

DMDM166971548.

Proteomic databases

PaxDbQ5SNT6.
PRIDEQ5SNT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355876; ENSP00000348138; ENSG00000152726.
ENST00000358474; ENSP00000351259; ENSG00000152726.
GeneID55747.
KEGGhsa:55747.
UCSCuc001jep.4. human.

Organism-specific databases

CTD55747.
GeneCardsGC10P047894.
H-InvDBHIX0025987.
HGNCHGNC:23417. FAM21B.
HPAHPA047844.
neXtProtNX_Q5SNT6.
PharmGKBPA134877872.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76301.
HOGENOMHOG000112469.
HOVERGENHBG055529.
InParanoidQ5SNT6.
OrthoDBEOG7GBFWP.
PhylomeDBQ5SNT6.
TreeFamTF329309.

Gene expression databases

BgeeQ5SNT6.
CleanExHS_FAM21B.
GenevestigatorQ5SNT6.

Family and domain databases

InterProIPR027308. FAM21.
[Graphical view]
PANTHERPTHR21669:SF4. PTHR21669:SF4. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi55747.
NextBio60723.
PROQ5SNT6.

Entry information

Entry nameFA21B_HUMAN
AccessionPrimary (citable) accession number: Q5SNT6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM