Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91ATPUniRule annotation1 Publication
Binding sitei57 – 571ATPUniRule annotation1 Publication
Binding sitei85 – 851ATPUniRule annotation1 Publication
Binding sitei91 – 911ATPUniRule annotation1 Publication
Binding sitei102 – 1021ATPUniRule annotation1 Publication
Binding sitei112 – 1121ATPUniRule annotation1 Publication
Active sitei115 – 1151Pros-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:TTHA0188
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Nucleoside diphosphate kinasePRO_0000137067Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA0188.

Structurei

Secondary structure

1
137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi10 – 145Combined sources
Helixi18 – 2811Combined sources
Beta strandi31 – 388Combined sources
Helixi42 – 487Combined sources
Helixi50 – 523Combined sources
Beta strandi53 – 575Combined sources
Helixi58 – 658Combined sources
Beta strandi70 – 778Combined sources
Helixi80 – 889Combined sources
Turni93 – 953Combined sources
Helixi101 – 1055Combined sources
Beta strandi113 – 1164Combined sources
Helixi120 – 13011Combined sources
Helixi133 – 1353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WKJX-ray2.00A/B1-137[»]
1WKKX-ray2.70A/B1-137[»]
1WKLX-ray2.20A/B1-137[»]
ProteinModelPortaliQ5SLV5.
SMRiQ5SLV5. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiAEHSERP.
PhylomeDBiQ5SLV5.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTFVMIKP DGVRRGLVGE ILARFERKGF RIAALKLMQI SQELAERHYA
60 70 80 90 100
EHREKPFFPG LVRFITSGPV VAMVLEGPGV VAEVRKMMGA THPKDALPGT
110 120 130
IRGDFATTID ENVIHGSATL EDAQREIALF FRPEELL
Length:137
Mass (Da):15,344
Last modified:December 21, 2004 - v1
Checksum:i750E673CA9C9FE3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70011.1.
RefSeqiWP_011227764.1. NC_006461.1.
YP_143454.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70011; BAD70011; BAD70011.
GeneIDi3169489.
KEGGittj:TTHA0188.
PATRICi23955317. VBITheThe93045_0186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70011.1.
RefSeqiWP_011227764.1. NC_006461.1.
YP_143454.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WKJX-ray2.00A/B1-137[»]
1WKKX-ray2.70A/B1-137[»]
1WKLX-ray2.20A/B1-137[»]
ProteinModelPortaliQ5SLV5.
SMRiQ5SLV5. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70011; BAD70011; BAD70011.
GeneIDi3169489.
KEGGittj:TTHA0188.
PATRICi23955317. VBITheThe93045_0186.

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224564.
KOiK00940.
OMAiAEHSERP.
PhylomeDBiQ5SLV5.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-197-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SLV5.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDK_THET8
AccessioniPrimary (citable) accession number: Q5SLV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.