SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SNT6

- FA21B_HUMAN

UniProt

Q5SNT6 - FA21B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
WASH complex subunit FAM21B
Gene
FAM21B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes By similarity.

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit FAM21B
Gene namesi
Name:FAM21B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23417. FAM21B.

Subcellular locationi

GO - Cellular componenti

  1. WASH complex Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. early endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12531253WASH complex subunit FAM21B
PRO_0000317300Add
BLAST

Proteomic databases

MaxQBiQ5SNT6.
PaxDbiQ5SNT6.
PRIDEiQ5SNT6.

PTM databases

PhosphoSiteiQ5SNT6.

Expressioni

Gene expression databases

BgeeiQ5SNT6.
CleanExiHS_FAM21B.
GenevestigatoriQ5SNT6.

Organism-specific databases

HPAiHPA047844.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct By similarity.

Protein-protein interaction databases

BioGridi120865. 7 interactions.
IntActiQ5SNT6. 2 interactions.
STRINGi9606.ENSP00000351259.

Structurei

3D structure databases

ProteinModelPortaliQ5SNT6.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM21 family.

Phylogenomic databases

eggNOGiNOG76301.
HOGENOMiHOG000112469.
HOVERGENiHBG055529.
InParanoidiQ5SNT6.
OMAiYFRITEN.
OrthoDBiEOG7GBFWP.
PhylomeDBiQ5SNT6.
TreeFamiTF329309.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SNT6-1 [UniParc]FASTAAdd to Basket

« Hide

MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN     50
YGLQVLDSAF EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI 100
GSKLFMEQED VGLGELSSEE GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS 150
DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE EEDIEDIEEN TRPKRSRPTS 200
FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE RRTPSDDEED 250
NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG 300
ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP 350
RKSPYGPPPT GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG 400
DLFKEKAVAS PEATVSQTDE NKARAEKKVT LSSSKNLKPS SETKTQKGLF 450
SDEEDSEDLF SSQSASKLKG ASLLPGKLPT SVSLFDDEDE EDNLFGGTAA 500
KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI PASQTHLASD 550
SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS 600
LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG 650
VKSVDKKVES AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP 700
WDKGTKPRTK TVLSLFDEEE DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG 750
VFQDEELLFS HKLQKDNDPD VDLFAGTKKT KLLEPSVGSL FGDDEDDDLF 800
SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK GIWKPETPQD 850
SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF 900
PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR 950
RPQTRAARRL AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG 1000
EDSTEEALAA AAAPWEGGPV PGVDRSPFAK SLGHSRGEAD LFDSGDIFST 1050
GTGSQSVERT KPKAKIAENP ANPPVGGKAK SPMFPALGEA SSDDDLFQSA 1100
KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI LTTQDIFEDD 1150
IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK 1200
SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF 1250
GGQ 1253
Length:1,253
Mass (Da):136,969
Last modified:February 5, 2008 - v2
Checksum:iC41DE76CC1BBFF3F
GO

Sequence cautioni

The sequence CAI17187.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. Translation: CAI17187.1. Sequence problems.
UniGeneiHs.365286.
Hs.449662.
Hs.645272.

Genome annotation databases

EnsembliENST00000355876; ENSP00000348138; ENSG00000152726.
ENST00000358474; ENSP00000351259; ENSG00000152726.
KEGGihsa:55747.
UCSCiuc001jep.4. human.

Polymorphism databases

DMDMi166971548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954360 Genomic DNA. Translation: CAI17187.1 . Sequence problems.
UniGenei Hs.365286.
Hs.449662.
Hs.645272.

3D structure databases

ProteinModelPortali Q5SNT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120865. 7 interactions.
IntActi Q5SNT6. 2 interactions.
STRINGi 9606.ENSP00000351259.

PTM databases

PhosphoSitei Q5SNT6.

Polymorphism databases

DMDMi 166971548.

Proteomic databases

MaxQBi Q5SNT6.
PaxDbi Q5SNT6.
PRIDEi Q5SNT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355876 ; ENSP00000348138 ; ENSG00000152726 .
ENST00000358474 ; ENSP00000351259 ; ENSG00000152726 .
KEGGi hsa:55747.
UCSCi uc001jep.4. human.

Organism-specific databases

GeneCardsi GC10P047894.
H-InvDB HIX0025987.
HGNCi HGNC:23417. FAM21B.
HPAi HPA047844.
neXtProti NX_Q5SNT6.
PharmGKBi PA134877872.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76301.
HOGENOMi HOG000112469.
HOVERGENi HBG055529.
InParanoidi Q5SNT6.
OMAi YFRITEN.
OrthoDBi EOG7GBFWP.
PhylomeDBi Q5SNT6.
TreeFami TF329309.

Miscellaneous databases

GenomeRNAii 55747.
NextBioi 60723.
PROi Q5SNT6.

Gene expression databases

Bgeei Q5SNT6.
CleanExi HS_FAM21B.
Genevestigatori Q5SNT6.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFA21B_HUMAN
AccessioniPrimary (citable) accession number: Q5SNT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi