Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

50S ribosomal protein L11

Gene

rplK

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. The stalk extends beyond the surface of the 70S ribosome and is preferentially stabilized in 70S versus 50S crystals.
In the 70S ribosome is in a position where it could interact transiently with the A site tRNA during translation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L11UniRule annotation
Gene namesi
Name:rplKUniRule annotation
Ordered Locus Names:TTHA0247
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001043991 – 14750S ribosomal protein L11Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

The protein probably contains twelve methyl groups; at least one lysine residue (Lys-3) is known to be trimethylated. Methylation of the protein is not required for function.2 Publications

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex. Contacts one of the L7 dimers.

Protein-protein interaction databases

IntActiQ5SLP6. 1 interactor.
MINTiMINT-4299414.
STRINGi300852.TTHA0247.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Helixi23 – 28Combined sources6
Turni29 – 31Combined sources3
Helixi34 – 44Combined sources11
Turni45 – 47Combined sources3
Beta strandi52 – 60Combined sources9
Beta strandi65 – 69Combined sources5
Helixi74 – 77Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EGVX-ray1.75B2-147[»]
4V42X-ray5.50BL9-116[»]
4V4PX-ray5.50L6-116[»]
4V4TX-ray6.46K1-141[»]
4V4XX-ray5.00BL1-147[»]
4V4YX-ray5.50BL1-147[»]
4V4ZX-ray4.51BL1-147[»]
4V51X-ray2.80K1-147[»]
4V5EX-ray3.45BK/DK1-147[»]
4V5FX-ray3.60BK/DK1-147[»]
4V5JX-ray3.10BK/DK1-147[»]
4V5Melectron microscopy7.80BK1-147[»]
4V5Nelectron microscopy7.60BK1-147[»]
4V68electron microscopy6.40BL2-139[»]
4V6FX-ray3.10DL1-147[»]
4V9HX-ray2.86BK1-147[»]
4W2EX-ray2.90K1-147[»]
4WPOX-ray2.80AL/CL1-147[»]
4WQFX-ray2.80AL/CL1-147[»]
4WQUX-ray2.80AL/CL1-147[»]
4WQYX-ray2.80AL/CL1-147[»]
5A9Zelectron microscopy4.70AJ4-137[»]
5AA0electron microscopy5.00AJ4-137[»]
5D8BX-ray3.63CB/G1-147[»]
5HAUX-ray3.001K/2K1-147[»]
5IMQelectron microscopy3.8031-147[»]
5IMRelectron microscopy-31-147[»]
5J8BX-ray2.60K1-147[»]
ProteinModelPortaliQ5SLP6.
SMRiQ5SLP6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLP6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L11P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UIK. Bacteria.
COG0080. LUCA.
HOGENOMiHOG000082123.
KOiK02867.
OMAiCKQFNAK.
PhylomeDBiQ5SLP6.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVVAVVKL QLPAGKATPA PPVGPALGQH GANIMEFVKA FNAATANMGD
60 70 80 90 100
AIVPVEITIY ADRSFTFVTK TPPASYLIRK AAGLEKGAHK PGREKVGRIT
110 120 130 140
WEQVLEIAKQ KMPDLNTTDL EAAARMIAGS ARSMGVEVVG APEVKDA
Length:147
Mass (Da):15,505
Last modified:December 21, 2004 - v1
Checksum:i3D8DECEBE85B5FE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → G AA sequence (PubMed:11154066).Curated1
Sequence conflicti23V → G in L10348 (PubMed:1447157).Curated1

Mass spectrometryi

Molecular mass is 15506.2 Da from positions 1 - 147. Determined by MALDI. Weight of the unmethylated protein.1 Publication
Molecular mass is 15675.1 Da from positions 1 - 147. Determined by MALDI. Weight of the methylated protein.1 Publication
Molecular mass is 15678 Da from positions 1 - 147. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70070.1.
L10348 Genomic DNA. No translation available.
RefSeqiWP_011174097.1. NC_006461.1.
YP_143513.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70070; BAD70070; BAD70070.
GeneIDi3168343.
KEGGittj:TTHA0247.
PATRICi23955441. VBITheThe93045_0247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70070.1.
L10348 Genomic DNA. No translation available.
RefSeqiWP_011174097.1. NC_006461.1.
YP_143513.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EGVX-ray1.75B2-147[»]
4V42X-ray5.50BL9-116[»]
4V4PX-ray5.50L6-116[»]
4V4TX-ray6.46K1-141[»]
4V4XX-ray5.00BL1-147[»]
4V4YX-ray5.50BL1-147[»]
4V4ZX-ray4.51BL1-147[»]
4V51X-ray2.80K1-147[»]
4V5EX-ray3.45BK/DK1-147[»]
4V5FX-ray3.60BK/DK1-147[»]
4V5JX-ray3.10BK/DK1-147[»]
4V5Melectron microscopy7.80BK1-147[»]
4V5Nelectron microscopy7.60BK1-147[»]
4V68electron microscopy6.40BL2-139[»]
4V6FX-ray3.10DL1-147[»]
4V9HX-ray2.86BK1-147[»]
4W2EX-ray2.90K1-147[»]
4WPOX-ray2.80AL/CL1-147[»]
4WQFX-ray2.80AL/CL1-147[»]
4WQUX-ray2.80AL/CL1-147[»]
4WQYX-ray2.80AL/CL1-147[»]
5A9Zelectron microscopy4.70AJ4-137[»]
5AA0electron microscopy5.00AJ4-137[»]
5D8BX-ray3.63CB/G1-147[»]
5HAUX-ray3.001K/2K1-147[»]
5IMQelectron microscopy3.8031-147[»]
5IMRelectron microscopy-31-147[»]
5J8BX-ray2.60K1-147[»]
ProteinModelPortaliQ5SLP6.
SMRiQ5SLP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SLP6. 1 interactor.
MINTiMINT-4299414.
STRINGi300852.TTHA0247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70070; BAD70070; BAD70070.
GeneIDi3168343.
KEGGittj:TTHA0247.
PATRICi23955441. VBITheThe93045_0247.

Phylogenomic databases

eggNOGiENOG4108UIK. Bacteria.
COG0080. LUCA.
HOGENOMiHOG000082123.
KOiK02867.
OMAiCKQFNAK.
PhylomeDBiQ5SLP6.

Miscellaneous databases

EvolutionaryTraceiQ5SLP6.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL11_THET8
AccessioniPrimary (citable) accession number: Q5SLP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.