30S ribosomal protein S6 - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

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Reviewed, UniProtKB/Swiss-Prot Q5SLP8 (RS6_THET8)

Last modified November 3, 2009. Version 45. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
30S ribosomal protein S6
Alternative name(s):
TS9

Gene names

Name:	rpsF
Ordered Locus Names:	TTHA0245

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Located on the outer edge of the platform on the body of the 30S subunit. HAMAP MF_00360
Subunit structure	Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S18. May make transient contacts with protein L2 of the 50S subunit during translation. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.14 Ref.15
Sequence similarities	Belongs to the ribosomal protein S6P family.
Mass spectrometry	Molecular mass is 11973 Da from positions 1 - 101. Determined by MALDI. Ref.3

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

101

30S ribosomal protein S6 HAMAP MF_00360

PRO_0000176863

Secondary structure

1

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101

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q5SLP8-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 4FEE8005C74902E5
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101

11,973

        10         20         30         40         50         60 
MRRYEVNIVL NPNLDQSQLA LEKEIIQRAL ENYGARVEKV EELGLRRLAY PIAKDPQGYF 

        70         80         90        100 
LWYQVEMPED RVNDLARELR IRDNVRRVMV VKSQEPFLAN A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus." Tsiboli P., Herfurth E., Choli T. Eur. J. Biochem. 226:169-177(1994) [PubMed: 7957245] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-16.
[3]	"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry." Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A. Proteomics 5:4818-4831(2005) [PubMed: 16287167] [Abstract] Cited for: MASS SPECTROMETRY.
[4]	"Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution." Clemons W.M. Jr., May J.L.C., Wimberly B.T., McCutcheon J.P., Capel M.S., Ramakrishnan V. Nature 400:833-840(1999) [PubMed: 10476960] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE 30S SUBUNIT.
[5]	"Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain." Agalarov S.C., Prasad G.S., Funke P.M., Stout C.D., Williamson J.R. Science 288:107-113(2000) [PubMed: 10753109] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A 30S SUBUNIT FRAGMENT.
[6]	"Structure of the 30S ribosomal subunit." Wimberly B.T., Brodersen D.E., Clemons W.M. Jr., Morgan-Warren R.J., Carter A.P., Vonrhein C., Hartsch T., Ramakrishnan V. Nature 407:327-339(2000) [PubMed: 11014182] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
[7]	"Structure of functionally activated small ribosomal subunit at 3.3 A resolution." Schluenzen F., Tocilj A., Zarivach R., Harms J., Gluehmann M., Janell D., Bashan A., Bartels H., Agmon I., Franceschi F., Yonath A. Cell 102:615-623(2000) [PubMed: 11007480] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[8]	"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit." Brodersen D.E., Clemons W.M. Jr., Carter A.P., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V. Cell 103:1143-1154(2000) [PubMed: 11163189] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[9]	"Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics." Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V. Nature 407:340-348(2000) [PubMed: 11014183] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 30S SUBUNIT.
[10]	"The path of messenger RNA through the ribosome." Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F. Cell 106:233-241(2001) [PubMed: 11511350] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[11]	"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3." Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F. EMBO J. 20:1829-1839(2001) [PubMed: 11296217] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[12]	"Crystal structure of an initiation factor bound to the 30S ribosomal subunit." Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., Ramakrishnan V. Science 291:498-501(2001) [PubMed: 11228145] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[13]	"Crystal structure of the ribosome at 5.5 A resolution." Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F. Science 292:883-896(2001) [PubMed: 11283358] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
[14]	"Recognition of cognate transfer RNA by the 30S ribosomal subunit." Ogle J.M., Brodersen D.E., Clemons W.M. Jr., Tarry M.J., Carter A.P., Ramakrishnan V. Science 292:897-902(2001) [PubMed: 11340196] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.11 ANGSTROMS) OF THE 30S SUBUNIT.
[15]	"Crystal structure of the 30S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16S RNA." Brodersen D.E., Clemons W.M. Jr., Carter A.P., Wimberly B.T., Ramakrishnan V. J. Mol. Biol. 316:725-768(2002) [PubMed: 11866529] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
+	Additional computationally mapped references.

Web resources

T.thermophilus ribosome structure and function

Cross-references

Sequence databases

AP008226 Genomic DNA. Translation: BAD70068.1.

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FJG	X-ray	3.00	F	1-101	[»]
1FKA	X-ray	3.30	F	1-101	[»]
1G1X	X-ray	2.60	A/F	1-98	[»]
1GIX	X-ray	5.50	I	1-101	[»]
1HNW	X-ray	3.40	F	1-101	[»]
1HNX	X-ray	3.40	F	1-101	[»]
1HNZ	X-ray	3.30	F	1-101	[»]
1HR0	X-ray	3.20	F	1-101	[»]
1I94	X-ray	3.20	F	1-101	[»]
1I95	X-ray	4.50	F	1-101	[»]
1I96	X-ray	4.20	F	1-101	[»]
1I97	X-ray	4.50	F	1-101	[»]
1IBK	X-ray	3.31	F	1-101	[»]
1IBL	X-ray	3.11	F	1-101	[»]
1IBM	X-ray	3.31	F	1-101	[»]
1J5E	X-ray	3.05	F	1-101	[»]
1JGO	X-ray	5.60	I	1-101	[»]
1JGP	X-ray	7.00	I	1-101	[»]
1JGQ	X-ray	5.00	I	1-101	[»]
1L1U	model	-	F	1-101	[»]
1N32	X-ray	3.00	F	1-101	[»]
1N33	X-ray	3.35	F	1-101	[»]
1N34	X-ray	3.80	F	1-101	[»]
1N36	X-ray	3.65	F	1-101	[»]
1PNS	X-ray	8.70	F	1-101	[»]
1PNX	X-ray	9.50	F	1-101	[»]
1XMO	X-ray	3.25	F	1-101	[»]
1XMQ	X-ray	3.00	F	1-101	[»]
1XNQ	X-ray	3.05	F	1-101	[»]
1XNR	X-ray	3.10	F	1-101	[»]
1YL4	X-ray	5.50	I	1-101	[»]
2B64	X-ray	5.90	F	1-101	[»]
2B9O	X-ray	6.46	F	1-101	[»]
2E5L	X-ray	3.30	F	1-101	[»]
2HGI	X-ray	5.00	I	1-101	[»]
2HGP	X-ray	5.50	I	1-101	[»]
2HGR	X-ray	4.51	I	1-101	[»]
2J00	X-ray	2.80	F	1-101	[»]
2J02	X-ray	2.80	F	1-101	[»]
2OW8	X-ray	3.71	g	-	[»]
2UU9	X-ray	3.10	F	1-101	[»]
2UUA	X-ray	2.90	F	1-101	[»]
2UUB	X-ray	2.90	F	1-101	[»]
2UUC	X-ray	3.10	F	1-101	[»]
2UXB	X-ray	3.10	F	1-101	[»]
2UXC	X-ray	2.90	F	1-101	[»]
2UXD	X-ray	3.20	F	1-101	[»]
2V46	X-ray	3.80	F	1-101	[»]
2V48	X-ray	3.80	F	1-101	[»]
2VQE	X-ray	2.50	F	1-101	[»]
2VQF	X-ray	2.90	F	1-101	[»]
2WDG	X-ray	3.30	F	1-101	[»]
2WDH	X-ray	3.30	F	1-101	[»]
2WDK	X-ray	3.50	F	1-101	[»]
2WDM	X-ray	3.50	F	1-101	[»]
2WH1	X-ray	3.45	F	1-101	[»]
2WH3	X-ray	3.45	F	1-101	[»]
2ZM6	X-ray	3.30	F	1-101	[»]
3FIC	electron microscopy	6.40	F	1-101	[»]

ModBase

Protein-protein interaction databases

STRING

Genome annotation databases

GeneID

GenomeReviews

Gene locus TTHA0245 in contig AP008226_GR.

KEGG

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

OMA

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA0245-MON.

Family and domain databases

HAMAP

MF_00360.
[Tree]

InterPro

IPR000529. Ribosomal_S6.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
[Graphical view]

Gene3D

G3DSA:3.30.70.60. Transl_elong_EF1B/rib_con. 1 hit.

Pfam

PF01250. Ribosomal_S6. 1 hit.
[Graphical view]

ProDom

PD003809. Ribosomal_S6. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00166. S6. 1 hit.

PROSITE

PS01048. RIBOSOMAL_S6. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

RS6_THET8

Accession

Primary (citable) accession number: Q5SLP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	December 21, 2004
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Ribosomal proteins

Ribosomal proteins families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents