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Protein
Submitted name:

Transcriptional regulator (TetR/AcrR family)

Gene

TTHA0167

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-176-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (TetR/AcrR family)Imported
Gene namesi
Ordered Locus Names:TTHA0167Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0167.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VUQX-ray2.05A/B/C/D3-189[»]
ProteinModelPortaliQ5SLX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation
Contains HTH tetR-type DNA-binding domain.SAAS annotation

Phylogenomic databases

eggNOGiNOG308430.
HOGENOMiHOG000105151.
OMAiYHETSID.
OrthoDBiEOG6PP9N1.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAMITPPGA GVKDKKRAIL EATLAVLRER GLSGLKMEEV ARRAEVGKGT
60 70 80 90 100
IYLYFRDKRD LLKALVEERT WAFYREVEEV VRRKAPFFVR LEEVLRRRLA
110 120 130 140 150
WVQEWRGLWA AVAREAMDDP TPWLKGLHEH YLRLLEELLR SGQSEGAVRT
160 170 180
GLSPRATAAV IAAMGCTPSL EVEAYLEHLM EVLRKGVEP
Length:189
Mass (Da):21,539
Last modified:December 21, 2004 - v1
Checksum:i866293AAC6B44D1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD69990.1.
RefSeqiYP_143433.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD69990; BAD69990; BAD69990.
GeneIDi3169667.
KEGGittj:TTHA0167.
PATRICi23955275. VBITheThe93045_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD69990.1.
RefSeqiYP_143433.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VUQX-ray2.05A/B/C/D3-189[»]
ProteinModelPortaliQ5SLX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD69990; BAD69990; BAD69990.
GeneIDi3169667.
KEGGittj:TTHA0167.
PATRICi23955275. VBITheThe93045_0165.

Phylogenomic databases

eggNOGiNOG308430.
HOGENOMiHOG000105151.
OMAiYHETSID.
OrthoDBiEOG6PP9N1.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-176-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "Structure and function of a TetR family transcriptional regulator, SbtR, from thermus thermophilus HB8."
    Agari Y., Sakamoto K., Yutani K., Kuramitsu S., Shinkai A.
    Proteins 81:1166-1178(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 3-189, ACTIVE SITE.

Entry informationi

Entry nameiQ5SLX6_THET8
AccessioniPrimary (citable) accession number: Q5SLX6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.