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Protein

Transmembrane protein 201

Gene

TMEM201

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).By similarity1 Publication
Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).2 Publications

GO - Molecular functioni

GO - Biological processi

  • centrosome localization Source: UniProtKB
  • fibroblast migration Source: Ensembl
  • nuclear envelope organization Source: UniProtKB
  • nuclear migration Source: Ensembl
  • protein localization to nuclear envelope Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 201
Alternative name(s):
Spindle-associated membrane protein 1
Gene namesi
Name:TMEM201
Synonyms:NET5, SAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188807.12.
HGNCiHGNC:33719. TMEM201.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 213Nuclear1 PublicationAdd BLAST213
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 297Perinuclear spaceCuratedAdd BLAST63
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 322NuclearCurated4
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 356Perinuclear spaceCuratedAdd BLAST13
Transmembranei357 – 374HelicalSequence analysisAdd BLAST18
Topological domaini375 – 644NuclearCuratedAdd BLAST270
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21
Topological domaini666Perinuclear spaceCurated1

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi48C → A: Impairs organization of the nuclear envelope; abolishes its localization to the nuclear envelope; impairs localization of SUN1 and EMD to the nuclear envelope. 1 Publication1
Mutagenesisi121C → A: Abolishes localization to the nuclear envelopee; abolishes its localization to the nuclear envelope; impairs localization of SUN1 and EMD to the nuclear envelope. 1 Publication1

Organism-specific databases

DisGeNETi199953.
OpenTargetsiENSG00000188807.
PharmGKBiPA162406359.

Polymorphism and mutation databases

BioMutaiTMEM201.
DMDMi74743441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171981 – 666Transmembrane protein 201Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5SNT2.
MaxQBiQ5SNT2.
PaxDbiQ5SNT2.
PeptideAtlasiQ5SNT2.
PRIDEiQ5SNT2.

PTM databases

iPTMnetiQ5SNT2.
PhosphoSitePlusiQ5SNT2.

Expressioni

Gene expression databases

BgeeiENSG00000188807.
CleanExiHS_TMEM201.
ExpressionAtlasiQ5SNT2. baseline and differential.
GenevisibleiQ5SNT2. HS.

Organism-specific databases

HPAiCAB039039.

Interactioni

Subunit structurei

Isoform 2 interacts with EMD (PubMed:21610090). Interacts with SUN2 and LMNA (By similarity). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP.By similarity1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EMDP504025EBI-11994282,EBI-489887

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128285. 10 interactors.
IntActiQ5SNT2. 13 interactors.
STRINGi9606.ENSP00000344503.

Structurei

3D structure databases

ProteinModelPortaliQ5SNT2.
SMRiQ5SNT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi441 – 520Ser-richAdd BLAST80

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4623. Eukaryota.
ENOG41123RR. LUCA.
GeneTreeiENSGT00390000002713.
HOGENOMiHOG000154619.
HOVERGENiHBG057857.
InParanoidiQ5SNT2.
OMAiEAWAFGQ.
OrthoDBiEOG091G07TP.
PhylomeDBiQ5SNT2.
TreeFamiTF106107.

Family and domain databases

InterProiView protein in InterPro
IPR018861. DUF2448.
IPR018617. Ima1_N.
PfamiView protein in Pfam
PF10476. DUF2448. 1 hit.
PF09779. Ima1_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SNT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGVSALLAR CPTAGLAGGL GVTACAAAGV LLYRIARRMK PTHTMVNCWF
60 70 80 90 100
CNQDTLVPYG NRNCWDCPHC EQYNGFQENG DYNKPIPAQY LEHLNHVVSS
110 120 130 140 150
APSLRDPSQP QQWVSSQVLL CKRCNHHQTT KIKQLAAFAP REEGRYDEEV
160 170 180 190 200
EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR QLRALLLSHQ FKRREADQTH
210 220 230 240 250
AQNFSSAVKS PVQVILLRAL AFLACAFLLT TALYGASGHF APGTTVPLAL
260 270 280 290 300
PPGGNGSATP DNGTTPGAEG WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV
310 320 330 340 350
VALGLLTCLL AMLLAGRIRL RRIDAFCTCL WALLLGLHLA EQHLQAASPS
360 370 380 390 400
WLDTLKFSTT SLCCLVGFTA AVATRKATGP RRFRPRRFFP GDSAGLFPTS
410 420 430 440 450
PSLAIPHPSV GGSPASLFIP SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS
460 470 480 490 500
RALSLGTIPS LTRADSGYLF SGSRPPSQVS RSGEFPVSDY FSLLSGSCPS
510 520 530 540 550
SPLPSPAPSV AGSVASSSGS LRHRRPLISP ARLNLKGQKL LLFPSPPGEA
560 570 580 590 600
PTTPSSSDEH SPHNGSLFTM EPPHVPRKPP LQDVKHALDL RSKLERGSAC
610 620 630 640 650
SNRSIKKEDD SSQSSTCVVD TTTRGCSEEA ATWRGRFGPS LVRGLLAVSL
660
AANALFTSVF LYQSLR
Length:666
Mass (Da):72,236
Last modified:December 21, 2004 - v1
Checksum:i19A4E0F866838525
GO
Isoform 2 (identifier: Q5SNT2-2) [UniParc]FASTAAdd to basket
Also known as: SAMP1

The sequence of this isoform differs from the canonical sequence as follows:
     388-392: FFPGD → SEKQP
     393-666: Missing.

Show »
Length:392
Mass (Da):43,382
Checksum:i12392DC351F26F8A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030915388 – 392FFPGD → SEKQP in isoform 2. 1 Publication5
Alternative sequenceiVSP_030916393 – 666Missing in isoform 2. 1 PublicationAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954705 Genomic DNA. Translation: CAI17268.1.
AL954705 Genomic DNA. Translation: CAI17269.1.
BC121187 mRNA. Translation: AAI21188.1.
BC137291 mRNA. Translation: AAI37292.1.
CCDSiCCDS30579.1. [Q5SNT2-2]
CCDS44055.2. [Q5SNT2-1]
RefSeqiNP_001010866.1. NM_001010866.3. [Q5SNT2-2]
NP_001124396.2. NM_001130924.2. [Q5SNT2-1]
XP_011539212.1. XM_011540910.2. [Q5SNT2-2]
UniGeneiHs.632365.
Hs.706017.

Genome annotation databases

EnsembliENST00000340305; ENSP00000344772; ENSG00000188807. [Q5SNT2-2]
ENST00000340381; ENSP00000344503; ENSG00000188807. [Q5SNT2-1]
GeneIDi199953.
KEGGihsa:199953.
UCSCiuc001apy.4. human. [Q5SNT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM201_HUMAN
AccessioniPrimary (citable) accession number: Q5SNT2
Secondary accession number(s): B9EH90, Q5SNT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM