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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

TTHA0232

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-240-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0232Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ5SLR1.

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0232.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQ9X-ray2.09C/F/I/L146-185[»]
ProteinModelPortaliQ5SLR1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLR1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281564.
KOiK00627.
OMAiERQEIVY.
PhylomeDBiQ5SLR1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEILMPEL AESVVEGEIL KWLVEEGDYL KKDQPFVEVM TDKVTVELPS
60 70 80 90 100
PYEGVLLKKL AKEGEVVKVH APIALIAEPG EAVEGVKEAP PVQAVEERSI
110 120 130 140 150
VEPGLPAKEE KEDLSLFKPD PTQVAVKNPF LSGEKPQEGA RPGRVLAVPA
160 170 180 190 200
ARKLARELGI PIEEVPGSGP LGRVRVEDVR AYAERRKAPP ERPEEGPQVL
210 220 230 240 250
PAGFPPPPKY APPKGYEHLE ERVPLRGIRR TIAQGLWQSH LYTVRTLNVD
260 270 280 290 300
EADLTELVRL RERLKPQAEA QGVKLTYLPF IVKAVVRALK KFPMLNTSLD
310 320 330 340 350
EERQEIVYKR YYHIGLAVAT ERGLIVPVVR DADRKSVLEL AQEIAELSQK
360 370 380 390 400
AREGRLAPEE VTGSTFTITN IGSVGATLSF PIIHLPDAAI LGVHSIRKRP
410 420 430 440 450
WVMPDGSIRP RDIMFLSLSF DHRLVDGAEA AMFTREVIRL LENPDLLLLE

M
Length:451
Mass (Da):50,179
Last modified:December 21, 2004 - v1
Checksum:i6D1B65E2535DC88E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70055.1.
RefSeqiWP_011227796.1. NC_006461.1.
YP_143498.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70055; BAD70055; BAD70055.
GeneIDi3168019.
KEGGittj:TTHA0232.
PATRICi23955407. VBITheThe93045_0231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70055.1.
RefSeqiWP_011227796.1. NC_006461.1.
YP_143498.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQ9X-ray2.09C/F/I/L146-185[»]
ProteinModelPortaliQ5SLR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0232.

Proteomic databases

PRIDEiQ5SLR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70055; BAD70055; BAD70055.
GeneIDi3168019.
KEGGittj:TTHA0232.
PATRICi23955407. VBITheThe93045_0231.

Phylogenomic databases

eggNOGiENOG4107QSN. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281564.
KOiK00627.
OMAiERQEIVY.
PhylomeDBiQ5SLR1.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-240-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SLR1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SLR1_THET8
AccessioniPrimary (citable) accession number: Q5SLR1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.