ID   Q5SLX6_THET8            Unreviewed;       189 AA.
AC   Q5SLX6;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=Transcriptional regulator (TetR/AcrR family) {ECO:0000313|EMBL:BAD69990.1};
GN   OrderedLocusNames=TTHA0167 {ECO:0000313|EMBL:BAD69990.1};
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852 {ECO:0000313|EMBL:BAD69990.1, ECO:0000313|Proteomes:UP000000532};
RN   [1] {ECO:0000313|EMBL:BAD69990.1, ECO:0000313|Proteomes:UP000000532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8 {ECO:0000313|Proteomes:UP000000532};
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:3VUQ}
RP   X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 3-189, AND DISULFIDE BONDS.
RX   PubMed=23408580; DOI=10.1002/prot.24266;
RA   Agari Y., Sakamoto K., Yutani K., Kuramitsu S., Shinkai A.;
RT   "Structure and function of a TetR family transcriptional regulator, SbtR,
RT   from thermus thermophilus HB8.";
RL   Proteins 81:1166-1178(2013).
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DR   EMBL; AP008226; BAD69990.1; -; Genomic_DNA.
DR   RefSeq; WP_011174174.1; NC_006461.1.
DR   RefSeq; YP_143433.1; NC_006461.1.
DR   PDB; 3VUQ; X-ray; 2.05 A; A/B/C/D=3-189.
DR   PDBsum; 3VUQ; -.
DR   AlphaFoldDB; Q5SLX6; -.
DR   SMR; Q5SLX6; -.
DR   EnsemblBacteria; BAD69990; BAD69990; BAD69990.
DR   GeneID; 3169667; -.
DR   KEGG; ttj:TTHA0167; -.
DR   PATRIC; fig|300852.9.peg.165; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_2_0; -.
DR   PhylomeDB; Q5SLX6; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR049445; TetR_SbtR-like_C.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF164; TRANSCRIPTIONAL REPRESSOR MCE3R; 1.
DR   Pfam; PF21597; TetR_C_43; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3VUQ};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000532}.
FT   DOMAIN          13..73
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        36..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT   DISULFID        166
FT                   /note="Interchain"
FT                   /evidence="ECO:0007829|PDB:3VUQ"
SQ   SEQUENCE   189 AA;  21539 MW;  866293AAC6B44D1F CRC64;
     MAAMITPPGA GVKDKKRAIL EATLAVLRER GLSGLKMEEV ARRAEVGKGT IYLYFRDKRD
     LLKALVEERT WAFYREVEEV VRRKAPFFVR LEEVLRRRLA WVQEWRGLWA AVAREAMDDP
     TPWLKGLHEH YLRLLEELLR SGQSEGAVRT GLSPRATAAV IAAMGCTPSL EVEAYLEHLM
     EVLRKGVEP
//