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Protein

Transmembrane protein 201

Gene

TMEM201

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32479-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 201
Alternative name(s):
Spindle-associated membrane protein 1
Gene namesi
Name:TMEM201
Synonyms:NET5, SAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33719. TMEM201.

Subcellular locationi

Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei357 – 374HelicalSequence analysisAdd BLAST18
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi199953.
OpenTargetsiENSG00000188807.
PharmGKBiPA162406359.

Polymorphism and mutation databases

BioMutaiTMEM201.
DMDMi74743441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171981 – 666Transmembrane protein 201Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5SNT2.
MaxQBiQ5SNT2.
PaxDbiQ5SNT2.
PeptideAtlasiQ5SNT2.
PRIDEiQ5SNT2.

PTM databases

iPTMnetiQ5SNT2.
PhosphoSitePlusiQ5SNT2.

Expressioni

Gene expression databases

BgeeiENSG00000188807.
CleanExiHS_TMEM201.
ExpressionAtlasiQ5SNT2. baseline and differential.
GenevisibleiQ5SNT2. HS.

Organism-specific databases

HPAiCAB039039.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128285. 9 interactors.
IntActiQ5SNT2. 9 interactors.
STRINGi9606.ENSP00000344503.

Structurei

3D structure databases

ProteinModelPortaliQ5SNT2.
SMRiQ5SNT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi441 – 520Ser-richAdd BLAST80

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4623. Eukaryota.
ENOG41123RR. LUCA.
GeneTreeiENSGT00390000002713.
HOGENOMiHOG000154619.
HOVERGENiHBG057857.
InParanoidiQ5SNT2.
OMAiEAWAFGQ.
OrthoDBiEOG091G07TP.
PhylomeDBiQ5SNT2.
TreeFamiTF106107.

Family and domain databases

InterProiIPR018861. DUF2448.
IPR018617. Ima1_N.
[Graphical view]
PfamiPF10476. DUF2448. 1 hit.
PF09779. Ima1_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SNT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGVSALLAR CPTAGLAGGL GVTACAAAGV LLYRIARRMK PTHTMVNCWF
60 70 80 90 100
CNQDTLVPYG NRNCWDCPHC EQYNGFQENG DYNKPIPAQY LEHLNHVVSS
110 120 130 140 150
APSLRDPSQP QQWVSSQVLL CKRCNHHQTT KIKQLAAFAP REEGRYDEEV
160 170 180 190 200
EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR QLRALLLSHQ FKRREADQTH
210 220 230 240 250
AQNFSSAVKS PVQVILLRAL AFLACAFLLT TALYGASGHF APGTTVPLAL
260 270 280 290 300
PPGGNGSATP DNGTTPGAEG WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV
310 320 330 340 350
VALGLLTCLL AMLLAGRIRL RRIDAFCTCL WALLLGLHLA EQHLQAASPS
360 370 380 390 400
WLDTLKFSTT SLCCLVGFTA AVATRKATGP RRFRPRRFFP GDSAGLFPTS
410 420 430 440 450
PSLAIPHPSV GGSPASLFIP SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS
460 470 480 490 500
RALSLGTIPS LTRADSGYLF SGSRPPSQVS RSGEFPVSDY FSLLSGSCPS
510 520 530 540 550
SPLPSPAPSV AGSVASSSGS LRHRRPLISP ARLNLKGQKL LLFPSPPGEA
560 570 580 590 600
PTTPSSSDEH SPHNGSLFTM EPPHVPRKPP LQDVKHALDL RSKLERGSAC
610 620 630 640 650
SNRSIKKEDD SSQSSTCVVD TTTRGCSEEA ATWRGRFGPS LVRGLLAVSL
660
AANALFTSVF LYQSLR
Length:666
Mass (Da):72,236
Last modified:December 21, 2004 - v1
Checksum:i19A4E0F866838525
GO
Isoform 2 (identifier: Q5SNT2-2) [UniParc]FASTAAdd to basket
Also known as: SAMP1

The sequence of this isoform differs from the canonical sequence as follows:
     388-392: FFPGD → SEKQP
     393-666: Missing.

Show »
Length:392
Mass (Da):43,382
Checksum:i12392DC351F26F8A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030915388 – 392FFPGD → SEKQP in isoform 2. 1 Publication5
Alternative sequenceiVSP_030916393 – 666Missing in isoform 2. 1 PublicationAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954705 Genomic DNA. Translation: CAI17268.1.
AL954705 Genomic DNA. Translation: CAI17269.1.
BC121187 mRNA. Translation: AAI21188.1.
BC137291 mRNA. Translation: AAI37292.1.
CCDSiCCDS30579.1. [Q5SNT2-2]
CCDS44055.2. [Q5SNT2-1]
RefSeqiNP_001010866.1. NM_001010866.3. [Q5SNT2-2]
NP_001124396.2. NM_001130924.2. [Q5SNT2-1]
XP_011539212.1. XM_011540910.2. [Q5SNT2-2]
UniGeneiHs.632365.
Hs.706017.

Genome annotation databases

EnsembliENST00000340305; ENSP00000344772; ENSG00000188807. [Q5SNT2-2]
ENST00000340381; ENSP00000344503; ENSG00000188807. [Q5SNT2-1]
GeneIDi199953.
KEGGihsa:199953.
UCSCiuc001apy.4. human. [Q5SNT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954705 Genomic DNA. Translation: CAI17268.1.
AL954705 Genomic DNA. Translation: CAI17269.1.
BC121187 mRNA. Translation: AAI21188.1.
BC137291 mRNA. Translation: AAI37292.1.
CCDSiCCDS30579.1. [Q5SNT2-2]
CCDS44055.2. [Q5SNT2-1]
RefSeqiNP_001010866.1. NM_001010866.3. [Q5SNT2-2]
NP_001124396.2. NM_001130924.2. [Q5SNT2-1]
XP_011539212.1. XM_011540910.2. [Q5SNT2-2]
UniGeneiHs.632365.
Hs.706017.

3D structure databases

ProteinModelPortaliQ5SNT2.
SMRiQ5SNT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128285. 9 interactors.
IntActiQ5SNT2. 9 interactors.
STRINGi9606.ENSP00000344503.

PTM databases

iPTMnetiQ5SNT2.
PhosphoSitePlusiQ5SNT2.

Polymorphism and mutation databases

BioMutaiTMEM201.
DMDMi74743441.

Proteomic databases

EPDiQ5SNT2.
MaxQBiQ5SNT2.
PaxDbiQ5SNT2.
PeptideAtlasiQ5SNT2.
PRIDEiQ5SNT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340305; ENSP00000344772; ENSG00000188807. [Q5SNT2-2]
ENST00000340381; ENSP00000344503; ENSG00000188807. [Q5SNT2-1]
GeneIDi199953.
KEGGihsa:199953.
UCSCiuc001apy.4. human. [Q5SNT2-1]

Organism-specific databases

CTDi199953.
DisGeNETi199953.
GeneCardsiTMEM201.
HGNCiHGNC:33719. TMEM201.
HPAiCAB039039.
neXtProtiNX_Q5SNT2.
OpenTargetsiENSG00000188807.
PharmGKBiPA162406359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4623. Eukaryota.
ENOG41123RR. LUCA.
GeneTreeiENSGT00390000002713.
HOGENOMiHOG000154619.
HOVERGENiHBG057857.
InParanoidiQ5SNT2.
OMAiEAWAFGQ.
OrthoDBiEOG091G07TP.
PhylomeDBiQ5SNT2.
TreeFamiTF106107.

Enzyme and pathway databases

BioCyciZFISH:G66-32479-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM201. human.
GenomeRNAii199953.
PROiQ5SNT2.

Gene expression databases

BgeeiENSG00000188807.
CleanExiHS_TMEM201.
ExpressionAtlasiQ5SNT2. baseline and differential.
GenevisibleiQ5SNT2. HS.

Family and domain databases

InterProiIPR018861. DUF2448.
IPR018617. Ima1_N.
[Graphical view]
PfamiPF10476. DUF2448. 1 hit.
PF09779. Ima1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM201_HUMAN
AccessioniPrimary (citable) accession number: Q5SNT2
Secondary accession number(s): B9EH90, Q5SNT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.