Q5SNT6 (FA21B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WASH complex subunit FAM21B

Gene names

Name:

FAM21B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.
Subunit structure	Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.
Subcellular location	Early endosome membrane By similarity.
Miscellaneous	In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.
Sequence similarities	Belongs to the FAM21 family.
Sequence caution	The sequence CAI17187.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Endosome Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	retrograde transport, endosome to Golgi Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	WASH complex Inferred from sequence or structural similarity. Source: UniProtKB early endosome Inferred from sequence or structural similarity. Source: UniProtKB early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1253	1253	WASH complex subunit FAM21B		PRO_0000317300

Sequences

	Sequence		Length	Mass (Da)
	Q5SNT6 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: C41DE76CC1BBFF3F	FASTA	1,253	136,969
	10 20 30 40 50 60 MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN YGLQVLDSAF 70 80 90 100 110 120 EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI GSKLFMEQED VGLGELSSEE 130 140 150 160 170 180 GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE 190 200 210 220 230 240 EEDIEDIEEN TRPKRSRPTS FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE 250 260 270 280 290 300 RRTPSDDEED NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG 310 320 330 340 350 360 ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP RKSPYGPPPT 370 380 390 400 410 420 GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG DLFKEKAVAS PEATVSQTDE 430 440 450 460 470 480 NKARAEKKVT LSSSKNLKPS SETKTQKGLF SDEEDSEDLF SSQSASKLKG ASLLPGKLPT 490 500 510 520 530 540 SVSLFDDEDE EDNLFGGTAA KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI 550 560 570 580 590 600 PASQTHLASD SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS 610 620 630 640 650 660 LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG VKSVDKKVES 670 680 690 700 710 720 AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP WDKGTKPRTK TVLSLFDEEE 730 740 750 760 770 780 DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG VFQDEELLFS HKLQKDNDPD VDLFAGTKKT 790 800 810 820 830 840 KLLEPSVGSL FGDDEDDDLF SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK 850 860 870 880 890 900 GIWKPETPQD SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF 910 920 930 940 950 960 PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR RPQTRAARRL 970 980 990 1000 1010 1020 AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG EDSTEEALAA AAAPWEGGPV 1030 1040 1050 1060 1070 1080 PGVDRSPFAK SLGHSRGEAD LFDSGDIFST GTGSQSVERT KPKAKIAENP ANPPVGGKAK 1090 1100 1110 1120 1130 1140 SPMFPALGEA SSDDDLFQSA KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI 1150 1160 1170 1180 1190 1200 LTTQDIFEDD IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK 1210 1220 1230 1240 1250 SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF GGQ

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL954360 Genomic DNA. Translation: CAI17187.1. Sequence problems.
IPI	IPI00884375.
RefSeq	NP_060702.1. NM_018232.1.
UniGene	Hs.365286. Hs.449662.
3D structure databases
ProteinModelPortal	Q5SNT6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5SNT6. 2 interactions.
STRING	9606.ENSP00000351259.
PTM databases
PhosphoSite	Q5SNT6.
Polymorphism databases
DMDM	166971548.
Proteomic databases
PaxDb	Q5SNT6.
PRIDE	Q5SNT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355876; ENSP00000348138; ENSG00000152726. ENST00000358474; ENSP00000351259; ENSG00000152726.
GeneID	55747.
KEGG	hsa:55747.
UCSC	uc001jep.4. human.
Organism-specific databases
CTD	55747.
GeneCards	GC10P047894.
H-InvDB	HIX0025987.
HGNC	HGNC:23417. FAM21B.
HPA	HPA047844.
neXtProt	NX_Q5SNT6.
PharmGKB	PA134877872.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG76301.
HOGENOM	HOG000112469.
HOVERGEN	HBG055529.
InParanoid	Q5SNT6.
Gene expression databases
ArrayExpress	Q5SNT6.
Bgee	Q5SNT6.
CleanEx	HS_FAM21B.
Genevestigator	Q5SNT6.
Family and domain databases
InterPro	IPR027308. FAM21. [Graphical view]
PANTHER	PTHR21669:SF4. PTHR21669:SF4. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55747.
NextBio	60723.

Entry information

Entry name

FA21B_HUMAN

Accession

Primary (citable) accession number: Q5SNT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.