Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5SLS7 (Q5SLS7_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183
Gene names
Ordered Locus Names:TTHA0216
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183

Pathway

Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183

Sequence similarities

Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
   LigandNAD PIRNR PIRNR000183
   Molecular functionOxidoreductase PIRNR PIRNR000183
   Technical term3D-structure PDB 2EEZ
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionalanine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5SLS7 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E17D5371113B726E

FASTA36938,633
        10         20         30         40         50         60 
MVIGVPKEIK TLENRVALTP GGVESLVRRG HTVLVERGAG EGSGLSDAEY ARAGAELVGR 

        70         80         90        100        110        120 
EEAWGAEMVV KVKEPLPEEY GFLREGLILF TYLHLAADRG LTEAMLRSGV TGIAYETVQL 

       130        140        150        160        170        180 
PDGTLPLLVP MSEVAGRMAP QVGAQFLEKP KGGRGVLLGG VPGVAPASVV ILGGGTVGTN 

       190        200        210        220        230        240 
AAKIALGMGA QVTILDVNHK RLQYLDDVFG GRVITLTATE ANIKKSVQHA DLLIGAVLVP 

       250        260        270        280        290        300 
GAKAPKLVTR DMLSLMKEGA VIVDVAVDQG GCVETIRPTT HAEPTYVVDG VVHYGVANMP 

       310        320        330        340        350        360 
GAVPRTSTFA LTNQTLPYVL KLAEKGLDAL LEDAALLKGL NTHKGRLTHP GVAEAFGLPY 


TPPEEALRG

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of alanine dehydrogenase from themus thermophilus."
Kumarevel T.S., Karthe P., Kuramitsu S., Yokoyama S.
Submitted (FEB-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70039.1.
RefSeqYP_143482.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EEZX-ray2.71A/C/D/E/F/G1-369[»]
ProteinModelPortalQ5SLS7.
SMRQ5SLS7. Positions 1-369.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SLS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3168110.
GenomeReviewsGene locus TTHA0216 in contig AP008226_GR.
KEGGttj:TTHA0216.
NMPDRfig|300852.3.peg.247.
PATRIC23955373. VBITheThe93045_0214.

Phylogenomic databases

eggNOGCOG0686.
HOGENOMHBG289735.
OMAMNIAEAV.
PhylomeDBQ5SLS7.
ProtClustDBCLSK445306.

Enzyme and pathway databases

BioCycTTHE300852:TTHA0216-MONOMER.

Family and domain databases

InterProIPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00259.
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. AlaDH. 1 hit.
PROSITEPS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5SLS7_THET8
AccessionPrimary (citable) accession number: Q5SLS7
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info