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Q5SLX1 (UPPP_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:TTHA0172
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151229

Regions

Transmembrane9 – 3123Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane240 – 26021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5SLX1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E295AB88E206BF6B

FASTA26128,345
        10         20         30         40         50         60 
MGRVSAWEAL LLGVVEGLTE FLPVSSTGHL TLLFHLLGLP VEEDPFLKTF LVAIQLGAIL 

        70         80         90        100        110        120 
AVLLLYGRRL AADRALWLRI AVAFVPTGVI GFLFYPLIKG VILGNDAVVA FFLFFVGAVL 

       130        140        150        160        170        180 
LFADRLAERA QYQDVKALPL ARVAWIGVFQ GLAALFPGTS RSGATILGGL LLGLNRQAAA 

       190        200        210        220        230        240 
EFSFLLALPT MFAAVGYDLW KSAPEVPEGG WSLLLLGFLA ALVTALVTVR WMLAFVARHG 

       250        260 
FRPFALYRMA LAAVYAFFFL R 

« Hide

References

[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD69995.1.
RefSeqYP_143438.1. NC_006461.1.

3D structure databases

ProteinModelPortalQ5SLX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA0172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD69995; BAD69995; BAD69995.
GeneID3169669.
KEGGttj:TTHA0172.
PATRIC23955285. VBITheThe93045_0170.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK245413.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-181-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_THET8
AccessionPrimary (citable) accession number: Q5SLX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families