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Protein

Transmembrane protein 201

Gene

TMEM201

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Isoform SAMP1: May define a distinct membrane domain in the vicinity of the mitotic spindle.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 201
Alternative name(s):
Spindle-associated membrane protein 1
Gene namesi
Name:TMEM201
Synonyms:NET5, SAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33719. TMEM201.

Subcellular locationi

Isoform SAMP1 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37418HelicalSequence analysisAdd
BLAST
Transmembranei645 – 66521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406359.

Polymorphism and mutation databases

BioMutaiTMEM201.
DMDMi74743441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Transmembrane protein 201PRO_0000317198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei454 – 4541PhosphoserineCombined sources
Modified residuei529 – 5291PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5SNT2.
MaxQBiQ5SNT2.
PaxDbiQ5SNT2.
PRIDEiQ5SNT2.

PTM databases

iPTMnetiQ5SNT2.
PhosphoSiteiQ5SNT2.

Expressioni

Gene expression databases

BgeeiQ5SNT2.
CleanExiHS_TMEM201.
ExpressionAtlasiQ5SNT2. baseline and differential.
GenevisibleiQ5SNT2. HS.

Organism-specific databases

HPAiCAB039039.

Interactioni

Protein-protein interaction databases

BioGridi128285. 9 interactions.
IntActiQ5SNT2. 2 interactions.
STRINGi9606.ENSP00000344503.

Structurei

3D structure databases

ProteinModelPortaliQ5SNT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi441 – 52080Ser-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4623. Eukaryota.
ENOG41123RR. LUCA.
GeneTreeiENSGT00390000002713.
HOGENOMiHOG000154619.
HOVERGENiHBG057857.
InParanoidiQ5SNT2.
OMAiEAWAFGQ.
OrthoDBiEOG7WT416.
PhylomeDBiQ5SNT2.
TreeFamiTF106107.

Family and domain databases

InterProiIPR018861. DUF2448.
IPR018617. Ima1_N.
[Graphical view]
PfamiPF10476. DUF2448. 1 hit.
PF09779. Ima1_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SNT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGVSALLAR CPTAGLAGGL GVTACAAAGV LLYRIARRMK PTHTMVNCWF
60 70 80 90 100
CNQDTLVPYG NRNCWDCPHC EQYNGFQENG DYNKPIPAQY LEHLNHVVSS
110 120 130 140 150
APSLRDPSQP QQWVSSQVLL CKRCNHHQTT KIKQLAAFAP REEGRYDEEV
160 170 180 190 200
EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR QLRALLLSHQ FKRREADQTH
210 220 230 240 250
AQNFSSAVKS PVQVILLRAL AFLACAFLLT TALYGASGHF APGTTVPLAL
260 270 280 290 300
PPGGNGSATP DNGTTPGAEG WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV
310 320 330 340 350
VALGLLTCLL AMLLAGRIRL RRIDAFCTCL WALLLGLHLA EQHLQAASPS
360 370 380 390 400
WLDTLKFSTT SLCCLVGFTA AVATRKATGP RRFRPRRFFP GDSAGLFPTS
410 420 430 440 450
PSLAIPHPSV GGSPASLFIP SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS
460 470 480 490 500
RALSLGTIPS LTRADSGYLF SGSRPPSQVS RSGEFPVSDY FSLLSGSCPS
510 520 530 540 550
SPLPSPAPSV AGSVASSSGS LRHRRPLISP ARLNLKGQKL LLFPSPPGEA
560 570 580 590 600
PTTPSSSDEH SPHNGSLFTM EPPHVPRKPP LQDVKHALDL RSKLERGSAC
610 620 630 640 650
SNRSIKKEDD SSQSSTCVVD TTTRGCSEEA ATWRGRFGPS LVRGLLAVSL
660
AANALFTSVF LYQSLR
Length:666
Mass (Da):72,236
Last modified:December 21, 2004 - v1
Checksum:i19A4E0F866838525
GO
Isoform SAMP1 (identifier: Q5SNT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-392: FFPGD → SEKQP
     393-666: Missing.

