Q5SMY5 (GRXS2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monothiol glutaredoxin-S2

Gene names

Name:	GRXS2
Ordered Locus Names:	Os01g0194600, LOC_Os01g09830
ORF Names:	P0001B06.21, P0498B01.7

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May only reduce GSH-thiol disulfides, but not protein disulfides Potential.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutaredoxin family. CC-type subfamily. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Monothiol glutaredoxin-S2		PRO_0000271271
Regions
	Domain	28 – 124	97	Glutaredoxin
Sites
	Metal binding	48	1	Iron-sulfur (2Fe-2S); shared with dimeric partner Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5SMY5 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 534CB55E9001EBCA	FASTA	125	12,799
	10 20 30 40 50 60 MQAVAAAAGM MRRGSLTIDP AGEEEAPAER VGRLVRESPV VVFARRGCYM AHVMRRLLAA 70 80 90 100 110 120 VGAHATVIEL EGGAAEEEEA ALGGGAALPA LFVGGDPVGG LEGLMGLHLS GRLVPRLREV GALCT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.
[5]	"Genome-wide analysis of plant glutaredoxin systems." Rouhier N., Couturier J., Jacquot J.-P. J. Exp. Bot. 57:1685-1696(2006) [PubMed: 16720602] [Abstract] Cited for: GENE FAMILY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP002537 Genomic DNA. Translation: BAD72201.1. AP003417 Genomic DNA. Translation: BAD72420.1. AP008207 Genomic DNA. Translation: BAF04201.1. AK102031 mRNA. No translation available.
RefSeq	NP_001042287.1. NM_001048822.1.
UniGene	Os.11166.
3D structure databases
ProteinModelPortal	Q5SMY5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os01g09830.1; LOC_Os01g09830.1; LOC_Os01g09830.
GeneID	4327316.
KEGG	osa:4327316.
Organism-specific databases
Gramene	Q5SMY5.
Phylogenomic databases
GeneTree	EPGT00050000006352.
HOGENOM	HBG728471.
PhylomeDB	Q5SMY5.
ProtClustDB	CLSN2691165.
Family and domain databases
InterPro	IPR011905. GlrX-like_pln_2. IPR002109. Glutaredoxin. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02189. GlrX-like_plant. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRXS2_ORYSJ

Accession

Primary (citable) accession number: Q5SMY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 21, 2004
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program