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Q5SNT6

- FA21B_HUMAN

UniProt

Q5SNT6 - FA21B_HUMAN

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Protein

WASH complex subunit FAM21B

Gene

FAM21B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes (By similarity).By similarity

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit FAM21B
Gene namesi
Name:FAM21B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:23417. FAM21B.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. membrane Source: UniProtKB-KW
  3. WASH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12531253WASH complex subunit FAM21BPRO_0000317300Add
BLAST

Proteomic databases

MaxQBiQ5SNT6.
PaxDbiQ5SNT6.
PRIDEiQ5SNT6.

PTM databases

PhosphoSiteiQ5SNT6.

Expressioni

Gene expression databases

BgeeiQ5SNT6.
CleanExiHS_FAM21B.
GenevestigatoriQ5SNT6.

Organism-specific databases

HPAiHPA047844.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

BioGridi120865. 8 interactions.
IntActiQ5SNT6. 2 interactions.
STRINGi9606.ENSP00000351259.

Structurei

3D structure databases

ProteinModelPortaliQ5SNT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM21 family.Curated

Phylogenomic databases

eggNOGiNOG76301.
HOGENOMiHOG000112469.
HOVERGENiHBG055529.
InParanoidiQ5SNT6.
OMAiYFRITEN.
OrthoDBiEOG7GBFWP.
PhylomeDBiQ5SNT6.
TreeFamiTF329309.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SNT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRLSGKSVR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD LIPKVQEAVN
60 70 80 90 100
YGLQVLDSAF EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI
110 120 130 140 150
GSKLFMEQED VGLGELSSEE GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS
160 170 180 190 200
DNEQNRHTTQ MSDEEEDDDG CDLFADSEKE EEDIEDIEEN TRPKRSRPTS
210 220 230 240 250
FADELAARIK GDAVGRVDEE PTTLPSGEAK PRKTLKEKKE RRTPSDDEED
260 270 280 290 300
NLFTPPKLTD EDFSPFGSGG GLFSGGKGLF DDEDEESDLF TEAPQDRQAG
310 320 330 340 350
ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSMK EPQKPEQPTP
360 370 380 390 400
RKSPYGPPPT GLFDDDDGDD DDDFFSAPHS KPSKTGKVQS TADIFGDEEG
410 420 430 440 450
DLFKEKAVAS PEATVSQTDE NKARAEKKVT LSSSKNLKPS SETKTQKGLF
460 470 480 490 500
SDEEDSEDLF SSQSASKLKG ASLLPGKLPT SVSLFDDEDE EDNLFGGTAA
510 520 530 540 550
KKQTLCLQAQ REEKAKASEL SKKKASALLF SSDEEDQWNI PASQTHLASD
560 570 580 590 600
SRSKGEPRDS GTLQSQEAKA VKKTSLFEED EEDDLFAIAK DSQKKTQRVS
610 620 630 640 650
LLFEDDVDSR GSLFGSPPTS VPPATKKKET VSEAPPLLFS DEEEKEAQLG
660 670 680 690 700
VKSVDKKVES AKESLKFGRT DVAESEKEGL LTRSAQETVK HSDLFSSSSP
710 720 730 740 750
WDKGTKPRTK TVLSLFDEEE DKMEDQNIIQ APQKEVGKGR DPDAHPKSTG
760 770 780 790 800
VFQDEELLFS HKLQKDNDPD VDLFAGTKKT KLLEPSVGSL FGDDEDDDLF
810 820 830 840 850
SSAKSQPLVQ EKKRVVKKDH SVDSFKNQKH PESIQGSKEK GIWKPETPQD
860 870 880 890 900
SSGLAPFKTK EPSTRIGKIQ ANLAINPAAL LPTAASQISE VKPVLPELAF
910 920 930 940 950
PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR
960 970 980 990 1000
RPQTRAARRL AAQESSETED MSVPRGPIAQ WADGAISPNG HRPQLRAASG
1010 1020 1030 1040 1050
EDSTEEALAA AAAPWEGGPV PGVDRSPFAK SLGHSRGEAD LFDSGDIFST
1060 1070 1080 1090 1100
GTGSQSVERT KPKAKIAENP ANPPVGGKAK SPMFPALGEA SSDDDLFQSA
1110 1120 1130 1140 1150
KPKPAKKTNT FPLLEDEDDL FTDQKVKKNE TKSNSQQDVI LTTQDIFEDD
1160 1170 1180 1190 1200
IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK
1210 1220 1230 1240 1250
SIFDDDMDDI FSSGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF

GGQ
Length:1,253
Mass (Da):136,969
Last modified:February 5, 2008 - v2
Checksum:iC41DE76CC1BBFF3F
GO

Sequence cautioni

The sequence CAI17187.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954360 Genomic DNA. Translation: CAI17187.1. Sequence problems.
UniGeneiHs.365286.
Hs.449662.
Hs.645272.

Genome annotation databases

UCSCiuc001jep.4. human.

Polymorphism databases

DMDMi166971548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954360 Genomic DNA. Translation: CAI17187.1 . Sequence problems.
UniGenei Hs.365286.
Hs.449662.
Hs.645272.

3D structure databases

ProteinModelPortali Q5SNT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120865. 8 interactions.
IntActi Q5SNT6. 2 interactions.
STRINGi 9606.ENSP00000351259.

PTM databases

PhosphoSitei Q5SNT6.

Polymorphism databases

DMDMi 166971548.

Proteomic databases

MaxQBi Q5SNT6.
PaxDbi Q5SNT6.
PRIDEi Q5SNT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc001jep.4. human.

Organism-specific databases

GeneCardsi GC10P047894.
H-InvDB HIX0025987.
HGNCi HGNC:23417. FAM21B.
HPAi HPA047844.
neXtProti NX_Q5SNT6.
PharmGKBi PA134877872.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76301.
HOGENOMi HOG000112469.
HOVERGENi HBG055529.
InParanoidi Q5SNT6.
OMAi YFRITEN.
OrthoDBi EOG7GBFWP.
PhylomeDBi Q5SNT6.
TreeFami TF329309.

Miscellaneous databases

NextBioi 60723.
PROi Q5SNT6.

Gene expression databases

Bgeei Q5SNT6.
CleanExi HS_FAM21B.
Genevestigatori Q5SNT6.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFA21B_HUMAN
AccessioniPrimary (citable) accession number: Q5SNT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3