Show »
Length:392
Mass (Da):43,382
Checksum:i12392DC351F26F8A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei388 – 3925FFPGD → SEKQP in isoform SAMP1. 1 PublicationVSP_030915
Alternative sequencei393 – 666274Missing in isoform SAMP1. 1 PublicationVSP_030916Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954705 Genomic DNA. Translation: CAI17268.1.
AL954705 Genomic DNA. Translation: CAI17269.1.
BC121187 mRNA. Translation: AAI21188.1.
BC137291 mRNA. Translation: AAI37292.1.
CCDSiCCDS30579.1. [Q5SNT2-2]
CCDS44055.2. [Q5SNT2-1]
RefSeqiNP_001010866.1. NM_001010866.3. [Q5SNT2-2]
NP_001124396.2. NM_001130924.2. [Q5SNT2-1]
XP_011539212.1. XM_011540910.1. [Q5SNT2-2]
UniGeneiHs.632365.
Hs.706017.

Genome annotation databases

EnsembliENST00000340305; ENSP00000344772; ENSG00000188807. [Q5SNT2-2]
ENST00000340381; ENSP00000344503; ENSG00000188807. [Q5SNT2-1]
GeneIDi199953.
KEGGihsa:199953.
UCSCiuc001apy.4. human. [Q5SNT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954705 Genomic DNA. Translation: CAI17268.1.
AL954705 Genomic DNA. Translation: CAI17269.1.
BC121187 mRNA. Translation: AAI21188.1.
BC137291 mRNA. Translation: AAI37292.1.
CCDSiCCDS30579.1. [Q5SNT2-2]
CCDS44055.2. [Q5SNT2-1]
RefSeqiNP_001010866.1. NM_001010866.3. [Q5SNT2-2]
NP_001124396.2. NM_001130924.2. [Q5SNT2-1]
XP_011539212.1. XM_011540910.1. [Q5SNT2-2]
UniGeneiHs.632365.
Hs.706017.

3D structure databases

ProteinModelPortaliQ5SNT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128285. 9 interactions.
IntActiQ5SNT2. 2 interactions.
STRINGi9606.ENSP00000344503.

PTM databases

iPTMnetiQ5SNT2.
PhosphoSiteiQ5SNT2.

Polymorphism and mutation databases

BioMutaiTMEM201.
DMDMi74743441.

Proteomic databases

EPDiQ5SNT2.
MaxQBiQ5SNT2.
PaxDbiQ5SNT2.
PRIDEiQ5SNT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340305; ENSP00000344772; ENSG00000188807. [Q5SNT2-2]
ENST00000340381; ENSP00000344503; ENSG00000188807. [Q5SNT2-1]
GeneIDi199953.
KEGGihsa:199953.
UCSCiuc001apy.4. human. [Q5SNT2-1]

Organism-specific databases

CTDi199953.
GeneCardsiTMEM201.
HGNCiHGNC:33719. TMEM201.
HPAiCAB039039.
neXtProtiNX_Q5SNT2.
PharmGKBiPA162406359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4623. Eukaryota.
ENOG41123RR. LUCA.
GeneTreeiENSGT00390000002713.
HOGENOMiHOG000154619.
HOVERGENiHBG057857.
InParanoidiQ5SNT2.
OMAiEAWAFGQ.
OrthoDBiEOG7WT416.
PhylomeDBiQ5SNT2.
TreeFamiTF106107.

Miscellaneous databases

ChiTaRSiTMEM201. human.
GenomeRNAii199953.
NextBioi89779.
PROiQ5SNT2.

Gene expression databases

BgeeiQ5SNT2.
CleanExiHS_TMEM201.
ExpressionAtlasiQ5SNT2. baseline and differential.
GenevisibleiQ5SNT2. HS.

Family and domain databases

InterProiIPR018861. DUF2448.
IPR018617. Ima1_N.
[Graphical view]
PfamiPF10476. DUF2448. 1 hit.
PF09779. Ima1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SAMP1).
    Tissue: Eye.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454 AND SER-529, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells."
    Buch C., Lindberg R., Figueroa R., Gudise S., Onischenko E., Hallberg E.
    J. Cell Sci. 122:2100-2107(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION (ISOFORM SAMP1).
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM201_HUMAN
AccessioniPrimary (citable) accession number: Q5SNT2
Secondary accession number(s): B9EH90, Q5SNT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: April 13, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.