Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5SM01

- Q5SM01_THET8

UniProt

Q5SM01 - Q5SM01_THET8

Protein
Submitted name:

Peptide chain release factor 2

Gene

TTHA0142

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.SAAS annotation

    GO - Molecular functioni

    1. translation release factor activity, codon specific Source: InterPro

    Keywords - Biological processi

    Protein biosynthesisSAAS annotation

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-150-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peptide chain release factor 2Imported
    Gene namesi
    Ordered Locus Names:TTHA0142Imported
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA0142.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B9MX-ray6.76Y28-378[»]
    2IHRX-ray2.50127-378[»]
    2WH1X-ray3.45Y31-369[»]
    2WH3X-ray3.45Y31-369[»]
    2X9RX-ray3.10Y31-369[»]
    2X9TX-ray3.10Y31-369[»]
    ProteinModelPortaliQ5SM01.
    SMRiQ5SM01. Positions 27-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SM01.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1186.
    HOGENOMiHOG000074814.
    KOiK02836.
    OMAiCYVDIQS.
    OrthoDBiEOG6TN48J.
    PhylomeDBiQ5SM01.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004374. PrfB.
    [Graphical view]
    PANTHERiPTHR11075:SF6. PTHR11075:SF6. 1 hit.
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00020. prfB. 1 hit.
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SM01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLASQSAIL VKVWTWNASR NAWKASGGIF DIPQKETRLK ELERRLEDPS    50
    LWNDPEAARK VSQEAARLRR TVDTFRSLES DLQGLLELME ELPAEEREAL 100
    KPELEEAAKK LDELYHQTLL NFPHAEKNAI LTIQPGAGGT EACDWAEMLL 150
    RMYTRFAERQ GFQVEVVDLT PGPEAGIDYA QILVKGENAY GLLSPEAGVH 200
    RLVRPSPFDA SGRRHTSFAG VEVIPEVDEE VEVVLKPEEL RIDVMRASGP 250
    GGQGVNTTDS AVRVVHLPTG ITVTCQTTRS QIKNKELALK ILKARLYELE 300
    RKKREEELKA LRGEVRPIEW GSQIRSYVLD KNYVKDHRTG LMRHDPENVL 350
    DGDLMDLIWA GLEWKAGRRQ GTEEVEAE 378
    Length:378
    Mass (Da):42,734
    Last modified:December 21, 2004 - v1
    Checksum:i55B4AC9C891AEEB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD69965.1.
    RefSeqiWP_011174207.1. NC_006461.1.
    YP_143408.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD69965; BAD69965; BAD69965.
    GeneIDi3168831.
    KEGGittj:TTHA0142.
    PATRICi23955223. VBITheThe93045_0140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD69965.1 .
    RefSeqi WP_011174207.1. NC_006461.1.
    YP_143408.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B9M X-ray 6.76 Y 28-378 [» ]
    2IHR X-ray 2.50 1 27-378 [» ]
    2WH1 X-ray 3.45 Y 31-369 [» ]
    2WH3 X-ray 3.45 Y 31-369 [» ]
    2X9R X-ray 3.10 Y 31-369 [» ]
    2X9T X-ray 3.10 Y 31-369 [» ]
    ProteinModelPortali Q5SM01.
    SMRi Q5SM01. Positions 27-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0142.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD69965 ; BAD69965 ; BAD69965 .
    GeneIDi 3168831.
    KEGGi ttj:TTHA0142.
    PATRICi 23955223. VBITheThe93045_0140.

    Phylogenomic databases

    eggNOGi COG1186.
    HOGENOMi HOG000074814.
    KOi K02836.
    OMAi CYVDIQS.
    OrthoDBi EOG6TN48J.
    PhylomeDBi Q5SM01.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-150-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SM01.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004374. PrfB.
    [Graphical view ]
    PANTHERi PTHR11075:SF6. PTHR11075:SF6. 1 hit.
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00020. prfB. 1 hit.
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579Imported.
    2. "Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon."
      Petry S., Brodersen D.E., Murphy F.V., Dunham C.M., Selmer M., Tarry M.J., Kelley A.C., Ramakrishnan V.
      Cell 123:1255-1266(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (6.76 ANGSTROMS) OF 28-378.
    3. "Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies."
      Zoldak G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlak E., Sprinzl M.
      Nucleic Acids Res. 35:1343-1353(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 27-378.
    4. "Insights into translational termination from the structure of RF2 bound to the ribosome."
      Weixlbaumer A., Jin H., Neubauer C., Voorhees R.M., Petry S., Kelley A.C., Ramakrishnan V.
      Science 322:953-956(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.45 ANGSTROMS) OF 31-369.
    5. "Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release."
      Jin H., Kelley A.C., Loakes D., Ramakrishnan V.
      Proc. Natl. Acad. Sci. U.S.A. 107:8593-8598(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 31-369.

    Entry informationi

    Entry nameiQ5SM01_THET8
    AccessioniPrimary (citable) accession number: Q5SM01
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3