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Protein

Dihydropteroate synthase

Gene

TTHA0191

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (TTHA0191)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Folate biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-200-MONOMER.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthaseUniRule annotation (EC:2.5.1.15UniRule annotation)
Short name:
DHPSUniRule annotation
Alternative name(s):
Dihydropteroate pyrophosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:TTHA0191Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0191.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DQWX-ray1.65A/B1-294[»]
2DZAX-ray1.90A/B1-294[»]
2DZBX-ray1.90A/B1-294[»]
ProteinModelPortaliQ5SLV2.
SMRiQ5SLV2. Positions 15-286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 280252Pterin-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DHPS family.UniRule annotation
Contains 1 pterin-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
HOGENOMiHOG000217509.
KOiK00796.
OMAiSIDTYHA.
PhylomeDBiQ5SLV2.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPPLGPTI IPPVRTLWLR DRALDLDRVR LLGVLNLTPD SFSDGGRYLD
60 70 80 90 100
PERALERARE MVAEGADILD LGAESTRPGA APVPVEEEKR RLLPVLEAVL
110 120 130 140 150
SLGVPVSVDT RKPEVAEEAL KLGAHLLNDV TGLRDERMVA LAARHGVAAV
160 170 180 190 200
VMHMPVPDPA TMMAHARYRD VVAEVKAFLE AQARRALSAG VPQVVLDPGF
210 220 230 240 250
GFGKLLEHNL ALLRRLDEIV ALGHPVLVGL SRKRTIGELS GVEDPAQRVH
260 270 280 290
GSVAAHLFAV MKGVRLLRVH DVRAHREALG VWEALYGGDR PSRA
Length:294
Mass (Da):31,849
Last modified:December 21, 2004 - v1
Checksum:i9EA7589A7B4D7A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70014.1.
RefSeqiWP_011227766.1. NC_006461.1.
YP_143457.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70014; BAD70014; BAD70014.
GeneIDi3168556.
KEGGittj:TTHA0191.
PATRICi23955323. VBITheThe93045_0189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70014.1.
RefSeqiWP_011227766.1. NC_006461.1.
YP_143457.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DQWX-ray1.65A/B1-294[»]
2DZAX-ray1.90A/B1-294[»]
2DZBX-ray1.90A/B1-294[»]
ProteinModelPortaliQ5SLV2.
SMRiQ5SLV2. Positions 15-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0191.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70014; BAD70014; BAD70014.
GeneIDi3168556.
KEGGittj:TTHA0191.
PATRICi23955323. VBITheThe93045_0189.

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
HOGENOMiHOG000217509.
KOiK00796.
OMAiSIDTYHA.
PhylomeDBiQ5SLV2.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.
BioCyciTTHE300852:GH8R-200-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SLV2.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SLV2_THET8
AccessioniPrimary (citable) accession number: Q5SLV2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.