SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SM01

- Q5SM01_THET8

UniProt

Q5SM01 - Q5SM01_THET8

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Peptide chain release factor 2
Gene
TTHA0142
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA By similarity.SAAS annotations

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesisSAAS annotations

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-150-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptide chain release factor 2Imported
Gene namesi
Ordered Locus Names:TTHA0142Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0142.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B9MX-ray6.76Y28-378[»]
2IHRX-ray2.50127-378[»]
2WH1X-ray3.45Y31-369[»]
2WH3X-ray3.45Y31-369[»]
2X9RX-ray3.10Y31-369[»]
2X9TX-ray3.10Y31-369[»]
ProteinModelPortaliQ5SM01.
SMRiQ5SM01. Positions 27-369.

Miscellaneous databases

EvolutionaryTraceiQ5SM01.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1186.
HOGENOMiHOG000074814.
KOiK02836.
OMAiCYVDIQS.
OrthoDBiEOG6TN48J.
PhylomeDBiQ5SM01.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004374. PrfB.
[Graphical view]
PANTHERiPTHR11075:SF6. PTHR11075:SF6. 1 hit.
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00020. prfB. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SM01-1 [UniParc]FASTAAdd to Basket

« Hide

MRLASQSAIL VKVWTWNASR NAWKASGGIF DIPQKETRLK ELERRLEDPS    50
LWNDPEAARK VSQEAARLRR TVDTFRSLES DLQGLLELME ELPAEEREAL 100
KPELEEAAKK LDELYHQTLL NFPHAEKNAI LTIQPGAGGT EACDWAEMLL 150
RMYTRFAERQ GFQVEVVDLT PGPEAGIDYA QILVKGENAY GLLSPEAGVH 200
RLVRPSPFDA SGRRHTSFAG VEVIPEVDEE VEVVLKPEEL RIDVMRASGP 250
GGQGVNTTDS AVRVVHLPTG ITVTCQTTRS QIKNKELALK ILKARLYELE 300
RKKREEELKA LRGEVRPIEW GSQIRSYVLD KNYVKDHRTG LMRHDPENVL 350
DGDLMDLIWA GLEWKAGRRQ GTEEVEAE 378
Length:378
Mass (Da):42,734
Last modified:December 21, 2004 - v1
Checksum:i55B4AC9C891AEEB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD69965.1.
RefSeqiWP_011174207.1. NC_006461.1.
YP_143408.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69965; BAD69965; BAD69965.
GeneIDi3168831.
KEGGittj:TTHA0142.
PATRICi23955223. VBITheThe93045_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD69965.1 .
RefSeqi WP_011174207.1. NC_006461.1.
YP_143408.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B9M X-ray 6.76 Y 28-378 [» ]
2IHR X-ray 2.50 1 27-378 [» ]
2WH1 X-ray 3.45 Y 31-369 [» ]
2WH3 X-ray 3.45 Y 31-369 [» ]
2X9R X-ray 3.10 Y 31-369 [» ]
2X9T X-ray 3.10 Y 31-369 [» ]
ProteinModelPortali Q5SM01.
SMRi Q5SM01. Positions 27-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD69965 ; BAD69965 ; BAD69965 .
GeneIDi 3168831.
KEGGi ttj:TTHA0142.
PATRICi 23955223. VBITheThe93045_0140.

Phylogenomic databases

eggNOGi COG1186.
HOGENOMi HOG000074814.
KOi K02836.
OMAi CYVDIQS.
OrthoDBi EOG6TN48J.
PhylomeDBi Q5SM01.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-150-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SM01.

Family and domain databases

Gene3Di 3.30.160.20. 1 hit.
InterProi IPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004374. PrfB.
[Graphical view ]
PANTHERi PTHR11075:SF6. PTHR11075:SF6. 1 hit.
Pfami PF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view ]
SMARTi SM00937. PCRF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00020. prfB. 1 hit.
PROSITEi PS00745. RF_PROK_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon."
    Petry S., Brodersen D.E., Murphy F.V., Dunham C.M., Selmer M., Tarry M.J., Kelley A.C., Ramakrishnan V.
    Cell 123:1255-1266(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (6.76 ANGSTROMS) OF 28-378.
  3. "Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies."
    Zoldak G., Redecke L., Svergun D.I., Konarev P.V., Voertler C.S., Dobbek H., Sedlak E., Sprinzl M.
    Nucleic Acids Res. 35:1343-1353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 27-378.
  4. "Insights into translational termination from the structure of RF2 bound to the ribosome."
    Weixlbaumer A., Jin H., Neubauer C., Voorhees R.M., Petry S., Kelley A.C., Ramakrishnan V.
    Science 322:953-956(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.45 ANGSTROMS) OF 31-369.
  5. "Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release."
    Jin H., Kelley A.C., Loakes D., Ramakrishnan V.
    Proc. Natl. Acad. Sci. U.S.A. 107:8593-8598(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 31-369.

Entry informationi

Entry nameiQ5SM01_THET8
AccessioniPrimary (citable) accession number: Q5SM01
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi