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Q5SLQ0 (RS18_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S18
Gene names
Name:rpsR
Ordered Locus Names:TTHA0243
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Located on the back of the platform of the 30S subunit where it stabilizes the close packing of several RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it probably interacts with the Shine-Dalgarno helix. HAMAP-Rule MF_00270

Subunit structure

Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6, also interacts with protein S11. Binds to the C-terminus of IF3 and to the central section of Era. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15

Sequence similarities

Belongs to the ribosomal protein S18P family.

Mass spectrometry

Molecular mass is 10101 Da from positions 2 - 88. Determined by MALDI. Ref.3

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 888730S ribosomal protein S18 HAMAP-Rule MF_00270
PRO_0000111250

Experimental info

Sequence conflict171S → T AA sequence Ref.2

Secondary structure

................. 88
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SLQ0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CFDE7AC4953EF809

FASTA8810,231
        10         20         30         40         50         60 
MSTKNAKPKK EAQRRPSRKA KVKATLGEFD LRDYRNVEVL KRFLSETGKI LPRRRTGLSA 

        70         80 
KEQRILAKTI KRARILGLLP FTEKLVRK 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus."
Tsiboli P., Herfurth E., Choli T.
Eur. J. Biochem. 226:169-177(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-26.
[3]"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
[4]"Structure of the 30S ribosomal subunit."
Wimberly B.T., Brodersen D.E., Clemons W.M. Jr., Morgan-Warren R.J., Carter A.P., Vonrhein C., Hartsch T., Ramakrishnan V.
Nature 407:327-339(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
[5]"Structure of functionally activated small ribosomal subunit at 3.3 A resolution."
Schluenzen F., Tocilj A., Zarivach R., Harms J., Gluehmann M., Janell D., Bashan A., Bartels H., Agmon I., Franceschi F., Yonath A.
Cell 102:615-623(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[6]"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Cell 103:1143-1154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[7]"Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Nature 407:340-348(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 30S SUBUNIT.
[8]"Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain."
Agalarov S.C., Prasad G.S., Funke P.M., Stout C.D., Williamson J.R.
Science 288:107-113(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A 30S SUBUNIT FRAGMENT.
[9]"The path of messenger RNA through the ribosome."
Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[10]"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3."
Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F.
EMBO J. 20:1829-1839(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[11]"Crystal structure of an initiation factor bound to the 30S ribosomal subunit."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., Ramakrishnan V.
Science 291:498-501(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[12]"Crystal structure of the ribosome at 5.5 A resolution."
Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F.
Science 292:883-896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
[13]"Recognition of cognate transfer RNA by the 30S ribosomal subunit."
Ogle J.M., Brodersen D.E., Clemons W.M. Jr., Tarry M.J., Carter A.P., Ramakrishnan V.
Science 292:897-902(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.11 ANGSTROMS) OF THE 30S SUBUNIT.
[14]"Crystal structure of the 30S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16S RNA."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Wimberly B.T., Ramakrishnan V.
J. Mol. Biol. 316:725-768(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
[15]"Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly."
Sharma M.R., Barat C., Wilson D.N., Booth T.M., Kawazoe M., Hori-Takemoto C., Shirouzu M., Yokoyama S., Fucini P., Agrawal R.K.
Mol. Cell 18:319-329(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (13.50 ANGSTROMS), INTERACTION WITH ERA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD70066.1.
RefSeqYP_143509.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FJGX-ray3.00R1-88[»]
1FKAX-ray3.30R1-88[»]
1G1XX-ray2.60C/H1-88[»]
1GIXX-ray5.50U1-88[»]
1HNWX-ray3.40R1-88[»]
1HNXX-ray3.40R1-88[»]
1HNZX-ray3.30R1-88[»]
1HR0X-ray3.20R1-88[»]
1I94X-ray3.20R2-88[»]
1I95X-ray4.50R2-88[»]
1I96X-ray4.20R2-88[»]
1I97X-ray4.50R2-88[»]
1IBKX-ray3.31R1-88[»]
1IBLX-ray3.11R1-88[»]
1IBMX-ray3.31R1-88[»]
1J5EX-ray3.05R1-88[»]
1JGOX-ray5.60U1-88[»]
1JGPX-ray7.00U1-88[»]
1JGQX-ray5.00U1-88[»]
1L1Umodel-R16-88[»]
1ML5electron microscopy14.00U1-88[»]
1N32X-ray3.00R1-88[»]
1N33X-ray3.35R1-88[»]
1N34X-ray3.80R1-88[»]
1N36X-ray3.65R1-88[»]
1PNSX-ray8.70R16-88[»]
1PNXX-ray9.50R16-88[»]
1X18electron microscopy13.50H16-88[»]
1XMOX-ray3.25R1-88[»]
1XMQX-ray3.00R1-88[»]
1XNQX-ray3.05R1-88[»]
1XNRX-ray3.10R1-88[»]
1YL4X-ray5.50U1-88[»]
2B64X-ray5.90R1-88[»]
2B9MX-ray6.76R1-88[»]
2B9OX-ray6.46R1-88[»]
2E5LX-ray3.30R2-88[»]
2F4VX-ray3.80R1-88[»]
2HGIX-ray5.00U1-88[»]
2HGPX-ray5.50U1-88[»]
2HGRX-ray4.51U1-88[»]
2HHHX-ray3.35R1-88[»]
2J00X-ray2.80R2-87[»]
2J02X-ray2.80R2-87[»]
2OW8X-ray3.71s-[»]
2UU9X-ray3.10R2-87[»]
2UUAX-ray2.90R1-88[»]
2UUBX-ray2.90R2-87[»]
2UUCX-ray3.10R2-87[»]
2UXBX-ray3.10R1-88[»]
2UXCX-ray2.90R1-88[»]
2UXDX-ray3.20R1-88[»]
2V46X-ray3.80R2-87[»]
2V48X-ray3.50R1-88[»]
2WDGX-ray3.30R1-88[»]
2WDHX-ray3.30R1-88[»]
2WDKX-ray3.50R1-88[»]
2WDMX-ray3.50R1-88[»]
2WH1X-ray3.45R1-88[»]
2WH3X-ray3.45R1-88[»]
2WRIX-ray3.60R1-88[»]
2WRKX-ray3.60R1-88[»]
2WRNX-ray3.60R1-88[»]
2WRQX-ray3.60R1-88[»]
2X9RX-ray3.10R1-88[»]
2X9TX-ray3.10R1-88[»]
2XFZX-ray3.20R1-88[»]
2XG1X-ray3.20R1-88[»]
2XQDX-ray3.10R1-88[»]
2XSYelectron microscopy7.80R1-88[»]
2XUYelectron microscopy7.60R1-88[»]
2Y0UX-ray3.10R1-88[»]
2Y0WX-ray3.10R1-88[»]
2Y0YX-ray3.10R1-88[»]
2Y10X-ray3.10R1-88[»]
2Y12X-ray3.10R1-88[»]
2Y14X-ray3.10R1-88[»]
2Y16X-ray3.10R1-88[»]
2Y18X-ray3.10R1-88[»]
2ZM6X-ray3.30R2-88[»]
3FICelectron microscopy6.40R19-88[»]
3HUWX-ray3.10R1-88[»]
3HUYX-ray3.10R1-88[»]
3I8GX-ray3.10U1-88[»]
3I8HX-ray3.10U1-88[»]
3I9BX-ray3.50U1-88[»]
3I9DX-ray3.50U1-88[»]
3KIQX-ray3.30r1-88[»]
3KISX-ray3.30r1-88[»]
3KIUX-ray3.60r1-88[»]
3KIXX-ray3.60r1-88[»]
3KNHX-ray3.00R1-88[»]
3KNJX-ray3.15R1-88[»]
3KNLX-ray3.45R1-88[»]
3KNNX-ray3.45R1-88[»]
3OGEX-ray3.00R1-88[»]
3OGYX-ray3.00R1-88[»]
3OHCX-ray3.00R1-88[»]
3OHDX-ray3.00R1-88[»]
3OHYX-ray3.00R1-88[»]
3OI0X-ray3.00R1-88[»]
3OI2X-ray3.10R1-88[»]
3OI4X-ray3.10R1-88[»]
3OTOX-ray3.69R1-88[»]
3T1HX-ray3.11R1-88[»]
3T1YX-ray2.80R1-88[»]
3TVFX-ray3.10U1-88[»]
3TVGX-ray3.10U1-88[»]
3UXSX-ray3.20R1-88[»]
3UXTX-ray3.20R1-88[»]
3UYDX-ray3.00U1-88[»]
3UYFX-ray3.00U1-88[»]
3UZ3X-ray3.30U1-88[»]
3UZ4X-ray3.30U1-88[»]
3UZ6X-ray3.00U1-88[»]
3UZ7X-ray3.00U1-88[»]
3UZGX-ray3.30U1-88[»]
3UZIX-ray3.30U1-88[»]
3UZLX-ray3.30U1-88[»]
3UZMX-ray3.30U1-88[»]
3V22X-ray3.00R1-88[»]
3V24X-ray3.00R1-88[»]
3V26X-ray3.10R1-88[»]
3V28X-ray3.10R1-88[»]
3V2CX-ray2.70R1-88[»]
3V2EX-ray2.70R1-88[»]
3V6UX-ray3.90R1-88[»]
3V6VX-ray3.90R1-88[»]
3ZN7X-ray3.10R1-88[»]
3ZNDX-ray3.10R1-88[»]
3ZVOX-ray3.80R1-88[»]
4ABRX-ray3.10R1-88[»]
4AQYX-ray3.50R1-88[»]
4B3MX-ray2.90R1-88[»]
4B3RX-ray3.00R1-88[»]
4B3SX-ray3.15R1-88[»]
4B3TX-ray3.00R1-88[»]
4B8FX-ray3.70R1-88[»]
4B8HX-ray3.70R1-88[»]
4BTCX-ray2.95R1-88[»]
4BYBX-ray3.35R1-88[»]
4BYDX-ray3.35R1-88[»]
4DH9X-ray3.20R1-88[»]
4DHBX-ray3.20R1-88[»]
4DR1X-ray3.60R1-88[»]
4DR2X-ray3.25R1-88[»]
4DR3X-ray3.35R1-88[»]
4DR4X-ray3.97R1-88[»]
4DR5X-ray3.45R1-88[»]
4DR6X-ray3.30R1-88[»]
4DR7X-ray3.75R1-88[»]
4DUYX-ray3.39R1-88[»]
4DUZX-ray3.65R1-88[»]
4DV0X-ray3.85R1-88[»]
4DV1X-ray3.85R1-88[»]
4DV2X-ray3.65R1-88[»]
4DV3X-ray3.55R1-88[»]
4DV4X-ray3.65R1-88[»]
4DV5X-ray3.68R1-88[»]
4DV6X-ray3.30R1-88[»]
4DV7X-ray3.29R1-88[»]
4EJ9X-ray3.52R1-88[»]
4EJAX-ray3.52R1-88[»]
4G5KX-ray3.30U1-88[»]
4G5MX-ray3.30U1-88[»]
4G5TX-ray3.10U1-88[»]
4G5VX-ray3.10U1-88[»]
4GKJX-ray3.30R16-88[»]
4GKKX-ray3.20R16-88[»]
4JI0X-ray3.49R1-88[»]
4JI1X-ray3.14R1-88[»]
4JI2X-ray3.64R1-88[»]
4JI3X-ray3.35R1-88[»]
4JI4X-ray3.69R1-88[»]
4JI5X-ray3.85R1-88[»]
4JI6X-ray3.55R1-88[»]
4JI7X-ray3.50R1-88[»]
4JI8X-ray3.74R1-88[»]
4JUWX-ray2.86R19-88[»]
4JV5X-ray3.16R19-88[»]
4JYAX-ray3.10R19-88[»]
4K0KX-ray3.40R19-88[»]
4K0LX-ray3.30R19-88[»]
4K0PX-ray3.30R19-88[»]
4KHPX-ray3.10R19-88[»]
ProteinModelPortalQ5SLQ0.
SMRQ5SLQ0. Positions 8-88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA0243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70066; BAD70066; BAD70066.
GeneID3169870.
KEGGttj:TTHA0243.
PATRIC23955431. VBITheThe93045_0243.

Phylogenomic databases

eggNOGCOG0238.
HOGENOMHOG000218466.
KOK02963.
OMAKMKFLAL.
OrthoDBEOG6PCQ4R.
ProtClustDBPRK00391.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-252-MONOMER.

Family and domain databases

Gene3D4.10.640.10. 1 hit.
HAMAPMF_00270. Ribosomal_S18.
InterProIPR001648. Ribosomal_S18.
IPR018275. Ribosomal_S18_CS.
[Graphical view]
PANTHERPTHR13479. PTHR13479. 1 hit.
PfamPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
PRINTSPR00974. RIBOSOMALS18.
ProDomPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF46911. SSF46911. 1 hit.
TIGRFAMsTIGR00165. S18. 1 hit.
PROSITEPS00057. RIBOSOMAL_S18. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5SLQ0.

Entry information

Entry nameRS18_THET8
AccessionPrimary (citable) accession number: Q5SLQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references