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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

TTHA0232

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
LigandPyruvateImported

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-240-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0232Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ5SLR1

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0232

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQ9X-ray2.09C/F/I/L145-185[»]
ProteinModelPortaliQ5SLR1
SMRiQ5SLR1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLR1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingInterPro annotationAdd BLAST76
Domaini146 – 183Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
HOGENOMiHOG000281564
KOiK00627
OMAiDNLCEVQ
PhylomeDBiQ5SLR1

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SLR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEILMPEL AESVVEGEIL KWLVEEGDYL KKDQPFVEVM TDKVTVELPS
60 70 80 90 100
PYEGVLLKKL AKEGEVVKVH APIALIAEPG EAVEGVKEAP PVQAVEERSI
110 120 130 140 150
VEPGLPAKEE KEDLSLFKPD PTQVAVKNPF LSGEKPQEGA RPGRVLAVPA
160 170 180 190 200
ARKLARELGI PIEEVPGSGP LGRVRVEDVR AYAERRKAPP ERPEEGPQVL
210 220 230 240 250
PAGFPPPPKY APPKGYEHLE ERVPLRGIRR TIAQGLWQSH LYTVRTLNVD
260 270 280 290 300
EADLTELVRL RERLKPQAEA QGVKLTYLPF IVKAVVRALK KFPMLNTSLD
310 320 330 340 350
EERQEIVYKR YYHIGLAVAT ERGLIVPVVR DADRKSVLEL AQEIAELSQK
360 370 380 390 400
AREGRLAPEE VTGSTFTITN IGSVGATLSF PIIHLPDAAI LGVHSIRKRP
410 420 430 440 450
WVMPDGSIRP RDIMFLSLSF DHRLVDGAEA AMFTREVIRL LENPDLLLLE

M
Length:451
Mass (Da):50,179
Last modified:December 21, 2004 - v1
Checksum:i6D1B65E2535DC88E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70055.1
RefSeqiWP_011227796.1, NC_006461.1
YP_143498.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70055; BAD70055; BAD70055
GeneIDi3168019
KEGGittj:TTHA0232
PATRICifig|300852.9.peg.231

Entry informationi

Entry nameiQ5SLR1_THET8
AccessioniPrimary (citable) accession number: Q5SLR1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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