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Q5SMG8 (MGTE_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium transporter mgtE
Gene names
Ordered Locus Names:TTHA1060
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a magnesium transporter. Ref.2

Subunit structure

Homodimer. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.2.

Sequence similarities

Belongs to the SLC41A transporter family.

Contains 2 CBS domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Magnesium transporter mgtE
PRO_0000363889

Regions

Topological domain1 – 277277Cytoplasmic
Transmembrane278 – 30528Helical; Name=1
Intramembrane306 – 32015
Transmembrane321 – 34424Helical; Name=2
Topological domain345 – 3517Cytoplasmic
Transmembrane352 – 38130Helical; Name=3
Intramembrane382 – 3854
Transmembrane386 – 41429Helical; Name=4
Intramembrane415 – 42410
Transmembrane425 – 44723Helical; Name=5
Topological domain448 – 4503Periplasmic
Domain138 – 20063CBS 1
Domain202 – 25857CBS 2

Sites

Metal binding911Magnesium 1
Metal binding951Magnesium 2
Metal binding1361Magnesium 2; via carbonyl oxygen
Metal binding2141Magnesium 3
Metal binding2161Magnesium 4
Metal binding2231Magnesium 5; via carbonyl oxygen
Metal binding2261Magnesium 5
Metal binding2471Magnesium 1
Metal binding2551Magnesium 3
Metal binding2581Magnesium 3
Metal binding2591Magnesium 4
Metal binding4181Magnesium 4
Metal binding4281Magnesium 6; via carbonyl oxygen
Metal binding4321Magnesium 6

Secondary structure

1 ...................................... 450
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SMG8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 6F5930DCDDB90B05

FASTA45050,078
        10         20         30         40         50         60 
MEEKLAVSLQ EALQEGDTRA LREVLEEIHP QDLLALWDEL KGEHRYVVLT LLPKAKAAEV 

        70         80         90        100        110        120 
LSHLSPEEQA EYLKTLPPWR LREILEELSL DDLADALQAV RKEDPAYFQR LKDLLDPRTR 

       130        140        150        160        170        180 
AEVEALARYE EDEAGGLMTP EYVAVREGMT VEEVLRFLRR AAPDAETIYY IYVVDEKGRL 

       190        200        210        220        230        240 
KGVLSLRDLI VADPRTRVAE IMNPKVVYVR TDTDQEEVAR LMADYDFTVL PVVDEEGRLV 

       250        260        270        280        290        300 
GIVTVDDVLD VLEAEATEDI HKLGAVDVPD LVYSEAGPVA LWLARVRWLV ILILTGMVTS 

       310        320        330        340        350        360 
SILQGFESVL EAVTALAFYV PVLLGTGGNT GNQSATLIIR ALATRDLDLR DWRRVFLKEM 

       370        380        390        400        410        420 
GVGLLLGLTL SFLLVGKVYW DGHPLLLPVV GVSLVLIVFF ANLVGAMLPF LLRRLGVDPA 

       430        440        450 
LVSNPLVATL SDVTGLLIYL SVARLLLEAV

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of the MgtE Mg(2+) transporter."
Hattori M., Tanaka Y., Fukai S., Ishitani R., Nureki O.
Nature 448:1072-1076(2007) [PubMed: 17700703] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70883.1.
RefSeqYP_144326.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YVXX-ray3.50A/B/C/D1-450[»]
2YVYX-ray2.30A1-275[»]
2YVZX-ray3.90A/B1-275[»]
2ZY9X-ray2.94A/B1-450[»]
ProteinModelPortalQ5SMG8.
SMRQ5SMG8. Positions 7-448.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SMG8.

Protein family/group databases

TCDB9.A.19.1.2. Mg2+ transporter-E (MgtE) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3168925.
GenomeReviewsGene locus TTHA1060 in contig AP008226_GR.
KEGGttj:TTHA1060.
NMPDRfig|300852.3.peg.1197.
PATRIC23957080. VBITheThe93045_1040.

Phylogenomic databases

eggNOGCOG2239.
HOGENOMHBG680933.
OMADPAIMAS.
PhylomeDBQ5SMG8.
ProtClustDBCLSK738242.

Enzyme and pathway databases

BioCycTTHE300852:TTHA1060-MONOMER.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR000644. Cysta_beta_synth_core.
IPR006668. Mg_transptr_MgtE_intracell_dom.
IPR006667. MgtE_Mg_transptr_membr.
IPR006669. MgtE_transporter.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK06213.
PfamPF00571. CBS. 2 hits.
PF01769. MgtE. 1 hit.
PF03448. MgtE_N. 1 hit.
[Graphical view]
SMARTSM00116. CBS. 2 hits.
SM00924. MgtE_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00400. MgtE. 1 hit.
PROSITEPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMGTE_THET8
AccessionPrimary (citable) accession number: Q5SMG8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 21, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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