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Q5SM01

- Q5SM01_THET8

UniProt

Q5SM01 - Q5SM01_THET8

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Protein
Submitted name:

Peptide chain release factor 2

Gene

TTHA0142

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.SAAS annotation

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesisSAAS annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-150-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptide chain release factor 2Imported
Gene namesi
Ordered Locus Names:TTHA0142Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0142.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B9MX-ray6.76Y28-378[»]
2IHRX-ray2.50127-378[»]
2WH1X-ray3.45Y31-369[»]
2WH3X-ray3.45Y31-369[»]
2X9RX-ray3.10Y31-369[»]
2X9TX-ray3.10Y31-369[»]
ProteinModelPortaliQ5SM01.
SMRiQ5SM01. Positions 27-369.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SM01.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1186.
HOGENOMiHOG000074814.
KOiK02836.
OMAiCYVDIQS.
OrthoDBiEOG6TN48J.
PhylomeDBiQ5SM01.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004374. PrfB.
[Graphical view]
PANTHERiPTHR11075:SF6. PTHR11075:SF6. 1 hit.
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00020. prfB. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SM01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLASQSAIL VKVWTWNASR NAWKASGGIF DIPQKETRLK ELERRLEDPS
60 70 80 90 100
LWNDPEAARK VSQEAARLRR TVDTFRSLES DLQGLLELME ELPAEEREAL
110 120 130 140 150
KPELEEAAKK LDELYHQTLL NFPHAEKNAI LTIQPGAGGT EACDWAEMLL
160 170 180 190 200
RMYTRFAERQ GFQVEVVDLT PGPEAGIDYA QILVKGENAY GLLSPEAGVH
210 220 230 240 250
RLVRPSPFDA SGRRHTSFAG VEVIPEVDEE VEVVLKPEEL RIDVMRASGP
260 270 280 290 300
GGQGVNTTDS AVRVVHLPTG ITVTCQTTRS QIKNKELALK ILKARLYELE
310 320 330 340 350
RKKREEELKA LRGEVRPIEW GSQIRSYVLD KNYVKDHRTG LMRHDPENVL
360 370
DGDLMDLIWA GLEWKAGRRQ GTEEVEAE
Length:378
Mass (Da):42,734
Last modified:December 21, 2004 - v1
Checksum:i55B4AC9C891AEEB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD69965.1.
RefSeqiYP_143408.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69965; BAD69965; BAD69965.
GeneIDi3168831.
KEGGittj:TTHA0142.
PATRICi23955223. VBITheThe93045_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD69965.1 .
RefSeqi YP_143408.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B9M X-ray 6.76 Y 28-378 [» ]
2IHR X-ray 2.50 1 27-378 [» ]
2WH1 X-ray 3.45 Y 31-369 [» ]
2WH3 X-ray 3.45 Y 31-369 [» ]
2X9R X-ray 3.10 Y 31-369 [» ]
2X9T X-ray 3.10 Y 31-369 [» ]
ProteinModelPortali Q5SM01.
SMRi Q5SM01. Positions 27-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD69965 ; BAD69965 ; BAD69965 .
GeneIDi 3168831.
KEGGi ttj:TTHA0142.
PATRICi 23955223. VBITheThe93045_0140.

Phylogenomic databases

eggNOGi COG1186.
HOGENOMi HOG000074814.
KOi K02836.
OMAi CYVDIQS.
OrthoDBi EOG6TN48J.
PhylomeDBi Q5SM01.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-150-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SM01.

Family and domain databases

Gene3Di 3.30.160.20. 1 hit.
InterProi IPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004374. PrfB.
[Graphical view ]
PANTHERi PTHR11075:SF6. PTHR11075:SF6. 1 hit.
Pfami PF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view ]
SMARTi SM00937. PCRF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00020. prfB. 1 hit.
PROSITEi PS00745. RF_PROK_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon."
    Petry S., Brodersen D.E., Murphy F.V., Dunham C.M., Selmer M., Tarry M.J., Kelley A.C., Ramakrishnan V.
    Cell 123:1255-1266(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (6.76 ANGSTROMS) OF 28-378.
  3. "Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies."
    Zoldak G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlak E., Sprinzl M.
    Nucleic Acids Res. 35:1343-1353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 27-378.
  4. "Insights into translational termination from the structure of RF2 bound to the ribosome."
    Weixlbaumer A., Jin H., Neubauer C., Voorhees R.M., Petry S., Kelley A.C., Ramakrishnan V.
    Science 322:953-956(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.45 ANGSTROMS) OF 31-369.
  5. "Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release."
    Jin H., Kelley A.C., Loakes D., Ramakrishnan V.
    Proc. Natl. Acad. Sci. U.S.A. 107:8593-8598(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 31-369.

Entry informationi

Entry nameiQ5SM01_THET8
AccessioniPrimary (citable) accession number: Q5SM01
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3