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Q5SM03

- MURA_THET8

UniProt

Q5SM03 - MURA_THET8

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Protein
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene
murA, TTHA0140
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Proton donor By similarity

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-148-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC:2.5.1.7)
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name:
EPT
Gene namesi
Name:murA
Ordered Locus Names:TTHA0140
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation
PRO_0000231292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0140.

Structurei

3D structure databases

ProteinModelPortaliQ5SM03.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiHGLEQMG.
OrthoDBiEOG68M4GK.
PhylomeDBiQ5SM03.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SM03-1 [UniParc]FASTAAdd to Basket

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MGVSRVLHVE GGTPLKGELR VYPAKNAALP ILAASLLTPE PITLVEVPRL    50
RDVEVMLELL AHLGTQYAWE GRTLHLQTPE IKSTHAPYEL VGQMRASFIV 100
WGALLARAGE GHVSMPGGCA FGFRPVDQHI KALEALGAEV WEEDGTFHAR 150
RTRPLSGRVV FDLPTVGGTE QAMLAVALGG EATLVQAAVE PEVVDLGHFL 200
ALLGAEVEGL GSPIVRIKGA PRLKGGTYRI IPDRIEAGTY LLAAAATRGS 250
LTLEGVRPDH LDALLDKLWR SGHRLEVGED WIRFRATPDP APFHVEAREY 300
PGFPTDLQPI ATAYLATVPG QSTVVDRIYP DRFTHVGELA RMGAELYLRD 350
RILTVQGRRL HGAQVKALDI RAGGALVVAA LSAEGASEIE GVYFLERGYE 400
HLTERLQALG ARVHLRESPV ALAAD 425
Length:425
Mass (Da):45,978
Last modified:December 21, 2004 - v1
Checksum:iC4E4872DC1F3529C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD69963.1.
RefSeqiWP_011227732.1. NC_006461.1.
YP_143406.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69963; BAD69963; BAD69963.
GeneIDi3169843.
KEGGittj:TTHA0140.
PATRICi23955219. VBITheThe93045_0138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD69963.1 .
RefSeqi WP_011227732.1. NC_006461.1.
YP_143406.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SM03.
ModBasei Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD69963 ; BAD69963 ; BAD69963 .
GeneIDi 3169843.
KEGGi ttj:TTHA0140.
PATRICi 23955219. VBITheThe93045_0138.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi HGLEQMG.
OrthoDBi EOG68M4GK.
PhylomeDBi Q5SM03.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci TTHE300852:GH8R-148-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiMURA_THET8
AccessioniPrimary (citable) accession number: Q5SM03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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